-
1
-
-
0032512459
-
The structure of GABPalpha/beta: An ETS domain- ankyrin repeat heterodimer bound to DNA
-
Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C,. 1998. The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. Science 279: 1037-1041.
-
(1998)
Science
, vol.279
, pp. 1037-1041
-
-
Batchelor, A.H.1
Piper, D.E.2
De La Brousse, F.C.3
McKnight, S.L.4
Wolberger, C.5
-
2
-
-
0032532157
-
Structure of human cyclin-dependent kinase inhibitor p19INK4d: Comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a
-
Baumgartner R, Fernandez-Catalan C, Winoto A, Huber R, Engh RA, Holak TA,. 1998. Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. Structure 6: 1279-1290.
-
(1998)
Structure
, vol.6
, pp. 1279-1290
-
-
Baumgartner, R.1
Fernandez-Catalan, C.2
Winoto, A.3
Huber, R.4
Engh, R.A.5
Holak, T.A.6
-
3
-
-
0031991891
-
Tumor suppressor p16INK4A: Determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4
-
Byeon IJ, Li J, Ericson K, Selby TL, Tevelev A, Kim HJ, O'Maille P, Tsai MD,. 1998. Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4. Mol Cell 1: 421-431.
-
(1998)
Mol Cell
, vol.1
, pp. 421-431
-
-
Byeon, I.J.1
Li, J.2
Ericson, K.3
Selby, T.L.4
Tevelev, A.5
Kim, H.J.6
O'Maille, P.7
Tsai, M.D.8
-
4
-
-
0036884829
-
The retinoblastoma tumour suppressor in development and cancer
-
Classon M, Harlow E,. 2002. The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer 2: 910-917.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 910-917
-
-
Classon, M.1
Harlow, E.2
-
5
-
-
67649303091
-
Simulation of different truncated p16 forms and in silico study of interaction with Cdk4
-
Fahham N, Ghahremani MH, Sardari S, Vaziri B, Ostad SN,. 2009. Simulation of different truncated p16 forms and in silico study of interaction with Cdk4. Cancer Inform 7: 1-11.
-
(2009)
Cancer Inform
, vol.7
, pp. 1-11
-
-
Fahham, N.1
Ghahremani, M.H.2
Sardari, S.3
Vaziri, B.4
Ostad, S.N.5
-
6
-
-
0033561310
-
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts
-
Fahraeus R, Lane DP,. 1999. The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. Embo J 18: 2106-2118.
-
(1999)
Embo J
, vol.18
, pp. 2106-2118
-
-
Fahraeus, R.1
Lane, D.P.2
-
7
-
-
0029177397
-
Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
-
Fahraeus R, Paramio JM, Ball KL, Lain S, Lane DP,. 1996. Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A. Curr Biol 6: 84-91.
-
(1996)
Curr Biol
, vol.6
, pp. 84-91
-
-
Fahraeus, R.1
Paramio, J.M.2
Ball, K.L.3
Lain, S.4
Lane, D.P.5
-
8
-
-
0033304571
-
Transfection of an inducible p16/CDKN2A construct mediates reversible growth inhibition and G1 arrest in the AtT20 pituitary tumor cell line
-
Frost SJ, Simpson DJ, Clayton RN, Farrell WE,. 1999. Transfection of an inducible p16/CDKN2A construct mediates reversible growth inhibition and G1 arrest in the AtT20 pituitary tumor cell line. Mol Endocrinol 13: 1801-1810.
-
(1999)
Mol Endocrinol
, vol.13
, pp. 1801-1810
-
-
Frost, S.J.1
Simpson, D.J.2
Clayton, R.N.3
Farrell, W.E.4
-
9
-
-
0033178714
-
Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas
-
Harada H, Nakagawa K, Iwata S, Saito M, Kumon Y, Sakaki S, Sato K, Hamada K,. 1999. Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas. Cancer Res 59: 3783-3789.
-
(1999)
Cancer Res
, vol.59
, pp. 3783-3789
-
-
Harada, H.1
Nakagawa, K.2
Iwata, S.3
Saito, M.4
Kumon, Y.5
Sakaki, S.6
Sato, K.7
Hamada, K.8
-
10
-
-
0028845142
-
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
-
Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, Davidson NE, Sidransky D, Baylin SB,. 1995. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55: 4525-4530.
-
(1995)
Cancer Res
, vol.55
, pp. 4525-4530
-
-
Herman, J.G.1
Merlo, A.2
Mao, L.3
Lapidus, R.G.4
Issa, J.P.5
Davidson, N.E.6
Sidransky, D.7
Baylin, S.B.8
-
11
-
-
0029052951
-
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
-
Koh J, Enders GH, Dynlacht BD, Harlow E,. 1995. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375: 506-510.
-
(1995)
Nature
, vol.375
, pp. 506-510
-
-
Koh, J.1
Enders, G.H.2
Dynlacht, B.D.3
Harlow, E.4
-
12
-
-
0033537672
-
Tumor suppressor INK4: Determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A
-
Li J, Byeon IJ, Ericson K, Poi MJ, O'Maille P, Selby T, Tsai MD,. 1999. Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. Biochemistry 38: 2930-2940.
-
(1999)
Biochemistry
, vol.38
, pp. 2930-2940
-
-
Li, J.1
Byeon, I.J.2
Ericson, K.3
Poi, M.J.4
O'Maille, P.5
Selby, T.6
Tsai, M.D.7
-
13
-
-
0028871672
-
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines
-
Li W, Fan J, Hochhauser D, Banerjee D, Zielinski Z, Almasan A, Yin Y, Kelly R, Wahl GM, Bertino JR,. 1995. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci U S A 92: 10436-10440.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10436-10440
-
-
Li, W.1
Fan, J.2
Hochhauser, D.3
Banerjee, D.4
Zielinski, Z.5
Almasan, A.6
Yin, Y.7
Kelly, R.8
Wahl, G.M.9
Bertino, J.R.10
-
14
-
-
0032981481
-
Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
-
McConnell BB, Gregory FJ, Stott FJ, Hara E, Peters G,. 1999. Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol Cell Biol 19: 1981-1989.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1981-1989
-
-
McConnell, B.B.1
Gregory, F.J.2
Stott, F.J.3
Hara, E.4
Peters, G.5
-
15
-
-
0031909709
-
Ankyrin for clues about the function of p16INK4a
-
McDonald NQ, Peters G,. 1998. Ankyrin for clues about the function of p16INK4a. Nat Struct Biol 5: 85-88.
-
(1998)
Nat Struct Biol
, vol.5
, pp. 85-88
-
-
McDonald, N.Q.1
Peters, G.2
-
16
-
-
0027374511
-
The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats
-
Michaely P, Bennett V,. 1993. The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. J Biol Chem 268: 22703-22709.
-
(1993)
J Biol Chem
, vol.268
, pp. 22703-22709
-
-
Michaely, P.1
Bennett, V.2
-
17
-
-
71449097361
-
P16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid- induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2
-
Obexer P, Hagenbuchner J, Rupp M, Salvador C, Holzner M, Deutsch M, Porto V, Kofler R, Unterkircher T, Ausserlechner MJ,. 2009. p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. J Biol Chem 284: 30933-30940.
-
(2009)
J Biol Chem
, vol.284
, pp. 30933-30940
-
-
Obexer, P.1
Hagenbuchner, J.2
Rupp, M.3
Salvador, C.4
Holzner, M.5
Deutsch, M.6
Porto, V.7
Kofler, R.8
Unterkircher, T.9
Ausserlechner, M.J.10
-
18
-
-
0037075887
-
Cyclin D-dependent kinases, INK4 inhibitors and cancer
-
Ortega S, Malumbres M, Barbacid M,. 2002. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 1602: 73-87.
-
(2002)
Biochim Biophys Acta
, vol.1602
, pp. 73-87
-
-
Ortega, S.1
Malumbres, M.2
Barbacid, M.3
-
19
-
-
0029739541
-
Retinoblastoma protein family in cell cycle and cancer: A review
-
DOI 10.1002/(SICI)1097-4644(199609)62:3<418::AID-JCB12>3.0.CO;2-E
-
Paggi MG, Baldi A, Bonetto F, Giordano A,. 1996. Retinoblastoma protein family in cell cycle and cancer: a review. J Cell Biochem 62: 418-430. (Pubitemid 26301541)
-
(1996)
Journal of Cellular Biochemistry
, vol.62
, Issue.3
, pp. 418-430
-
-
Paggi, M.G.1
Baldi, A.2
Bonetto, F.3
Giordano, A.4
-
20
-
-
0029980941
-
Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma
-
Parry D, Peters G,. 1996. Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma. Mol Cell Biol 16: 3844-3852.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 3844-3852
-
-
Parry, D.1
Peters, G.2
-
21
-
-
0033574614
-
Mechanisms of cyclin-dependent kinase regulation: Structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors
-
Pavletich NP,. 1999. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J Mol Biol 287: 821-828.
-
(1999)
J Mol Biol
, vol.287
, pp. 821-828
-
-
Pavletich, N.P.1
-
22
-
-
0034683576
-
A novel function for the tumor suppressor p16(INK4a): Induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor
-
Plath T, Detjen K, Welzel M, von Marschall Z, Murphy D, Schirner M, Wiedenmann B, Rosewicz S,. 2000. A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor. J Cell Biol 150: 1467-1478.
-
(2000)
J Cell Biol
, vol.150
, pp. 1467-1478
-
-
Plath, T.1
Detjen, K.2
Welzel, M.3
Von Marschall, Z.4
Murphy, D.5
Schirner, M.6
Wiedenmann, B.7
Rosewicz, S.8
-
23
-
-
0035205924
-
Expression of cell-cycle mediators in ovarian cancer cells after transfection with p16(INK4a), p21(WAF1/Cip-1), and p53
-
Ramirez PT, Gershenson DM, Tortolero-Luna G, Ramondetta LM, Fightmaster D, Wharton JT, Wolf JK,. 2001. Expression of cell-cycle mediators in ovarian cancer cells after transfection with p16(INK4a), p21(WAF1/Cip-1), and p53. Gynecol Oncol 83: 543-548.
-
(2001)
Gynecol Oncol
, vol.83
, pp. 543-548
-
-
Ramirez, P.T.1
Gershenson, D.M.2
Tortolero-Luna, G.3
Ramondetta, L.M.4
Fightmaster, D.5
Wharton, J.T.6
Wolf, J.K.7
-
24
-
-
0038277105
-
Tumor cell senescence in cancer treatment
-
Roninson IB,. 2003. Tumor cell senescence in cancer treatment. Cancer Res 63: 2705-2715.
-
(2003)
Cancer Res
, vol.63
, pp. 2705-2715
-
-
Roninson, I.B.1
-
25
-
-
0032541623
-
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
-
Russo AA, Tong L, Lee JO, Jeffrey PD, Pavletich NP,. 1998. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395: 237-243.
-
(1998)
Nature
, vol.395
, pp. 237-243
-
-
Russo, A.A.1
Tong, L.2
Lee, J.O.3
Jeffrey, P.D.4
Pavletich, N.P.5
-
26
-
-
0031586589
-
The tumor suppressor protein p16INK4a
-
Serrano M,. 1997. The tumor suppressor protein p16INK4a. Exp Cell Res 237: 7-13.
-
(1997)
Exp Cell Res
, vol.237
, pp. 7-13
-
-
Serrano, M.1
-
27
-
-
0029715628
-
CDKN2A (p16INK4A) somatic and germline mutations
-
Smith-Sorensen B, Hovig E,. 1996. CDKN2A (p16INK4A) somatic and germline mutations. Hum Mutat 7: 294-303.
-
(1996)
Hum Mutat
, vol.7
, pp. 294-303
-
-
Smith-Sorensen, B.1
Hovig, E.2
-
28
-
-
0037228879
-
Sequential unfolding of ankyrin repeats in tumor suppressor p16
-
Tang KS, Fersht AR, Itzhaki LS,. 2003. Sequential unfolding of ankyrin repeats in tumor suppressor p16. Structure 11: 67-73.
-
(2003)
Structure
, vol.11
, pp. 67-73
-
-
Tang, K.S.1
Fersht, A.R.2
Itzhaki, L.S.3
-
29
-
-
0033613908
-
Stability and folding of the tumour suppressor protein p16
-
Tang KS, Guralnick BJ, Wang WK, Fersht AR, Itzhaki LS,. 1999. Stability and folding of the tumour suppressor protein p16. J Mol Biol 285: 1869-1886.
-
(1999)
J Mol Biol
, vol.285
, pp. 1869-1886
-
-
Tang, K.S.1
Guralnick, B.J.2
Wang, W.K.3
Fersht, A.R.4
Itzhaki, L.S.5
-
30
-
-
0029665942
-
Tumor suppressor p16(INK4A): Structural characterization of wild-type and mutant proteins by NMR and circular dichroism
-
DOI 10.1021/bi960211+
-
Tevelev A, Byeon IJ, Selby T, Ericson K, Kim HJ, Kraynov V, Tsai MD,. 1996. Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism. Biochemistry 35: 9475-9487. (Pubitemid 26320054)
-
(1996)
Biochemistry
, vol.35
, Issue.29
, pp. 9475-9487
-
-
Tevelev, A.1
Byeon, I.L.2
Selby, T.3
Ericson, K.4
Kim, H.-J.5
Kraynov, V.6
Tsai, M.-D.7
-
31
-
-
12244305549
-
Structural analysis of the inhibition of Cdk4 and Cdk6 by p16(INK4a) through molecular dynamics simulations
-
Villacanas O, Perez JJ, Rubio-Martinez J,. 2002. Structural analysis of the inhibition of Cdk4 and Cdk6 by p16(INK4a) through molecular dynamics simulations. J Biomol Struct Dyn 20: 347-358.
-
(2002)
J Biomol Struct Dyn
, vol.20
, pp. 347-358
-
-
Villacanas, O.1
Perez, J.J.2
Rubio-Martinez, J.3
-
32
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg RA,. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
33
-
-
0029115349
-
Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells
-
Whitaker NJ, Bryan TM, Bonnefin P, Chang AC, Musgrove EA, Braithwaite AW, Reddel RR,. 1995. Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells. Oncogene 11: 971-976.
-
(1995)
Oncogene
, vol.11
, pp. 971-976
-
-
Whitaker, N.J.1
Bryan, T.M.2
Bonnefin, P.3
Chang, A.C.4
Musgrove, E.A.5
Braithwaite, A.W.6
Reddel, R.R.7
-
34
-
-
28944443306
-
The co-transfection of p16(INK4a) and p14(ARF) genes into human lung cancer cell line A549 and the effects on cell growth and chemosensitivity
-
Xie QC, Hu YD, Wang LL, Chen ZT, Diao XW, Wang ZX, Guan HJ, Zhu B, Sun JG, Duan YZ, Chen FL, Nian WQ,. 2005. The co-transfection of p16(INK4a) and p14(ARF) genes into human lung cancer cell line A549 and the effects on cell growth and chemosensitivity. Colloids Surf B Biointerfaces 46: 188-196.
-
(2005)
Colloids Surf B Biointerfaces
, vol.46
, pp. 188-196
-
-
Xie, Q.C.1
Hu, Y.D.2
Wang, L.L.3
Chen, Z.T.4
Diao, X.W.5
Wang, Z.X.6
Guan, H.J.7
Zhu, B.8
Sun, J.G.9
Duan, Y.Z.10
Chen, F.L.11
Nian, W.Q.12
-
35
-
-
0028979432
-
Mutational effects on the p16INK4a tumor suppressor protein
-
Yang R, Gombart AF, Serrano M, Koeffler HP,. 1995. Mutational effects on the p16INK4a tumor suppressor protein. Cancer Res 55: 2503-2506.
-
(1995)
Cancer Res
, vol.55
, pp. 2503-2506
-
-
Yang, R.1
Gombart, A.F.2
Serrano, M.3
Koeffler, H.P.4
-
36
-
-
0029664738
-
Analysis of p16INK4a and its interaction with CDK4
-
Yang R, Serrano M, Slater J, Leung E, Koeffler HP,. 1996. Analysis of p16INK4a and its interaction with CDK4. Biochem Biophys Res Commun 218: 254-259.
-
(1996)
Biochem Biophys Res Commun
, vol.218
, pp. 254-259
-
-
Yang, R.1
Serrano, M.2
Slater, J.3
Leung, E.4
Koeffler, H.P.5
-
37
-
-
0033568342
-
Biologic and biochemical analyses of p16(INK4a) mutations from primary tumors
-
Yarbrough WG, Buckmire RA, Bessho M, Liu ET,. 1999. Biologic and biochemical analyses of p16(INK4a) mutations from primary tumors. J Natl Cancer Inst 91: 1569-1574.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1569-1574
-
-
Yarbrough, W.G.1
Buckmire, R.A.2
Bessho, M.3
Liu, E.T.4
-
38
-
-
0033585104
-
Tumor suppressor INK4: Comparisons of conformational properties between p16(INK4A) and p18(INK4C)
-
Yuan C, Li J, Selby TL, Byeon IJ, Tsai MD,. 1999. Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C). J Mol Biol 294: 201-211.
-
(1999)
J Mol Biol
, vol.294
, pp. 201-211
-
-
Yuan, C.1
Li, J.2
Selby, T.L.3
Byeon, I.J.4
Tsai, M.D.5
-
39
-
-
0034674169
-
A minimum folding unit in the ankyrin repeat protein p16(INK4)
-
Zhang B, Peng Z,. 2000. A minimum folding unit in the ankyrin repeat protein p16(INK4). J Mol Biol 299: 1121-1132.
-
(2000)
J Mol Biol
, vol.299
, pp. 1121-1132
-
-
Zhang, B.1
Peng, Z.2
-
40
-
-
0037150075
-
Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis
-
Zhang B, Peng ZY,. 2002. Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis. Biochemistry 41: 6293-6302.
-
(2002)
Biochemistry
, vol.41
, pp. 6293-6302
-
-
Zhang, B.1
Peng, Z.Y.2
|