Glutathione redox regulates lipopolysaccharide-induced IL-12 production through p38 mitogen-activated protein kinase activation in human monocytes: Role of glutathione redox in IFN-γ priming of IL-12 production

Journal of Leukocyte Biology

Volumn 71, Issue 2, 2002, Pages 339-347

  Utsugi, Mitsuyoshi ^a,b,c   Dobashi, Kunio ^a,b,c   Koga, Yasuhiko ^a,b,c   Shimizu, Yasuo ^a,b,c   Ishizuka, Tamotsu ^a,b,c   Iizuka, Kunihiko ^a,b,c   Hamuro, Junji ^a,b,c   Nakazawa, Tsugio ^a,b,c   Mori, Masatomo ^a,b,c  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c AJINOMOTO CO INC   (Japan)

Author keywords

Antigen presenting cell; Immune response; Signal transduction

Indexed keywords

GAMMA INTERFERON; GLUTATHIONE; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MALEIC ACID DIETHYL ESTER; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MONOCYTE; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OXIDATION; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; REDUCTION;

CELLS, CULTURED; ENZYME ACTIVATION; GLUTATHIONE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 0036486712     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Trinchieri, G. (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
2. Gubler, U., Chua, A. O., Schoenhaut, D. S., Dwyer, C. M., McComas, W., Motyka, R., Nabavi, N., Wolitzky, A. G., Quinn, P. M., Familletti, P. C., Gately, M. K. (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88, 4143-4147.
3. D'Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi. J., Kubin, M., Aste, M., Chan, S. H., Kobayashi, M., Young, D., Nickbarg, E., Chizzonite, R., Wolf, S. F., Trinchieri, G. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176, 1387-1398.
4. Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C., Vezzio, N., Hakimi, J., Gately, M., Delespesse, G. (1995) Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25, 1125-1128.
5. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A., Alber, G. (1996) Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184, 747-752.
6. Hayes, M. P., Wang, J., Norcross, M. A. (1995) Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes. Blood 86, 646-650.
7. Snijders, A., Hilkens, C. M. U., van der Pouw Kraan, T. C. T. M., Engel, M., Aarden, L. A., Kapsenberg, M. L. (1996) Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol. 156, 1207-1212.
8. Meister A. (1989) Molecular Properties and Clinical Applications. In Glutathione Centennial. Academic Press, New York.
9. Nakamura, H., Nakamura, K., Yodoi, J. (1997) Redox regulation of cellular activation. Annu. Rev. Immunol. 15, 351-369.
10. Lawrence, B. P., Will, Y., Reed, D. J., Kerkvliet, N. I. (2000) Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses. Eur. J. Immunol. 30, 1902-1910.
11. Suthanthiran, M., Anderson, M. E., Sharma, V. K., Meister, A. (1990) Clutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc. Natl. Acad. Sci. USA 87, 3343-3347.
12. Gmunder, H., Droge, W. (1991) Differential effects of glutathione depletion on T cell subsets. Cell. Immunol. 138, 229-237.
13. Peterson, J. D., Herzenberg, L. A., Vasquez, K., Waltenbaugh, C. (1998) Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc. Natl. Acad. Sci. USA 95, 3071-3076.
14. Hamuro, J., Murata, Y., Suzuki, M. (1999) The triggering and healing of tumor stromal inflammatory reactions regulated by oxidative and reductive macrophages. Gann Monogr. Cancer Res. 48, 161-172.
15. Whitmarsh, A. J., Davis, R. J. (1996) Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med. 74, 589-607.
16. Liu, M. K., Herrera-Velit, P., Brownsey, R. W., Reiner, N. E. (1994) CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J. Immunol. 153, 2642-2652.
17. Hambleton, J., Weinstein, S. L., Lem, L., DeFranco, A. L. (1996) Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. USA 93, 2774-2778.
18. Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W., Strickler, J. E., McLaughlin, M. M., Siemens, I. R., Fisher, S. M., Livi, G. P., White, J. R., Adams, J. L., Young, P. R. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746.
19. Feng, G. J., Goodridge, H. S., Harnett, M. M., Wei, X. Q., Nikolaev, A. V., Higson, A. P., Liew, F. Y. (1999) Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J. Immunol. 163, 6403-6412.
20. Lu, H. T., Yangm D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J., Flavell, R. A. (1999) Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18, 1845-1857.
21. Suzuki, Y. J., Forman, H. J., Sevanian, A. (1997) Oxidants as stimulators of signal transduction. Free Radic. Biol. Med. 22, 269-285.
22. Ziegler, D. M. (1985) Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation. Annu. Rev. Biochem. 54, 305-329.
23. Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R., Lee, J. C. (1993) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364, 229-233.
24. Kubin, M., Chow, J. M., Trinchieri, G. (1993) Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83, 1847-1855.
25. Buchmuller-Rouiller, Y., Corradin, S. B., Smith, J., Schneider, P., Ransijn, A., Jongeneel, C. V., Mauel, J. (1995) Role of glutathione in macrophage activation: effect of cellular glutathione depletion on nitrite production and leishmanicidal activity. Cell. Immunol. 164, 73-80.
26. Tietze, F. (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27, 502-522.
27. Griffith, O. W. (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106, 207-212.
28. Wolf, S. F., Temple, P. A., Kobayashi, M., Young, D., Dicig, M., Lowe, L., Dzialo, R., Fitz, L., Ferenz, C., Hewick, R. M., Kelleher, K., Herrmann, S. H., Clark, S. C., Azzoni, L., Chan, S. H., Trinchieri, G., Perussia, B. (1991) Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146, 3074-3081.
29. Cleveland, M. G., Gorham, J. D., Murphy, T. L., Tuomanen, E., Murphy, K. M. (1996) Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect. Immun. 64, 1906-1912.
30. Arcari, P., Martinelli, R., Salvatore, F. (1984) The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species. Nucleic Acids Res. 12, 9179-9189.
31. Chomczynski, P., Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
32. Deneke, S. M., Fanburg, B. L. (1989) Regulation of cellular glutathione. Am. J. Physiol. 257, L163-L173.
33. Hasko, G., Szabo, C. (1999) IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responses. Br. J. Pharmacol. 127, 1295-1304.
34. Wellner, V. P., Anderson, M. E., Puri, R. N., Jensen, G. L., Meister, A. (1984) Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts. Proc. Natl. Acad. Sci. USA 81, 4732-4735.
35. Vos, T. A., Goor, H., Tuyt, L., Jager-Krikken, A., Leuvenink, R., Kuipers, F., Jansen, P. L., Moshage, H. (1999) Expression of inducible nitric oxide synthase in endotoxemic rat hepatocytes is dependent on the cellular glutathione status. Hepatology 29, 421-426.
36. Ma, X., Chow, J. M., Gri, G., Carra, G., Gerosa, F., Wolf, S. F., Dzialo, R., Trinchieri, G. (1996) The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183, 147-157.
37. Murphy, T. L., Cleveland, M. G., Kulesza, P., Magram, J., Murphy, K. M. (1995) Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol. Cell. Biol. 15, 5258-5267.
38. Ma, X., Neurath, M., Gri, G., Trinchieri, G. (1997) Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J. Biol. Chem. 272, 10389-10395.
39. Gerrard, T. L., Siegel, J. P., Dyer, D. R., Zoon, K. C. (1987) Differential effects of interferon-alpha and interferon-gamma on interleukin 1 secretion by monocytes. J. Immunol. 138, 2535-2540.
40. Arend, W. P., D'Angelo, S., Joslin, F. G. (1988) Regulation of interleukin 1 production in human monocytes. I. Effects of gamma-interferon and cycloheximide. Clin. Exp. Immunol. 74, 377-381.
41. Dobashi, K., Aihara, M., Araki, T., Shimizu, Y., Utsugi, M., Iizuka, K., Murata, Y., Hamuro, J., Nakazawa, T., Mori, M. (2001) Regulation of LPS induced IL-12 production by IFN-gamma and IL-4 through intracellular glutathione status in human alveolar macrophages. Clin. Exp. Immunol. 124, 290-296.
42. Hashimoto, S., Gon, Y., Matsumoto, K., Takeshita, I., Asai, Y., Asai, Y., Machino, T., Horie, T. (2000) Regulation by intracellular glutathione of TNF-alpha-induced p38 MAP kinase activation and RANTES production by human pulmonary vascular endothelial cells. Allergy 55, 463-469.
43. Thomas, J. A., Poland, B., Honzatko, R. (1995) Protein sulfhydryls and their role in the antioxidant function of protein S-thiolation. Arch. Biochem. Biophys. 319, 1-9.
44. Park, H. S., Park, E., Kim, M. S., Ahn, K., Kim, I. Y., Choi, E. J. (2000) Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism. J. Biol. Chem. 275, 2527-2531.