메뉴 건너뛰기




Volumn 37, Issue 6, 2010, Pages 1627-1638

Rodent-specific hypoxia response elements enhance PAI-1 expression through HIF-1 or HIF-2 in mouse hepatoma cells

Author keywords

Enhancer; Hepa1c1c7 cells; Hypoxia; Hypoxia inducible factor 1; Hypoxia inducible factor 2; Hypoxia response element; Plasminogen activator inhibitor 1; Protein DNA interaction; Transcription

Indexed keywords

DEOXYRIBONUCLEASE I; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; UNCLASSIFIED DRUG;

EID: 78649964350     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000817     Document Type: Article
Times cited : (25)

References (44)
  • 1
    • 33846199233 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Central regulators of the tumor phenotype
    • Gordan JD and Simon MC: Hypoxia-inducible factors: Central regulators of the tumor phenotype. Curr Opin Genet Dev 17: 71-77, 2007.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 71-77
    • Gordan, J.D.1    Simon, M.C.2
  • 2
    • 0034116376 scopus 로고    scopus 로고
    • The PAS superfamily: Sensors of environmental and developmental signals
    • Gu YZ, Hogenesch JB and Bradfield CA: The PAS superfamily: Sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol 40: 519-561, 2000.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 519-561
    • Gu, Y.Z.1    Hogenesch, J.B.2    Bradfield, C.A.3
  • 3
    • 0032872915 scopus 로고    scopus 로고
    • Remembrance of things PAS: Regulation of development by bHLH-PAS proteins
    • Crews ST and Fan CM: Remembrance of things PAS: Regulation of development by bHLH-PAS proteins. Curr Opin Genet Dev 9: 580-587, 1999.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 580-587
    • Crews, S.T.1    Fan, C.M.2
  • 4
    • 0033991530 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1: Mechanisms and consequences
    • Semenza GL: Expression of hypoxia-inducible factor 1: Mechanisms and consequences. Biochem Pharmacol 59: 47-53, 2000.
    • (2000) Biochem Pharmacol , vol.59 , pp. 47-53
    • Semenza, G.L.1
  • 5
    • 33751169387 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1)
    • Ke Q and Costa M: Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 70: 1469-1480, 2006.
    • (2006) Mol Pharmacol , vol.70 , pp. 1469-1480
    • Ke, Q.1    Costa, M.2
  • 6
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL: HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 7
    • 0032167429 scopus 로고    scopus 로고
    • Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
    • Pinsky DJ, Liao H, Lawson CA, et al: Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest 102: 919-928, 1998. (Pubitemid 28419237)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.5 , pp. 919-928
    • Pinsky, D.J.1    Liao, H.2    Lawson, C.A.3    Yan, S.-F.4    Chen, J.5    Carmeliet, P.6    Loskutoff, D.J.7    Stern, D.M.8
  • 8
    • 0032795850 scopus 로고    scopus 로고
    • Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes
    • Kietzmann T, Roth U and Jungermann K: Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 94: 4177-4185, 1999.
    • (1999) Blood , vol.94 , pp. 4177-4185
    • Kietzmann, T.1    Roth, U.2    Jungermann, K.3
  • 9
    • 0037085780 scopus 로고    scopus 로고
    • Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1
    • Fink T, Kazlauskas A, Poellinger L, Ebbesen P and Zachar V: Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood 99: 2077-2083, 2002.
    • (2002) Blood , vol.99 , pp. 2077-2083
    • Fink, T.1    Kazlauskas, A.2    Poellinger, L.3    Ebbesen, P.4    Zachar, V.5
  • 10
    • 0035353174 scopus 로고    scopus 로고
    • The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site
    • Samoylenko A, Roth U, Jungermann K and Kietzmann T: The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site. Blood 97: 2657-2666, 2001.
    • (2001) Blood , vol.97 , pp. 2657-2666
    • Samoylenko, A.1    Roth, U.2    Jungermann, K.3    Kietzmann, T.4
  • 11
    • 0035816732 scopus 로고    scopus 로고
    • Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase
    • Gorlach A, Diebold I, Schini-Kerth VB, et al: Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res 89: 47-54, 2001.
    • (2001) Circ Res , vol.89 , pp. 47-54
    • Gorlach, A.1    Diebold, I.2    Schini-Kerth, V.B.3
  • 12
    • 0033958906 scopus 로고    scopus 로고
    • Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the CNS and brain injuries following dramatic circulatory arrests: An immunohistochemical study
    • Dietzmann K, von Bossanyi P, Krause D, Wittig H, Mawrin C and Kirches E: Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the cns and brain injuries following dramatic circulatory arrests: An immunohistochemical study. Pathol Res Pract 196: 15-21, 2000. (Pubitemid 30046522)
    • (2000) Pathology Research and Practice , vol.196 , Issue.1 , pp. 15-21
    • Dietzmann, K.1    Bossanyi, P.V.2    Krause, D.3    Wittig, H.4    Mawrin, Ch.5    Kirches, E.6
  • 13
    • 13844306360 scopus 로고    scopus 로고
    • Pivotal role of plasminogen-activator inhibitor 1 in vascular disease
    • Agirbasli M: Pivotal role of plasminogen-activator inhibitor 1 in vascular disease. Int J Clin Pract 59: 102-106, 2005.
    • (2005) Int J Clin Pract , vol.59 , pp. 102-106
    • Agirbasli, M.1
  • 14
    • 0035863308 scopus 로고    scopus 로고
    • Direct evidence of the importance of stromal urokinase plasminogen activator (UPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model
    • Frandsen TL, Holst-Hansen C, Nielsen BS, et al: Direct evidence of the importance of stromal urokinase plasminogen activator (UPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model. Cancer Res 61: 532-537, 2001.
    • (2001) Cancer Res , vol.61 , pp. 532-537
    • Frandsen, T.L.1    Holst-Hansen, C.2    Nielsen, B.S.3
  • 15
    • 0042804870 scopus 로고    scopus 로고
    • Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice
    • Almholt K, Nielsen BS, Frandsen TL, Brunner N, Dano K and Johnsen M: Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice. Oncogene 22: 4389-4397, 2003.
    • (2003) Oncogene , vol.22 , pp. 4389-4397
    • Almholt, K.1    Nielsen, B.S.2    Frandsen, T.L.3    Brunner, N.4    Dano, K.5    Johnsen, M.6
  • 16
    • 0035911151 scopus 로고    scopus 로고
    • The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies
    • Bajou K, Masson V, Gerard RD, et al: The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. J Cell Biol 152: 777-784, 2001.
    • (2001) J Cell Biol , vol.152 , pp. 777-784
    • Bajou, K.1    Masson, V.2    Gerard, R.D.3
  • 17
    • 0034014726 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis
    • Kwaan HC, Wang J, Svoboda K and Declerck PJ: Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis. Br J Cancer 82: 1702-1708, 2000.
    • (2000) Br J Cancer , vol.82 , pp. 1702-1708
    • Kwaan, H.C.1    Wang, J.2    Svoboda, K.3    Declerck, P.J.4
  • 18
    • 0025122368 scopus 로고
    • The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1
    • Prendergast GC, Diamond LE, Dahl D and Cole MD: The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol 10: 1265-1269, 1990.
    • (1990) Mol Cell Biol , vol.10 , pp. 1265-1269
    • Prendergast, G.C.1    Diamond, L.E.2    Dahl, D.3    Cole, M.D.4
  • 19
    • 0029144441 scopus 로고
    • Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53
    • Kunz C, Pebler S, Otte J and von der Ahe D: Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53. Nucleic Acids Res 23: 3710-3717, 1995.
    • (1995) Nucleic Acids Res , vol.23 , pp. 3710-3717
    • Kunz, C.1    Pebler, S.2    Otte, J.3    Von Der Ahe, D.4
  • 20
    • 31344473450 scopus 로고    scopus 로고
    • The complex between urokinase (uPA) and its type-1 inhibitor (PAI-1) in pulmonary adenocarcinoma: Relation to prognosis
    • Pappot H, Pedersen AN, Brunner N and Christensen IJ: The complex between urokinase (uPA) and its type-1 inhibitor (PAI-1) in pulmonary adenocarcinoma: Relation to prognosis. Lung Cancer 51: 193-200, 2006.
    • (2006) Lung Cancer , vol.51 , pp. 193-200
    • Pappot, H.1    Pedersen, A.N.2    Brunner, N.3    Christensen, I.J.4
  • 21
    • 33845330925 scopus 로고    scopus 로고
    • Prognostic value of PAI1 in invasive breast cancer: Evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression
    • Sternlicht MD, Dunning AM, Moore DH, et al: Prognostic value of PAI1 in invasive breast cancer: Evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiol Biomarkers Prev 15: 2107-2114, 2006.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 2107-2114
    • Sternlicht, M.D.1    Dunning, A.M.2    Moore, D.H.3
  • 22
    • 0342680018 scopus 로고    scopus 로고
    • Drug resistant tumor cells have increased levels of tumor markers for invasion and metastasis
    • Osmak M, Niksic D, Brozovic A, Ristov AA, Vrhovec I and Skrk J: Drug resistant tumor cells have increased levels of tumor markers for invasion and metastasis. Anticancer Res 19: 3193-3197, 1999.
    • (1999) Anticancer Res , vol.19 , pp. 3193-3197
    • Osmak, M.1    Niksic, D.2    Brozovic, A.3    Ristov, A.A.4    Vrhovec, I.5    Skrk, J.6
  • 23
    • 0032508691 scopus 로고    scopus 로고
    • Hypoxia-inducible mammalian gene expression analyzed in vivo at a tata-driven promoter and at an initiator-driven promoter
    • Okino ST, Chichester CH and Whitlock JP Jr: Hypoxia-inducible mammalian gene expression analyzed in vivo at a tata-driven promoter and at an initiator-driven promoter. J Biol Chem 273: 23837-23843, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 23837-23843
    • Okino, S.T.1    Chichester, C.H.2    Whitlock Jr., J.P.3
  • 24
    • 0004326807 scopus 로고    scopus 로고
    • Cytochrome p450 gene regulation. Analysis of protein-DNA interactions in situ
    • Okino ST and Whitlock JP Jr: Cytochrome p450 gene regulation. Analysis of protein-DNA interactions in situ. Methods Mol Biol 107: 395-404, 1998.
    • (1998) Methods Mol Biol , vol.107 , pp. 395-404
    • Okino, S.T.1    Whitlock Jr., J.P.2
  • 25
    • 0030588298 scopus 로고    scopus 로고
    • Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia
    • Salceda S, Beck I and Caro J: Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch Biochem Biophys 334: 389-394, 1996.
    • (1996) Arch Biochem Biophys , vol.334 , pp. 389-394
    • Salceda, S.1    Beck, I.2    Caro, J.3
  • 26
    • 0033867776 scopus 로고    scopus 로고
    • Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation
    • Dachs GU and Tozer GM: Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation. Eur J Cancer 36: 1649-1660, 2000.
    • (2000) Eur J Cancer , vol.36 , pp. 1649-1660
    • Dachs, G.U.1    Tozer, G.M.2
  • 27
    • 0033538431 scopus 로고    scopus 로고
    • Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene
    • Ding H, Benotmane AM, Suske G, Collen D and Belayew A: Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. J Biol Chem 274: 19573-19580, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 19573-19580
    • Ding, H.1    Benotmane, A.M.2    Suske, G.3    Collen, D.4    Belayew, A.5
  • 28
    • 0028891906 scopus 로고
    • The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site
    • Kvietikova I, Wenger RH, Marti HH and Gassmann M: The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res 23: 4542-4550, 1995.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4542-4550
    • Kvietikova, I.1    Wenger, R.H.2    Marti, H.H.3    Gassmann, M.4
  • 29
    • 0025895483 scopus 로고
    • Mediators of induction of augmented expression of plasminogen activator inhibitor type-1 in Hep G2 cells by platelets
    • Hopkins WE, Westerhausen DR, Fujii S, Billadello JJ and Sobel BE: Mediators of induction of augmented expression of plasminogen activator inhibitor type-1 in Hep G2 cells by platelets. Thromb Haemost 66: 239-245, 1991.
    • (1991) Thromb Haemost , vol.66 , pp. 239-245
    • Hopkins, W.E.1    Westerhausen, D.R.2    Fujii, S.3    Billadello, J.J.4    Sobel, B.E.5
  • 30
    • 0035987585 scopus 로고    scopus 로고
    • Hypoxia enhances the expression of plasminogen activator inhibitor-1 in human lung cancer cells, EBC-1
    • Kimura D, Imaizumi T, Tamo W, et al: Hypoxia enhances the expression of plasminogen activator inhibitor-1 in human lung cancer cells, EBC-1. Tohoku J Exp Med 196: 259-267, 2002.
    • (2002) Tohoku J Exp Med , vol.196 , pp. 259-267
    • Kimura, D.1    Imaizumi, T.2    Tamo, W.3
  • 31
    • 33847373884 scopus 로고    scopus 로고
    • Molecular regulation of the PAI-1 gene by hypoxia: Contributions of Egr-1, HIF-1alpha, and C/EBPalpha
    • Liao H, Hyman MC, Lawrence DA and Pinsky DJ: Molecular regulation of the PAI-1 gene by hypoxia: Contributions of Egr-1, HIF-1alpha, and C/EBPalpha. FASEB J 21: 935-949, 2007.
    • (2007) FASEB J , vol.21 , pp. 935-949
    • Liao, H.1    Hyman, M.C.2    Lawrence, D.A.3    Pinsky, D.J.4
  • 32
    • 0033388858 scopus 로고    scopus 로고
    • In vivo cross-linking and immunoprecipitation for studying dynamic protein:DNA associations in a chromatin environment
    • Kuo MH and Allis CD: In vivo cross-linking and immunoprecipitation for studying dynamic protein:DNA associations in a chromatin environment. Methods 19: 425-433, 1999.
    • (1999) Methods , vol.19 , pp. 425-433
    • Kuo, M.H.1    Allis, C.D.2
  • 33
    • 0024431684 scopus 로고
    • In vivo footprinting of a muscle-specific enhancer by ligation mediated PCR
    • Mueller PR and Wold B: In vivo footprinting of a muscle-specific enhancer by ligation mediated PCR. Science 246: 780-786, 1989.
    • (1989) Science , vol.246 , pp. 780-786
    • Mueller, P.R.1    Wold, B.2
  • 34
    • 0032900187 scopus 로고    scopus 로고
    • Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells
    • Wojta J, Kaun C, Breuss JM, et al: Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells. Lab Invest 79: 427-438, 1999.
    • (1999) Lab Invest , vol.79 , pp. 427-438
    • Wojta, J.1    Kaun, C.2    Breuss, J.M.3
  • 36
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • Yu F, White SB, Zhao Q and Lee FS: HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 98: 9630-9635, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9630-9635
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4
  • 37
    • 31144440795 scopus 로고    scopus 로고
    • Mammalian gene expression program resiliency: The roles of multiple coactivator mechanisms in hypoxia-responsive transcription
    • Kasper LH and Brindle PK: Mammalian gene expression program resiliency: The roles of multiple coactivator mechanisms in hypoxia-responsive transcription. Cell Cycle 5: 142-146, 2006.
    • (2006) Cell Cycle , vol.5 , pp. 142-146
    • Kasper, L.H.1    Brindle, P.K.2
  • 38
    • 33745685879 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway
    • Carroll VA and Ashcroft M: Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway. Cancer Res 66: 6264-6270, 2006.
    • (2006) Cancer Res , vol.66 , pp. 6264-6270
    • Carroll, V.A.1    Ashcroft, M.2
  • 39
    • 4143078131 scopus 로고    scopus 로고
    • The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells
    • Sato M, Tanaka T, Maemura K, et al: The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am J Respir Cell Mol Biol 31: 209-215, 2004.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 209-215
    • Sato, M.1    Tanaka, T.2    Maemura, K.3
  • 40
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 41
    • 0344608877 scopus 로고    scopus 로고
    • Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
    • Chen J, Zhao S, Nakada K, et al: Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 162: 1283-1291, 2003.
    • (2003) Am J Pathol , vol.162 , pp. 1283-1291
    • Chen, J.1    Zhao, S.2    Nakada, K.3
  • 42
    • 0036682284 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
    • Rapisarda A, Uranchimeg B, Scudiero DA, et al: Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 62: 4316-4324, 2002.
    • (2002) Cancer Res , vol.62 , pp. 4316-4324
    • Rapisarda, A.1    Uranchimeg, B.2    Scudiero, D.A.3
  • 43
    • 3142622930 scopus 로고    scopus 로고
    • Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
    • Kung AL, Zabludoff SD, France DS, et al: Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6: 33-43, 2004.
    • (2004) Cancer Cell , vol.6 , pp. 33-43
    • Kung, A.L.1    Zabludoff, S.D.2    France, D.S.3
  • 44
    • 25444523184 scopus 로고    scopus 로고
    • Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
    • Kong D, Park EJ, Stephen AG, et al: Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res 65: 9047-9055, 2005.
    • (2005) Cancer Res , vol.65 , pp. 9047-9055
    • Kong, D.1    Park, E.J.2    Stephen, A.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.