A minimum folding unit in the ankyrin repeat protein p16(INK4)

Journal of Molecular Biology

Volumn 299, Issue 4, 2000, Pages 1121-1132

  Zhang, Bin ^a   Peng, Zheng Yu ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Ankyrin repeat; Autonomous folding unit; p16(INK4); p16C; Protein folding

Indexed keywords

ANKYRIN; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; DNA FRAGMENT; HELIX LOOP HELIX PROTEIN; PROTEIN P16;

ALGORITHM; ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; ESCHERICHIA COLI; GENETIC ENGINEERING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN FOLDING; TUMOR SUPPRESSOR GENE;

EID: 0034674169     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3803     Document Type: Article

References (42)

1. Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene
2. The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein
3. Structure of human cyclin-dependent kinase inhibitor p19(INK4d): Comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a)
4. Protein stability curves
5. Hundreds of ankyrin-like repeats in functionally diverse proteins: Mobile modules that cross phyla horizontally?
6. Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila
7. Crystal structure of the complex of the cyclin D-dependent kinase cdk6 bound to the cell-cycle inhibitor p19(INK4D)
8. Tumor suppressor p16(INK4A): Determination of solution structure and analyses of its interaction with cyclin dependent kinase 4
9. A new approach to the calculation of secondary structures of globular proteins by optical rotatory dispersion and circular dichroism
10. Spectroscopic determination of tryptophan and tyrosine in proteins
11. Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
12. A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a β-sheet structure
13. Topological characteristics of helical repeat proteins
14. Secondary structure of an armadillo single repeat from the APC protein
15. Three-dimensional structure of the armadillo repeat region of β-catenin
16. A cell cycle regulator potentially involved in genesis of many tumor types
17. Amphipathic β structure of a leucinerich repeat peptide
18. Computer-aided interpretation of analytical sedimentation data for proteins
19. Tumor suppressor INK4: Determination of the solution structure of p18(INK4C) and demonstration of the functional significance of loops in p18(INK4C) and p16(INK4A)
20. Structure of the cyclin-dependent kinase inhibitor p19(INK4D)
21. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins
22. A new Saccharomyces cerevisiae ankyrin repeat-encoding gene required for a normal rate of cell proliferation
23. A census of protein repeats
24. Ankyrin for clues about the function of p16(INK4a)
25. The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats
26. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
27. Determination and analysis of urea and guanidine hydrochloride denaturation curves
28. Autonomous protein folding units
29. Thermodynamic problems of protein structure
30. 15N NMR relaxation experiments at two field strengths
31. The p16(INK4a)/CDKN2A tumor suppressor and its relatives
32. Structural basis for inhibition of the cyclin-dependent kinase cdk6 by tumor suppressor p16(INK4A)
33. The ankyrin repeat: A diversity of interactions on a common structural framework
34. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
35. Use of T7 RNA polymerase to direct expression of cloned genes
36. Stability and folding of the tumour suppressor protein p16
37. Tumor suppressor p16(INK4A): Structural characterization of wild-type and mutant proteins by NMR and circular dichroism
38. Genome sequence of the nematode C. elegans: A platform for investigating biology
39. Crystal structure of cdk4/6 inhibitory protein p18(INK4C) provides insights into ankyrin-like repeat structure/function and tumor-derived p16(INK4) mutations
40. Tumor suppressor INK4: Comparisons of conformational properties between p16(INK4A) and p18(INK4C)
41. Defective folding of mutant p16(INK4) proteins encoded by tumor-derived alleles