Simvastatin treatment induces morphology alterations and apoptosis in murine cochlear neuronal cells

Acta Oto-Laryngologica

Volumn 129, Issue 2, 2009, Pages 166-174

  Park, Do Sim ^a   So, Hong Seob ^a   Lee, Jeong Han ^a   Park, Hyun Young ^a   Lee, Young Jin ^a   Cho, Ji Hyun ^a   Yoon, Kui Hyun ^a   Park, Channy ^a   Yun, Kijung ^a   Park, Raekil ^a  

^a Wonkwang University School of Medicine   (South Korea)

Author keywords

Apoptosis; Cochlea; HMG CoA reductase inhibitors; Neuron; Simvastatin

Indexed keywords

CASPASE 3; CYTOSKELETON PROTEIN; DNA; MEVALONIC ACID; NEUROFILAMENT PROTEIN; SIMVASTATIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARDIOVASCULAR EFFECT; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL IMMORTALIZATION; COCHLEA INJURY; DNA DETERMINATION; DRUG EFFECT; ENZYME ACTIVATION; EXPLANT; MOUSE; NERVE CELL CULTURE; NEUROBLAST; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPIRAL GANGLION; STAINING;

ANIMALS; ANIMALS, NEWBORN; ANTICHOLESTEREMIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE; CELL SURVIVAL; COCHLEAR NERVE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; MICE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SPIRAL GANGLION;

EID: 60549113364     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480802163358     Document Type: Article

References (20)

1. Dirks AJ, Jones KM. Statin-induced apoptosis and skeletal myopathy. Am J Physiol Cell Physiol 2006;291:C1208-12.
2. Law M, Rudnicka AR. Statin safety: a systematic review. Am J Cardiol 2006;97:52C-60C.
3. Zipp F, Waiczies S, Aktas O, Neuhaus O, Hemmer B, Schraven B, et al. Impact of HMG-CoA reductase inhibition on brain pathology. Trends Pharmacol Sci 2007;28:342-9.
4. Borghi C, Modugno GC, Pirodda A. Possible role of HMG-CoA reductase inhibitors for the treatment of sudden sensorineural hearing loss (SSHL). Med Hypotheses 2002;58:399-402.
5. Tavintharan S, Ong CN, Jeyaseelan K, Sivakumar M, Lim SC, Sum CF. Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a possible role in statin-induced hepatotoxicity? Toxicol Appl Pharmacol 2007;223:173-9.
6. Davidson MH, Stein EA, Dujovne CA, Hunninghake DB, Weiss SR, Knopp RH, et al. The efficacy and six-week tolerability of simvastatin 80 and 160 mg/day. Am J Cardiol 1997;79:38-42.
7. Rosenson RS. Current overview of statin-induced myopathy. Am J Med 2004;116:408-16.
8. Thibault A, Samid D, Tompkins AC, Figg WD, Cooper MR, Hohl RJ, et al. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin Cancer Res 1996;2:483-91.
9. de Langen JJ, van Puijenbroek EP. HMG-CoA-reductase inhibitors and neuropathy: reports to the Netherlands Pharmacovigilance Centre. Neth J Med 2006;64:334-8.
10. García-Román N, Alvarez AM, Toro MJ, Montes A, Lorenzo MJ. Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. Mol Cell Neurosci 2001;17:329-41.
11. Schulz JG, Bösel J, Stoeckel M, Megow D, Dirnagl U, Endres M. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. J Neurochem 2004;89:24-32.
12. Gaist D, Jeppesen U, Andersen M, García Rodríguez LA, Hallas J, Sindrup SH. Statins and risk of polyneuropathy: a case-control study. Neurology 2002;58:1333-7.
13. Nicholl AJ, Kneebone A, Davies D, Cacciabue-Rivolta DI, Rivolta MN, Coffey P, et al. Differentiation of an auditory neuronal cell line suitable for cell transplantation. Eur J Neurosci 2005;22:343-53.
14. Zhao J, Mao Y, Qi J. Expression of cytoskeleton and apoptosis related genes after cerebral infarction. Neurol Res 2006;28:71-5.
15. Koch G, Benz C, Schmidt G, Olenik C, Aktories K. Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton. J Pharmacol Exp Ther 1997;283:901-9.
16. Holmberg E, Nordstrom T, Gross M, Kluge B, Zhang SX, Doolen S. Simvastatin promotes neurite outgrowth in the presence of inhibitory molecules found in central nervous system injury. J Neurotrauma 2006;23:1366-78.
17. Neuvonen PJ, Jalava KM. Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther 1996;60:54-61.
18. Syka J, Ouda L, Nachtigal P, Solichová D, Semecký V. Atorvastatin slows down the deterioration of inner ear function with age in mice. Neurosci Lett 2007;411:112-6.
19. Olzowy B, Canis M, Hempel JM, Mazurek B, Suckfüll M. Effect of atorvastatin on progression of sensorineural hearing loss and tinnitus in the elderly: results of a prospective, randomized, double-blind clinical trial. Otol Neurotol 2007;28:455-8.
20. Cadoni G, Scipione S, Agostino S, Addolorato G, Cianfrone F, Leggio L, et al. Coenzyme Q 10 and cardiovascular risk factors in idiopathic sudden sensorineural hearing loss patients. Otol Neurotol 2007;28:878-83.