Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists

Biopolymers - Peptide Science Section

Volumn 90, Issue 4, 2008, Pages 503-511

  Tomita, Kenji ^a   Oishi, Shinya ^a   Ohno, Hiroaki ^a   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

CF HN hydrogen bonding; GPR54; Kisspeptin; Structure activity relationship

Indexed keywords

AMIDES; AMINES; BINDING ENERGY; CHEMICAL REACTIONS; DERIVATIVES; FLUORINE; HYDROGEN; HYDROGEN BONDS; NONMETALS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN; PATHOLOGY;

AMIDE HYDROGENS; BINDING AFFINITIES; C-TERMINUS; CANCER METASTASIS; CARBONYL OXYGEN; CF-HN HYDROGEN BONDING; ELECTROSTATIC REPULSIONS; ENDOCRINE SYSTEMS; FLUORINE ATOMS; FLUORINE SUBSTITUENTS; GONADOTROPIN-RELEASING HORMONE; GPR54; HYDROGEN BONDINGS; KISSPEPTIN; N TERMINALS; NMR ANALYSES; PARTIAL STRUCTURES; PENTAPEPTIDES; PROTEIN-COUPLED RECEPTORS; STERIC HINDRANCES; STRUCTURE-ACTIVITY RELATIONSHIP;

ORGANIC POLYMERS;

2 (N BENZOYLPHENYLALANYL) 3 PHENYLPROPIONIC ACID METHYL ESTER; 2 [N ( 2 FLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC ACID METHYL ESTER; 2 [N ( 2,3 DIFLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC METHYL ESTER; 2 [N ( 2,3,4 TRIFLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC ACID METHYL ESTER; 2 [N ( 2,4 DIFLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC METHYL ESTER; 2 [N ( 2,4,5 TRIFLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC METHYL ESTER; 2 [N ( 2,4,6 TRIFLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC ACID METHYL ESTER; 2 [N ( 2,5 DIFLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC ACID METHYL ESTER; 2 [N ( 3 FLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC METHYL ESTER; 2 [N ( 3,5 DIFLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC METHYL ESTER; 2 [N ( 4 FLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC ACID; 2 [N (PENTAFLUOROBENZOYL)PHENYLALANYL] 3 PHENYLPROPIONIC ACID METHYL ESTER; 2 FLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; 2,3 DIFLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; 2,3,4 TRIFLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; 2,4 DIFLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; 2,4,5 TRIFLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; 2,4,6 TRIFLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; 2,5 DIFLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; 3 FLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; 3,5 DIFLUOROBENZOIC ACID PHENYLGLYCYLLEUCYLARGINYLTRYPTOPHAN; ANTIMETASTATIC AGENT; ANTINEOPLASTIC AGENT; FLUOROBENZOYL PENTAPEPTIDE; G PROTEIN COUPLED RECEPTOR 54; PENTAPEPTIDE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; FLUOROBENZENES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52949139006     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20968     Document Type: Article

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