Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition

Journal of Clinical Investigation

Volumn 102, Issue 5, 1998, Pages 919-928

  Pinsky, David J ^a   Liao, Hui ^a   Lawson, Charles A ^a   Yan, Shi Fang ^a   Chen, Jingxian ^a   Carmeliet, Peter ^b   Loskutoff, David J ^c   Stern, David M ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Fibrinolysis; Hypoxia; Plasminogen activator; Plasminogen activator inhibitor 1; Transgenic mice

Indexed keywords

MESSENGER RNA; PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRIN DEPOSITION; FIBRINOLYSIS; GENE EXPRESSION REGULATION; HYPOXIA; LUNG; MACROPHAGE; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN INDUCTION;

EID: 0032167429     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI307     Document Type: Article

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