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Volumn 1-4, Issue , 2006, Pages 637-672

Mouse Models in Aging Research

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EID: 78650158744     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369454-6/50074-1     Document Type: Chapter
Times cited : (41)

References (156)
  • 1
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • B.N. Ames, M.K. Shigenaga and T.M. Hagen (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Froc NatlAcad Sci USA 90 7915-7922
    • (1993) Froc NatlAcad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 2
    • 0029838022 scopus 로고    scopus 로고
    • L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males
    • J.R. Archer and D.E. Harrison (1996) L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. J Gerontol A Biol Sci Med Sci 51 B448-B453
    • (1996) J Gerontol A Biol Sci Med Sci , vol.51 , pp. B448-B453
    • Archer, J.R.1    Harrison, D.E.2
  • 4
    • 0030177439 scopus 로고    scopus 로고
    • The uses of intraspecific variation in aging research
    • S.N. Austad (1996) The uses of intraspecific variation in aging research. Exp Gerontol 31 453-4463
    • (1996) Exp Gerontol , vol.31 , pp. 453-4463
    • Austad, S.N.1
  • 5
    • 0348047391 scopus 로고    scopus 로고
    • The retardation of aging by caloric restriction: its significance in the transgenic era
    • J.L. Barger, R.L. Walford and R. Weindruch (2003) The retardation of aging by caloric restriction: its significance in the transgenic era. Exp Gerontol 38 1343-1351
    • (2003) Exp Gerontol , vol.38 , pp. 1343-1351
    • Barger, J.L.1    Walford, R.L.2    Weindruch, R.3
  • 7
    • 0033039097 scopus 로고    scopus 로고
    • Revisiting the role of fat mass in the life exten-sion induced by caloric restriction. J
    • N. Barzilai and G. Gupta (1999) Revisiting the role of fat mass in the life exten-sion induced by caloric restriction. J. Gerontol 54 B89-B96
    • (1999) Gerontol , vol.54 , pp. B89-B96
    • Barzilai, N.1    Gupta, G.2
  • 8
    • 0030748533 scopus 로고    scopus 로고
    • Long-term treatment of male F344 rats with deprenyl: assess-ment of effects on longevity, behavior, and brain function
    • P.C. Bickford, C.E. Actams, S.J. Boyson, P. Curella, G.A. Gerhardt, C. Heron, et al. (1997) Long-term treatment of male F344 rats with deprenyl: assess-ment of effects on longevity, behavior, and brain function. Neurobiol Aging 18 309-318
    • (1997) Neurobiol Aging , vol.18 , pp. 309-318
    • Bickford, P.C.1    Actams, C.E.2    Boyson, S.J.3    Curella, P.4    Gerhardt, G.A.5    Heron, C.6
  • 9
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • M. Blüher, B.B. Kahn and C.R. Kahn (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 572-574
    • (2003) Science , vol.299 , pp. 572-574
    • Blüher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 10
    • 0018133545 scopus 로고
    • Predicting death from behavioral test performance. J
    • J. Botwinick, R. West and N. Storandt (1978) Predicting death from behavioral test performance. J. Gerontol 33 755-762
    • (1978) Gerontol , vol.33 , pp. 755-762
    • Botwinick, J.1    West, R.2    Storandt, N.3
  • 11
    • 0025841730 scopus 로고
    • Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice
    • R.T. Bronson and R.D. Lipman (1991) Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. Growth Dev Aging 55 169-184
    • (1991) Growth Dev Aging , vol.55 , pp. 169-184
    • Bronson, R.T.1    Lipman, R.D.2
  • 14
    • 0028212032 scopus 로고
    • The effect of a long term (6 months) treatment with (-) deprenyl on antioxidant enzyme activities in selective brain regions in old female Fischer 344 rats
    • M. Carrillo, K. Kitani, S. Kanai, Y. Sato, K. Miyasaka and G.O. Ivy (1994) The effect of a long term (6 months) treatment with (-) deprenyl on antioxidant enzyme activities in selective brain regions in old female Fischer 344 rats. Biochem Pharmacol 47 1333-1338
    • (1994) Biochem Pharmacol , vol.47 , pp. 1333-1338
    • Carrillo, M.1    Kitani, K.2    Kanai, S.3    Sato, Y.4    Miyasaka, K.5    Ivy, G.O.6
  • 15
    • 0032840413 scopus 로고    scopus 로고
    • Food restriction-like effects of dehydroepiandrosterone: decreased lymphocyte numbers and functions with increased apoptosis
    • F. Catalina, V. Kumar, L. Milewich and M. Bennett (1999) Food restriction-like effects of dehydroepiandrosterone: decreased lymphocyte numbers and functions with increased apoptosis. Proc Soc Exp Biol Med 221 326-335
    • (1999) Proc Soc Exp Biol Med , vol.221 , pp. 326-335
    • Catalina, F.1    Kumar, V.2    Milewich, L.3    Bennett, M.4
  • 16
    • 0027764702 scopus 로고
    • Evolutionary mechanisms of senescence
    • B. Charlesworth (1993) Evolutionary mechanisms of senescence. Genetica 91 11-19
    • (1993) Genetica , vol.91 , pp. 11-19
    • Charlesworth, B.1
  • 17
    • 4644245973 scopus 로고    scopus 로고
    • Accelerated senes-cence prone mouse-8 shows early onset of deficits in spatial learning and memory in the radial six-arm water maze
    • G.H. Chen, Y.J. Wang, X.M. Wang and J.N. Zhou (2004) Accelerated senes-cence prone mouse-8 shows early onset of deficits in spatial learning and memory in the radial six-arm water maze. Physiol Behav 82 883-890
    • (2004) Physiol Behav , vol.82 , pp. 883-890
    • Chen, G.H.1    Wang, Y.J.2    Wang, X.M.3    Zhou, J.N.4
  • 18
    • 0032920969 scopus 로고    scopus 로고
    • Development and aging of primitive hematopoietic stem cells in BALB/cBy mice
    • J. Chen, C.M. Astle and D.E. Harrison (1999) Development and aging of primitive hematopoietic stem cells in BALB/cBy mice. Exp Hematol 27 928-935
    • (1999) Exp Hematol , vol.27 , pp. 928-935
    • Chen, J.1    Astle, C.M.2    Harrison, D.E.3
  • 19
    • 0034008968 scopus 로고    scopus 로고
    • Genetic regulation of primitive hematopoietic stem cell senescence
    • J. Chen, C.M. Astle and D.E. Harrison (2000) Genetic regulation of primitive hematopoietic stem cell senescence. Exp Hematol 28 442-450
    • (2000) Exp Hematol , vol.28 , pp. 442-450
    • Chen, J.1    Astle, C.M.2    Harrison, D.E.3
  • 20
    • 0142195931 scopus 로고    scopus 로고
    • Hematopoietic senescence is post-poned and hematopoietic stem cell function is enhanced by dietary restriction
    • J. Chen, C.M. Astle and D.E. Harrison (2003) Hematopoietic senescence is post-poned and hematopoietic stem cell function is enhanced by dietary restriction. Exp Hematol 31 1097-1103
    • (2003) Exp Hematol , vol.31 , pp. 1097-1103
    • Chen, J.1    Astle, C.M.2    Harrison, D.E.3
  • 21
    • 0026352187 scopus 로고
    • Suggested guidelines for the housing and husbandry of rodents for aging studies
    • G. Clough (1991) Suggested guidelines for the housing and husbandry of rodents for aging studies. Neurobiol Aging 12 653-658
    • (1991) Neurobiol Aging , vol.12 , pp. 653-658
    • Clough, G.1
  • 22
    • 0014693213 scopus 로고
    • Test-battery to measure aging-rate in man
    • A. Comfort (1969) Test-battery to measure aging-rate in man. Lancet 27 1411-1415
    • (1969) Lancet , vol.27 , pp. 1411-1415
    • Comfort, A.1
  • 23
    • 0034455827 scopus 로고    scopus 로고
    • Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
    • K.T. Coschigano, D. Clemmons, L.L. Bellush and J.J. Kopchick (2000) Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141 2608-2613
    • (2000) Endocrinology , vol.141 , pp. 2608-2613
    • Coschigano, K.T.1    Clemmons, D.2    Bellush, L.L.3    Kopchick, J.J.4
  • 24
    • 0041419437 scopus 로고    scopus 로고
    • Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span
    • K.T. Coschigano, A.N. Holland, M.E. Riders, E.O. List, A. Flyvbjerg and J.J. Kopchick (2003) Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 144 3799-3810
    • (2003) Endocrinology , vol.144 , pp. 3799-3810
    • Coschigano, K.T.1    Holland, A.N.2    Riders, M.E.3    List, E.O.4    Flyvbjerg, A.5    Kopchick, J.J.6
  • 25
    • 0002456078 scopus 로고
    • Design and analysis of aging studies
    • Aging E.J. Masoro (Eds), New York: Oxford University Press
    • P.T. Costa Jr. and R.R. McCrae (1995) Design and analysis of aging studies. Aging E.J. Masoro (Eds) Handbook of physiology, Section 11 New York: Oxford University Press 25-36
    • (1995) Handbook of physiology, Section 11 , pp. 25-36
    • Costa, P.T.1    McCrae, R.R.2
  • 26
    • 13744258936 scopus 로고    scopus 로고
    • The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging
    • J.P. de Magalhaes, J.A. Cabrai and D. Magalhaes (2005) The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics 169 265-274
    • (2005) Genetics , vol.169 , pp. 265-274
    • de Magalhaes, J.P.1    Cabrai, J.A.2    Magalhaes, D.3
  • 28
    • 0025087733 scopus 로고
    • Differences in expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice
    • D.N. Ernst, M.V. Hobbs, B.E. Torbett, A.L. Glasebrook, M.A. Rehse, K. Bottomly, et al. (1990) Differences in expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol 145 1295-1302
    • (1990) J Immunol , vol.145 , pp. 1295-1302
    • Ernst, D.N.1    Hobbs, M.V.2    Torbett, B.E.3    Glasebrook, A.L.4    Rehse, M.A.5    Bottomly, K.6
  • 29
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late life diseases, and frailty
    • W.B. Ershler and E.T. Keller (2000) Age-associated increased interleukin-6 gene expression, late life diseases, and frailty. Ann Rev Med 51 245-270
    • (2000) Ann Rev Med , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 30
    • 0015529108 scopus 로고
    • Lymphocytes, hormones and ageing
    • N. Fabris, W Pierpaoli and E. Sorkin (1972) Lymphocytes, hormones and ageing. Nature 240 557-559
    • (1972) Nature , vol.240 , pp. 557-559
    • Fabris, N.1    Pierpaoli, W.2    Sorkin, E.3
  • 31
    • 0032855098 scopus 로고    scopus 로고
    • Warning: the use of heterogeneous mice may seriously damage your research
    • M. Festing (1999) Warning: the use of heterogeneous mice may seriously damage your research. Neurbiol Aging 20 237-244
    • (1999) Neurbiol Aging , vol.20 , pp. 237-244
    • Festing, M.1
  • 33
    • 11444257052 scopus 로고    scopus 로고
    • Developmental origins of aging in brain and blood vessels: an overview
    • C.E. Finch (2005) Developmental origins of aging in brain and blood vessels: an overview. Neurobiol Aging 26 281-291
    • (2005) Neurobiol Aging , vol.26 , pp. 281-291
    • Finch, C.E.1
  • 34
    • 0019268979 scopus 로고
    • Studies on ovarian-hypothalamic-pituitary interac-tions during reproductive aging in C57BL/6J mice
    • C.E. Finch, L.S. Felicio, K. Flurkey, D.M. Gee, C.V. Mobbs, J.F. Nelson and H.H. Osterburg (1980) Studies on ovarian-hypothalamic-pituitary interac-tions during reproductive aging in C57BL/6J mice. Peptides 1 163-175
    • (1980) Peptides , vol.1 , pp. 163-175
    • Finch, C.E.1    Felicio, L.S.2    Flurkey, K.3    Gee, D.M.4    Mobbs, C.V.5    Nelson, J.F.6    Osterburg, H.H.7
  • 35
    • 0021492228 scopus 로고
    • Ovarian and steroidal influences on neuroendocrine aging processes in female rodents
    • C.E. Finch, L.S. Felicio, C.V. Mobbs and J.F. Nelson (1984) Ovarian and steroidal influences on neuroendocrine aging processes in female rodents. Endocrine Rev 5 467-497
    • (1984) Endocrine Rev , vol.5 , pp. 467-497
    • Finch, C.E.1    Felicio, L.S.2    Mobbs, C.V.3    Nelson, J.F.4
  • 36
    • 0024414994 scopus 로고
    • Limitations of interpretation of age-related changes in hor-mone levels: illustration by effects of thyroid hormones on cardiac and skeletal muscle. J
    • J.R. Florini (1989) Limitations of interpretation of age-related changes in hor-mone levels: illustration by effects of thyroid hormones on cardiac and skeletal muscle. J. Gerontol 44 B107-B109
    • (1989) Gerontol , vol.44 , pp. B107-B109
    • Florini, J.R.1
  • 37
    • 0024448419 scopus 로고
    • Skeletal muscle fiber types and myosin ATPase activity do not change with age or growth hormone administration
    • J.R. Florini and D.Z. Ewton (1989) Skeletal muscle fiber types and myosin ATPase activity do not change with age or growth hormone administration. J Gerontol 44 BUO-lll
    • (1989) J Gerontol , vol.44 , pp. BUO-lll
    • Florini, J.R.1    Ewton, D.Z.2
  • 38
    • 84884420650 scopus 로고    scopus 로고
    • Gerontology
    • G.D. Considine, PH. Kulik (Eds), 9th ed., New York: John Wiley & Sons, Inc
    • K. Flurkey (2001) Gerontology. G.D. Considine, PH. Kulik (Eds) Van Nostrand's scientific encyclopedia 9th ed. New York: John Wiley & Sons, Inc. 1614-1620
    • (2001) Van Nostrand's scientific encyclopedia , pp. 1614-1620
    • Flurkey, K.1
  • 40
    • 0006866013 scopus 로고
    • Use of genetic models to investigate the hypophyseal regulation of senescence
    • D.E. Harrison (Eds), Caldwell, NJ: Telford Press
    • K. Flurkey and D.E. Harrison (1990) Use of genetic models to investigate the hypophyseal regulation of senescence. D.E. Harrison (Eds) enetic effects on aging II Caldwell, NJ: Telford Press 437-456
    • (1990) enetic effects on aging II , pp. 437-456
    • Flurkey, K.1    Harrison, D.E.2
  • 41
    • 0026505797 scopus 로고
    • Memory T lymphocyte hypore-sponsiveness to non-cognate stimuli: a key factor in age-related immunodeficiency
    • K. Flurkey, M. Stadecker and R.A. Miller (1992) Memory T lymphocyte hypore-sponsiveness to non-cognate stimuli: a key factor in age-related immunodeficiency. Eur J Immunol 22 931-935
    • (1992) Eur J Immunol , vol.22 , pp. 931-935
    • Flurkey, K.1    Stadecker, M.2    Miller, R.A.3
  • 42
    • 0035811073 scopus 로고    scopus 로고
    • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    • K. Flurkey, J. Papaconstantinou, R.A. Miller and D.E. Harrison (2001) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A 98 6736-6741
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6736-6741
    • Flurkey, K.1    Papaconstantinou, J.2    Miller, R.A.3    Harrison, D.E.4
  • 43
    • 0036132447 scopus 로고    scopus 로고
    • The Snell dwarf muta-tion Pitldw can increase life span in mice
    • K. Flurkey, J. Papaconstantinou and D.E. Harrison (2002) The Snell dwarf muta-tion Pitldw can increase life span in mice. Mech Ageing Dev 123 121-130
    • (2002) Mech Ageing Dev , vol.123 , pp. 121-130
    • Flurkey, K.1    Papaconstantinou, J.2    Harrison, D.E.3
  • 45
    • 0013942563 scopus 로고
    • The moulding of senescence by natural selection
    • W.D. Hamilton (1966) The moulding of senescence by natural selection. J Theor Biol 12 12-45
    • (1966) J Theor Biol , vol.12 , pp. 12-45
    • Hamilton, W.D.1
  • 46
    • 0142059585 scopus 로고    scopus 로고
    • Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice
    • J.M. Harper, N. Wolf, A.T. Galecki, S.L. Pinkosky and R.A. Miller (2003) Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice. Mech Ageing Dev 124 801-810
    • (2003) Mech Ageing Dev , vol.124 , pp. 801-810
    • Harper, J.M.1    Wolf, N.2    Galecki, A.T.3    Pinkosky, S.L.4    Miller, R.A.5
  • 47
    • 2342665620 scopus 로고    scopus 로고
    • Body weight, hor-mones and T cell subsets as predictors of life span in genetically heterogeneous mice
    • J.M. Harper, A.T. Galecki, D.T. Burke and R.A. Miller (2004) Body weight, hor-mones and T cell subsets as predictors of life span in genetically heterogeneous mice. Mech Ageing Dev 125 381-390
    • (2004) Mech Ageing Dev , vol.125 , pp. 381-390
    • Harper, J.M.1    Galecki, A.T.2    Burke, D.T.3    Miller, R.A.4
  • 48
    • 0015505909 scopus 로고
    • Normal function of transplanted mouse erythrocyte pre-cursors for 21 months beyond donor life spans
    • D.E. Harrison (1972) Normal function of transplanted mouse erythrocyte pre-cursors for 21 months beyond donor life spans. Nat New Biol 237 220-222
    • (1972) Nat New Biol , vol.237 , pp. 220-222
    • Harrison, D.E.1
  • 49
    • 0012304514 scopus 로고
    • Cell and tissue transplantation: a means of studying the aging process
    • nd ed., New York: Van Nostrand Reinhold Co
    • D.E. Harrison (1985) Cell and tissue transplantation: a means of studying the aging process. C E. Finch, E.L. Schneider (Eds) Handbook of the biology of aging 2nd ed. New York: Van Nostrand Reinhold Co. 322-350
    • (1985) Handbook of the biology of aging , pp. 322-350
    • Harrison, D.E.1
  • 50
    • 0028113030 scopus 로고
    • Potential misinterpretations using models of accelerated aging. J
    • D.E. Harrison (1994) Potential misinterpretations using models of accelerated aging. J. Gerontol Biol Sci 49 B245
    • (1994) Gerontol Biol Sci , vol.49 , pp. B245
    • Harrison, D.E.1
  • 51
    • 0031216231 scopus 로고    scopus 로고
    • Animal models showing “accelerated aging” are more likely to be useful for pathology than for mechanisms of aging
    • D.E. Harrison (1997) Animal models showing “accelerated aging” are more likely to be useful for pathology than for mechanisms of aging. Growth Dev Aging 61 167-168
    • (1997) Growth Dev Aging , vol.61 , pp. 167-168
    • Harrison, D.E.1
  • 52
    • 0017805239 scopus 로고
    • Measurement of changes in mouse tail col-lagen with age: temperature dependence and procedural details
    • D.E. Harrison and J.R. Archer (1978) Measurement of changes in mouse tail col-lagen with age: temperature dependence and procedural details. Exp Gerontol 13 75-82
    • (1978) Exp Gerontol , vol.13 , pp. 75-82
    • Harrison, D.E.1    Archer, J.R.2
  • 53
    • 0021048571 scopus 로고
    • Physiological assays for biological age in mice: relationship of collagen, renal function and longevity
    • D.E. Harrison and J.R. Archer (1983) Physiological assays for biological age in mice: relationship of collagen, renal function and longevity. Exp Aging Res 9 245-251
    • (1983) Exp Aging Res , vol.9 , pp. 245-251
    • Harrison, D.E.1    Archer, J.R.2
  • 54
    • 0023099924 scopus 로고
    • Genetic effects on responses to food restric-tion in aging mice
    • D.E. Harrison and J.R. Archer (1987) Genetic effects on responses to food restric-tion in aging mice. J Nutr 117 376-382
    • (1987) J Nutr , vol.117 , pp. 376-382
    • Harrison, D.E.1    Archer, J.R.2
  • 55
    • 0023682911 scopus 로고
    • Biomarkers of aging: tissue markers, future research needs, strategies, directions and priorities
    • D.E. Harrison and J.R. Archer (1988) Biomarkers of aging: tissue markers, future research needs, strategies, directions and priorities. Exp Gerontol 23 309-321
    • (1988) Exp Gerontol , vol.23 , pp. 309-321
    • Harrison, D.E.1    Archer, J.R.2
  • 56
    • 0020403099 scopus 로고
    • Loss of stem cell repopulating ability upon transplantation: effects of donor age, cell number, and transplantation proce-dure. J
    • D.E. Harrison and C.M. Astle (1982) Loss of stem cell repopulating ability upon transplantation: effects of donor age, cell number, and transplantation proce-dure. J. Exp Med 156 1767-1779
    • (1982) Exp Med , vol.156 , pp. 1767-1779
    • Harrison, D.E.1    Astle, C.M.2
  • 57
    • 0030939638 scopus 로고    scopus 로고
    • Selection for maximum longevity in mice
    • D.E. Harrison and T.H. Roderick (1997) Selection for maximum longevity in mice. Exp Gerontol 32 65-78
    • (1997) Exp Gerontol , vol.32 , pp. 65-78
    • Harrison, D.E.1    Roderick, T.H.2
  • 58
    • 0017833969 scopus 로고
    • Tail collagen aging in mice of thirteen different genotypes and two species: relationship to biological age
    • D.E. Harrison, J.R. Archer, G.A. Sacher and KM. Boyce (1978) Tail collagen aging in mice of thirteen different genotypes and two species: relationship to biological age. Exp Gerontol 13 63-73
    • (1978) Exp Gerontol , vol.13 , pp. 63-73
    • Harrison, D.E.1    Archer, J.R.2    Sacher, G.A.3    Boyce, K.M.4
  • 59
    • 0020384525 scopus 로고
    • The effect of hypophysectomy on thymic aging in mice
    • D.E. Harrison, J.R. Archer and C.M. Astle (1982) The effect of hypophysectomy on thymic aging in mice. J Immunol 129 2673-2677
    • (1982) J Immunol , vol.129 , pp. 2673-2677
    • Harrison, D.E.1    Archer, J.R.2    Astle, C.M.3
  • 60
    • 0001001689 scopus 로고
    • Effects of food restriction on aging: separation of food intake and adiposity
    • D.E. Harrison, J.R. Archer and C.M. Astle (1984) Effects of food restriction on aging: separation of food intake and adiposity. Proc NatlAcad Sci USA 81 1835-1838
    • (1984) Proc NatlAcad Sci USA , vol.81 , pp. 1835-1838
    • Harrison, D.E.1    Archer, J.R.2    Astle, C.M.3
  • 61
    • 0024380947 scopus 로고
    • Effects of age on transplantable primitive immuno-hematopoietic stem cell (PSC) numbers and functions
    • D.E. Harrison, C.M. Astle and M. Stone (1989) Effects of age on transplantable primitive immuno-hematopoietic stem cell (PSC) numbers and functions. J Immunol 142 3833-3840
    • (1989) J Immunol , vol.142 , pp. 3833-3840
    • Harrison, D.E.1    Astle, C.M.2    Stone, M.3
  • 62
    • 0343830627 scopus 로고
    • Genes regulate effects of dietary restriction
    • L. Fishbein (Eds), New York: Springer-Verlag
    • D.E. Harrison, J.R. Archer and B. Kent (1991) Genes regulate effects of dietary restriction. L. Fishbein (Eds) Biological effects of dietary restriction New York: Springer-Verlag 264-286
    • (1991) Biological effects of dietary restriction , pp. 264-286
    • Harrison, D.E.1    Archer, J.R.2    Kent, B.3
  • 63
    • 0027893247 scopus 로고
    • Primitive hemo-poietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation, and covariance calculations
    • D.E. Harrison, CT. Jordan, R.K. Zhong and C.M. Astle (1993) Primitive hemo-poietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation, and covariance calculations. Exp Hematol 21 206-219
    • (1993) Exp Hematol , vol.21 , pp. 206-219
    • Harrison, D.E.1    Jordan, C.T.2    Zhong, R.K.3    Astle, C.M.4
  • 64
    • 4544377929 scopus 로고    scopus 로고
    • Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity
    • P. Hasty and J. Vijg (2004) Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell 3 55
    • (2004) Aging Cell , vol.3 , pp. 55
    • Hasty, P.1    Vijg, J.2
  • 65
    • 0023628408 scopus 로고
    • Increase in life expectancy for mice fed diethyl-hydroxylamine (DEHA)
    • J. Heicklen and E. Brown (1987) Increase in life expectancy for mice fed diethyl-hydroxylamine (DEHA). J Gerontol 42 674-680
    • (1987) J Gerontol , vol.42 , pp. 674-680
    • Heicklen, J.1    Brown, E.2
  • 66
    • 0031749354 scopus 로고    scopus 로고
    • Mortality and biomarkers of aging in heterogeneous stock (HS) mice. J
    • D.A. Heller, KM. Ahern, J.T. Stout and G.E. McClearn (1998) Mortality and biomarkers of aging in heterogeneous stock (HS) mice. J. Gerontol 53A B217-B230
    • (1998) Gerontol , vol.53A , pp. B217-B230
    • Heller, D.A.1    Ahern, K.M.2    Stout, J.T.3    McClearn, G.E.4
  • 67
    • 0000521753 scopus 로고
    • Exercise
    • E.J. Masoro (Eds), New York: Oxford University Press, Section 11, Aging
    • J.O. Holloszy and W.M. Kohrt (1995) Exercise. E.J. Masoro (Eds) Handbook of physiology New York: Oxford University Press 633-666. Section 11, Aging
    • (1995) Handbook of physiology , pp. 633-666
    • Holloszy, J.O.1    Kohrt, W.M.2
  • 69
    • 0021080969 scopus 로고
    • Towards the behavioral assessment of biological aging in the laboratory mouse: concepts, terminology and objectives
    • D.K. Ingram (1983) Towards the behavioral assessment of biological aging in the laboratory mouse: concepts, terminology and objectives. Exp Aging Res 9 225-238
    • (1983) Exp Aging Res , vol.9 , pp. 225-238
    • Ingram, D.K.1
  • 70
    • 0022897807 scopus 로고
    • Assessing the predictive validity of psy-chomotor tests as measures of biological age in mice
    • D.K. Ingram and M.A. Reynolds (1986) Assessing the predictive validity of psy-chomotor tests as measures of biological age in mice. Exp Aging Res 12 155-162
    • (1986) Exp Aging Res , vol.12 , pp. 155-162
    • Ingram, D.K.1    Reynolds, M.A.2
  • 71
    • 0020362754 scopus 로고
    • Physiological and behavioral correlates of lifespan in aged C57BL/6J mice
    • D.K. Ingram, J.R. Archer, D.E. Harrison and M.A. Reynolds (1982) Physiological and behavioral correlates of lifespan in aged C57BL/6J mice. Exp Gerontol 17 295-303
    • (1982) Exp Gerontol , vol.17 , pp. 295-303
    • Ingram, D.K.1    Archer, J.R.2    Harrison, D.E.3    Reynolds, M.A.4
  • 72
    • 0036141752 scopus 로고    scopus 로고
    • Mouse loci asso-ciated with life span exhibit sex-specific and epistatic effects
    • A.U. Jackson, A.T. Galecki, D.T. Burke and R.A. Miller (2002) Mouse loci asso-ciated with life span exhibit sex-specific and epistatic effects. J Gerontol 57 B9-B15
    • (2002) J Gerontol , vol.57 , pp. B9-B15
    • Jackson, A.U.1    Galecki, A.T.2    Burke, D.T.3    Miller, R.A.4
  • 73
    • 0028260335 scopus 로고
    • (-) Deprenyl increases the lifespan as well as activities of Superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions in Fischer rats
    • K. Kitani, S. Kanai, M.C. Carrillo and G.O. Ivy (1994) (-) Deprenyl increases the lifespan as well as activities of Superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions in Fischer rats. Ann N Y Acad Sci 717 72-78
    • (1994) Ann N Y Acad Sci , vol.717 , pp. 72-78
    • Kitani, K.1    Kanai, S.2    Carrillo, M.C.3    Ivy, G.O.4
  • 74
    • 0018561650 scopus 로고
    • Age-related changes in the immune system of mice of eight medium and long-lived strains and hybrids. I. Organ, cellular and activity changes
    • M.M.B. Kay, J. Mendoza, J. Diven, T. Denton, N. Union and M. Lajiness (1979) Age-related changes in the immune system of mice of eight medium and long-lived strains and hybrids. I. Organ, cellular and activity changes. Mech Ageing Dev 11 295-346
    • (1979) Mech Ageing Dev , vol.11 , pp. 295-346
    • Kay, M.M.B.1    Mendoza, J.2    Diven, J.3    Denton, T.4    Union, N.5    Lajiness, M.6
  • 75
    • 0036132118 scopus 로고    scopus 로고
    • Optimizing detection of QTLs retarding aging: choice of statistical model and animal requirements
    • S. Klebanov and D.E. Harrison (2002) Optimizing detection of QTLs retarding aging: choice of statistical model and animal requirements. Mech Ageing Dev 123 131-144
    • (2002) Mech Ageing Dev , vol.123 , pp. 131-144
    • Klebanov, S.1    Harrison, D.E.2
  • 77
    • 0035213017 scopus 로고    scopus 로고
    • Heritability of life span in mice and its implication for direct and indirect selection for longevity
    • S. Klebanov, K. Flurkey, T.H. Roderick, J.R. Archer, M.C. Astle, J. Chen and D.E. Harrison (2001) Heritability of life span in mice and its implication for direct and indirect selection for longevity. Genetica 110 209-218
    • (2001) Genetica , vol.110 , pp. 209-218
    • Klebanov, S.1    Flurkey, K.2    Roderick, T.H.3    Archer, J.R.4    Astle, M.C.5    Chen, J.6    Harrison, D.E.7
  • 78
    • 22544449911 scopus 로고    scopus 로고
    • Adipose tissue transplantation protects ob/ob mice from obesity, nor-malizes insulin sensitivity and restores fertility
    • S. Klebanov, M.C. Astle, O. DeSimone, V. Ablamunits and D.E. Harrison (2005) Adipose tissue transplantation protects ob/ob mice from obesity, nor-malizes insulin sensitivity and restores fertility. J Endocrinol 186 203-211
    • (2005) J Endocrinol , vol.186 , pp. 203-211
    • Klebanov, S.1    Astle, M.C.2    DeSimone, O.3    Ablamunits, V.4    Harrison, D.E.5
  • 79
    • 0024267460 scopus 로고
    • The striatal dopamine dependency of life span in male rats: longevity study with (-) deprenyl
    • J. Knoll (1988) The striatal dopamine dependency of life span in male rats: longevity study with (-) deprenyl. Mech Ageing Dev 46 237-262
    • (1988) Mech Ageing Dev , vol.46 , pp. 237-262
    • Knoll, J.1
  • 80
    • 0028834176 scopus 로고
    • The role of thymus in the aging of Th cell subpopulations and age-associated alteration of cytokine production by these cells
    • C. Kurashima, M. Utsuyama, M. Kasai, S.A. Ishijima, A. Konno and K. Hirokawa (1995) The role of thymus in the aging of Th cell subpopulations and age-associated alteration of cytokine production by these cells. Int Immunol 7 97-104
    • (1995) Int Immunol , vol.7 , pp. 97-104
    • Kurashima, C.1    Utsuyama, M.2    Kasai, M.3    Ishijima, S.A.4    Konno, A.5    Hirokawa, K.6
  • 81
    • 0036734833 scopus 로고    scopus 로고
    • Evidence that brain-derived neu-rotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    • J. Lee, W. Duan and M.P. Mattson (2002) Evidence that brain-derived neu-rotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82 1367-1375
    • (2002) J Neurochem , vol.82 , pp. 1367-1375
    • Lee, J.1    Duan, W.2    Mattson, M.P.3
  • 82
    • 0024475129 scopus 로고
    • Pgp-lhi lymphocytes accumulate with age in mice and respond poorly to concanavalin A
    • A. Lerner, T. Yamada and R.A. Miller (1989) Pgp-lhi lymphocytes accumulate with age in mice and respond poorly to concanavalin A. EurJ Immunol 19 977-982
    • (1989) EurJ Immunol , vol.19 , pp. 977-982
    • Lerner, A.1    Yamada, T.2    Miller, R.A.3
  • 84
    • 0032527920 scopus 로고    scopus 로고
    • Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice
    • R.D. Lipman, R.T. Bronson, D. Wu, D.E. Smith, R. Prior, G. Cao, et al. (1998) Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice. Mech Ageing Dev 103 269-284
    • (1998) Mech Ageing Dev , vol.103 , pp. 269-284
    • Lipman, R.D.1    Bronson, R.T.2    Wu, D.3    Smith, D.E.4    Prior, R.5    Cao, G.6
  • 86
    • 0033377755 scopus 로고    scopus 로고
    • Effects of genotype and diet on age-related lesions in ad libitum fed and calorie-restricted F344, BN, and BNF3F1 rats
    • R.D. Lipman, G.E. Dallai and R.T. Bronson (1999) Effects of genotype and diet on age-related lesions in ad libitum fed and calorie-restricted F344, BN, and BNF3F1 rats. J Gerontol A Biol Sci Med Sci 54 B478-B491
    • (1999) J Gerontol A Biol Sci Med Sci , vol.54 , pp. B478-B491
    • Lipman, R.D.1    Dallai, G.E.2    Bronson, R.T.3
  • 89
    • 0022048716 scopus 로고
    • Does food restriction retard aging by reducing metabolic rate?
    • R.J.M. McCarter, E.J. Masoro and B.P. Yu (1985) Does food restriction retard aging by reducing metabolic rate? Am J Physiol 248 488-490
    • (1985) Am J Physiol , vol.248 , pp. 488-490
    • McCarter, R.J.M.1    Masoro, E.J.2    Yu, B.P.3
  • 90
    • 0032878512 scopus 로고    scopus 로고
    • Genes as gerontological variables: uni-form genotypes
    • G.E. McClearn and S.M. Hof er S.M. (1999) Genes as gerontological variables: uni-form genotypes. Neurobiol Aging 20 95-104
    • (1999) Neurobiol Aging , vol.20 , pp. 95-104
    • McClearn, G.E.1    Hof, S.M.2
  • 91
    • 0032879787 scopus 로고    scopus 로고
    • Genes as gerontological variables: genet-ically heterogeneous stocks and complex systems
    • G.E. McClearn and S.M. Hofer (1999) Genes as gerontological variables: genet-ically heterogeneous stocks and complex systems. Neurobiol Aging 20 147-156
    • (1999) Neurobiol Aging , vol.20 , pp. 147-156
    • McClearn, G.E.1    Hofer, S.M.2
  • 92
    • 0017840139 scopus 로고
    • Genetic syndromes in man with potential relevance to the pathology of aging
    • D. Bergsma, D.E. Harrison (Eds), New York: Alan R. Liss, Inc., Section I
    • G.N. Martin (1978) Genetic syndromes in man with potential relevance to the pathology of aging. D. Bergsma, D.E. Harrison (Eds) Genetic effect on aging New York: Alan R. Liss, Inc. 5-39. Section I
    • (1978) Genetic effect on aging , pp. 5-39
    • Martin, G.N.1
  • 93
    • 0021245012 scopus 로고
    • Nutrition as a modulator of the aging process
    • E.J. Masoro (1984) Nutrition as a modulator of the aging process. The Physiologist 27 98-101
    • (1984) The Physiologist , vol.27 , pp. 98-101
    • Masoro, E.J.1
  • 94
    • 0026341970 scopus 로고
    • Use of rodents as models for the study of “normal aging”: conceptual and practical issues
    • E.J. Masoro (1991) Use of rodents as models for the study of “normal aging”: conceptual and practical issues. Neurobiol Aging 12 639-643
    • (1991) Neurobiol Aging , vol.12 , pp. 639-643
    • Masoro, E.J.1
  • 95
    • 0002546845 scopus 로고
    • Aging: current concepts
    • E.J. Masoro (Eds), New York: Oxford University Press, Section 11, Aging
    • E.J. Masoro (1995) Aging: current concepts. E.J. Masoro (Eds) Handbook of physiology New York: Oxford University Press 3-24. Section 11, Aging
    • (1995) Handbook of physiology , pp. 3-24
    • Masoro, E.J.1
  • 96
    • 0026526384 scopus 로고
    • Dietary restriction alters characteristics of glucose fuel use. J
    • E.J. Masoro, R.J. McCarter, M.S. Katz and C.A. McMahan (1992) Dietary restriction alters characteristics of glucose fuel use. J. Gerontol 47 B202-B208
    • (1992) Gerontol , vol.47 , pp. B202-B208
    • Masoro, E.J.1    McCarter, R.J.2    Katz, M.S.3    McMahan, C.A.4
  • 97
    • 0036304650 scopus 로고    scopus 로고
    • Modification of brain aging and neurodegenerative disorders by genes, and diet restriction
    • M.P. Mattson, S.L. Chan and W. Duan (2002) Modification of brain aging and neurodegenerative disorders by genes, and diet restriction. Physiol Rev 82 637-672
    • (2002) Physiol Rev , vol.82 , pp. 637-672
    • Mattson, M.P.1    Chan, S.L.2    Duan, W.3
  • 98
    • 0004220736 scopus 로고
    • London: H.K. Lewis, (Monograph of lecture delivered at University College, London, 6 Dec 1951)
    • P.B. Medawar (1952) An unsolved problem of biology. London: H.K. Lewis (Monograph of lecture delivered at University College, London, 6 Dec 1951)
    • (1952) An unsolved problem of biology
    • Medawar, P.B.1
  • 100
    • 0000697659 scopus 로고
    • Immune system
    • E.J. Masoro (Eds), New York: Oxford University Press, Section 11, Aging
    • R.A. Miller (1995) Immune system. E.J. Masoro (Eds) Handbook of physiology New York: Oxford University Press 555-590. Section 11, Aging
    • (1995) Handbook of physiology , pp. 555-590
    • Miller, R.A.1
  • 101
    • 0035074534 scopus 로고    scopus 로고
    • Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, geneti-cally hetrogenous mouse population
    • R.A. Miller (2001) Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, geneti-cally hetrogenous mouse population. J Gerontol A Biol Med Sci 56 B180-B186
    • (2001) J Gerontol A Biol Med Sci , vol.56 , pp. B180-B186
    • Miller, R.A.1
  • 102
    • 4444327055 scopus 로고    scopus 로고
    • 'Accelerated aging': a primrose path to insight?
    • R.A. Miller (2004) 'Accelerated aging': a primrose path to insight? Aging Cell 3 47-51
    • (2004) Aging Cell , vol.3 , pp. 47-51
    • Miller, R.A.1
  • 103
    • 84855413338 scopus 로고    scopus 로고
    • Principles of animal use for gerontological research
    • P.M. Conn (Eds), New York: Elsevier, Chapter 3
    • R.A. Miller (2006) Principles of animal use for gerontological research. P.M. Conn (Eds) Handbook for models of human aging New York: Elsevier 21-31. Chapter 3
    • (2006) Handbook for models of human aging , pp. 21-31
    • Miller, R.A.1
  • 104
    • 0032777536 scopus 로고    scopus 로고
    • Lifelong treatment with oral DHEA sulfate does not preserve immune function, prevent disease, or improve survival in genetically heterogeneous mice
    • R.A. Miller and C. Chrisp (1999) Lifelong treatment with oral DHEA sulfate does not preserve immune function, prevent disease, or improve survival in genetically heterogeneous mice. J Am Geriatr Soc 47 960-966
    • (1999) J Am Geriatr Soc , vol.47 , pp. 960-966
    • Miller, R.A.1    Chrisp, C.2
  • 105
    • 0036681649 scopus 로고    scopus 로고
    • T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice
    • R.A. Miller and C. Chrisp (2002) T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice. J Immunol 169 1619-1625
    • (2002) J Immunol , vol.169 , pp. 1619-1625
    • Miller, R.A.1    Chrisp, C.2
  • 106
    • 0034053957 scopus 로고    scopus 로고
    • Principles of animal use for gerontological research. J
    • R.A. Miller and N.L. Nadon (2000) Principles of animal use for gerontological research. J. Gerontol A Biol Sci Med Sci 55A B117-B123
    • (2000) Gerontol A Biol Sci Med Sci , vol.55A , pp. B117-B123
    • Miller, R.A.1    Nadon, N.L.2
  • 108
    • 0032877158 scopus 로고    scopus 로고
    • Exotic mice as models for aging research, polemic and prospectus
    • R.A. Miller, S.N. Austad, D. Burke, C. Chrisp, R. Dysko, et al. (1999) Exotic mice as models for aging research, polemic and prospectus. Neurobiol Aging 20 217-231
    • (1999) Neurobiol Aging , vol.20 , pp. 217-231
    • Miller, R.A.1    Austad, S.N.2    Burke, D.3    Chrisp, C.4    Dysko, R.5
  • 110
    • 0034893757 scopus 로고    scopus 로고
    • Lack of an effect of vitamin E on lifespan of mice
    • A.A. Morley and K.J. Trainor (2001) Lack of an effect of vitamin E on lifespan of mice. Biogerontology 2 109-112
    • (2001) Biogerontology , vol.2 , pp. 109-112
    • Morley, A.A.1    Trainor, K.J.2
  • 111
    • 0343005385 scopus 로고
    • Disease patterns in aging inbred mouse strains: interaction of genetics and environment
    • D. Bergsma, D.E. Harrison (Eds), New York: Alan R. Liss
    • D.D. Myers (1978) Disease patterns in aging inbred mouse strains: interaction of genetics and environment. D. Bergsma, D.E. Harrison (Eds) Genetic effects on aging New York: Alan R. Liss 41-53
    • (1978) Genetic effects on aging , pp. 41-53
    • Myers, D.D.1
  • 112
    • 6944248738 scopus 로고    scopus 로고
    • Maintaining aged rodents for biogerontology research
    • N. Nadon (2004) Maintaining aged rodents for biogerontology research. Lab Anim 33 36-41
    • (2004) Lab Anim , vol.33 , pp. 36-41
    • Nadon, N.1
  • 113
    • 84884448733 scopus 로고
    • Prevention of AKR leukemia by thymectomy at varying ages
    • K. Nakakuki, H. Shisa and Y. Nishizuka (1967) Prevention of AKR leukemia by thymectomy at varying ages. Acta Haemat 38 317
    • (1967) Acta Haemat , vol.38 , pp. 317
    • Nakakuki, K.1    Shisa, H.2    Nishizuka, Y.3
  • 114
    • 20044366932 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes
    • HJ. Pan, P. Reifsnyder, D.E. Vance, Q. Xiao and E.H. Leiter (2005) Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes. Diabetes 54 1854-1862
    • (2005) Diabetes , vol.54 , pp. 1854-1862
    • Pan, H.J.1    Reifsnyder, P.2    Vance, D.E.3    Xiao, Q.4    Leiter, E.H.5
  • 115
    • 0027469970 scopus 로고
    • Optimality, mutation and the evolution of ageing
    • L. Partridge and N.H. Barton (1993) Optimality, mutation and the evolution of ageing. Nature 362 305-311
    • (1993) Nature , vol.362 , pp. 305-311
    • Partridge, L.1    Barton, N.H.2
  • 116
    • 0028013595 scopus 로고
    • Selecting animal models of human aging. Inbred strains often exhibit less biological uniformity than Fl hybrids
    • J.P. Phelan and S.N. Austad (1994) Selecting animal models of human aging. Inbred strains often exhibit less biological uniformity than Fl hybrids. J Gerontol 4 Bl-Bll
    • (1994) J Gerontol , vol.4 , pp. Bl-Bll
    • Phelan, J.P.1    Austad, S.N.2
  • 117
    • 20044394908 scopus 로고    scopus 로고
    • Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse
    • Epub 2004 Nov 9
    • M.T. Pletcher, P. McClurg, S. Batalov, A.I. Su, S.W. Barnes and E. Lagler E.et al (2004) Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol 2 e393 Epub 2004 Nov 9
    • (2004) PLoS Biol 2 , vol.e393
    • Pletcher, M.T.1    McClurg, P.2    Batalov, S.3    Su, A.I.4    Barnes, S.W.5    Lagler, E.6
  • 118
    • 0026718001 scopus 로고
    • Age-related changes in LFA-1 expression, cell adhesion, and PHA-induced proliferation by lymphocytes from senescence-accelerated mouse (SAM) -P/8 and SAM-R/1 substrains
    • D.C. Powers, J.E. Morley and J.F. Flood (1992) Age-related changes in LFA-1 expression, cell adhesion, and PHA-induced proliferation by lymphocytes from senescence-accelerated mouse (SAM) -P/8 and SAM-R/1 substrains. Cell Immunol 141 444-456
    • (1992) Cell Immunol , vol.141 , pp. 444-456
    • Powers, D.C.1    Morley, J.E.2    Flood, J.F.3
  • 119
    • 0033119046 scopus 로고    scopus 로고
    • Dietary intervention at middle-age: caloric restriction but not dehydroepiandrosterone sulfate increases life span and lifetime cancer incidence in mice
    • T.D. Pugh, T.D. Oberley and R. Weindruch (1999) Dietary intervention at middle-age: caloric restriction but not dehydroepiandrosterone sulfate increases life span and lifetime cancer incidence in mice. Cancer Res 59 1642-1648
    • (1999) Cancer Res , vol.59 , pp. 1642-1648
    • Pugh, T.D.1    Oberley, T.D.2    Weindruch, R.3
  • 120
    • 4243843266 scopus 로고
    • The evidence for pituitary and thyroid control of aging: is age reversal a myth or reality? The search for a “death hormone
    • W. Regelson, F.M. Sinex (Eds), New York: Allen R. Liss, Inc
    • W. Regelson (1983) The evidence for pituitary and thyroid control of aging: is age reversal a myth or reality? The search for a “death hormone. W. Regelson, F.M. Sinex (Eds) Intervention in the aging process, Part B: Basic research and preclinical screening New York: Allen R. Liss, Inc. 3-52
    • (1983) Intervention in the aging process, Part B: Basic research and preclinical screening , pp. 3-52
    • Regelson, W.1
  • 121
    • 0001557938 scopus 로고
    • Selection for radiation resistance in mice
    • T.H. Roderick (1963) Selection for radiation resistance in mice. Genetics 48 205-216
    • (1963) Genetics , vol.48 , pp. 205-216
    • Roderick, T.H.1
  • 123
    • 0000977247 scopus 로고
    • Laboratory evolution of postponed senescence in
    • M.R. Rose (1984) Laboratory evolution of postponed senescence in. Drosophila melanogaster. Evolution 38 1004-1010
    • (1984) Drosophila melanogaster. Evolution , vol.38 , pp. 1004-1010
    • Rose, M.R.1
  • 125
    • 0002598664 scopus 로고
    • Lifespan and aging patterns
    • nd ed., New York: Dover Publications, Inc
    • E.S. Russell (1966) Lifespan and aging patterns. E.L. Green (Eds) Biology of the laboratory mouse 2nd ed. New York: Dover Publications, Inc. 511-520
    • (1966) Biology of the laboratory mouse , pp. 511-520
    • Russell, E.S.1
  • 126
    • 0011057941 scopus 로고
    • Genetic considerations in the selection of rodent species and strains for research on aging
    • D.C. Gibson (Eds), U.S. Gov. Printing Office No. 1746-0010
    • E.S. Russell (1972) Genetic considerations in the selection of rodent species and strains for research on aging. D.C. Gibson (Eds) In Development of the rodent as a model system of aging NIH, NICHD Pub. No. 72-121 U.S. Gov. Printing Office No. 1746-0010 33-53
    • (1972) In Development of the rodent as a model system of aging NIH, NICHD Pub. No. 72-121 , pp. 33-53
    • Russell, E.S.1
  • 127
    • 0017844690 scopus 로고
    • Longevity, aging and comparative cellular and molecular biology of the house mouse, Mus musculus, and the white-footed mouse, Peromyscus leucopus
    • New York: The National Foundation- March of Dimes, A. R. Liss, Inc
    • G.A. Sacher and R.W. Hart (1978) Longevity, aging and comparative cellular and molecular biology of the house mouse, Mus musculus, and the white-footed mouse, Peromyscus leucopus. Genetic effects on aging, birth defects Original Article Series XIV No. 1. New York: The National Foundation- March of Dimes, A. R. Liss, Inc. 71-96
    • (1978) Genetic effects on aging, birth defects Original Article Series XIV No. 1 , pp. 71-96
    • Sacher, G.A.1    Hart, R.W.2
  • 128
    • 21144434217 scopus 로고    scopus 로고
    • Extension of murine lifespan by overexpression of catalase targeted to mitochondria
    • S.E. Schriner, N.J. Linford, G.M. Martin, P. Treuting, C.E. Ogbura, M. Emond, et al. (2005) Extension of murine lifespan by overexpression of catalase targeted to mitochondria. Science 308 1909-1911
    • (2005) Science , vol.308 , pp. 1909-1911
    • Schriner, S.E.1    Linford, N.J.2    Martin, G.M.3    Treuting, P.4    Ogbura, C.E.5    Emond, M.6
  • 129
    • 0018757962 scopus 로고
    • Inhibition of spontaneous breast cancer formation in female C3H (Avy/a) mice by long-term treatment with dehydroepiandros-terone
    • A.G. Schwartz (1979) Inhibition of spontaneous breast cancer formation in female C3H (Avy/a) mice by long-term treatment with dehydroepiandros-terone. Cancer Res 39 1129-1132
    • (1979) Cancer Res , vol.39 , pp. 1129-1132
    • Schwartz, A.G.1
  • 130
    • 0019770685 scopus 로고
    • Inhibition of 7,12-dimethylbenz[a] anthracene-and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone
    • A.G. Schwartz and R.H. Tannen (1981) Inhibition of 7,12-dimethylbenz[a] anthracene-and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone. Carcinogenesis 2 1335-1337
    • (1981) Carcinogenesis , vol.2 , pp. 1335-1337
    • Schwartz, A.G.1    Tannen, R.H.2
  • 131
    • 0015466216 scopus 로고
    • Articular aging in osteoarthrosis in dwarf mice
    • R. Silberburg (1972) Articular aging in osteoarthrosis in dwarf mice. Pathol Microbiol 38 417-430
    • (1972) Pathol Microbiol , vol.38 , pp. 417-430
    • Silberburg, R.1
  • 132
    • 84884434488 scopus 로고
    • The pituitary in relation to skeletal aging and disease
    • A.V Everitt, J.A. Burgess (Eds), Springfield, IL: Charles C. Thomas
    • R. Silberburg (1976) The pituitary in relation to skeletal aging and disease. A.V Everitt, J.A. Burgess (Eds) Hypothalamus pituitary and aging Springfield, IL: Charles C. Thomas 209-238
    • (1976) Hypothalamus pituitary and aging , pp. 209-238
    • Silberburg, R.1
  • 133
    • 19044387714 scopus 로고    scopus 로고
    • c-Kit expression and stem cell factor-induced hematopoietic cell proliferation are up-regu-lated in aged B6D2F1 mice. J
    • A.L. Smith, F.M Ellison, J.P. McCoy Jr. and J. Chen (2005) c-Kit expression and stem cell factor-induced hematopoietic cell proliferation are up-regu-lated in aged B6D2F1 mice. J. Gerontol B 60 448-456
    • (2005) Gerontol B , vol.60 , pp. 448-456
    • Smith, A.L.1    Ellison, F.M.2    McCoy, J.P.3    Chen, J.4
  • 134
    • 0036628724 scopus 로고    scopus 로고
    • Role of oxidative stress and protein oxidation in the aging process
    • R.S. Sohal (2002) Role of oxidative stress and protein oxidation in the aging process. Free Radie Biol Med 33 37-44
    • (2002) Free Radie Biol Med , vol.33 , pp. 37-44
    • Sohal, R.S.1
  • 135
    • 0021416752 scopus 로고
    • Animals in aging research: requirements, pitfalls and a challenge for the laboratory animal specialist
    • H.A. Solleveld and C.F. Hollander (1984) Animals in aging research: requirements, pitfalls and a challenge for the laboratory animal specialist. Vet Q 6 96-101
    • (1984) Vet Q , vol.6 , pp. 96-101
    • Solleveld, H.A.1    Hollander, C.F.2
  • 136
    • 22144444220 scopus 로고    scopus 로고
    • Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span
    • W.E. Sonntag, C.S. Carter, Y Ikeno, K. Ekenstedt, C.S. Carlson, R.F. Loeser, et al. (2005) Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology 146 2920-2932
    • (2005) Endocrinology , vol.146 , pp. 2920-2932
    • Sonntag, W.E.1    Carter, C.S.2    Ikeno, Y.3    Ekenstedt, K.4    Carlson, C.S.5    Loeser, R.F.6
  • 137
    • 0022377731 scopus 로고
    • The involution of the ageing human thymic epithelium is independent of puberty: a morpho-metric study
    • G.G. Steinmann, B. Klaus and H.K. Muller-Hermelink (1985) The involution of the ageing human thymic epithelium is independent of puberty: a morpho-metric study. Scand J Immunol 22 563-575
    • (1985) Scand J Immunol , vol.22 , pp. 563-575
    • Steinmann, G.G.1    Klaus, B.2    Muller-Hermelink, H.K.3
  • 139
    • 0030896787 scopus 로고    scopus 로고
    • Senescence-accelerated mouse: a novel murine model of senescence
    • T. Takeda, M. Hosokawa and K. Higuchi (1997) Senescence-accelerated mouse: a novel murine model of senescence. Exp Gerontol 32 105-109
    • (1997) Exp Gerontol , vol.32 , pp. 105-109
    • Takeda, T.1    Hosokawa, M.2    Higuchi, K.3
  • 140
    • 0041666387 scopus 로고    scopus 로고
    • The role of stem cells in aging
    • G. Van Zant and Y Liang (2003) The role of stem cells in aging. Exp Hematol 31 659-672
    • (2003) Exp Hematol , vol.31 , pp. 659-672
    • Van Zant, G.1    Liang, Y.2
  • 141
    • 13444249466 scopus 로고    scopus 로고
    • Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant. J
    • M. Vergara, M. Smith-Wheelock, J.M. Harper, R. Sigler and R.A. Miller (2004) Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant. J. Gerontol 59 1244-1250
    • (2004) Gerontol , vol.59 , pp. 1244-1250
    • Vergara, M.1    Smith-Wheelock, M.2    Harper, J.M.3    Sigler, R.4    Miller, R.A.5
  • 142
    • 0037028155 scopus 로고    scopus 로고
    • The mosaic structure of variation in the laboratory mouse genome
    • C.M. Wade, E.J. Kulbokas E.J.3rd, A.W. Kirby, M.C. Zody, J.C. Mullikin, et al. (2002) The mosaic structure of variation in the laboratory mouse genome. Nature 420 574-578
    • (2002) Nature , vol.420 , pp. 574-578
    • Wade, C.M.1    Kulbokas, E.J.2    Kirby, A.W.3    Zody, M.C.4    Mullikin, J.C.5
  • 143
    • 11844280278 scopus 로고    scopus 로고
    • Genetics of variation in HDL cholesterol in humans and mice
    • X. Wang and B. Paigen (2005) Genetics of variation in HDL cholesterol in humans and mice. Cire Res 96 27-42
    • (2005) Cire Res , vol.96 , pp. 27-42
    • Wang, X.1    Paigen, B.2
  • 144
    • 17144398839 scopus 로고    scopus 로고
    • Genome-wide search for new genes controlling plasma lipid concentrations in mice and humans
    • X. Wang and B. Paigen (2005) Genome-wide search for new genes controlling plasma lipid concentrations in mice and humans. Curr Opin Lipidol 16 127-137
    • (2005) Curr Opin Lipidol , vol.16 , pp. 127-137
    • Wang, X.1    Paigen, B.2
  • 145
    • 4644219642 scopus 로고    scopus 로고
    • Haplotype analysis in multiple crosses to identify a QTL gene
    • X. Wang, R. Korstanje, D. Higgins and B. Paigen (2004) Haplotype analysis in multiple crosses to identify a QTL gene. Genome Res 14 1767-1772
    • (2004) Genome Res , vol.14 , pp. 1767-1772
    • Wang, X.1    Korstanje, R.2    Higgins, D.3    Paigen, B.4
  • 146
    • 0037726549 scopus 로고    scopus 로고
    • Models of accelerated ageing can be informa-tive about the molecular mechanisms of ageing and/or age-related pathology
    • H.R. Warner and F. Sierra (2003) Models of accelerated ageing can be informa-tive about the molecular mechanisms of ageing and/or age-related pathology. Mech Ageing Dev 124 581-587
    • (2003) Mech Ageing Dev , vol.124 , pp. 581-587
    • Warner, H.R.1    Sierra, F.2
  • 147
    • 0343962628 scopus 로고    scopus 로고
    • Meeting report: program for testing biological interventions to promote healthy aging
    • H.R. Warner, D. Ingram, R.A. Miller, N.L. Nadon and A.G. Richardson (2000) Meeting report: program for testing biological interventions to promote healthy aging. Mech Ageing Dev 115 199-208
    • (2000) Mech Ageing Dev , vol.115 , pp. 199-208
    • Warner, H.R.1    Ingram, D.2    Miller, R.A.3    Nadon, N.L.4    Richardson, A.G.5
  • 148
    • 3342945004 scopus 로고
    • Murine chromosomal regions influencing life span
    • D.E. Harrison (Eds), Caldwell, NJ: The Telford Press, Inc
    • A.L.M. Watson, R.S. German, R.M. Williams and E.J. Yunis (1990) Murine chromosomal regions influencing life span. D.E. Harrison (Eds) Genetic effects on aging II Caldwell, NJ: The Telford Press, Inc. 473-488
    • (1990) Genetic effects on aging II , pp. 473-488
    • Watson, A.L.M.1    German, R.S.2    Williams, R.M.3    Yunis, E.J.4
  • 149
    • 0010454467 scopus 로고
    • Animal models
    • E.J. Masoro (Eds), New York: Oxford University Press, Section 11, Aging
    • R. Weindruch (1995) Animal models. E.J. Masoro (Eds) Handbook of physiology New York: Oxford University Press 37-52. Section 11, Aging
    • (1995) Handbook of physiology , pp. 37-52
    • Weindruch, R.1
  • 150
    • 0025775451 scopus 로고
    • Concerns about rodent models for aging research. J
    • R. Weindruch and E.J. Masoro (1991) Concerns about rodent models for aging research. J. Gerontol Biol Sci 46 B87-B88
    • (1991) Gerontol Biol Sci , vol.46 , pp. B87-B88
    • Weindruch, R.1    Masoro, E.J.2
  • 151
    • 0022517746 scopus 로고
    • The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake
    • R. Weindruch, R.L. Walford, S. Fligiel and D. Guthrie (1986) The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr 116 641-654
    • (1986) J Nutr , vol.116 , pp. 641-654
    • Weindruch, R.1    Walford, R.L.2    Fligiel, S.3    Guthrie, D.4
  • 152
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection and the evolution of senes-cence
    • G.C. Williams (1957) Pleiotropy, natural selection and the evolution of senes-cence. Evolution 11 398-411
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1
  • 153
    • 6344280944 scopus 로고    scopus 로고
    • Pathological changes in the liver of a senescence accelerated mouse strain (SAMP8) : a mouse model for the study of liver disease
    • X. Ye, H.C. Meeker, P.B. Kozlowski, J. Weigel, K.C. Wang, H. Imaki and R.I. Carp (2004) Pathological changes in the liver of a senescence accelerated mouse strain (SAMP8) : a mouse model for the study of liver disease. Histol Histopathol 4 1141-1151
    • (2004) Histol Histopathol , vol.4 , pp. 1141-1151
    • Ye, X.1    Meeker, H.C.2    Kozlowski, P.B.3    Weigel, J.4    Wang, K.C.5    Imaki, H.6    Carp, R.I.7
  • 154
    • 0000498145 scopus 로고
    • Putative interventions
    • E.J. Masoro (Eds), New York: Oxford University Press, Section 11, Aging
    • B.P. Yu (1995) Putative interventions. E.J. Masoro (Eds) Handbook of physiology New York: Oxford University Press 613-632. Section 11, Aging
    • (1995) Handbook of physiology , pp. 613-632
    • Yu, B.P.1
  • 155
    • 12844250051 scopus 로고    scopus 로고
    • Genetic regulation of hematopoietic stem cell exhaustion during development and growth
    • R. Yuan, C.M. Astle, J. Chen and D.E. Harrison (2005) Genetic regulation of hematopoietic stem cell exhaustion during development and growth. Exp Hematol 33 243-250
    • (2005) Exp Hematol , vol.33 , pp. 243-250
    • Yuan, R.1    Astle, C.M.2    Chen, J.3    Harrison, D.E.4
  • 156
    • 0030003016 scopus 로고    scopus 로고
    • Distinct developmental patterns of short-term and long-term functioning lymphoid and myeloid pre-cursors defined by competitive limiting dilution analysis in vivo
    • R.K. Zhong, C.M. Astle and D.E. Harrison (1996) Distinct developmental patterns of short-term and long-term functioning lymphoid and myeloid pre-cursors defined by competitive limiting dilution analysis in vivo. J Immunol 157 138-145
    • (1996) J Immunol , vol.157 , pp. 138-145
    • Zhong, R.K.1    Astle, C.M.2    Harrison, D.E.3


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