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For elegant examples and discussion of some autocatalytic organometallic reactions, see:
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The bisubstrate reaction templates reported by Kelly and co-workers are prototypes for small molecule reciprocal replicators. In these systems, only one of the two complementary molecules is synthesized in a crosscatalytic reaction. For details, see:
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The descriptors cis and trans identify the relative stereochemistry of the three protons located on the bicyclic fused ring structure formed in the cycloaddition reaction between the nitrone and the maleimide. In the cis cycloadduct, all three protons lie on the same face of the fused ring system. In the trans cycloadduct, the two protons originally located on the maleimide are located on the opposite face to the proton originating from the nitrone
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a is arrived at by assuming there is no cooperativity in the binding process, i.e. the connection effective molarity is 1 M. Experimentally, in cases where we have been able to measure the connection EM directly, we have always observed values 0.8 M < EM < 5 M, therefore we believe that a value of 1 M is a reasonable estimate for the simulations For an analysis of the importance of autocatalytic processes in proposed primordial reactions, see:
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