Low-dose γ-rays modify CD4+ T cell signalling response to simulated solar particle event protons in a mouse model

International Journal of Radiation Biology

Volumn 87, Issue 1, 2011, Pages 24-35

  Rizvi, Asma ^a   Pecaut, Michael J ^a   Slater, James M ^a   Subramaniam, Shruti ^a   Gridley, Daila S ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cytokines; particle radiation; signalling pathways; solar flare; T lymphocytes

Indexed keywords

CD3 ANTIBODY; CELL PROTEIN; COBALT 57; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTON; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GAMMA RADIATION; INTRACELLULAR SIGNALING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PARTICLE RADIATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SIMULATION; SOLAR PARTICLE EVENT; SPLEEN; SUPERNATANT;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTONS; SIGNAL TRANSDUCTION; SOLAR ACTIVITY; SPACE SIMULATION; ZAP-70 PROTEIN-TYROSINE KINASE;

MUS;

EID: 78650121843     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2010.518206     Document Type: Article

References (46)

1. Aguado E, Martinez-Florensa M, Aparicio P. 2006. Activation of T lymphocytes and the role of the adapter LAT. Transplantation Immunology 17:23-26. (Pubitemid 44828797)
2. Andarawewa KL, Paupert J, Pal A, Barcellos-Hoff MH. 2007. New rationales for using TGFbeta inhibitors in radiotherapy. International Journal of Radiation Biology 83:803-811. (Pubitemid 350219100)
3. Attar M, Molaie Kondolousy Y, Khansari N. 2007. Effect of high dose natural ionizing radiation on the immune system of the exposed residents of Ramsar Town, Iran. Iranian Journal of Allergy, Asthma, and Immunology 6:73-78. (Pubitemid 47203951)
4. Belka C, Marini P, Lepple-Wienhues A, Budach W, Jekle A, Los M, Lang F, Schulze-Osthoff K, Gulbins E, Bamberg M. 1999. The tyrosine kinase Lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation. Oncogene 18:4983-4992. (Pubitemid 29425305)
5. Cai L, Liu SZ. 1990. Induction of cytogenetic adaptive response of somatic and germ cells in vivo and in vitro by low-dose Xirradiation. International Journal of Radiation Biology 58:187-194. (Pubitemid 20216904)
6. Cemerski S, Cantagrel A, van Meerwijk J P, Romagnoli P. 2002. Reactive oxygen species differentially affect T cell receptorsignaling pathways. The Journal of Biological Chemistry 277: 19585-19593. (Pubitemid 34967471)
7. Cemerski S, van Meerwijk JP, Romagnoli P. 2003. Oxidativestress- induced T lymphocyte hyporesponsiveness is caused by structural modification rather than proteasomal degradation of crucial TCR signaling molecules. European Journal of Immunology 33:2178-2185. (Pubitemid 37010035)
8. Chen W, Frank ME, Jin W, Wahl SM. 2001. TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 14:715-725. (Pubitemid 32592419)
9. Coleman MA, Yin E, Peterson LE, Nelson D, Sorensen K, Tucker JD, Wyrobek AJ. 2005. Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response. Radiation Research 164:369-382. (Pubitemid 41368945)
10. Cooper D, Pellis NR. 1998. Suppressed PHA activation of T lymphocytes in simulated microgravity is restored by direct activation of protein kinase C. Journal of Leukocyte Biology 63:550-562. (Pubitemid 28193767)
11. Coutrakon GB, Benton ER, Gridley DS, Hickey T, Hubbard J, Koss P, Moyers MF, Nelson GA, Pecaut MJ, Sanders E, Shahnazi K. 2007. Simulation of a 36 h solar particle event at LLUMC using a proton beam scanning system. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 261(1-2):791-794. (Pubitemid 47042940)
12. Cramers P, Atanasova P, Vrolijk H, Darroudi F, van Zeeland AA, Huiskamp R, Mullenders LH, Kleinjans JC. 2005. Preexposure to low doses: Modulation of X-ray-induced DNA damage and repair? Radiation Research 164:383-390. (Pubitemid 41368946)
13. Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C, Cheng JF, Chen DJ. 2005. Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: A comparative study of low and high doses. Radiation Research 164:17-26. (Pubitemid 40885226)
14. Dodeller F, Schulze-Koops H. 2006. The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells. Arthritis Research and Therapy 8:205.
15. Dutta J, Fan Y, Gupta N, Fan G, Gelinas C. 2006. Current insights into the regulation of programmed cell death by NFkappaB. Oncogene 25:6800-6816. (Pubitemid 44657853)
16. Feinendegen LE. 2005. Evidence for beneficial low level radiation effects and radiation hormesis. The British Journal of Radiology 78:3-7. (Pubitemid 40277127)
17. Finke JH, Zea AH, Stanley J, Longo DL, Mizoguchi H, Tubbs RR, Wiltrout RH, O'Shea JJ, Kudoh S, Klein E. 1993. Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma. Cancer Research 53:5613-5616. (Pubitemid 23360259)
18. Gajendiran N, Tanaka K, Kumaravel TS, Kamada N. 2001. Neutron-induced adaptive response studied in go human lymphocytes using the comet assay. Journal of Radiation Research (Tokyo) 42:91-101. (Pubitemid 33658574)
19. Gridley DS, Coutrakon GB, Rizvi A, Bayeta EJ, Luo-Owen X, Makinde AY, Baqai F, Koss P, Slater JM, Pecaut MJ. 2008a. Low-dose photons modify liver response to simulated solar particle event protons. Radiation Research 169:280-287. (Pubitemid 351521763)
20. Gridley DS, Pecaut MJ, Rizvi A, Coutrakon GB, Luo-Owen X, Makinde AY, Slater JM. 2009. Low-dose, low-dose-rate proton radiation modulates CD4(+) T cell gene expression. International Journal of Radiation Biology 85:250-261.
21. Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Coutrakon GB, Koss P, Slater JM, Pecaut MJ. 2008b. Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons. In Vivo 22:159-169.
22. Hales NW, Yamauchi K, Alicea A, Sundaresan A, Pellis NR, Kulkarni AD. 2002. A countermeasure to ameliorate immune dysfunction in in vitro simulated microgravity environment: role of cellularnucleotide nutrition. In Vitro Cellular and Developmental Biology- Animal 38:213-217. (Pubitemid 34975845)
23. Han SK, Song JY, Yun YS, Yi SY. 2006. Effect of gamma radiation on cytokine expression and cytokine-receptor mediated STAT activation. International Journal of Radiation Biology 82:686-697.
24. Iwanaga M, Mori K, Iida T, Urata Y, Matsuo T, Yasunaga A, Shibata S, Kondo T. 1998. Nuclear factor kappa b dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in t98g human glioblastoma cells. Free Radical Biology & Medicine 24:1256-1268. (Pubitemid 28246741)
25. Lee JW, Sung NY, Kim JK, Kim JH, Raghavendran HR, Yoo YC, Shin MH, Byun MW. 2008. ffect of gamma irradiation on spleen cell function and cytotoxicity of doxorubicin. hemicobiological Interactions 173:205-214.
26. Li N, Karin M. 1999. Is NF-kappaB the sensor of oxidative stress? Federation of American Societies for Experimental Biology Journal 13:1137-1143.
27. Lin PS, Ho KC, Sung SJ, Tsai S. 1993. Cytotoxicity and manganese superoxide dismutase induction by tumor necrosis factor-alpha and ionizing radiation in MCF-7 human breast carcinoma cells. Lymphokine and Cytokine Research 12:303-308. (Pubitemid 23305113)
28. Lyng FM, Maguire P, McClean B, Seymour C, Mothersill C. 2006. The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiation Research 165:400-409.
29. Maurice MM, Lankester AC, Bezemer A.C, Geertsma MF, Tak PP, Breedveld FC, van Lier RA, Verweij CL. 1997. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. Journal of Immunology 159:2973-2978. (Pubitemid 127681320)
30. McBride WH, Chiang CS, Olson JL, Wang CC, Hong JH, Pajonk F, Dougherty GJ, Iwamoto KS, Pervan M, Liao YP. 2004. A sense of danger from radiation. Radiation Research 162:1-19. (Pubitemid 39044714)
31. Okazaki R, Ootsuyama A, Norimura T. 2007. TP53 and TP53- related genes associated with protection from apoptosis in the radioadaptive response. Radiation Research 167:51-57. (Pubitemid 46106797)
32. Otsuka K, Koana T, Tauchi H, Sakai K. 2006. Activation of antioxidative enzymes induced by low-dose-rate whole-body gamma irradiation: Adaptive response in terms of initial DNA damage. Radiation Research 166:474-478. (Pubitemid 44353430)
33. Pardali K, Moustakas A. 2007. Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochimica et Biophysica Acta 1775:21-62. (Pubitemid 44881193)
34. Sasaki MS, Ejima Y, Tachibana A, Yamada T, Ishizaki K, Shimizu T, Nomura T. 2002. DNA damage response pathway in radioadaptive response. Mutation Research 504:101-118. (Pubitemid 34775104)
35. Schulz EG, Mariani L, Radbruch A, Hofer T. 2009. Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity 30:673-683.
36. Sen P, Chakraborty PK, Raha S. 2007. Activation of p38MAPK by repetitive low-grade oxidative stress leads to pro-survival effects. Biochimica et Biophysica Acta 1773:367-374. (Pubitemid 46275069)
37. Sonnenfeld G. 2002. The immune system in space and microgravity. Medicine and Science in Sports and Exercise 34:2021-2027. (Pubitemid 35440425)
38. Sonnenfeld G, Foster M, Morton D, Bailliard F, Fowler NA, Hakenewerth AM, Bates R, Miller ES Jr. 1998. Spaceflight and development of immune responses. Journal of Applied Physiology 85:1429-1433. (Pubitemid 28465073)
39. Stefanova I, Saville MW, Peters C, Cleghorn FR, Schwartz D, Venzon DJ, Weinhold KJ, Jack N, Bartholomew C, Blattner WA, Yarchoan R, Bolen JB, Horak ID. 1996. HIV infectioninduced posttranslational modification of T cell signaling molecules associated with disease progression. The Journal of Clinical Investigation 98:1290-1297. (Pubitemid 26322053)
40. Sundaresan A, Risin D, Pellis NR. 2002. Loss of signal transduction and inhibition of lymphocyte locomotion in a ground-based model of microgravity. In Vitro Cellular and Developmental Biology- Animal 38:118-122. (Pubitemid 34538205)
41. Sundaresan A, Risin D, Pellis NR. 2004. Modeled microgravityinduced protein kinase C isoform expression in human lymphocytes. Journal of Applied Physiology 96:2028-2033. (Pubitemid 38661479)
42. Tian J, Pecaut MJ, Slater JM, Gridley DS. 2009. Spaceflight modulates expression of extracellular matrix, adhesion and profibrotic molecules in mouse lung. Journal of Applied Physiology 108:162-171.
43. Townsend LW. 2005. Implications of the space radiation environment for human exploration in deep space. Radiation Protection Dosimetry 115:44-50. (Pubitemid 43103379)
44. Wang T, Zhang X, Li JJ. 2002. The role of NF-kappaB in the regulation of cell stress responses. International Immunopharmacology 2:1509-1520. (Pubitemid 35223232)
45. Zea AH, Ochoa MT, Ghosh P, Longo DL, Alvord WG, Valderrama L, Falabella R, Harvey LK, Saravia N, Moreno LH, Ochoa AC. 1998. Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy. Infection and Immunity 66:499-504. (Pubitemid 28074188)
46. Zhao WH, Li L, Zhang B, Zhang WD, Zong M, Tang JD, Zhang HY, Li S. 2008. Enhancement of CD4+ T cell activities and modulation of Th1/Th2 lineage development in radiated tumor-bearing rats treated with male zooid of Antheraea pernyi extracts. World Journal of Gastroenterology 14:2094-2099. (Pubitemid 351795833)