-
1
-
-
33846199233
-
Hypoxia-inducible factors: Central regulators of the tumor phenotype
-
Gordan JD and Simon MC: Hypoxia-inducible factors: Central regulators of the tumor phenotype. Curr Opin Genet Dev 17: 71-77, 2007.
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 71-77
-
-
Gordan, J.D.1
Simon, M.C.2
-
2
-
-
0034116376
-
The PAS superfamily: Sensors of environmental and developmental signals
-
Gu YZ, Hogenesch JB and Bradfield CA: The PAS superfamily: Sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol 40: 519-561, 2000.
-
(2000)
Annu Rev Pharmacol Toxicol
, vol.40
, pp. 519-561
-
-
Gu, Y.Z.1
Hogenesch, J.B.2
Bradfield, C.A.3
-
3
-
-
0032872915
-
Remembrance of things PAS: Regulation of development by bHLH-PAS proteins
-
Crews ST and Fan CM: Remembrance of things PAS: Regulation of development by bHLH-PAS proteins. Curr Opin Genet Dev 9: 580-587, 1999.
-
(1999)
Curr Opin Genet Dev
, vol.9
, pp. 580-587
-
-
Crews, S.T.1
Fan, C.M.2
-
4
-
-
0033991530
-
Expression of hypoxia-inducible factor 1: Mechanisms and consequences
-
Semenza GL: Expression of hypoxia-inducible factor 1: Mechanisms and consequences. Biochem Pharmacol 59: 47-53, 2000.
-
(2000)
Biochem Pharmacol
, vol.59
, pp. 47-53
-
-
Semenza, G.L.1
-
5
-
-
33751169387
-
Hypoxia-inducible factor-1 (HIF-1)
-
Ke Q and Costa M: Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 70: 1469-1480, 2006.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1469-1480
-
-
Ke, Q.1
Costa, M.2
-
6
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza GL: HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
-
(2000)
J Appl Physiol
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
7
-
-
0032167429
-
Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
-
Pinsky DJ, Liao H, Lawson CA, et al: Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest 102: 919-928, 1998. (Pubitemid 28419237)
-
(1998)
Journal of Clinical Investigation
, vol.102
, Issue.5
, pp. 919-928
-
-
Pinsky, D.J.1
Liao, H.2
Lawson, C.A.3
Yan, S.-F.4
Chen, J.5
Carmeliet, P.6
Loskutoff, D.J.7
Stern, D.M.8
-
8
-
-
0032795850
-
Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes
-
Kietzmann T, Roth U and Jungermann K: Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 94: 4177-4185, 1999.
-
(1999)
Blood
, vol.94
, pp. 4177-4185
-
-
Kietzmann, T.1
Roth, U.2
Jungermann, K.3
-
9
-
-
0037085780
-
Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1
-
Fink T, Kazlauskas A, Poellinger L, Ebbesen P and Zachar V: Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood 99: 2077-2083, 2002.
-
(2002)
Blood
, vol.99
, pp. 2077-2083
-
-
Fink, T.1
Kazlauskas, A.2
Poellinger, L.3
Ebbesen, P.4
Zachar, V.5
-
10
-
-
0035353174
-
The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site
-
Samoylenko A, Roth U, Jungermann K and Kietzmann T: The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site. Blood 97: 2657-2666, 2001.
-
(2001)
Blood
, vol.97
, pp. 2657-2666
-
-
Samoylenko, A.1
Roth, U.2
Jungermann, K.3
Kietzmann, T.4
-
11
-
-
0035816732
-
Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase
-
Gorlach A, Diebold I, Schini-Kerth VB, et al: Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res 89: 47-54, 2001.
-
(2001)
Circ Res
, vol.89
, pp. 47-54
-
-
Gorlach, A.1
Diebold, I.2
Schini-Kerth, V.B.3
-
12
-
-
0033958906
-
Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the CNS and brain injuries following dramatic circulatory arrests: An immunohistochemical study
-
Dietzmann K, von Bossanyi P, Krause D, Wittig H, Mawrin C and Kirches E: Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the cns and brain injuries following dramatic circulatory arrests: An immunohistochemical study. Pathol Res Pract 196: 15-21, 2000. (Pubitemid 30046522)
-
(2000)
Pathology Research and Practice
, vol.196
, Issue.1
, pp. 15-21
-
-
Dietzmann, K.1
Bossanyi, P.V.2
Krause, D.3
Wittig, H.4
Mawrin, Ch.5
Kirches, E.6
-
13
-
-
13844306360
-
Pivotal role of plasminogen-activator inhibitor 1 in vascular disease
-
Agirbasli M: Pivotal role of plasminogen-activator inhibitor 1 in vascular disease. Int J Clin Pract 59: 102-106, 2005.
-
(2005)
Int J Clin Pract
, vol.59
, pp. 102-106
-
-
Agirbasli, M.1
-
14
-
-
0035863308
-
Direct evidence of the importance of stromal urokinase plasminogen activator (UPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model
-
Frandsen TL, Holst-Hansen C, Nielsen BS, et al: Direct evidence of the importance of stromal urokinase plasminogen activator (UPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model. Cancer Res 61: 532-537, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 532-537
-
-
Frandsen, T.L.1
Holst-Hansen, C.2
Nielsen, B.S.3
-
15
-
-
0042804870
-
Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice
-
Almholt K, Nielsen BS, Frandsen TL, Brunner N, Dano K and Johnsen M: Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice. Oncogene 22: 4389-4397, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 4389-4397
-
-
Almholt, K.1
Nielsen, B.S.2
Frandsen, T.L.3
Brunner, N.4
Dano, K.5
Johnsen, M.6
-
16
-
-
0035911151
-
The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies
-
Bajou K, Masson V, Gerard RD, et al: The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. J Cell Biol 152: 777-784, 2001.
-
(2001)
J Cell Biol
, vol.152
, pp. 777-784
-
-
Bajou, K.1
Masson, V.2
Gerard, R.D.3
-
17
-
-
0034014726
-
Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis
-
Kwaan HC, Wang J, Svoboda K and Declerck PJ: Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis. Br J Cancer 82: 1702-1708, 2000.
-
(2000)
Br J Cancer
, vol.82
, pp. 1702-1708
-
-
Kwaan, H.C.1
Wang, J.2
Svoboda, K.3
Declerck, P.J.4
-
18
-
-
0025122368
-
The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1
-
Prendergast GC, Diamond LE, Dahl D and Cole MD: The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol 10: 1265-1269, 1990.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 1265-1269
-
-
Prendergast, G.C.1
Diamond, L.E.2
Dahl, D.3
Cole, M.D.4
-
19
-
-
0029144441
-
Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53
-
Kunz C, Pebler S, Otte J and von der Ahe D: Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53. Nucleic Acids Res 23: 3710-3717, 1995.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 3710-3717
-
-
Kunz, C.1
Pebler, S.2
Otte, J.3
Von Der Ahe, D.4
-
20
-
-
31344473450
-
The complex between urokinase (uPA) and its type-1 inhibitor (PAI-1) in pulmonary adenocarcinoma: Relation to prognosis
-
Pappot H, Pedersen AN, Brunner N and Christensen IJ: The complex between urokinase (uPA) and its type-1 inhibitor (PAI-1) in pulmonary adenocarcinoma: Relation to prognosis. Lung Cancer 51: 193-200, 2006.
-
(2006)
Lung Cancer
, vol.51
, pp. 193-200
-
-
Pappot, H.1
Pedersen, A.N.2
Brunner, N.3
Christensen, I.J.4
-
21
-
-
33845330925
-
Prognostic value of PAI1 in invasive breast cancer: Evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression
-
Sternlicht MD, Dunning AM, Moore DH, et al: Prognostic value of PAI1 in invasive breast cancer: Evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiol Biomarkers Prev 15: 2107-2114, 2006.
-
(2006)
Cancer Epidemiol Biomarkers Prev
, vol.15
, pp. 2107-2114
-
-
Sternlicht, M.D.1
Dunning, A.M.2
Moore, D.H.3
-
22
-
-
0342680018
-
Drug resistant tumor cells have increased levels of tumor markers for invasion and metastasis
-
Osmak M, Niksic D, Brozovic A, Ristov AA, Vrhovec I and Skrk J: Drug resistant tumor cells have increased levels of tumor markers for invasion and metastasis. Anticancer Res 19: 3193-3197, 1999.
-
(1999)
Anticancer Res
, vol.19
, pp. 3193-3197
-
-
Osmak, M.1
Niksic, D.2
Brozovic, A.3
Ristov, A.A.4
Vrhovec, I.5
Skrk, J.6
-
23
-
-
0032508691
-
Hypoxia-inducible mammalian gene expression analyzed in vivo at a tata-driven promoter and at an initiator-driven promoter
-
Okino ST, Chichester CH and Whitlock JP Jr: Hypoxia-inducible mammalian gene expression analyzed in vivo at a tata-driven promoter and at an initiator-driven promoter. J Biol Chem 273: 23837-23843, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 23837-23843
-
-
Okino, S.T.1
Chichester, C.H.2
Whitlock Jr., J.P.3
-
24
-
-
0004326807
-
Cytochrome p450 gene regulation. Analysis of protein-DNA interactions in situ
-
Okino ST and Whitlock JP Jr: Cytochrome p450 gene regulation. Analysis of protein-DNA interactions in situ. Methods Mol Biol 107: 395-404, 1998.
-
(1998)
Methods Mol Biol
, vol.107
, pp. 395-404
-
-
Okino, S.T.1
Whitlock Jr., J.P.2
-
25
-
-
0030588298
-
Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia
-
Salceda S, Beck I and Caro J: Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch Biochem Biophys 334: 389-394, 1996.
-
(1996)
Arch Biochem Biophys
, vol.334
, pp. 389-394
-
-
Salceda, S.1
Beck, I.2
Caro, J.3
-
26
-
-
0033867776
-
Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation
-
Dachs GU and Tozer GM: Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation. Eur J Cancer 36: 1649-1660, 2000.
-
(2000)
Eur J Cancer
, vol.36
, pp. 1649-1660
-
-
Dachs, G.U.1
Tozer, G.M.2
-
27
-
-
0033538431
-
Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene
-
Ding H, Benotmane AM, Suske G, Collen D and Belayew A: Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. J Biol Chem 274: 19573-19580, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 19573-19580
-
-
Ding, H.1
Benotmane, A.M.2
Suske, G.3
Collen, D.4
Belayew, A.5
-
28
-
-
0028891906
-
The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site
-
Kvietikova I, Wenger RH, Marti HH and Gassmann M: The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res 23: 4542-4550, 1995.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 4542-4550
-
-
Kvietikova, I.1
Wenger, R.H.2
Marti, H.H.3
Gassmann, M.4
-
29
-
-
0025895483
-
Mediators of induction of augmented expression of plasminogen activator inhibitor type-1 in Hep G2 cells by platelets
-
Hopkins WE, Westerhausen DR, Fujii S, Billadello JJ and Sobel BE: Mediators of induction of augmented expression of plasminogen activator inhibitor type-1 in Hep G2 cells by platelets. Thromb Haemost 66: 239-245, 1991.
-
(1991)
Thromb Haemost
, vol.66
, pp. 239-245
-
-
Hopkins, W.E.1
Westerhausen, D.R.2
Fujii, S.3
Billadello, J.J.4
Sobel, B.E.5
-
30
-
-
0035987585
-
Hypoxia enhances the expression of plasminogen activator inhibitor-1 in human lung cancer cells, EBC-1
-
Kimura D, Imaizumi T, Tamo W, et al: Hypoxia enhances the expression of plasminogen activator inhibitor-1 in human lung cancer cells, EBC-1. Tohoku J Exp Med 196: 259-267, 2002.
-
(2002)
Tohoku J Exp Med
, vol.196
, pp. 259-267
-
-
Kimura, D.1
Imaizumi, T.2
Tamo, W.3
-
31
-
-
33847373884
-
Molecular regulation of the PAI-1 gene by hypoxia: Contributions of Egr-1, HIF-1alpha, and C/EBPalpha
-
Liao H, Hyman MC, Lawrence DA and Pinsky DJ: Molecular regulation of the PAI-1 gene by hypoxia: Contributions of Egr-1, HIF-1alpha, and C/EBPalpha. FASEB J 21: 935-949, 2007.
-
(2007)
FASEB J
, vol.21
, pp. 935-949
-
-
Liao, H.1
Hyman, M.C.2
Lawrence, D.A.3
Pinsky, D.J.4
-
32
-
-
0033388858
-
In vivo cross-linking and immunoprecipitation for studying dynamic protein:DNA associations in a chromatin environment
-
Kuo MH and Allis CD: In vivo cross-linking and immunoprecipitation for studying dynamic protein:DNA associations in a chromatin environment. Methods 19: 425-433, 1999.
-
(1999)
Methods
, vol.19
, pp. 425-433
-
-
Kuo, M.H.1
Allis, C.D.2
-
33
-
-
0024431684
-
In vivo footprinting of a muscle-specific enhancer by ligation mediated PCR
-
Mueller PR and Wold B: In vivo footprinting of a muscle-specific enhancer by ligation mediated PCR. Science 246: 780-786, 1989.
-
(1989)
Science
, vol.246
, pp. 780-786
-
-
Mueller, P.R.1
Wold, B.2
-
34
-
-
0032900187
-
Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells
-
Wojta J, Kaun C, Breuss JM, et al: Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells. Lab Invest 79: 427-438, 1999.
-
(1999)
Lab Invest
, vol.79
, pp. 427-438
-
-
Wojta, J.1
Kaun, C.2
Breuss, J.M.3
-
36
-
-
0035859692
-
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F, White SB, Zhao Q and Lee FS: HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 98: 9630-9635, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
37
-
-
31144440795
-
Mammalian gene expression program resiliency: The roles of multiple coactivator mechanisms in hypoxia-responsive transcription
-
Kasper LH and Brindle PK: Mammalian gene expression program resiliency: The roles of multiple coactivator mechanisms in hypoxia-responsive transcription. Cell Cycle 5: 142-146, 2006.
-
(2006)
Cell Cycle
, vol.5
, pp. 142-146
-
-
Kasper, L.H.1
Brindle, P.K.2
-
38
-
-
33745685879
-
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway
-
Carroll VA and Ashcroft M: Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway. Cancer Res 66: 6264-6270, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 6264-6270
-
-
Carroll, V.A.1
Ashcroft, M.2
-
39
-
-
4143078131
-
The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells
-
Sato M, Tanaka T, Maemura K, et al: The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am J Respir Cell Mol Biol 31: 209-215, 2004.
-
(2004)
Am J Respir Cell Mol Biol
, vol.31
, pp. 209-215
-
-
Sato, M.1
Tanaka, T.2
Maemura, K.3
-
40
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
41
-
-
0344608877
-
Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
-
Chen J, Zhao S, Nakada K, et al: Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 162: 1283-1291, 2003.
-
(2003)
Am J Pathol
, vol.162
, pp. 1283-1291
-
-
Chen, J.1
Zhao, S.2
Nakada, K.3
-
42
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A, Uranchimeg B, Scudiero DA, et al: Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 62: 4316-4324, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
-
43
-
-
3142622930
-
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
-
Kung AL, Zabludoff SD, France DS, et al: Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6: 33-43, 2004.
-
(2004)
Cancer Cell
, vol.6
, pp. 33-43
-
-
Kung, A.L.1
Zabludoff, S.D.2
France, D.S.3
-
44
-
-
25444523184
-
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
-
Kong D, Park EJ, Stephen AG, et al: Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res 65: 9047-9055, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 9047-9055
-
-
Kong, D.1
Park, E.J.2
Stephen, A.G.3
|