An approach to rational ligand-design based on a thermodynamic analysis

Recent Patents on Biotechnology

Volumn 4, Issue 3, 2010, Pages 183-188

  Ui, Mihoko ^a,b   Tsumoto, Kouhei ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c THE UNIVERSITY OF TOKYO   (Japan)

Author keywords

Antibody; Ciguatoxin; Fragment design; Isothermal titration calorimetry (itc); Ligand screening; Thermodynamic analysis

Indexed keywords

ANTIBODIES; ANTIGENS; CALORIMETERS; CALORIMETRY; ENTHALPY; ENTROPY; HYDROGEN BONDS; ISOTHERMS; LEAD COMPOUNDS; STRUCTURAL DESIGN; TITRATION; VAN DER WAALS FORCES;

BINDING ENTHALPIES; CIGUATOXIN; EFFECTIVE TOOL; FRAGMENT DESIGN; ISOTHERMAL TITRATION CALORIMETRY; LIGAND DESIGN; LIGAND SCREENINGS; TARGET PROTEINS; THERMO DYNAMIC ANALYSIS;

LIGANDS;

CIGUATOXIN; TOXIN ANTIBODY;

ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; ANTIGEN ANTIBODY REACTION; ARTICLE; ENTHALPY; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; THERMODYNAMICS;

EID: 78650020361     PISSN: 18722083     EISSN: None     Source Type: Journal    
DOI: 10.2174/187220810793611482     Document Type: Article

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