International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function

Pharmacological Reviews

Volumn 62, Issue 4, 2010, Pages 565-578

  Kirby, Helen R ^a   Maguire, Janet J ^a   Colledge, William H ^a   Davenport, Anthony P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; IODINE 125; ISOPROTEIN; KISSPEPTIN 10; LEPTIN; MESSENGER RNA;

ATHEROSCLEROTIC PLAQUE; DIABETES MELLITUS; GENE MUTATION; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; ISOTOPE LABELING; MELANOMA; METASTASIS; MOUSE; NEUROENDOCRINE SYSTEM; NONHUMAN; OBESITY; OVARY POLYCYSTIC DISEASE; PRECOCIOUS PUBERTY; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RAT; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

ANIMALS; HUMANS; ORGAN SPECIFICITY; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; TERMINOLOGY AS TOPIC;

EID: 78650092251     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.110.002774     Document Type: Review

References (185)

1. Adachi S, Yamada S, Takatsu Y, Matsui H, Kinoshita M, Takase K, Sugiura H, Ohtaki T, Matsumoto H, Uenoyama Y, et al. (2007) Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. J Reprod Dev 53:367-378.
2. Arai AC and Orwig N (2008) Factors that regulate KiSS1 gene expression in the hippocampus. Brain Res 1243:10-18.
3. Arai AC, Xia YF, Suzuki E, Kessler M, Civelli O, and Nothacker HP (2005) Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells. J Neurophysiol 94:3648-3652.
4. Armstrong RA, Reynolds RM, Leask R, Shearing CH, Calder AA, and Riley SC (2009) Decreased serum levels of kisspeptin in early pregnancy are associated with intra-uterine growth restriction and pre-eclampsia. Prenat Diagn 29:982-985.
5. Becker JA, Mirjolet JF, Bernard J, Burgeon E, Simons MJ, Vassart G, Parmentier M, and Libert F (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem Biophys Res Commun 326:677-686.
6. Bilban M, Ghaffari-Tabrizi N, Hintermann E, Bauer S, Molzer S, Zoratti C, Malli R, Sharabi A, Hiden U, Graier W, et al. (2004) Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. J Cell Sci 117:1319-1328.
7. Biran J, Ben-Dor S, and Levavi-Sivan B (2008) Molecular identification and functional characterization of the kisspeptin/kisspeptin receptor system in lower vertebrates. Biol Reprod 79:776-786.
8. Bowe JE, King AJ, Kinsey-Jones JS, Foot VL, Li XF, O'Byrne KT, Persaud SJ, and Jones PM (2009) Kisspeptin stimulation of insulin secretion: mechanisms of action in mouse islets and rats. Diabetologia 52:855-862.
9. Brailoiu GC, Dun SL, Ohsawa M, Yin D, Yang J, Chang JK, Brailoiu E, and Dun NJ., Chang JK, Brailoiu E, and Dun NJ (2005) KiSS-1 expression and metastin-like immunoreactivity in the rat brain. J Comp Neurol 481:314-329. (Pubitemid 40023540)
10. Caraty A, Smith JT, Lomet D, Ben Saïd S, Morrissey A, Cognie J, Doughton B, Baril G, Briant C, and Clarke IJ (2007) Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes. Endocrinology 148:5258-5267.
11. Carrillo M, Zanuy S, Felip A, Bayarri MJ, Molés G, and Gómez A (2009) Hormonal and environmental control of puberty in perciform fish: the case of sea bass. Ann NY Acad Sci 1163:49-59.
12. Castaño JP, Martínez-Fuentes AJ, Gutiérrez-Pascual E, Vaudry H, Tena-Sempere M, and Malagón MM (2009) Intracellular signaling pathways activated by kisspeptins through GPR54: do multiple signals underlie function diversity? Peptides 30:10-15.
13. Castellano JM, Gaytan M, Roa J, Vigo E, Navarro VM, Bellido C, Dieguez C, Aguilar E, Sánchez-Criado JE, Pellicer A, Pinilla L, Gaytan F, and Tena-Sempere M., Aguilar E, Sánchez-Criado JE, Pellicer A, Pinilla L, Gaytan F, and Tena-Sempere M (2006a) Expression of KiSS-1 in rat ovary: putative local regulator of ovulation? Endocrinology 147:4852-4862.
14. Castellano JM, Navarro VM, Fernández-Fernández R, Castaño JP, Malagón MM, Aguilar E, Dieguez C, Magni P, Pinilla L, and Tena-Sempere M (2006b) Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat. Mol Cell Endocrinol 257-258:75-83. (Pubitemid 44292423)
15. Castellano JM, Navarro VM, Fernández-Fernández R, Nogueiras R, Tovar S, Roa J, Vazquez MJ, Vigo E, Casanueva FF, Aguilar E, et al. (2005) Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology 146:3917-3925.
16. Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, García-Galiano D, Vigo E, Dieguez C, Aguilar E, Pinilla L, et al. (2009) Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology 150:784-794.
17. Clarke IJ, Smith JT, Caraty A, Goodman RL, and LehmanMN(2009) Kisspeptin and seasonality in sheep. Peptides 30:154-163.
18. Clarkson J, d'Anglemont de Tassigny X, Colledge WH, Caraty A, and Herbison AE (2009) Distribution of kisspeptin neurones in the adult female mouse brain. J Neuroendocrinol 21:673-682.
19. Clarkson J and Herbison AE (2006) Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons. Endocrinology 147:5817-5825. (Pubitemid 44833498)
20. Clements MK, McDonald TP, Wang R, Xie G, O'Dowd BF, George SR, Austin CP, and Liu Q (2001) FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun 284:1189-1193. (Pubitemid 32917964)
21. Colledge WH (2009a) Kisspeptins and GnRH neuronal signalling. Trends Endocrinol Metab 20:115-121.
22. Colledge WH (2009b) Transgenic mouse models to study Gpr54/kisspeptin physiology. Peptides 30:34-41.
23. Curtis AE, Cooke JH, Baxter JE, Parkinson JR, Bataveljic A, Ghatei MA, Bloom SR, and Murphy KG (2010) A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10. Am J Physiol Endocrinol Metab 298:E296-E303.
24. d'Anglemont de Tassigny X, Fagg LA, Carlton MB, and Colledge WH (2008) Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals. Endocrinology 149:3926-3932.
25. d'Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, Zahn D, Franceschini I, Caraty A, Carlton MB, et al. (2007) Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci USA 104:10714-10719.
26. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, and Milgrom E (2003) Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100:10972-10976. (Pubitemid 37140137)
27. Decourt C, Tillet Y, Caraty A, Franceschini I, and Briant C (2008) Kisspeptin immunoreactive neurons in the equine hypothalamus Interactions with GnRH neuronal system. J Chem Neuroanat 36:131-137.
28. Dhar DK, Naora H, Kubota H, Maruyama R, Yoshimura H, Tonomoto Y, Tachibana M, Ono T, Otani H, and Nagasue N (2004) Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. Int J Cancer 111:868-872. (Pubitemid 39096235)
29. Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, McGowan BM, Amber V, Patel S, Ghatei MA, et al. (2005) Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab 90:6609-6615. (Pubitemid 41759323)
30. Dhillo WS, Chaudhri OB, Thompson EL, Murphy KG, Patterson M, Ramachandran R, Nijher GK, Amber V, Kokkinos A, Donaldson M, et al. (2007) Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women. J Clin Endocrinol Metab 92:3958-3966.
31. Dhillo WS, Savage P, Murphy KG, Chaudhri OB, Patterson M, Nijher GM, Foggo VM, Dancey GS, Mitchell H, Seckl MJ, et al. (2006) Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment. Am J Physiol Endocrinol Metab 291:E878-E884.
32. Dumalska I, Wu M, Morozova E, Liu R, van den Pol A, and Alreja M (2008) Excitatory effects of the puberty-initiating peptide kisspeptin and group I metabotropic glutamate receptor agonists differentiate two distinct subpopulations of gonadotropin-releasing hormone neurons. J Neurosci 28:8003-8013.
33. Dungan HM, Gottsch ML, Zeng H, Gragerov A, Bergmann JE, Vassilatis DK, Clifton DK, and Steiner RA (2007) The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci 27:12088-12095. (Pubitemid 350072118)
34. Estrada KM, Clay CM, Pompolo S, Smith JT, and Clarke IJ (2006) Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback. J Neuroendocrinol 18:806-809. (Pubitemid 44340517)
35. Farina A, Sekizawa A, Purwosunu Y, Rizzo N, Banzola I, Concu M, Morano D, Giommi F, Bevini M, Mabrook M, et al. (2006) Quantitative distribution of a panel of circulating mRNA in preeclampsia versus controls. Prenat Diagn 26:1115-1120.
36. Felip A, Zanuy S, Pineda R, Pinilla L, Carrillo M, Tena-Sempere M, and Gómez A (2008) Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals. Mol Cell Endocrinol 312:61-71.
37. Filby AL, van Aerle R, Duitman J, and Tyler CR (2008) The kisspeptin/gonadotropin-releasing hormone pathway and molecular signaling of puberty in fish. Biol Reprod 78:278-289.
38. Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, and Caraty A (2006) Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett 401:225-230.
39. Funes S, Hedrick JA, Vassileva G, Markowitz L, Abbondanzo S, Golovko A, Yang S, Monsma FJ, and Gustafson EL (2003) The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun 312:1357-1363.
40. Gao GL, Liu LD, Zou XS, and Chen WX (2007) [Expression of KiSS-1, matrix metalloproteinase-9, nuclear factor-kappaBp65 in ovarian tumour.] Zhonghua Fu Chan Ke Za Zhi 42:34-38.
41. Gianetti E and Seminara S (2008) Kisspeptin and KISS1R: a critical pathway in the reproductive system. Reproduction 136:295-301.
42. Goldberg SF, Miele ME, Hatta N, Takata M, Paquette-Straub C, Freedman LP, and Welch DR (2003) Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP. Cancer Res 63:432-440. (Pubitemid 36152504)
43. Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, and Steiner RA (2004) A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145:4073-4077.
44. Gottsch ML, Clifton DK, and Steiner RA (2009) From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides 30:4-9.
45. Greives TJ, Mason AO, Scotti MA, Levine J, Ketterson ED, Kriegsfeld LJ, and Demas GE (2007) Environmental control of kisspeptin: implications for seasonal reproduction. Endocrinology 148:1158-1166.
46. Guan-Zhen Y, Ying C, Can-Rong N, Guo-Dong W, Jian-Xin Q, and Jie-Jun W (2007) Reduced protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) in lymph node and liver metastases of gastric cancer. Int J Exp Pathol 88:175-183. (Pubitemid 46743980)
47. Gutiérrez-Pascual E, Leprince J, Martínez-Fuentes AJ, Ségalas-Milazzo I, Pineda R, Roa J, Duran-Prado M, Guilhaudis L, Desperrois E, Lebreton A, et al. (2009) In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides. Mol Pharmacol 76:58-67.
48. Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, and Herbison AE (2005) Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci 25:11349-11356.
49. Harms JF, Welch DR, and Miele ME (2003) KISS1 metastasis suppression and emergent pathways. Clin Exp Metastasis 20:11-18.
50. Hashizume T, Saito H, Sawada T, Yaegashi T, Ezzat AA, Sawai K, and Yamashita T (2010) Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats. Anim Reprod Sci 118:37-41.
51. Hata K, Dhar DK, Watanabe Y, Nakai H, and Hoshiai H (2007) Expression of metastin and a G-protein-coupled receptor (AXOR12) in epithelial ovarian cancer. European Journal of Cancer 43:1452-1459. (Pubitemid 46874063)
52. Hauge-Evans AC, Richardson CC, Milne HM, Christie MR, Persaud SJ, and Jones PM (2006) A role for kisspeptin in islet function. Diabetologia 49:2131-2135.
53. Herbison AE, de Tassigny X, Doran J, and Colledge WH (2010) Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. Endocrinology 151:312-321.
54. Hori A, Honda S, Asada M, Ohtaki T, Oda K, Watanabe T, Shintani Y, Yamada T, Suenaga M, Kitada C, et al. (2001) Metastin suppresses the motility and growth of CHO cells transfected with its receptor. Biochem Biophys Res Commun 286:958-963.
55. Horikoshi Y, Matsumoto H, Takatsu Y, Ohtaki T, Kitada C, Usuki S, and Fujino M (2003) Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. J Clin Endocrinol Metab 88:914-919.
56. Hou YK, Wang Y, Cong WM, and Wu MC (2007) [Expression of tumor metastasis-suppressor gene KiSS-1 and matrix metalloproteinase-9 in portal vein tumor thrombus of hepatocellular carcinoma.] Ai Zheng 26:591-595.
57. Ikeguchi M, Hirooka Y, and Kaibara N (2003) Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. J Cancer Res Clin Oncol 129:531-535.
58. Ikeguchi M, Yamaguchi K, and Kaibara N (2004) Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. Clin Cancer Res 10:1379-1383.
59. Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, and Steiner RA (2004) Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 80:264-272.
60. Janneau JL, Maldonado-Estrada J, Tachdjian G, Miran I, Motté N, Saulnier P, Sabourin JC, Coté JF, Simon B, Frydman R, et al. (2002) Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. J Clin Endocrinol Metab 87:5336-5339.
61. Jiang T, Zhang SL, Lin B, Meng LR, and Gao H (2005) Expression and clinical significance of KISS-1 and GPR54 mRNA in endometrial carcinoma. Zhonghua Zhong Liu Za Zhi 27:229-231.
62. Kalamatianos T, Grimshaw SE, Poorun R, Hahn JD, and Coen CW (2008) Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats. J Neuroendocrinol 20:1089-1097.
63. Kanda S, Akazome Y, Matsunaga T, Yamamoto N, Yamada S, Tsukamura H, Maeda K, and Oka Y (2008) Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (oryzias latipes). Endocrinology 149:2467-2476. (Pubitemid 351574521)
64. Kauffman AS, Clifton DK, and Steiner RA (2007a) Emerging ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci 30:504-511.
65. Kauffman AS, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA, and Tena-Sempere M (2007b) Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology 148:1774-1783.
66. Kauffman AS, Park JH, McPhie-Lalmansingh AA, Gottsch ML, Bodo C, Hohmann JG, Pavlova MN, Rohde AD, Clifton DK, Steiner RA, et al. (2007c) The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci 27:8826-8835.
67. Keen KL, Wegner FH, Bloom SR, Ghatei MA, and Terasawa E (2008) An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo. Endocrinology 149:4151-4157.
68. Kinoshita M, Tsukamura H, Adachi S, Matsui H, Uenoyama Y, Iwata K, Yamada S, Inoue K, Ohtaki T, Matsumoto H, et al. (2005) Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. Endocrinology 146:4431-4436.
69. Kirby H, Mead E, Maguire J, Pitkin S, Colledge W, d'Anglemont de Tassigny X, and Davenport A (2008) Kisspeptins as inotropic agents in human and mouse heart. Proc Physiol Soc 11:PC152.
70. Kitahashi T, Ogawa S, and Parhar IS (2009) Cloning and expression of kiss2 in the zebrafish and medaka. Endocrinology 150:821-831.
71. Kostadima L, Pentheroudakis G, and Pavlidis N (2007) The missing kiss of life: transcriptional activity of the metastasis suppressor gene KiSS1 in early breast cancer. Anticancer Res 27:2499-2504.
72. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, et al. (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 276:34631-34636.
73. Kuohung W and Kaiser UB (2006) GPR54 and KiSS-1: role in the regulation of puberty and reproduction. Rev Endocr Metab Disord 7:257-263. (Pubitemid 46399311)
74. Kutzleb C, Busmann A, Wendland M, and Maronde E (2005) Discovery of novel regulatory peptides by reverse pharmacology: spotlight on chemerin and the RF-amide peptides metastin and QRFP. Curr Protein Pept Sci 6:265-278.
75. Lapatto R, Pallais JC, Zhang D, Chan YM, Mahan A, Cerrato F, Le WW, Hoffman GE, and Seminara SB (2007) Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology 148:4927-4936.
76. Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, et al. (1999) Discovery of a receptor related to the galanin receptors. FEBS Lett 446:103-107.
77. Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, and Welch DR (1996) KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. Journal of the National Cancer Institute 88:1731-1737.
78. Lee JH and Welch DR (1997a) Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display. Int J Cancer 71:1035-1044.
79. Lee JH and Welch DR (1997b) Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res 57:2384-2387.
80. Lee YR, Tsunekawa K, Moon MJ, Um HN, Hwang JI, Osugi T, Otaki N, Sunakawa Y, Kim K, Vaudry H, et al. (2009) Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. Endocrinology 150:2837-2846.
81. Lents CA, Heidorn NL, Barb CR, and Ford JJ (2008) Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts. Reproduction 135:879-887.
82. Li D, Yu W, and Liu M (2009) Regulation of KiSS1 gene expression. Peptides 30:130-138.
83. Li S, Ren J, Yang G, Guo Y, and Huang L (2008) Characterization of the porcine Kisspeptins receptor gene and evaluation as candidate for timing of puberty in sows. J Anim Breed Genet 125:219-227.
84. Liang S and Yang ZL (2007) [Expression of KiSS-1mRNA in pancreatic ductal adenocarcinoma and non-cancerous pancreatic tissues in SD rats.] Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:109-113.
85. Liu X, Lee K, and Herbison AE (2008) Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology 149:4605-4614.
86. Magee C, Foradori CD, Bruemmer JE, Arreguin-Arevalo JA, McCue PM, Handa RJ, Squires EL, and Clay CM (2009) Biological and anatomical evidence for kisspeptin regulation of the hypothalamic-pituitary-gonadal axis of estrous horse mares. Endocrinology 150:2813-2821.
87. Marot D, Bieche I, Aumas C, Esselin S, Bouquet C, Vacher S, Lazennec G, Perricaudet M, Kuttenn F, Lidereau R, et al. (2007) High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors. Endocr Relat Cancer 14:691-702.
88. Martin TA, Watkins G, and Jiang WG (2005) KiSS-1 expression in human breast cancer. Clin Exp Metastasis 22:503-511. (Pubitemid 41750702)
89. Masui T, Doi R, Mori T, Toyoda E, Koizumi M, Kami K, Ito D, Peiper SC, Broach JR, Oishi S, et al. (2004) Metastin and its variant forms suppress migration of pancreatic cancer cells. Biochem Biophys Res Commun 315:85-92.
90. Matsui H, Takatsu Y, Kumano S, Matsumoto H, and Ohtaki T (2004) Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun 320:383-388.
91. Mead EJ, Maguire JJ, Kuc RE, and Davenport AP (2007a) Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Br J Pharmacol 151:1143-1153.
92. Mead EJ, Maguire JJ, Kuc RE, and Davenport AP (2007b) Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels. Endocrinology 148:140-147.
93. Mechaly AS, Viñas J, and Piferrer F (2009) Identification of two isoforms of the Kisspeptin-1 receptor (kiss1r) generated by alternative splicing in a modern teleost, the Senegalese sole (Solea senegalensis). Biol Reprod 80:60-69.
94. Messager S (2005a) Kisspeptin and its receptor: new gatekeepers of puberty. J Neuroendocrinol 17:687-688.
95. Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, et al. (2005b) Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci USA 102:1761-1766.
96. Miele ME, Jewett MD, Goldberg SF, Hyatt DL, Morelli C, Gualandi F, Rimessi P, Hicks DJ, Weissman BE, Barbanti-Brodano G, et al. (2000) A human melanoma metastasis-suppressor locus maps to 6q16.3-q23. Int J Cancer 86:524-528.
97. Miele ME, Robertson G, Lee JH, Coleman A, McGary CT, Fisher PB, Lugo TG, and Welch DR (1996) Metastasis suppressed, but tumorigenicity and local invasiveness unaffected, in the human melanoma cell line MelJuSo after introduction of human chromosomes 1 or 6. Mol Carcinog 15:284-299.
98. Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, and Juul A (2009) Comparison of the effects of peripherally administered kisspeptins. Regul Pept 152:95-100.
99. Mitchell DC, Stafford LJ, Li D, Bar-Eli M, and Liu M (2007 Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity protein-1 and its coactivator DRIP-130. Oncogene 26:1739-1747.
100. Mohamed JS, Benninghoff AD, Holt GJ, and Khan IA (2007) Developmental expression of the G protein-coupled receptor 54 and three GnRH mRNAs in the teleost fish cobia. J Mol Endocrinol 38:235-244.
101. Moon JS, Lee YR, Oh DY, Hwang JI, Lee JY, Kim JI, Vaudry H, Kwon HB, and Seong JY (2009) Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin. Peptides 30:171-179.
102. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, et al. (2001) AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem 276:28969-28975.
103. Navarro VM, Castellano JM, Fernández-Fernández R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, and Tena-Sempere M., Pinilla L, and Tena-Sempere M (2004a) Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145:4565-4574.
104. Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Barreiro ML, Casanueva FF, Aguilar E, Dieguez C, et al. (2005a) Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology 146:1689-1697.
105. Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Nogueiras R, Vazquez MJ, Barreiro ML, Magni P, et al. (2005b) Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology 146:156-163.
106. Navarro VM, Castellano JM, García-Galiano D, and Tena-Sempere M (2007) Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin. Rev Endocr Metab Disord 8:11-20.
107. Navarro VM, Fernández-Fernández R, Castellano JM, Roa J, Mayen A, Barreiro ML, Gaytan F, Aguilar E, Pinilla L, Dieguez C, et al. (2004b) Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol 561:379-386.
108. Navenot JM, Fujii N, and Peiper SC (2009a) Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis. Mol Pharmacol 75:1300-1306.
109. Navenot JM, Fujii N, and Peiper SC (2009b) KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis. Mol Pharmacol 75:1074-1083.
110. Navenot JM, Wang Z, Chopin M, Fujii N, and Peiper SC (2005) Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins. Cancer Res 65:10450-10456.
111. Niida A, Wang Z, Tomita K, Oishi S, Tamamura H, Otaka A, Navenot JM, Broach JR, Peiper SC, and Fujii N (2006) Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity. Bioorg Med Chem Lett 16:134-137.
112. Nocillado JN, Levavi-Sivan B, Carrick F, and Elizur A (2007) Temporal expression of G-protein-coupled receptor 54 (GPR54), gonadotropin-releasing hormones (GnRH), and dopamine receptor D2 (drd2) in pubertal female grey mullet, Mugil cephalus. Gen Comp Endocrinol 150:278-287.
113. Oakley AE, Clifton DK, and Steiner RA (2009) Kisspeptin signaling in the brain. Endocr Rev 30:713-743.
114. Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, et al. (2009) Gonadotrophin- releasing hormone pulse generator activity in the hypothalamus of the goat. J Neuroendocrinol 21:813-821.
115. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, et al. (2001) Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411:613-617.
116. Orsini MJ, Klein MA, Beavers MP, Connolly PJ, Middleton SA, and Mayo KH (2007) Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening. J Med Chem 50:462-471.
117. Pampillo M, Camuso N, Taylor JE, Szereszewski JM, Ahow MR, Zajac M, Millar RP, Bhattacharya M, and Babwah AV (2009) Regulation of GPR54 signaling by GRK2 and beta-arrestin. Mol Endocrinol 23:2060-2074.
118. Panidis D, Rousso D, Koliakos G, Kourtis A, Katsikis I, Farmakiotis D, Votsi E, and Diamanti-Kandarakis E (2006) Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome. Fertil Steril 85:1778-1783.
119. Parhar IS, Ogawa S, and Sakuma Y (2004) Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish. Endocrinology 145:3613-3618.
120. Paul MJ, Pyter LM, Freeman DA, Galang J, and Prendergast BJ (2009) Photic and nonphotic seasonal cues differentially engage hypothalamic kisspeptin and RF-amide-related peptide mRNA expression in Siberian hamsters. J Neuroendocrinol 21:1007-1014.
121. Pheng V, Uenoyama Y, Homma T, Inamoto Y, Takase K, Yoshizawa-Kumagaye K, Isaka S, Watanabe TX, Ohkura S, Tomikawa J, et al. (2009) Potencies of centrally- or peripherally-injected full-length kisspeptin or its C-terminal decapeptide on LH release in intact male rats. J Reprod Dev 55:378-382.
122. Pielecka-Fortuna J, Chu Z, and Moenter SM (2008) Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology 149:1979-1986.
123. Pineda R, Garcia-Galiano D, Roseweir A, Romero M, Sanchez-Garrido MA, Ruiz-Pino F, Morgan K, Pinilla L, Millar RP, and Tena-Sempere M (2010) Critical roles of kisspeptins in female puberty and preovulatory gonadotropin surges as revealed by a novel antagonist. Endocrinology 151:722-730.
124. Plant TM, Ramaswamy S, and Dipietro MJ (2006) Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges. Endocrinology 147:1007-1013.
125. Pompolo S, Pereira A, Estrada KM, and Clarke IJ (2006) Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain. Endocrinology 147:804-810.
126. Qiao C, Wang CH, Shang T, and Lin QD (2005) [Clinical significance of KiSS-1 and matrix metalloproteinase-9 expression in trophoblasts of women with preeclampsia and their relation to perinatal outcome of neonates.] Zhonghua Fu Chan Ke Za Zhi 40:585-590.
127. Quaynor S, Hu L, Leung PK, Feng H, Mores N, Krsmanovic LZ, and Catt KJ (2007) Expression of a functional G protein-coupled receptor 54-kisspeptin autoregulatory system in hypothalamic gonadotropin-releasing hormone neurons. Mol Endocrinol 21:3062-3070.
128. Ramaswamy S, Gibbs RB, and Plant TM (2009) Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones. J Neuroendocrinol 21:795-804.
129. Ramaswamy S, Guerriero KA, Gibbs RB, and Plant TM (2008) Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy. Endocrinology 149:4387-4395.
130. Ramaswamy S, Seminara SB, Pohl CR, DiPietro MJ, Crowley WF Jr, and Plant TM (2007) Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta). Endocrinology 148:3364-3370.
131. Revel FG, Ansel L, Klosen P, Saboureau M, Pévet P, Mikkelsen JD, and Simonneaux V (2007) Kisspeptin: a key link to seasonal breeding. Rev Endocr Metab Disord 8:57-65.
132. Reynolds RM, Logie JJ, Roseweir AK, McKnight AJ, and Millar RP (2009) A role for kisspeptins in pregnancy: facts and speculations. Reproduction 138:1-7.
133. Richard N, Corvaisier S, Camacho E, and Kottler ML (2009) KiSS-1 and GPR54 at the pituitary level: overview and recent insights. Peptides 30:123-129.
134. Richard N, Galmiche G, Corvaisier S, Caraty A, and Kottler ML (2008) KiSS-1 and GPR54 genes are co-expressed in rat gonadotrophs and differentially regulated in vivo by oestradiol and gonadotrophin-releasing hormone. J Neuroendocrinol 20:381-393.
135. Ringel MD, Hardy E, Bernet VJ, Burch HB, Schuppert F, Burman KD, and Saji M (2002) Metastin receptor is overexpressed in papillary thyroid cancer and
136. Roa J, Castellano JM, Navarro VM, Handelsman DJ, Pinilla L, and Tena-SempereM (2009) Kisspeptins and the control of gonadotropin secretion in male and female rodents. Peptides 30:57-66.
137. Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, Pineda R, Diéguez C, Aguilar E, Pinilla L, and Tena-SempereM(2008a) Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. Am J Physiol Endocrinol Metab 294:E1088-E1096.
138. Roa J, Vigo E, Castellano JM, Gaytan F, García-Galiano D, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, et al. (2008b) Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors. Endocrinology 149:5783-5790.
139. Roa J, Vigo E, Castellano JM, Gaytan F, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, et al. (2008c) Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge. Endocrinology 149:1627-1637.
140. Rometo AM, Krajewski SJ, Voytko ML, and Rance NE (2007) Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab 92:2744-2750.
141. Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, et al. (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci 29:3920-3929.
142. Sanchez-Carbayo M, Belbin TJ, Scotlandi K, Prystowsky M, Baldini N, Childs G, and Cordon-Cardo C (2003) Expression profiling of osteosarcoma cells transfected with MDR1 and NEO genes: regulation of cell adhesion, apoptosis, and tumor suppression-related genes. Lab Invest 83:507-517.
143. Schmid K, Wang X, Haitel A, Sieghart W, Peck-Radosavljevic M, Bodingbauer M, Rasoul-Rockenschaub S, and Wrba F (2007) KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study. Virchows Arch 450:143-149.
144. Seminara SB (2006) Mechanisms of Disease: the first kiss-a crucial role for kisspeptin- 1 and its receptor, G-protein-coupled receptor 54, in puberty and reproduction. Nat Clin Pract Endocrinol Metab 2:328-334.
145. Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF Jr, and Plant TM (2006) Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology 147:2122-2126.
146. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS, Jr., Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF, Jr., Aparicio SA, and Colledge WH (2003) The GPR54 gene as a regulator of puberty. N Engl J Med 349:1614-1627.
147. Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, and Plant TM (2005) Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci USA 102:2129-2134.
148. Shibata M, Friedman RL, Ramaswamy S, and Plant TM (2007) Evidence that down regulation of hypothalamic KiSS-1 expression is involved in the negative feedback action of testosterone to regulate luteinising hormone secretion in the adult male rhesus monkey (Macaca mulatta). J Neuroendocrinol 19:432-438.
149. Shirasaki F, Takata M, Hatta N, and Takehara K (2001) Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23. Cancer Res 61:7422-7425.
150. Silvestre RA, Egido EM, Hernández R, and Marco J (2008) Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J Endocrinol 196:283-290.
151. Simonneaux V, Ansel L, Revel FG, Klosen P, Pévet P, and Mikkelsen JD (2009) Kisspeptin and the seasonal control of reproduction in hamsters. Peptides 30:146-153.
152. Smith JT, Acohido BV, Clifton DK, and Steiner RA (2006a) KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol 18:298-303.
153. Smith JT and Clarke IJ (2007) Kisspeptin expression in the brain: catalyst for the initiation of puberty. Rev Endocr Metab Disord 8:1-9.
154. Smith JT, Clay CM, Caraty A, and Clarke IJ (2007) KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology 148:1150-1157.
155. Smith JT, Coolen LM, Kriegsfeld LJ, Sari IP, Jaafarzadehshirazi MR, Maltby M, Bateman K, Goodman RL, Tilbrook AJ, Ubuka T, et al. (2008) Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology 149:5770-5782.
156. Smith JT, Cunningham MJ, Rissman EF, Clifton DK, and Steiner RA (2005a) Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146:3686-3692.
157. Smith JT, Dungan HM, Stoll EA, Gottsch ML, Braun RE, Eacker SM, Clifton DK, and Steiner RA (2005b) Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology 146:2976-2984.
158. Smith JT, Popa SM, Clifton DK, Hoffman GE, and Steiner RA (2006b) Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci 26:6687-6694.
159. Stafford LJ, Xia C, Ma W, Cai Y, and Liu M (2002) Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res 62:5399-5404.
160. Stark AM, Tongers K, Maass N, Mehdorn HM, and Held-Feindt J (2005) Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. J Cancer Res Clin Oncol 131:191-198.
161. Stathatos N, Bourdeau I, Espinosa AV, Saji M, Vasko VV, Burman KD, Stratakis CA, and Ringel MD (2005) KiSS-1/G protein-coupled receptor 54 metastasis suppressor pathway increases myocyte-enriched calcineurin interacting protein 1 expression and chronically inhibits calcineurin activity. J Clin Endocrinol Metab 90:5432-5440.
162. Takino T, Koshikawa N, Miyamori H, Tanaka M, Sasaki T, Okada Y, Seiki M, and Sato H (2003) Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. Oncogene 22:4617-4626.
163. Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, and Latronico AC (2008) A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med 358:709-715.
164. Tena-Sempere M (2006a) GPR54 and kisspeptin in reproduction. Hum Reprod Update 12:631-639.
165. Tena-Sempere M (2006b) The roles of kisspeptins and G protein-coupled receptor-54 in pubertal development. Curr Opin Pediatr 18:442-447.
166. Terao Y, Kumano S, Takatsu Y, Hattori M, Nishimura A, Ohtaki T, and Shintani Y (2004) Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta. Biochim Biophys Acta 1678:102-110.
167. Thompson EL, Amber V, Stamp GW, Patterson M, Curtis AE, Cooke JH, Appleby GF, Dhillo WS, Ghatei MA, Bloom SR, et al. (2009) Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms. Br J Pharmacol 156:609-625.
168. Thompson EL, Murphy KG, Patterson M, Bewick GA, Stamp GW, Curtis AE, Cooke JH, Jethwa PH, Todd JF, Ghatei MA, et al. (2006) Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats. Am J Physiol Endocrinol Metab 291:E1074-E1082.
169. Thompson EL, Patterson M, Murphy KG, Smith KL, Dhillo WS, Todd JF, Ghatei MA, and Bloom SR (2004) Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J Neuroendocrinol 16:850-858.
170. Tomikawa J, Homma T, Tajima S, Shibata T, Inamoto Y, Takase K, Inoue N, Ohkura S, Uenoyama Y, Maeda K, et al. (2010) Molecular characterization and estrogen regulation of hypothalamic KISS1 gene in the pig. Biol Reprod 82:313-319.
171. Tomita K, Narumi T, Niida A, Oishi S, Ohno H, and Fujii N (2007) Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres. Biopolymers 88:272-278.
172. Tomita K, Niida A, Oishi S, Ohno H, Cluzeau J, Navenot JM, Wang ZX, Peiper SC, and Fujii N (2006) Structure-activity relationship study on small peptidic GPR54 agonists. Bioorg Med Chem 14:7595-7603.
173. Tomita K, Oishi S, Ohno H, and Fujii N (2008) Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists. Biopolymers 90:503-511.
174. van Aerle R, Kille P, Lange A, and Tyler CR (2008) Evidence for the existence of a functional Kiss1/Kiss1 receptor pathway in fish. Peptides 29:57-64.
175. Vanhoutte PM, Humphrey PP, and Spedding M (1996) X. International Union of Pharmacology recommendations for nomenclature of new receptor subtypes. Pharmacol Rev 48:1-2.
176. Wacker JL, Feller DB, Tang XB, Defino MC, Namkung Y, Lyssand JS, Mhyre AJ, Tan X, Jensen JB, and Hague C (2008) Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. J Biol Chem 283:31068-31078.
177. Wagner GC, Johnston JD, Clarke IJ, Lincoln GA, and Hazlerigg DG (2008) Redefining the limits of day length responsiveness in a seasonal mammal. Endocrinology 149:32-39.
178. Welch DR, Chen P, Miele ME, McGary CT, Bower JM, Stanbridge EJ, and Weissman BE (1994) Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity. Oncogene 9:255-262. (Pubitemid 24020957)
179. West A, Vojta PJ, Welch DR, and Weissman BE (1998) Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). Genomics 54:145-148.
180. Yan C, Wang H, and Boyd DD (2001) KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Balpha -induced block of p65/p50 nuclear translocation. J Biol Chem 276:1164-1172.
181. Yang B, Jiang Q, Chan T, Ko WK, and Wong AO (2010) Goldfish kisspeptin: molecular cloning, tissue distribution of transcript expression, and stimulatory effects on prolactin, growth hormone and luteinizing hormone secretion and gene expression via direct actions at the pituitary level. Gen Comp Endocrinol 165:60-71.
182. Yao HL, Yang ZL, Li YG, and Liu GW (2007) [In situ hybridization study on the expression of Kiss-1 and KAI-1 metastasis suppressor genes in gastric cancer.] Zhonghua Wei Chang Wai Ke Za Zhi 10:274-277.
183. Zhang C, Roepke TA, Kelly MJ, and Rønnekleiv OK (2008) Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels. J Neurosci 28:4423-4434.
184. Zhang SL, Yu Y, Jiang T, Lin B, and Gao H (2005) [Expression and significance of KiSS-1 and its receptor GPR54 mRNA in epithelial ovarian cancer.] Zhonghua Fu Chan Ke Za Zhi 40:689-692.
185. Zohrabian VM, Nandu H, Gulati N, Khitrov G, Zhao C, Mohan A, Demattia J, Braun A, Das K, Murali R, et al. (2007) Gene expression profiling of metastatic brain cancer. Oncol Rep 18:321-328.