Simvastatin impairs murine melanoma growth

Lipids in Health and Disease

Volumn 9, Issue , 2010, Pages

  Favero, Giovani M ^a,b   Otuki, Michel F ^a   Oliveira, Karen A ^a   Bohatch Jr , Milton S ^a   Borelli, Primavera ^b   Barros, Francisco E ^b   Maria, Durvanei A ^c   Fernandes, Daniel ^a   Bydlowski, Sergio P ^b  

^a STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUTO BUTANTAN   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; SIMVASTATIN; ANTINEOPLASTIC AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BONE MARROW CELL; CANCER INHIBITION; CANCER SIZE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DIPLOIDY; DRUG CYTOTOXICITY; DRUG EFFECT; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HYPODIPLOID; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; MALE; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; SPLEEN CELL; ANIMAL; C57BL MOUSE; CELL CYCLE; FLOW CYTOMETRY; LIVER; PATHOLOGY; SPLEEN; TUMOR CELL LINE;

MURINAE; MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; FLOW CYTOMETRY; LIVER; MALE; MELANOMA; MICE; MICE, INBRED C57BL; SIMVASTATIN; SPLEEN;

EID: 78650108941     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-9-142     Document Type: Article

References (29)

1. Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals 2003. J Shepherd DB Hunninghake P Barter JM McKenney HG Hutchinson, Atheroscler Suppl 2004 5 115 123 10.1016/j. atherosclerosissup.2004.08.032 15531284
2. Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. P Rise C Colombo C Galli, J Lipid Res 1997 38 1299 1307 9254057
3. Concentration and distribution of ubiquinone (coenzyme Q), the endogenous lipid antioxidant, in the rat lens: effect of treatment with simvastatin. RJ Cenedella AR Neely P Sexton, Mol Vis 2005 11 594 602 16110301
4. Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. J Martinez-Botas AJ Ferruelo Y Suarez C Fernandez D Gomez-Coronado MA Lasuncion, Biochim Biophys Acta 2001 1532 185 194 11470239
5. Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity. RE Duncan A El Sohemy MC Archer, J Biol Chem 2004 279 33079 33084 10.1074/jbc.M400732200 15155733
6. Regulatory role of mevalonate in the growth of normal and neoplastic human mammary epithelial cells. O Larsson H Blegen, Anticancer Res 1993 13 1075 1079 8352528
7. Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. S Rao DC Porter X Chen T Herliczek M Lowe K Keyomarsi, Proc Natl Acad Sci USA 1999 96 7797 7802 10.1073/pnas.96.14.7797 10393901
8. Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells. EA Collisson C Kleer M Wu A De SS Gambhir SD Merajver MS Kolodney, Mol Cancer Ther 2003 2 941 948 14578459
9. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. T Kusama M Mukai T Iwasaki M Tatsuta Y Matsumoto H Akedo M Inoue H Nakamura, Gastroenterology 2002 122 308 317 10.1053/gast.2002.31093 11832446
10. Simvastatin treatment induces morphology alterations and apoptosis in murine cochlear neuronal cells. DS Park HS So JH Lee HY Park YJ Lee JH Cho KH Yoon C Park K Yun R Park, Acta Otolaryngol 2009 129 166 174 10.1080/ 00016480802163358 18607908
11. Cell cycle-specific effects of lovastatin. M Jakobisiak S Bruno JS Skierski Z Darzynkiewicz, Proc Natl Acad Sci USA 1991 88 3628 3632 10.1073/pnas.88.9.3628 1673788
12. Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity. RM Pereira NE Andrades N Paulino AC Sawaya MN Eberlin MC Marcucci GM Favero EM Novak SP Bydlowski, Molecules 2007 12 1352 1366 10.3390/12071352 17909491
13. Downregulation of TNF-alpha and VEGF expression by Sp1 decoy oligodeoxynucleotides in mouse melanoma tumor. EM Novak M Metzger R Chammas M da Costa K Dantas C Manabe J Pires AC de Oliveira SP Bydlowski, Gene Ther 2003 10 1992 1997 10.1038/sj.gt.3302111 14528323
14. Protein-energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model. RA Fock MA Vinolo AR Crisma K Nakajima MM Rogero P Borelli, J Nutr Sci Vitaminol (Tokyo) 2008 54 371 377 10.3177/jnsv.54.371 19001768
15. Gamma-glutamyltranspeptidase in murine lymphomas. AA Stark J Hochman E Levy L Barr-Nea A Goldschmied-Reouven M Amizur, Eur J Cancer Clin Oncol 1986 22 77 87 10.1016/0277-5379(86)90345-7 2869949
16. Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates. P Borelli FE Barros K Nakajima SL Blatt B Beutler J Pereira M Tsujita GM Favero RA Fock, Braz J Med Biol Res 2009 42 523 530 10.1590/S0100-879X2009000600008 19448901
17. Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. SA Cormier AG Taranova C Bedient T Nguyen C Protheroe R Pero D Dimina SI Ochkur K O'Neill D Colbert TR Lombari S Constant MP McGarry JJ Lee NA Lee, J Leukoc Biol 2006 79 1131 1139 10.1189/jlb.0106027 16617160
18. Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. A Saito N Saito W Mol H Furukawa A Tsutsumida A Oyama M Sekido S Sasaki Y Yamamoto, Melanoma Res 2008 18-2 85 94 10.1097/CMR.0b013e3282f60097 (Pubitemid 351398262)
19. The statins as anticancer agents. KK Chan AM Oza LL Siu, Clin Cancer Res 2003 9 10 19 12538446
20. Cholesterol inhibition, cancer, and chemotherapy. H Buchwald, Lancet 1992 339 1154 1156 10.1016/0140-6736(92)90744-N 1349377
21. Potential antitumor effects of statins (Review). M Jakobisiak J Golab, Int J Oncol 2003 23 1055 1069 12963986
22. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. A Wachtershauser B Akoglu J Stein, Carcinogenesis 2001 22 1061 1067 10.1093/carcin/22.7.1061 11408350
23. Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis. R Gniadecki, Biochem Biophys Res Commun 2004 320 165 169 10.1016/j.bbrc.2004.05.145 15207716
24. Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. R Kleemann L Verschuren BJ de Rooij J Lindeman MM de Maat AJ Szalai HM Princen T Kooistra, Blood 2004 103 4188 4194 10.1182/blood-2003-11-3791 14976045
25. The role of Rho-associated kinase in differential regulation by statins of interleukin-1beta- and lipopolysaccharide-mediated nuclear factor kappaB activation and inducible nitric-oxide synthase gene expression in vascular smooth muscle cells. CY Wei KC Huang YH Chou PF Hsieh KH Lin WW Lin, Mol Pharmacol 2006 69 960 967 16317111
26. Further support for the statins as antiinflammatory and immunomodulatory agents: comment on the review by Abeles and Pillinger and the editorial by Arnaud and Mach. KN Schikler, Arthritis Rheum 2006 54 2347 10.1002/art.21959 16802384
27. Topical simvastatin: preclinical evidence for a treatment of skin inflammatory conditions. MF Otuki EF Pietrovski DA Cabrini, J Dermatol Sci 2006 44 45 47 10.1016/j.jdermsci.2006.04.006 16759838
28. Inflammatory demyelinating polyneuropathy: a complication of immunotherapy in malignant melanoma. DA Anthoney I Bone TR Evans, Ann Oncol 2000 11 1197 1200 10.1023/A:1008362714023 11061619
29. The potential of statins as part of anti-cancer treatment. S Sleijfer GA van der AS Planting G Stoter J Verweij, Eur J Cancer 2005 41 516 522 10.1016/j.ejca.2004.12.009 15737555