Do gene variants influencing adult adiposity affect birth weight? a population-based study of 24 loci in 4,744 danish individuals

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Andersson, Ehm A ^a   Pilgaard, Kasper ^b   Pisinger, Charlotta ^c   Harder, Marie N ^a   Grarup, Niels ^a   Færch, Kristine ^b   Sandholt, Camilla ^a   Poulsen, Pernille ^b,f   Witte, Daniel R ^b   Jørgensen, Torben ^c,e   Vaag, Allan ^b   Pedersen, Oluf ^a,d   Hansen, Torben ^a,e  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b STENO DIABETES CENTER   (Denmark)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^f NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHROPOMETRIC PARAMETERS; ARTICLE; BIRTH WEIGHT; BODY COMPOSITION; BODY MASS; CONTROLLED STUDY; DENMARK; FETUS GROWTH; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HIGH BIRTH WEIGHT; HUMAN; LOW BIRTH WEIGHT; OBESITY; POPULATION GENETICS; PREDICTION; PREMATURITY; WAIST CIRCUMFERENCE; WEIGHT INDEX; ALLELE; BIOLOGICAL MODEL; FEMALE; GENETICS; NEWBORN; PREGNANCY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOSITY; ALLELES; BIRTH WEIGHT; BODY COMPOSITION; BODY MASS INDEX; DENMARK; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MODELS, GENETIC; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY;

EID: 78649876749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014190     Document Type: Article

References (30)

1. Parsons TJ, Power C, Logan S, Summerbell CD (1999) Childhood predictors of adult obesity: a systematic review. Int J Obes Relat Metab Disord 23 Suppl 8: S1-107.
2. Leong NM, Mignone LI, Newcomb PA, Titus-Ernstoff L, Baron JA, et al. (2003) Early life risk factors in cancer: the relation of birth weight to adult obesity. Int J Cancer 103: 789-791.
3. Curhan GC, Chertow GM, Willett WC, Spiegelman D, Colditz GA, et al. (1996) Birth weight and adult hypertension and obesity in women. Circulation 94: 1310-1315.
4. Ehrenberg HM, Mercer BM, Catalano PM (2004) The influence of obesity and diabetes on the prevalence of macrosomia. Am J Obstet Gynecol 191: 964-968.
5. Bouret SG (2009) Early life origins of obesity: role of hypothalamic programming. J Pediatr Gastroenterol Nutr 48 Suppl 1: S31-38.
6. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
7. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
8. Benzinou M, Creemers JW, Choquet H, Lobbens S, Dina C, et al. (2008) Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet 40: 943-945.
9. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.
10. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
11. Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41: 157-159.
12. Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, et al. (2009) Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 5: e1000508.
13. Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, et al. (2009) NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 5: e1000539.
14. Liu YJ, Liu XG, Wang L, Dina C, Yan H, et al. (2008) Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet 17: 1803-1813.
15. Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 40: 716-718.
16. Almen MS, Jacobsson JA, Shaik JH, Olszewski PK, Cedernaes J, et al. The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children. BMC Med Genet 11: 58.
17. Elks CE, Loos RJ, Sharp SJ, Langenberg C, Ring SM, et al. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med 7: e1000284.
18. Hardy R, Wills AK, Wong A, Elks CE, Wareham NJ, et al. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 19: 545-552.
19. Petry CJ, Lopez-Bermejo A, Diaz M, Sebastiani G, Ong KK, et al. Association between a common variant near MC4R and change in body mass index develops by two weeks of age. Horm Res Paediatr 73: 275-280.
20. Cauchi S, Stutzmann F, Cavalcanti-Proenca C, Durand E, Pouta A, et al. (2009) Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. J Mol Med 87: 537-546.
21. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet.
22. Lopez-Bermejo A, Petry CJ, Diaz M, Sebastiani G, de Zegher F, et al. (2008) The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks. J Clin Endocrinol Metab 93: 1501-1505.
23. Rzehak P, Scherag A, Grallert H, Sausenthaler S, Koletzko S, et al. Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years. Obes Facts 3: 173-180.
24. Jorgensen T, Borch-Johnsen K, Thomsen TF, Ibsen H, Glumer C, et al. (2003) A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur J Cardiovasc Prev Rehabil 10: 377-386.
25. Pilgaard K, Færch K, Poulsen P, Larsen C, Andersson EA, et al. Impact of size at birth and prematurity on adult anthropometry in 4744 middle-aged Danes? The Inter99 study Journal of Developmental Origins of Health and Disease FirstView, 1-10.
26. Sandholt CH, Sparso T, Grarup N, Albrechtsen A, Almind K, et al. Combined analyses of 20 common obesity susceptibility variants. Diabetes.
27. Ranadive SA, Vaisse C (2008) Lessons from extreme human obesity: monogenic disorders. Endocrinol Metab Clin North Am 37: 733-751, x.
28. van Vliet-Ostaptchouk JV, Hofker MH, van der Schouw YT, Wijmenga C, Onland-Moret NC (2009) Genetic variation in the hypothalamic pathways and its role on obesity. Obes Rev 10: 593-609.
29. Andersson EA, Pilgaard K, Pisinger C, Harder MN, Grarup N, et al. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. Diabetologia.
30. Freathy RM, Weedon MN, Bennett A, Hypponen E, Relton CL, et al. (2007) Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet 80: 1150-1161.