Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung

Inhalation Toxicology

Volumn 13, Issue 6, 2001, Pages 497-511

  Wright, J L ^a   Jeng, A Y ^a   Battistini, B ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 BIPHENYLYL) 1 (1H TETRAZOL 5 YL)ETHYLAMINOMETHYLPHOSPHONIC ACID; CGS 24592; ENDOTHELIN; ENDOTHELIN CONVERTING ENZYME INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE; MEMBRANE METALLOENDOPEPTIDASE INHIBITOR; PHOSPHORAMIDON; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY WALL; ARTICLE; BLOOD VESSEL WALL; CELL PROLIFERATION; CIGARETTE SMOKING; CONTROLLED STUDY; ENDOTHELIUM; ENZYME INHIBITION; LUNG ALVEOLUS EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; RAT; RESPIRATORY EPITHELIUM;

ANIMALIA; NICOTIANA TABACUM;

EID: 0034956355     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370151131873     Document Type: Article

References (48)

1. Effects of acute and chronic cigarette smoking on the expression of ET-1 mRNA of the cardiovascular tissues in rats
2. Endothelin-induced responses in the pulmonary system
3. Growth regulatory properties of endothelins
4. Growth factor activity of endothelin on vascular smooth muscle
5. Comparative studies of DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or primarily heat tobacco
6. Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage
7. B receptors
8. Endothelin-A receptor antagonist BQ-610 blocks cigarette smoke-induced mitogenesis in rat airways and vessels
9. Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme
10. Non-peptidic inhibitors of neutral endopeptidase 24.11
11. Non-peptidic inhibitors of neutral endopeptidase 24.11. Discovery and optimization of potency
12. Regulation of airway neurogenic inflammation by neutral endopeptidase
13. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease
14. Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine deficiency
15. Endothelial dysfunction in human disease
16. Endothelin-1 is elevated in monocrotaline pulmonary hypertension
17. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
18. Endothelin-1 promotes mitogenesis in airway smooth muscle cells
19. Morphologic changes in the muscular pulmonary arteries: Relationship to cigarette smoking, airway disease, and emphysema
20. Endothelin antagonism inhibits pulmonary vascular remodeling in canine chronic pulmonary embolism
21. Pulmonary vascular remodeling distal to pulmonary artery ligation is accompanied by upregulation of endothelin receptors and nitric oxide synthase
22. Small airways dimensions in asthma and in chronic obstructive pulmonary disease
23. A simple method for the representative sampling of lungs of diverse size
24. Endothelin converting enzyme (ECE) activity in human vascular smooth muscle
25. Effects of long-term cigarette smoking on endothelium-dependent responses in humans
26. Structure in endothelin-1 infused guinea pigs in vivo
27. A receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis
28. Endothelin-converting enzymes
29. The comparative mechanics and morphology of airways in asthma and in chronic obstructive pulmonary disease
30. Endothelial dysfunction in pulmonary arteries of patients with mild COPD
31. Endothelin antagonism with bosentan: A review of potential applications
32. Molecular characterization of endothelin receptors
33. The endothelium and control of blood vessel function in health and disease
34. Cigarette smoke causes rapid cell proliferation in small airways and associated pulmonary arteries
35. Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension
36. Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX
37. The effect of latent adenovirus 5 infection on cigarette smoke-induced lung inflammation
38. Direct comparison of bromodeoxyuridine and Ki-67 labelling indices in human tumours
39. Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia
40. The relationship of increased pulmonary artery pressure and airflow obstruction to emphysema
41. Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig
42. The effect of smoking cessation on pulmonary and cardiovascular function and structure
43. Dissociation of chronic vascular cell proliferation and vascular contractility after chronic cigarette smoke exposure
44. Glutathione levels play a role in cigarette smoke induced cell proliferation in the rat lung
45. Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes
46. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
47. Modulation of endothelin production and metabolism in guinea-pig tracheal epithelial cells by peptidase inhibitors
48. Increased plasma endothelin-1 in heavy and light smokers