HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: An analysis of 622 nuclear families

Tissue Antigens

Volumn 62, Issue 2, 2003, Pages 162-169

  Hermann, Robert ^a   Turpeinen, H ^a   Laine, A P ^a   Veijola, R ^a,b   Knip, M ^a,c   Simell, O ^a   Sipila I ^c   Akerblom H K ^c   Ilonen, J ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Genetic susceptibility; HLA DQ; Population screening; Type 1 diabetes

Indexed keywords

HLA DQ ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN;

ARTICLE; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA SEQUENCE; FAMILY STUDY; FEMALE; FINLAND; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC EPIDEMIOLOGY; GENETIC RECOMBINATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SEQUENCE ANALYSIS;

ADULT; CHILD; DIABETES MELLITUS, TYPE 1; FEMALE; FINLAND; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; MALE;

EID: 0042664186     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2003.00071.x     Document Type: Article

References (38)

1. Davies JL, Kawaguchi Y, Bennett ST et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994: 371: 130-6.
2. Hashimoto L, Habita C, Beressi JP et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 1994: 371: 161-4.
3. Undlien DE, Friede T, Rammensee HG et al. HLA-encoded genetic predisposition in IDDM. DR4 subtypes may be associated with different degrees of protection. Diabetes 1997: 46: 143-9.
4. She JX. Susceptibility to type I diabetes. HLA-DQ and DR revisited. Immunol Today 1996: 17: 323-9.
5. Nejentsev S, Gombos Z, Laine AP et al. Non-class II HLA gene associated with type 1 diabetes maps to the 240- kb region near HLA-B. Diabetes 2000: 49: 2217-21.
6. Noble JA, Valdes AM, Bugawan TL, et al. locus affects susceptibility to type 1 diabetes. Hum Immunol 2002: 63: 657-64.
7. Lie BA, Sollid LM, Ascher H et al. A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease. Tissue Antigens 1999: 54: 162-8.
8. Ilonen J, Koskinen S, Nejentsev S et al. HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region. Tissue Antigens 1997: 49: 532-4.
9. Park Y, Eisenbarth GS. Genetic susceptibility factors of Type 1 diabetes in Asians. Diabetes Metab Res Rev 2001: 17: 2-11.
10. Nejentsev S, Koskinen S, Sjoroos M et al. Distribution of insulin-dependent diabetes mellitus (IDDM) -related HLA alleles correlates with the difference in IDDM incidence in four populations of the Eastern Baltic region. Tissue Antigens 1998: 52: 473-7.
11. Cucca F, Muntoni F, Lampis R et al. Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. Hum Immunol 1993: 37: 85-94.
12. Falk CT, Rubinstein P. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 1987: 51: 227-33.
13. Zavattari P, Lampis R, Motzo C et al. Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1-DRB1 disease loci. Hum Mol Genet 2001: 10: 881-9.
14. Nejentsev S, Sjoroos M, Soukka T et al. Population-based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland: selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 loci. Diabet Med 1999: 16: 985-92.
15. Knip M. Prediction and prevention of type 1 diabetes. Acta Paediatr Suppl 1998: 425: 54-62.
16. Kupila A, Muona P, Simell T et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 2001: 44: 290-7.
17. Miller SA, Dykes DD, Polesky HFA. simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 1988: 16: 1215.
18. Laaksonen M, Pastinen T, Sjoroos M et al. HLA class II associated risk and protection against multiple sclerosis- a Finnish family study. J Neuroimmunol 2002: 122: 140-5.
19. Thomson G. Mapping disease genes: family-based association studies. Am J Hum Genet 1995: 57: 487-98.
20. Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 2000: 23: 1516-26.
21. Sanjeevi CB, Hook P, Landin-Olsson M et al. DR4 subtypes and their molecular properties in a population-based study of Swedish childhood diabetes. Tissue Antigens 1996: 47: 275-83.
22. Petrone A, Bugawan TL, Mesturino CA et al. The distribution of HLA class II susceptible/protective haplotypes could partially explain the low incidence of type 1 diabetes in continental Italy (Lazio region). Tissue Antigens 2001: 58: 385-94.
23. Cucca F, Lampis R, Frau F et al. The distribution of DR4 haplotypes in Sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci. Hum Immunol 1995: 43: 301-8.
24. Kwon OJ, Brautbar C, Weintrob N et al. Immunogenetics of HLA class II in Israeli Ashkenazi Jewish, Israeli non- Ashkenazi Jewish, and in Israeli Arab IDDM patients. Hum Immunol 2001: 62: 85-91.
25. Noble JA, Valdes AM, Cook M, Klitz W, Thomson G, Erlich HA. The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 1996: 59: 1134-48.
26. Ilonen J, Sjoroos M, Knip M et al. Estimation of genetic risk for type 1 diabetes. Am J Med Genet 2002: 115: 30-6.
27. Petrone A, Battelino T, Krzisnik C et al. Similar incidence of type 1 diabetes in two ethnically different populations (Italy and Slovenia) is sustained by similar HLA susceptible/protective haplotype frequencies. Tissue Antigens 2002: 60: 244-53.
28. Hermann R, Mijovic CH, Rayner M et al. HLA alleles and IDDM in children in Hungary: a comparison with Finland. Hum Immunol 2001: 62: 391-8.
29. Chuang LM, Wu HP, Tsai WY, Lin BJ, Tai TY. Transcomplementation of HLA DQA1-DQB1 in DR3/DR4 and DR3/DR9 heterozygotes and IDDM in Taiwanese families. Diabetes Care 1995: 18: 1483-6.
30. Kawabata Y, Ikegami H, Kawaguchi Y et al. Asian-Specific HLA Haplotypes Reveal Heterogeneity of the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Type 1 Diabetes. Diabetes 2002: 51: 545-51.
31. Schipper RF, Koeleman BP, Bruining GJ et al. HLA dass II associations with Type 1 diabetes mellitus: a multivariate approach. Tissue Antigens 2001: 57: 144-50.
32. Undlien DE, Kockum I, Ronningen KS et al. HLA associations in type 1 diabetes among patients not carrying high- risk DR3-DQ2 or DR4-DQ8 haplotypes. Tissue Antigens 1999: 54: 543-51.
33. Tait BD, Drummond BP, Varney MD, Harrison LCHLA-DRB. 1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus. Eur J Immunogenet 1995: 22: 289-97.
34. Ronningen KS, Gjertsen HA, Iwe T et al. alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites. Diabetes 1991: 40: 759-63.
35. Cinek O, Kolouskova S, Snajderova M et al. HLA class II genetic association of type 1 diabetes mellitus in Czech children. Pediatric Diabetes 2001: 2: 98-102.
36. Pugliese A, Gianani R, Moromisato R et al. HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes 1995: 44: 608-13.
37. Sanjeevi CBHLA-DQ. 6-mediated protection in IDDM. Hum Immunol 2000: 61: 148-53.
38. Hermann R, Knip M, Veijola R et al. Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes - indication of an increased enviromnental pressure? Diabetologia 2003: 46: 420-425.