-
1
-
-
27844493246
-
Immunopathogenic role of TH1 cells in autoimmune diabetes: Evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model
-
Hung, J. T., J. H. Liao, Y. C. Lin, H. Y. Chang, S. F. Wu, T. H. Chang, J. T. Kung, S. L. Hsieh, H. McDevitt, and H. K. Sytwu. 2005. Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model. J. Autoimmun. 25: 181-192.
-
(2005)
J. Autoimmun.
, vol.25
, pp. 181-192
-
-
Hung, J.T.1
Liao, J.H.2
Lin, Y.C.3
Chang, H.Y.4
Wu, S.F.5
Chang, T.H.6
Kung, J.T.7
Hsieh, S.L.8
McDevitt, H.9
Sytwu, H.K.10
-
2
-
-
0030271678
-
Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice
-
Rabinovitch, A., W. L. Suarez-Pinzon, and O. Sorensen. 1996. Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice. J. Autoimmun. 9: 645-651.
-
(1996)
J. Autoimmun.
, vol.9
, pp. 645-651
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.L.2
Sorensen, O.3
-
3
-
-
0031423760
-
The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
-
Delovitch, T. L., and B. Singh. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7: 727-738.
-
(1997)
Immunity
, vol.7
, pp. 727-738
-
-
Delovitch, T.L.1
Singh, B.2
-
4
-
-
0028922437
-
Genetic control of autoimmune diabetes in the NOD mouse
-
Wicker, L. S., J. A. Todd, and L. B. Peterson. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13: 179-200.
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 179-200
-
-
Wicker, L.S.1
Todd, J.A.2
Peterson, L.B.3
-
5
-
-
0033939014
-
Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: Elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-a and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice
-
Alleva, D. G., R. P. Pavlovich, C. Grant, S. B. Kaser, and D. I. Beller. 2000. Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-a and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice. Diabetes 49: 1106-1115.
-
(2000)
Diabetes
, vol.49
, pp. 1106-1115
-
-
Alleva, D.G.1
Pavlovich, R.P.2
Grant, C.3
Kaser, S.B.4
Beller, D.I.5
-
6
-
-
0036644326
-
Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-κ B expression and binding to the IL-12 p40 promoter
-
Liu, J., and D. Beller. 2002. Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-κ B expression and binding to the IL-12 p40 promoter. J. Immunol. 169: 581-586.
-
(2002)
J. Immunol.
, vol.169
, pp. 581-586
-
-
Liu, J.1
Beller, D.2
-
7
-
-
0037408257
-
Distinct pathways for NF-κ B regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetesprone mouse strains
-
Liu, J., and D. I. Beller. 2003. Distinct pathways for NF-κ B regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetesprone mouse strains. J. Immunol. 170: 4489-4496.
-
(2003)
J. Immunol.
, vol.170
, pp. 4489-4496
-
-
Liu, J.1
Beller, D.I.2
-
8
-
-
0037441994
-
NF-κ B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages
-
Sen, P., S. Bhattacharyya, M. Wallet, C. P. Wong, B. Poligone, M. Sen, A. S. Baldwin, Jr., and R. Tisch. 2003. NF-κ B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J. Immunol. 170: 1770-1780.
-
(2003)
J. Immunol.
, vol.170
, pp. 1770-1780
-
-
Sen, P.1
Bhattacharyya, S.2
Wallet, M.3
Wong, C.P.4
Poligone, B.5
Sen, M.6
Baldwin Jr., A.S.7
Tisch, R.8
-
9
-
-
0036700932
-
Myeloid dendritic cells in non-obese diabetic mice have elevated costimulatory and T helper-1-inducing abilities
-
Marleau, A. M., and B. Singh. 2002. Myeloid dendritic cells in non-obese diabetic mice have elevated costimulatory and T helper-1-inducing abilities. J. Autoimmun. 19: 23-35.
-
(2002)
J. Autoimmun.
, vol.19
, pp. 23-35
-
-
Marleau, A.M.1
Singh, B.2
-
10
-
-
0036006693
-
Elevated NF-κB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function
-
Poligone, B., D. J. Weaver, Jr., P. Sen, A. S. Baldwin, Jr., and R. Tisch. 2002. Elevated NF-κB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J. Immunol. 168: 188-196.
-
(2002)
J. Immunol.
, vol.168
, pp. 188-196
-
-
Poligone, B.1
Weaver Jr., D.J.2
Sen, P.3
Baldwin Jr., A.S.4
Tisch, R.5
-
11
-
-
0035424898
-
Dendritic cells from nonobese diabetic mice exhibit a defect in NF-κ B regulation due to a hyperactive IκB kinase
-
Weaver, D. J., Jr., B. Poligone, T. Bui, U. M. Abdel-Motal, A. S. Baldwin, Jr., and R. Tisch. 2001. Dendritic cells from nonobese diabetic mice exhibit a defect in NF-κ B regulation due to a hyperactive IκB kinase. J. Immunol. 167: 1461-1468.
-
(2001)
J. Immunol.
, vol.167
, pp. 1461-1468
-
-
Weaver Jr., D.J.1
Poligone, B.2
Bui, T.3
Abdel-Motal, U.M.4
Baldwin Jr., A.S.5
Tisch, R.6
-
12
-
-
45949097728
-
Differential contributions of APC subsets to T cell activation in nonobese diabetic mice
-
Marleau, A. M., K. L. Summers, and B. Singh. 2008. Differential contributions of APC subsets to T cell activation in nonobese diabetic mice. J. Immunol. 180: 5235-5249.
-
(2008)
J. Immunol.
, vol.180
, pp. 5235-5249
-
-
Marleau, A.M.1
Summers, K.L.2
Singh, B.3
-
13
-
-
0025808629
-
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
-
Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familletti, and M. K. Gately. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88: 4143-4147.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 4143-4147
-
-
Gubler, U.1
Chua, A.O.2
Schoenhaut, D.S.3
Dwyer, C.M.4
McComas, W.5
Motyka, R.6
Nabavi, N.7
Wolitzky, A.G.8
Quinn, P.M.9
Familletti, P.C.10
Gately, M.K.11
-
14
-
-
0037313578
-
Interleukin-12 and the regulation of innate resistance and adaptive immunity
-
Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3: 133-146.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 133-146
-
-
Trinchieri, G.1
-
15
-
-
58149386381
-
The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
-
D'Alise, A. M., V. Auyeung, M. Feuerer, J. Nishio, J. Fontenot, C. Benoist, and D. Mathis. 2008. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc. Natl. Acad. Sci. USA 105: 19857-19862.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19857-19862
-
-
D'Alise, A.M.1
Auyeung, V.2
Feuerer, M.3
Nishio, J.4
Fontenot, J.5
Benoist, C.6
Mathis, D.7
-
16
-
-
0032513227
-
Synergistic regulation of the human interleukin-12 p40 promoter by NFκB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages
-
Gri, G., D. Savio, G. Trinchieri, and X. Ma. 1998. Synergistic regulation of the human interleukin-12 p40 promoter by NFκB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages. J. Biol. Chem. 273: 6431-6438.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 6431-6438
-
-
Gri, G.1
Savio, D.2
Trinchieri, G.3
Ma, X.4
-
17
-
-
0030872393
-
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins
-
Plevy, S. E., J. H. M. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17: 4572-4588.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4572-4588
-
-
Plevy, S.E.1
Gemberling, J.H.M.2
Hsu, S.3
Dorner, A.J.4
Smale, S.T.5
-
18
-
-
67650724069
-
Regulation and function of NF-κB transcription factors in the immune system
-
Vallabhapurapu, S., and M. Karin. 2009. Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 27: 693-733.
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
19
-
-
37849186195
-
IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-κB activity
-
Wang, J., Y. Minemoto, A. Lin, Y. Li, B. Shen, and J. Zhang. 2007. IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-κB activity. Mol. Immunol. 44: 2139-2143.
-
(2007)
Mol. Immunol.
, vol.44
, pp. 2139-2143
-
-
Wang, J.1
Minemoto, Y.2
Lin, A.3
Li, Y.4
Shen, B.5
Zhang, J.6
-
20
-
-
0346496017
-
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
-
Huang, Q., J. Yang, Y. Lin, C. Walker, J. Cheng, Z. G. Liu, and B. Su. 2004. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat. Immunol. 5: 98-103.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 98-103
-
-
Huang, Q.1
Yang, J.2
Lin, Y.3
Walker, C.4
Cheng, J.5
Liu, Z.G.6
Su, B.7
-
21
-
-
66749134594
-
Targeting innate immunity protein kinase signalling in inflammation
-
Gaestel, M., A. Kotlyarov, and M. Kracht. 2009. Targeting innate immunity protein kinase signalling in inflammation. Nat. Rev. Drug Discov. 8: 480-499.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 480-499
-
-
Gaestel, M.1
Kotlyarov, A.2
Kracht, M.3
-
22
-
-
34249331264
-
Novel strategies for inhibition of the p38 MAPK pathway
-
Zhang, J., B. Shen, and A. Lin. 2007. Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol. Sci. 28: 286-295.
-
(2007)
Trends Pharmacol. Sci.
, vol.28
, pp. 286-295
-
-
Zhang, J.1
Shen, B.2
Lin, A.3
-
23
-
-
0026778409
-
Signal transduction from cell surface to nucleus in development and disease
-
Karin, M. 1992. Signal transduction from cell surface to nucleus in development and disease. FASEB J. 6: 2581-2590.
-
(1992)
FASEB J.
, vol.6
, pp. 2581-2590
-
-
Karin, M.1
-
24
-
-
0033118982
-
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
-
Lu, H. T., D. D. Yang, M. Wysk, E. Gatti, I. Mellman, R. J. Davis, and R. A. Flavell. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18: 1845-1857.
-
(1999)
EMBO J.
, vol.18
, pp. 1845-1857
-
-
Lu, H.T.1
Yang, D.D.2
Wysk, M.3
Gatti, E.4
Mellman, I.5
Davis, R.J.6
Flavell, R.A.7
-
25
-
-
0036486712
-
Glutathione redox regulates lipopolysaccharide-induced IL-12 production through p38mitogen-activated protein kinase activation in human monocytes: Role of glutathione redox in IFN-g priming of IL-12 production
-
Utsugi, M., K. Dobashi, Y. Koga, Y. Shimizu, T. Ishizuka, K. Iizuka, J. Hamuro, T. Nakazawa, and M. Mori. 2002. Glutathione redox regulates lipopolysaccharide-induced IL-12 production through p38mitogen-activated protein kinase activation in human monocytes: role of glutathione redox in IFN-g priming of IL-12 production. J. Leukoc. Biol. 71: 339-347.
-
(2002)
J. Leukoc. Biol.
, vol.71
, pp. 339-347
-
-
Utsugi, M.1
Dobashi, K.2
Koga, Y.3
Shimizu, Y.4
Ishizuka, T.5
Iizuka, K.6
Hamuro, J.7
Nakazawa, T.8
Mori, M.9
-
26
-
-
0032740614
-
Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase
-
Feng, G. J., H. S. Goodridge, M. M. Harnett, X. Q. Wei, A. V. Nikolaev, A. P. Higson, and F. Y. Liew. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J. Immunol. 163: 6403-6412.
-
(1999)
J. Immunol.
, vol.163
, pp. 6403-6412
-
-
Feng, G.J.1
Goodridge, H.S.2
Harnett, M.M.3
Wei, X.Q.4
Nikolaev, A.V.5
Higson, A.P.6
Liew, F.Y.7
-
27
-
-
0038784487
-
C-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: Role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production
-
Utsugi, M., K. Dobashi, T. Ishizuka, K. Endou, J. Hamuro, Y. Murata, T. Nakazawa, and M. Mori. 2003. c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production. J. Immunol. 171: 628-635.
-
(2003)
J. Immunol.
, vol.171
, pp. 628-635
-
-
Utsugi, M.1
Dobashi, K.2
Ishizuka, T.3
Endou, K.4
Hamuro, J.5
Murata, Y.6
Nakazawa, T.7
Mori, M.8
-
28
-
-
33746111852
-
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
-
Wan, Y. Y., H. Chi, M. Xie, M. D. Schneider, and R. A. Flavell. 2006. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 7: 851-858.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 851-858
-
-
Wan, Y.Y.1
Chi, H.2
Xie, M.3
Schneider, M.D.4
Flavell, R.A.5
-
29
-
-
65449158398
-
MEKK3 is essential for lymphopenia-induced T cell proliferation and survival
-
Wang, X., X. Chang, V. Facchinetti, Y. Zhuang, and B. Su. 2009. MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. J. Immunol. 182: 3597-3608.
-
(2009)
J. Immunol.
, vol.182
, pp. 3597-3608
-
-
Wang, X.1
Chang, X.2
Facchinetti, V.3
Zhuang, Y.4
Su, B.5
-
30
-
-
63649162155
-
Regulation of NF-κB-dependent T cell activation and development by MEKK3
-
Shinohara, H., S. Yamasaki, S. Maeda, T. Saito, and T. Kurosaki. 2009. Regulation of NF-κB-dependent T cell activation and development by MEKK3. Int. Immunol. 21: 393-401.
-
(2009)
Int. Immunol.
, vol.21
, pp. 393-401
-
-
Shinohara, H.1
Yamasaki, S.2
Maeda, S.3
Saito, T.4
Kurosaki, T.5
-
31
-
-
0344406188
-
+ T cells reveals an essential requirement for nuclear factor κB in regulating mature T cell survival and in vivo function
-
+ T cells reveals an essential requirement for nuclear factor κB in regulating mature T cell survival and in vivo function. J. Exp. Med. 197: 861-874.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 861-874
-
-
Zheng, Y.1
Vig, M.2
Lyons, J.3
Van Parijs, L.4
Beg, A.A.5
-
32
-
-
0037443540
-
Inhibition of NF-κB activity in T and NK cells results in defective effector cell expansion and production of IFN-γ required for resistance to Toxoplasma gondii
-
Tato, C. M., A. Villarino, J. H. Caamaño, M. Boothby, and C. A. Hunter. 2003. Inhibition of NF-κB activity in T and NK cells results in defective effector cell expansion and production of IFN-γ required for resistance to Toxoplasma gondii. J. Immunol. 170: 3139-3146.
-
(2003)
J. Immunol.
, vol.170
, pp. 3139-3146
-
-
Tato, C.M.1
Villarino, A.2
Caamaño, J.H.3
Boothby, M.4
Hunter, C.A.5
-
33
-
-
47249116959
-
Activation of NF-κB1 by OX40 contributes to antigen-driven T cell expansion and survival
-
Song, J., T. So, and M. Croft. 2008. Activation of NF-κB1 by OX40 contributes to antigen-driven T cell expansion and survival. J. Immunol. 180: 7240-7248.
-
(2008)
J. Immunol.
, vol.180
, pp. 7240-7248
-
-
Song, J.1
So, T.2
Croft, M.3
-
34
-
-
30444457217
-
Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways
-
Zhang, D., V. Facchinetti, X. Wang, Q. Huang, J. Qin, and B. Su. 2006. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways. EMBO J. 25: 97-107.
-
(2006)
EMBO J.
, vol.25
, pp. 97-107
-
-
Zhang, D.1
Facchinetti, V.2
Wang, X.3
Huang, Q.4
Qin, J.5
Su, B.6
-
35
-
-
76749126360
-
Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-α-induced cell death
-
Wang, J., R. Tang, M. Lv, J. Zhang, and B. Shen. 2010. Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-α-induced cell death. Mol. Cancer 9: 6.
-
(2010)
Mol. Cancer
, vol.9
, pp. 6
-
-
Wang, J.1
Tang, R.2
Lv, M.3
Zhang, J.4
Shen, B.5
-
36
-
-
0034050739
-
Mekk3 is essential for early embryonic cardiovascular development
-
Yang, J., M. Boerm, M. McCarty, C. Bucana, I. J. Fidler, Y. Zhuang, and B. Su. 2000. Mekk3 is essential for early embryonic cardiovascular development. Nat. Genet. 24: 309-313.
-
(2000)
Nat. Genet.
, vol.24
, pp. 309-313
-
-
Yang, J.1
Boerm, M.2
McCarty, M.3
Bucana, C.4
Fidler, I.J.5
Zhuang, Y.6
Su, B.7
-
37
-
-
0035478060
-
Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury
-
Yakovlev, A. G., K. Ota, G. Wang, V. Movsesyan, W. L. Bao, K. Yoshihara, and A. I. Faden. 2001. Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. J. Neurosci. 21: 7439-7446.
-
(2001)
J. Neurosci.
, vol.21
, pp. 7439-7446
-
-
Yakovlev, A.G.1
Ota, K.2
Wang, G.3
Movsesyan, V.4
Bao, W.L.5
Yoshihara, K.6
Faden, A.I.7
-
38
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
Favata, M. F., K. Y. Horiuchi, E. J. Manos, A. J. Daulerio, D. A. Stradley, W. S. Feeser, D. E. Van Dyk, W. J. Pitts, R. A. Earl, F. Hobbs, et al. 1998. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273: 18623-18632.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
Feeser, W.S.6
Van Dyk, D.E.7
Pitts, W.J.8
Earl, R.A.9
Hobbs, F.10
-
39
-
-
0035923665
-
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
-
Bennett, B. L., D. T. Sasaki, B. W. Murray, E. C. O'Leary, S. T. Sakata, W. Xu, J. C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, et al. 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98: 13681-13686.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13681-13686
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
O'Leary, E.C.4
Sakata, S.T.5
Xu, W.6
Leisten, J.C.7
Motiwala, A.8
Pierce, S.9
Satoh, Y.10
-
40
-
-
0028988138
-
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
-
Cuenda, A., J. Rouse, Y. N. Doza, R. Meier, P. Cohen, T. F. Gallagher, P. R. Young, and J. C. Lee. 1995. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364: 229-233.
-
(1995)
FEBS Lett.
, vol.364
, pp. 229-233
-
-
Cuenda, A.1
Rouse, J.2
Doza, Y.N.3
Meier, R.4
Cohen, P.5
Gallagher, T.F.6
Young, P.R.7
Lee, J.C.8
-
41
-
-
18544406054
-
SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
-
Underwood, D. C., R. R. Osborn, C. J. Kotzer, J. L. Adams, J. C. Lee, E. F. Webb, D. C. Carpenter, S. Bochnowicz, H. C. Thomas, D. W. Hay, and D. E. Griswold. 2000. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J. Pharmacol. Exp. Ther. 293: 281-288.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.293
, pp. 281-288
-
-
Underwood, D.C.1
Osborn, R.R.2
Kotzer, C.J.3
Adams, J.L.4
Lee, J.C.5
Webb, E.F.6
Carpenter, D.C.7
Bochnowicz, S.8
Thomas, H.C.9
Hay, D.W.10
Griswold, D.E.11
-
42
-
-
0038035216
-
T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: Role of distal sequences in the 3′-untranslated region of COX-2 mRNA
-
Faour, W. H., A. Mancini, Q. W. He, and J. A. Di Battista. 2003. T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: role of distal sequences in the 3′-untranslated region of COX-2 mRNA. J. Biol. Chem. 278: 26897-26907.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 26897-26907
-
-
Faour, W.H.1
Mancini, A.2
He, Q.W.3
Di Battista, J.A.4
-
43
-
-
4644223114
-
Discovery and characterization of a substrate selective p38α inhibitor
-
Davidson, W., L. Frego, G. W. Peet, R. R. Kroe, M. E. Labadia, S. M. Lukas, R. J. Snow, S. Jakes, C. A. Grygon, C. Pargellis, and B. G. Werneburg. 2004. Discovery and characterization of a substrate selective p38α inhibitor. Biochemistry 43: 11658-11671.
-
(2004)
Biochemistry
, vol.43
, pp. 11658-11671
-
-
Davidson, W.1
Frego, L.2
Peet, G.W.3
Kroe, R.R.4
Labadia, M.E.5
Lukas, S.M.6
Snow, R.J.7
Jakes, S.8
Grygon, C.A.9
Pargellis, C.10
Werneburg, B.G.11
-
44
-
-
31144452241
-
Essential role of MAPK phosphatase-1 in the negative control of innate immune responses
-
Salojin, K. V., I. B. Owusu, K. A. Millerchip, M. Potter, K. A. Platt, and T. Oravecz. 2006. Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J. Immunol. 176: 1899-1907.
-
(2006)
J. Immunol.
, vol.176
, pp. 1899-1907
-
-
Salojin, K.V.1
Owusu, I.B.2
Millerchip, K.A.3
Potter, M.4
Platt, K.A.5
Oravecz, T.6
-
45
-
-
31344442772
-
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
-
Zhao, Q., X. Wang, L. D. Nelin, Y. Yao, R. Matta, M. E. Manson, R. S. Baliga, X. Meng, C. V. Smith, J. A. Bauer, et al. 2006. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J. Exp. Med. 203: 131-140.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 131-140
-
-
Zhao, Q.1
Wang, X.2
Nelin, L.D.3
Yao, Y.4
Matta, R.5
Manson, M.E.6
Baliga, R.S.7
Meng, X.8
Smith, C.V.9
Bauer, J.A.10
-
46
-
-
0036721164
-
Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells
-
Mori, N., Y. Yamada, S. Ikeda, Y. Yamasaki, K. Tsukasaki, Y. Tanaka, M. Tomonaga, N. Yamamoto, and M. Fujii. 2002. Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100: 1828-1834.
-
(2002)
Blood
, vol.100
, pp. 1828-1834
-
-
Mori, N.1
Yamada, Y.2
Ikeda, S.3
Yamasaki, Y.4
Tsukasaki, K.5
Tanaka, Y.6
Tomonaga, M.7
Yamamoto, N.8
Fujii, M.9
-
47
-
-
68549139888
-
Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells
-
Fang, S., J. Fu, X. Yuan, C. Han, L. Shi, Y. Xin, L. Luo, and Z. Yin. 2009. Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells. Cell. Immunol. 259: 49-55.
-
(2009)
Cell. Immunol.
, vol.259
, pp. 49-55
-
-
Fang, S.1
Fu, J.2
Yuan, X.3
Han, C.4
Shi, L.5
Xin, Y.6
Luo, L.7
Yin, Z.8
-
48
-
-
0035175577
-
A defect in central tolerance in NOD mice
-
Kishimoto, H., and J. Sprent. 2001. A defect in central tolerance in NOD mice. Nat. Immunol. 2: 1025-1031.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 1025-1031
-
-
Kishimoto, H.1
Sprent, J.2
-
49
-
-
15244338878
-
Defective central tolerance induction in NOD mice: Genomics and genetics
-
Zucchelli, S., P. Holler, T. Yamagata, M. Roy, C. Benoist, and D. Mathis. 2005. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 22: 385-396.
-
(2005)
Immunity
, vol.22
, pp. 385-396
-
-
Zucchelli, S.1
Holler, P.2
Yamagata, T.3
Roy, M.4
Benoist, C.5
Mathis, D.6
-
50
-
-
77950367657
-
Two mechanistically and temporally distinct NF-κB activation pathways in IL-1 signaling
-
Yamazaki, K., J. Gohda, A. Kanayama, Y. Miyamoto, H. Sakurai, M. Yamamoto, S. Akira, H. Hayashi, B. Su, and J. Inoue. 2009. Two mechanistically and temporally distinct NF-κB activation pathways in IL-1 signaling. Sci. Signal. 2: 1-11.
-
(2009)
Sci. Signal.
, vol.2
, pp. 1-11
-
-
Yamazaki, K.1
Gohda, J.2
Kanayama, A.3
Miyamoto, Y.4
Sakurai, H.5
Yamamoto, M.6
Akira, S.7
Hayashi, H.8
Su, B.9
Inoue, J.10
-
51
-
-
33845898737
-
Steady-state and inflammatory dendriticcell development
-
Shortman, K., and S. H. Naik. 2007. Steady-state and inflammatory dendriticcell development. Nat. Rev. Immunol. 7: 19-30.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 19-30
-
-
Shortman, K.1
Naik, S.H.2
-
52
-
-
25444496153
-
Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colonystimulating factor overproduction
-
Litherland, S. A., K. M. Grebe, N. S. Belkin, E. Paek, J. Elf, M. Atkinson, L. Morel, M. J. Clare-Salzler, and M. McDuffie. 2005. Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte- macrophage colonystimulating factor overproduction. J. Immunol. 175: 4561-4565.
-
(2005)
J. Immunol.
, vol.175
, pp. 4561-4565
-
-
Litherland, S.A.1
Grebe, K.M.2
Belkin, N.S.3
Paek, E.4
Elf, J.5
Atkinson, M.6
Morel, L.7
Clare-Salzler, M.J.8
McDuffie, M.9
-
53
-
-
0141886225
-
Cuttine edge: Diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice
-
Simpson, P. B., M. S. Mistry, R. A. Maki, W. Yang, D. A. Schwarz, E. B. Johnson, F. M. Lio, and D. G. Alleva. 2003. Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice. J. Immunol. 171: 3333-3337.
-
(2003)
J. Immunol.
, vol.171
, pp. 3333-3337
-
-
Simpson, P.B.1
Mistry, M.S.2
Maki, R.A.3
Yang, W.4
Schwarz, D.A.5
Johnson, E.B.6
Lio, F.M.7
Alleva, D.G.8
-
54
-
-
43649105125
-
+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope
-
+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope. J. Autoimmun. 31: 30-41.
-
(2008)
J. Autoimmun.
, vol.31
, pp. 30-41
-
-
Yang, J.1
Danke, N.2
Roti, M.3
Huston, L.4
Greenbaum, C.5
Pihoker, C.6
James, E.7
Kwok, W.W.8
-
56
-
-
61449187505
-
Regulatory T cells overturned: The effectors fight back
-
Walker, L. S. K. 2009. Regulatory T cells overturned: the effectors fight back. Immunology 126: 466-474.
-
(2009)
Immunology
, vol.126
, pp. 466-474
-
-
Walker, L.S.K.1
|