Interferon-β activates multiple signaling cascades in primary human microglia

Journal of Neurochemistry

Volumn 81, Issue 6, 2002, Pages 1361-1371

  Kim, Mee Ohk ^a   Si, Qiusheng ^a   Zhou, Jian Nian ^a   Pestell, Richard G ^a   Brosnan, Celia F ^a   Locker, Joseph ^a   Lee, Sunhee C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Brain; Chemokine; ERK; Nuclear factor B (NF B); Stat1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BETA INTERFERON; DNA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; RANTES; SERINE; STAT PROTEIN; TRANSCRIPTION FACTOR AP 1; TYROSINE;

ANTIMICROBIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CYTOKINE PRODUCTION; DNA BINDING; DOSE RESPONSE; ENZYME PHOSPHORYLATION; INFLAMMATION; MACROPHAGE; MICROGLIA; MOLECULAR MECHANICS; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; VIRUS INFECTION;

CELLS, CULTURED; CHEMOKINES; CHEMOKINES, CC; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FETUS; FLAVONOIDS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; INTERFERON-BETA; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; PYRIDINES; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0036316724     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00949.x     Document Type: Article

References (55)

1. Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates
2. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necorsis factor-α gene expression in endotoxin-stimulated primary glial cultures
3. ATF and Jun transcription factors, acting through an Ets/CRE promoter module, mediate lipopolysaccharide inducibility of the chemokine RANTES in monocytic Mono Mac 6 cells
4. HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway
5. Multiple cis regulatory elements control RANTES promoter activity in alveolar epithelial cells infected with respiratory syncytial virus
6. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
7. Retrovirally mediated IFN-beta transduction of macrophages induces resistance to HIV, correlated with up-regulation of RANTES production and down-regulation of C-C chemokine receptor-5 expression
8. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signalling proteins
9. Requirement for MAP kinase (ERK2) activity in interferon alpha- and beta-stimulated gene expression through STAT proteins
10. Serine phosphorylation of STATs
11. Mechanism of interferon beta action in multiple sclerosis
12. Transcriptional regulation in the immune system: All roads lead to AP-1
13. Induction of the transcription factor IRF-1 and interferonβ mRNAs by cytokines and activators of second-messanger pathways
14. Regulation of RANTES chemokine gene expression requires cooperation between NF-kB and IFN-regulatory factor transcription factors
15. p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons
16. C/EBP, NF-kappaB, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene
17. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
18. CCR3 and CCR5 are co-receptors for HIV-I infection of microglia
19. Type I interferon induces inhibitory 16-kD CCAAT/enhancer binding protein (C/EBP) beta, repressing the HIV-1 long terminal repeat in macrophages: Pulmonary tuberculosis alters C/EBP expression, enhancing HIV-1 replication
20. Distinct patterns of stimulus-inducible chemokine mRNA accumulation in human fetal astrocytes and microglia
21. Selective inhibition of human glial inducible nitric oxide synthase expression by interferon-beta: Implications for multiple sclerosis
22. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6
23. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
24. NF-kappaB and cell-cycle regulation: The cyclin connection
25. The regulation of AP-1 activity by mitogen activated protein kinases
26. Role of MIP-1β and RANTES in HIV-1 infection of microglia: Inhibition of infection and induction by IFNβ
27. p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells
28. Characterization of human fetal dissociated CNS cultures with an emphasis on microglia
29. Interferons are critical regulators of IL-1b and IL-1ra expression in human fetal microglia
30. Modulation of IL-1β and TNFα signaling by P2 purinergic receptors in human fetal astrocytes
31. Triggering of peritoneal macrophages with IFN-α/β attenuates the expression of inducible nitric oxide synthase through a decrease in NF-kB activation
32. IFNβ acts downstream of IFNr induced class II transactivator messenger RNA accumulation to block major histocompatibility complex II gene expression and requires the 48kD DNA binding protein, ISGF3-r
33. Chemokines - Chemotactic cytokines in inflammation
34. Differential induction of β-chemokines by type I and type II interferons in human microglia
35. PAF-induced RANTES Production by Human Airway Smooth Muscle Cells Requires Both p38 MAP Kinase and Erk
36. Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
37. Multiple signals converging on NF-kB
38. Interleukin-1 beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors
39. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo
40. Convergence of TNFalpha and IFNgamma signalling pathways through synergistic induction of IRF-I/ISGF-2 is mediated by a composite GAS/kappaB promoter element
41. An ATF/CREB-binding site is essential for cell-specific and inducible transcription of the murine MIP-Iβ cytokine gene
42. Ligation of CD11b and CD11c beta (2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protien 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB
43. Chemokines
44. Interferon beta induces interleukin-10 expression: Relevance to multiple sclerosis
45. Regulation of NF-kB activation by MAP kinase cascade
46. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
47. How cells respond to interferons
48. The effect of interferon-beta on bloodbrain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis
49. Interferon beta-1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase-9
50. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
51. Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes
52. The interferons: Biological effects, mechanisms of action, and use in multiple sclerosis
53. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
54. IFNalpha/beta promotes cell survival by activating NF-kappa B
55. Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt