Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies

Pediatric Diabetes

Volumn 11, Issue 8, 2010, Pages 513-520

  Delli, Ahmed J ^a   Lindblad, Bengt ^b   Carlsson, Annelie ^c   Forsander, Gun ^b   Ivarsson, Sten A ^a   Ludvigsson, Johnny ^d   Marcus, Claude ^e   Lernmark, Åke ^a  

^a LUND UNIVERSITY   (Sweden)

^b QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

2 autoantibodies; DQ genes; GAD65 autoantibodies; IA; Insulin autoantibodies; Migration; T1DM HLA

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; ISLET ANTIGEN 2 AUTOANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; DIABETIC PATIENT; FEMALE; GENETIC RISK; GENOTYPE; HAPLOTYPE; HUMAN; IMMIGRATION; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RACE DIFFERENCE; SCHOOL CHILD; SWEDEN;

ADOLESCENT; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; EMIGRANTS AND IMMIGRANTS; FEMALE; GLUTAMATE DECARBOXYLASE; HLA-DQ ANTIGENS; HUMANS; INFANT; ISLETS OF LANGERHANS; MALE; SWEDEN;

EID: 78649762200     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/j.1399-5448.2010.00637.x     Document Type: Article

References (37)

1. International Diabetes Federation (IDF). World Atlas of Diabetes, 3rd edition. 2006 [Online]. [cited 2008 March 2]; (available from).
2. Harjutsalo V, Sjoberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008: 371:1777-1782.
3. Soltesz G, Patterson CC, Dahlquist G. Worldwide childhood type 1 diabetes incidence - what can we learn from epidemiology? Pediatr Diabetes 2007: 8 (Suppl. 6): 6-14.
4. Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 2000: 23: 1516-1526.
5. Eliasson M, Bostrom G. Chapter 5.2: major public health problems - diabetes. Scand J Public Health Suppl 2006: 67: 59-68.
6. Notkins AL, Lernmark A. Autoimmune type 1 diabetes: resolved and unresolved issues. J Clin Invest 2001: 108: 1247-1252.
7. Hawa MI, Leslie RD. Early induction of type 1 diabetes. Clin Exp Immunol 2001: 126: 181-183.
8. Van Der Werf N, Kroese FG, Rozing J, Hillebrands JL. Viral infections as potential triggers of type 1 diabetes. Diabetes Metab Res Rev 2007: 23: 169-183.
9. Knip M, Akerblom HK. Early nutrition and later diabetes risk. Adv Exp Med Biol 2005: 569:142-150.
10. Vaarala O. Environmental causes: dietary causes. Endocrinol Metab Clin North Am 2004: 33: 17-26, vii.
11. Virtanen SM, Knip M. Nutritional risk predictors of beta cell autoimmunity and type 1 diabetes at a young age. Am J Clin Nutr 2003: 78: 1053-1067.
12. Hypponen E, Kenward MG, Virtanen SM et al. Infant feeding, early weight gain, and risk of type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes Care 1999: 22:1961-1965.
13. Redondo MJ, Eisenbarth GS. Genetic control of autoimmunity in Type I diabetes and associated disorders. Diabetologia 2002: 45: 605-622.
14. Kockum I, Sanjeevi CB, Eastman S, Landin-Olsson M, Dahlquist G, Lernmark A. Complex interaction between HLA DR and DQ in conferring risk for childhood type 1 diabetes. Eur J Immunogenet 1999: 26: 361-372.
15. Todd JA, Walker NM, Cooper JD et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007: 39: 857-864.
16. Miao D, Yu L, Eisenbarth GS. Role of autoantibodies in type 1 diabetes. Front Biosci 2007: 12:1889-1898.
17. Eisenbarth GS, Jeffrey J. The natural history of type 1A diabetes. Arq Bras Endocrinol Metabol 2008: 52: 146-155.
18. Kwon OJ, Brautbar C, Weintrob N et al. Immunogenetics of HLA class II in Israeli Ashkenazi Jewish, Israeli non-Ashkenazi Jewish, and in Israeli Arab IDDM patients. Hum Immunol 2001: 62: 85-91.
19. Cataldo F. Early onset of Type 1 diabetes mellitus in immigrant children from developing countries to Western Europe: the role of environmental factors? J Endocrinol Invest 2005: 28: 574-575.
20. Hjern A, Soderstrom U. Parental country of birth is a major determinant of childhood type 1 diabetes in Sweden. Pediatr Diabetes 2008: 9: 35-39.
21. Feltbower RG, Bodansky HJ, McKinney PA, Houghton J, Stephenson CR, Haigh D. Trends in the incidence of childhood diabetes in south Asians and other children in Bradford, UK. Diabet Med 2002: 19: 162-166.
22. Serrano-Rios M, Goday A, Martinez Larrad T. Migrant populations and the incidence of type 1 diabetes mellitus: an overview of the literature with a focus on the Spanish-heritage countries in Latin America. Diabetes Metab Res Rev 1999: 15: 113-132.
23. Neu A, Willasch A, Ehehalt S, Kehrer M, Hub R, Ranke MB. Diabetes incidence in children of different nationalities: an epidemiological approach to the pathogenesis of diabetes. Diabetologia 2001: 44 (Suppl. 3):B21-26.
24. Zung A, Elizur M, Weintrob N et al. Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment. Hum Immunol 2004: 65: 1463-1468.
25. Podar T, Laporte RE, Tuomilehto J, Shubnikov E. Risk of childhood type 1 diabetes for Russians in Estonia and Siberia. Int J Epidemiol 1993: 22:262-267.
26. The Expert Committee on the Diagnosis and Classifcation of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes Mellitus. Diabetes Care 2003: 26: 3160-3167.
27. Sjoroos M, Iitia A, Ilonen J, Reijonen H, Lovgren T. Triple-label hybridization assay for type-1 diabetes-related HLA alleles. Biotechniques 1995: 18: 870-877.
28. Lynch KF, Lernmark B, Merlo J, Cilio CM, Ivarsson SA, Lernmark A. Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype. J Perinatol 2008: 28: 211-217.
29. Graham J, Hagopian WA, Kockum I et al. Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 2002: 51: 1346-1355.
30. Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC. HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes. J Immunol 2004: 172: 3955-3962.
31. Dahlquist G, Mustonen L. Analysis of 20 years of prospective registration of childhood onset diabetes time trends and birth cohort effects. Swedish Childhood Diabetes Study Group. Acta Paediatr 2000: 89: 1231-1237.
32. Kontiainen S, Scheinin T, Schlenzka A, Maenpaa J, Groop L, Koskimies S. Differences in HLA types in children with insulin-dependent diabetes diagnosed in 1960s, 1970s and 1980s. Lancet 1988: 2: 219.
33. Hermann R, Knip M, Veijola R et al. Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes-indication of an increased environmental pressure? Diabetologia 2003: 46: 420-425.
34. Hermann R, Turpeinen H, Laine AP et al. HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families. Tissue Antigens 2003: 62: 162-169.
35. Erlich H, Valdes AM, Noble J et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008: 57: 1084-1092.
36. Resic-Lindehammer S, Larsson K, Ortqvist E et al. Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk. Acta Diabetol 2008: 45: 231-235.
37. Podar T, Tuomilehto-Wolf E, Tuomilehto J, LaPorte RE, Adojaan B. Insulin-dependent diabetes mellitus in native Estonians and immigrants to Estonia. Am J Epidemiol 1992: 135: 1231-6.