Effect of high dose natural ionizing radiation on the immune system of the exposed residents of Ramsar Town, Iran

Iranian Journal of Allergy, Asthma and Immunology

Volumn 6, Issue 2, 2007, Pages 73-78

  Attar, Massoud ^a   Kondolousy, Yaghob Molaie ^b   Khansari, Nemat ^b,c  

^a Sattarkhan Diagnostic Laboratory   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Antioxidant; FRAP; IFN ; IL 10; IL 2; IL 4; Ionizing radiation; NBT; Phagocytosis

Indexed keywords

ANTIOXIDANT; FREE RADICAL; GAMMA INTERFERON; HEMAGGLUTININ; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ADULT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENVIRONMENTAL RADIOACTIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; INFECTION; INFLAMMATION; IONIZING RADIATION; IRAN; LEUKOCYTE MIGRATION; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; NEUTROPHIL; PHAGOCYTOSIS; RADIATION DOSE; RADIATION INJURY; TH1 CELL; TH2 CELL;

ADULT; BACKGROUND RADIATION; FEMALE; FREE RADICALS; HUMANS; IMMUNE SYSTEM; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; IRAN; LYMPHOCYTES; MALE; MIDDLE AGED; NEUTROPHILS; RADIATION DOSAGE; TH1 CELLS; TH2 CELLS;

EID: 34547627200     PISSN: 17351502     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Forster L, Forster P, Lutz-Bonengel S, Willkomm H, Brinkmann B. Natural radioactivity and human mitochondrial DNA mutations. Proc Natl Acad Sci U S A 2002; 99(21):13950-4.
2. Ghiassi-Nejad M, Mortazavi SM, Cameron JR, Niroomand-rad A, Karam PA. Very high background radiation areas of Ramsar, Iran: preliminary biological studies. Health Phys 2002; 82(1):87-93.
3. Aghamiri SM, Ghorbani Z, Darafsheh A. Torabzadeh H, Fathivand AA, Minuchehr A, Jalinoos A. 226Ra concentration in the teeth of habitants of areas with high level of natural radioactivity in Ramsar. J Environ Radioact 2006; 89(3):212-8.
4. Rydberg B. Radiation-induced DNA damage and chromatin structure. Acta Oncol 2001; 40(6):682-5.
5. Masoomi JR, Mohammadi SH, Amini M, Ghiassi-Nejad M. High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE). J Environ Radioact 2006; 86(2):176-86.
6. Riley P.A. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 1994; 65(1):27-33.
7. Okamoto H, Tatara A. Effect of low-Gamma irradiation on the cell cycle duration of barley roots. Environ Exp Bot 1994; 35:379-88.
8. Taguchi Y, Tsutsumi N, Tatara A, Eguchi H, Taano S. Effect of low-dose Gamma-irradiation on the root apical meristem of barely. Environ Mut Res Commun 1994; 16:205-9.
9. Salter L, Hewitt CN. Ozon-hydrocarbon interactions in plants. Phytochem 1992; 31:4045-50.
10. Wolff SP, Dean RT. Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysis. Biochem J 1986; 234(2):399-403.
11. Soto J, Quindos LS, Sanchez-Barcelo EJ. Influence of low doses of radiation due to 222Rn on proliferation of fibroblasts and MCF-7 human breast cancer cells in vitro. Sci Total Environ 1996; 181(3):181-5.
12. Pecaut MJ, Nelson GA, Gridley DS. Dose and dose rate effects of whole-body gamma-irradiation: I. Lymphocytes and lymphoid organs. In Vivo 2001; 15(3):195-208.
13. Cameron JR. Moderate dose rate ionizing radiation increases longevity. Br J Radiol 2005; 78(925):11-3
14. Luckey TD. Hormesis revisited. ROS Magazine 1998; 3:20-1.
15. Mayr A., Pawlas S. Unexpected effects of a whole body irradiation on the mortality rate of baby mice after an experimental infection with the vesicular stomatitis virus (VSV). Zentralbl Veterinarmed B 1989; 36(8):577-83.
16. Stone R. Health protection activities of the plutonium project. Proc Am Philos Soc 1942; 90:11-9.
17. Luckey TD. Low-dose irradiation reduces cancer death. Rad Protect Manag 1997; 14:58-64.
18. Moss W, Eckhardt R. The human plutonium injection experiments. Los Alamos Sci 1995; 23:177-233.
19. Spiers FW, Lucas HF, Rundo J, Anast GA. Leukaemia incidence in the U.S. dial workers. Health Phys 1983; 44 Suppl 1:65-72.
20. Schull WJ, Otake M, Neel JV. Genetic effects of the atomic bombs: a reappraisal. Science 1981; 213(4513):1220-7.
21. Sohrabi M, Alirezazadeh N, Tajik Ahmadi H. A survey of 222Rn concentrations in domestic water supplies of Iran. Health Phys 1998; 75(4):417-21.
22. Ghiassi-Nejad M, Zakeri F, Assaei RG, Kariminia A. Long-term immune and cytogenetic effects of high level natural radiation on Ramsar inhabitants in Iran. J Environ Radioact 2004; 74(1-3):107-16.
23. Mohammadi S, Taghavi-Dehghani M, Gharaati MR, Masoomi R, Ghiassi-Nejad M. Adaptive response of blood lymphocytes of inhabitants residing in high background radiation areas of ramsar- micronuclei, apoptosis and comet assays. J Radiat Res (Tokyo) 2006; 47(3-4):279-85.
24. Islam LN, Nabi AH, Ahmed KM, Sultana N. Endotoxins of enteric pathogens are chemotactic factors for human neutrophils. J Biochem Mol Biol 2002; 35(5):482-7
25. Benzie IF, Strain JJ. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measure of total antioxidant power and ascorbic acid concentration. Methods Enzymol 1999; 299:15-27.
26. Shin SJ, Chang CF, Chang CD, McDonough SP, Thompson B, Yoo HS, et al. In vitro cellular immune responses to recombinant antigens of Mycobacterium avium subsp. paratuberculosis. Infect Immun 2005; 73(8):5074-85.
27. Islam LN, Wilkinson PC Evaluation of methods for isolating human peripheral blood monocytes. Studies on chemotactic locomotion and other functional characteristics. J Immunol Methods 1989; 121(1):75-84.
28. Matusiewicz R, Lebiedowski K, Kowalczyk M, Czajkowski M, Stempniak M. Ability of peripheral blood neutrophils from patients with infectious bronchial asthma to engulf latex particles and reduce nitroblue tetrazolium. Arch Immunol Ther Exp (Warsz) 1988; 36(1):55-9.
29. Srikumar R, Jeya Parthasarathy N, Sheela Devi R. Immunomodulatory activity of triphala on neutrophil functions. Biol Pharm Bull 2005; 28(8):1398-403.
30. Liu SZ. On radiation hormesis expressed in the immune system. Crit Rev Toxicol 2003; 33(3-4):431-41.
31. Meeran SM, Katiyar S, Elmets CA, Katiyar SK. Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice. Mol Cancer Ther 2006; 5(7):1660-8.
32. Zdrojewicz Z, Belowska-Bien K. Radon and ionizing radiation in the human body]. Postepy Hig Med Dosw (Online) 2004; 58:150-7.
33. Wall BF, Kendall GM, Edwards AA, Bouffler S, Muirhead CR, Meara JR. What are the risks from medical X-rays and other low dose radiation? Br J Radiol 2006; 79(940):285-94.
34. Jha AN, Sharma T. Enhanced frequency of chromosome aberrations in workers occupationally exposed to diagnostic X-rays. Mutat Res 1991; 260(4):343-8.
35. Godekmerdan A, Ozden M, Ayar A, Gursu MF, Ozan AT, Serhatlioglu S. Diminished cellular and humoral immunity in workers occupationally exposed to low levels of ionizing radiation. Arch Med Res 2004; 35(4):324-8.
36. Hrycek A, Czernecka-Micinski A, Klucinski P, Badowski R. Peripheral blood lymphocytes and selected serum interleukins in workers operating X-ray equipment. Toxicol Lett 2002; 132(2):101-7.
37. Ibuki Y, Goto R. Contribution of inflammatory cytokine release to activation of resident peritoneal macrophages after in vivo low-dose gamma-irradiation. J Radiat Res (Tokyo) 1999; 40(3):253-62.