Small molecule inhibitors of IκB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo

FASEB Journal

Volumn 24, Issue 11, 2010, Pages 4545-4555

  Idris, Aymen I ^a   Krishnan, Maala ^a   Simic, Petra ^b   Landao Bassonga, Euphemie ^a   Mollat, Patrick ^c   Vukicevic, Slobodan ^b   Ralston, Stuart H ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c Galapagos Société Par Actions Simplifiée Unipersonnelle   (France)

Author keywords

IKK; NF B; Osteoblast; Osteoporosis; TAK1

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; CELASTROL; INTERLEUKIN 1BETA; OSTEOCLAST DIFFERENTIATION FACTOR; PARTHENOLIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOLYSIS; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; SHAM PROCEDURE; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BONE RESORPTION; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; I-KAPPA B KINASE; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MICE; OSTEOCLASTS; OVARIECTOMY; QUINOXALINES; SESQUITERPENES; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 78649853549     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-164095     Document Type: Article

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