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Volumn 16, Issue 45, 2010, Pages 13304-13318

Integrating replication-based selection strategies in dynamic covalent systems

Author keywords

autocatalysis; dynamic covalent chemistry; self replication; supramolecular chemistry; template synthesis

Indexed keywords

ATTRACTIVE STRATEGIES; AUTOCATALYSIS; AUTOCATALYTIC; COMPLEX REACTIONS; CONTROLLED PROCESS; COVALENT BOND FORMATION; COVALENT SYSTEMS; DYNAMIC COMBINATORIAL LIBRARY; DYNAMIC COVALENT CHEMISTRY; FREE ENERGY LANDSCAPE; LIBRARY COMPONENTS; NONLINEAR KINETICS; REACTION NETWORK; RELATIVE FREE ENERGY; REPLICATORS; SELECTION STRATEGIES; SELF-REPLICATIONS; TARGET STRUCTURE; TEMPLATE SYNTHESIS; TEMPLATE-DIRECTED SYNTHESIS; TIME FRAME;

EID: 78649899385     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201000423     Document Type: Article
Times cited : (60)

References (57)
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    • note
    • Emergent properties arise when a group of simple species cooperate within a system, giving rise to more complex behavior that is a result of their collective interactions. The system-level or emergent features are not a property of any single component of the system and cannot be predicted or deduced readily from behavior of the individual simple components. Key to the development of system-level or emergent properties is the number and type of interconnections between the simple components of the system. Although the number of interconnections in a system increases combinatorially with the number of components, simply having a large number of interconnections is not enough by itself to guarantee emergent behavior. The topology of the interconnections is also critical. Therefore, chemical networks that exhibit significant degrees of mutually catalytic relationships between their components, increasing the level of feedback within the system, are more likely to develop system-level properties than a large collection of weakly interacting compounds.
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    • For some recent examples, see
    • For some recent examples, see
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    • 78649833941 scopus 로고    scopus 로고
    • Templates in Chemistry I,", whole volume
    • "Templates in Chemistry I," Top. Curr. Chem. 2005, 248, whole volume
    • (2005) Top. Curr. Chem. , vol.248
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    • 78649891948 scopus 로고    scopus 로고
    • Templates in Chemistry II, whole volume
    • "Templates in Chemistry II, Top. Curr. Chem. 2005, 249, whole volume.
    • (2005) Top. Curr. Chem. , vol.249
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    • 78649847442 scopus 로고    scopus 로고
    • Although strong product duplexes are a hindrance in the case of small-molecule replicators, it is unlikely that duplex dissociation will ever be rate limiting. Therefore, aggressive optimization of the acceleration of the covalent-bond-forming step, which is rate limiting, is of utmost importance
    • Although strong product duplexes are a hindrance in the case of small-molecule replicators, it is unlikely that duplex dissociation will ever be rate limiting. Therefore, aggressive optimization of the acceleration of the covalent-bond-forming step, which is rate limiting, is of utmost importance.
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    • 78649837841 scopus 로고    scopus 로고
    • 3 was determined to be 14a ppm by using Karl Fischer titration. For this study, we considered aldehyde 26 and imine template 27 both to crystallize with one molecule of water
    • 3 was determined to be 14a ppm by using Karl Fischer titration. For this study, we considered aldehyde 26 and imine template 27 both to crystallize with one molecule of water.
  • 44
    • 78649831399 scopus 로고    scopus 로고
    • 4-Bromophenylacetic acid (1a equiv) was added to the control reaction between 25 and 28 to ensure that the acid concentration was the same as in reactions involving aldehyde 26
    • 4-Bromophenylacetic acid (1a equiv) was added to the control reaction between 25 and 28 to ensure that the acid concentration was the same as in reactions involving aldehyde 26.
  • 45
    • 78649821115 scopus 로고    scopus 로고
    • The concentration of new imine 27 formed is simply the total concentration of 27 at a given time point less the initial concentration of 27 at t=0
    • The concentration of new imine 27 formed is simply the total concentration of 27 at a given time point less the initial concentration of 27 at t=0.
  • 51
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    • The irreversible process could also be a highly cooperative and, hence, nonlinear one, such as crystallization; for examples of systems that may operate in this manner, see
    • The irreversible process could also be a highly cooperative and, hence, nonlinear one, such as crystallization; for examples of systems that may operate in this manner, see:, J. M. A. Carnall, C. A. Waudby, A. M. Belenguer, M. C. A. Stuart, J. J. P. Peyralans, S. Otto, Science 2010, 327, 1502.
    • (2010) Science , vol.327 , pp. 1502
    • Carnall, J.M.A.1    Waudby, C.A.2    Belenguer, A.M.3    Stuart, M.C.A.4    Peyralans, J.J.P.5    Otto, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.