Structural analysis of the inhibition of cdk4 and cdk6 by p16INK4a through Molecular Dynamics Simulations

Journal of Biomolecular Structure and Dynamics

Volumn 20, Issue 3, 2002, Pages 347-358

  Villacañas, Óscar ^a   Pérez, Juan J ^b   Rubio Martínez, Jaime ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PROTEIN P16; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN; WATER;

ARTICLE; BINDING SITE; CALCULATION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COMPUTER PROGRAM; CRYSTAL STRUCTURE; DRUG DESIGN; ENERGY; ENZYME CONFORMATION; ENZYME INHIBITOR COMPLEX; ENZYME INHIBITOR INTERACTION; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TEMPERATURE; TUMOR SUPPRESSOR GENE; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; BINDING SITES; CELL CYCLE; CELL DIVISION; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TEMPERATURE;

EID: 12244305549     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2002.10506853     Document Type: Article

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