Nutritional risk predictors of β cell autoimmunity and type 1 diabetes at a young age

American Journal of Clinical Nutrition

Volumn 78, Issue 6, 2003, Pages 1053-1067

  Virtanen, Suvi M ^a,b,c   Knip, Mikael ^c,d  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF TAMPERE   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Autoimmunity; Etiology; Growth; Nutrition; Preclinical diabetes; Type 1 diabetes; cell function

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; NICOTINAMIDE; NITROSO DERIVATIVE; VITAMIN D; ZINC; HLA ANTIGEN;

AGE DISTRIBUTION; AUTOIMMUNITY; BREAST FEEDING; DIET; DISEASE COURSE; ENVIRONMENTAL FACTOR; GENETIC RISK; GENETIC SUSCEPTIBILITY; GEOGRAPHY; HLA SYSTEM; HUMAN; INCIDENCE; INFANT FEEDING; INSULIN DEPENDENT DIABETES MELLITUS; MILK; MONOZYGOTIC TWINS; NUTRITION; OBESITY; PANCREAS ISLET BETA CELL; REVIEW; RISK ASSESSMENT; RISK FACTOR; SAMPLE SIZE; ANIMAL; CASE CONTROL STUDY; CHILD; COHORT ANALYSIS; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; PANCREAS ISLET; PHYSIOLOGY; WEIGHT GAIN;

ANIMALS; AUTOIMMUNITY; BREAST FEEDING; CASE-CONTROL STUDIES; CHILD; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HUMANS; ISLETS OF LANGERHANS; MILK; RISK FACTORS; WEIGHT GAIN;

EID: 0642306552     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/78.6.1053     Document Type: Review

References (201)

1. Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspective on disease pathogenesis. Lancet 2001;358:221-9.
2. Barnett AH, Eff C, Leslie RDG, Pyke DA. Diabetes in identical twins. A study of 200 pairs. Diabetologia 1981;20:87-93.
3. Kaprio J, Tuomilehto J, Koskenvuo M, et al. Concordance for type I (insulin-dependent) and type II (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 1992;35:1060-7.
4. Green A, Patterson CC. Trends in the incidence of childhood-onset diabetes in Europe 1989-1998. Diabetologia 2001;44(suppl):B3-8.
5. Onkamo P, Väänänen S, Karvonen M, Tuomilehto J. Worldwide increase in incidence of type I diabetes - the analysis of the data on published incidence trends. Diabetologia 1999;42:1395-403.
6. Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J. Incidence of childhood type 1 diabetes worldwide. Diabetes Care 2000;23:1516-25.
7. Gale EAM. The rise of childhood type 1 diabetes in the 20th Century. Diabetes 2002;51:3353-61.
8. Bingley PJ, Gale EAM. Rising incidence of IDDM in Europe. Diabetes Care 1989;12:289-95.
9. Ilonen J, Reijonen H, Herva E, et al. Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish population. Diabetes Care 1996;19:795-800.
10. Knip M, Åkerblom HK. Putative environmental factors in Type 1 diabetes Diabetes Metab Rev 1998;14:31-67.
11. Virtanen SM, Aro A. Dietary factors in the aetiology of diabetes. Ann Med 1994;26:469-78.
12. Knip M. Natural course of preclinical type 1 diabetes. Horm Res 2002;57(suppl):6-11.
13. Knip M. Can we predict type 1 diabetes in the general population? Diabetes Care 2002;25:623-5.
14. Bingley PJ, Bonifacio E, Williams AJK, Genovese S, Bottazzo GF, Gale EAM. Prediction of IDDM in the general populations, strategies based on combinations of autoantibody markers. Diabetes 1997;46: 1701-10.
15. LaGasse JM, Brantley MS, Leech NJ, et al. Successful prospective prediction of type 1 diabetes in schoolchildren by multiple defined autoantibodies: eight year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care 2002;25:505-11.
16. Ziegler A-G, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 1999;48:460-8.
17. Kimpimäki T, Kupila A, Hämälainen A-M, et al. The first signs of β-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 2001;86: 4782-8.
18. Kupila A, Muona P, Ronkainen M, et al. Genetic risk determines the emergence of diabetes-associated autoantibodies in young children. Diabetes 2002;51:646-51.
19. Kimpimäki T, Kulmala P, Savola K, et al. Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. J Clin Endocrinol Metab 2000;85:1126-30.
20. Sabbah E, Savola K, Ebeling T, et al. Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes mellitus. Diabetes Care 2000;23:1326-32.
21. Karvonen M, Pitkäniemi M, Pitkäniemi J, Kohtamäki K, Tajima N, Tuomilehto J for the World Health Organization DIAMOND Project Group. Sex difference in the incidence of insulin-dependent diabetes mellitus: an analysis of the recent epidemiological data. Diabetes Metab Rev 1997;13:275-91.
22. Williams AJK, Bingley PJ, Moore WPT, Gale EAM, ENDIT Screening Group. Islet autoantibodies, nationality and gender: a multinational screening study in first-degree relatives of patients with type I diabetes. Diabetologia 2002;45:217-23
23. Houssay BA, Martínez C. Experimental diabetes and diet. Science 1947;23:548-9.
24. Lazarow A, Liambies J, Tousch AJ. Protection against diabetes with nicotinamide. J Lab Med 1950;36:249-58.
25. Stauffacher W, Burr I, Gutzeit A, Beaven D, Veleminsky J, Renold AE. Streptozotocin diabetes: time course of irreversible B-cell damage: further observations on prevention by nicotinamide. Proc Soc Exp Biol Med 1970;133:194-200.
26. Gale EAM. Perspectives in diabetes. The discovery of type 1 diabetes. Diabetes 2001;50:217-26.
27. Baum JD, Ounsted M, Smith MA. Weight gain in infancy and subsequent development of diabetes mellitus in childhood. Lancet 1975;2:866.
28. Helgason T, Jonasson MR. Evidence for a food additive as a cause of ketosis-prone diabetes. Lancet 1981;2:716-20.
29. Yamada K, Nonaka K, Hanafusa T, Miyazaki A, Toyoshima H, Tarui S. Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice. Diabetes 1982;31:749-53.
30. Borch-Johnsen K, Mandrup-Poulsen T, Zachau-Christiansen B, et al Relation between breastfeeding and incidence rates of insulin-dependent diabetes mellitus. Lancet 1984;2:1083-6.
31. Elliot RB, Martin JM. Dietary protein: a trigger of insulin-dependent diabetes in the BB rat? Diabetologia 1984;26:297-9.
32. Scott FW, Mongeau R, Kardish M, Hatina G, Trick KD, Wojcinski Z. Diet can prevent diabetes in the BB rat. Diabetes 1985;34:1059-62.
33. Behrens WA, Scott FW, Madère R, Trick K, Hanna K. Effect of dietary vitamin E on the vitamin E status in the BB rat during development and after the onset of diabetes. Ann Nutr Metab 1986; 30:157-65.
34. Elliott RB, Reddy SN, Bibby NJ, Kida K. Dietary prevention of diabetes in the non-obese diabetic mouse. Diabetologia 1988;31: 62-4.
35. Glatthaar C, Whittall DE, Welbom TA, et al. Diabetes in Western Australian children: descriptive epidemiology. Med J Aust 1988;148: 117-23.
36. Wright JR, Lefkowith JB, Schreiner G, Lacy PE. Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. Proc Natl Acad Sci U S A 1988;85:6137-41.
37. Linn T, Noke M, Woerle M, et al. Fish oil-enriched diet and reduction of low-dose streptozotocin-induced hyperglycemia. Diabetes 1989; 38: 402-11.
38. Coleman DL, Kuzava JE, Leiter EH. Effect of diet on incidence of diabetes in non-obese diabetic mice Diabetes 1990;39:432-6.
39. Dahlquist G, Blom LG, Persson L-Å, Sandström A, Wall S. Dietary factors and the nsk of developing insulin dependent diabetes in childhood. BMJ 1990;300:1302-6.
40. Tuomilehto J, Tuomilehto-Wolf E, Virtala E, LaPorte R. Coffee consumption as trigger for insulin-dependent diabetes mellitus in childhood. BMJ 1990;300:642-3
41. 3 serum concentrations at the onset of immune-mediated type 1 (insulin-dependent) diabetes mellitus. Diabetes Res 1991;16:145-8.
42. Dahlquist G, Blom L, Lönnberg G. The Swedish childhood diabetes study - a multivanate analysis of risk determinants for diabetes in different age groups Diabetologia 1991;34:757-62.
43. Elliot RB, Chase HP. Prevention or delay of type 1 (insulin-dependent) diabetes meihtus in children using nicotinamide. Diabetologia 1991;34:362-5.
44. Hoorfar J, Scott FW, Cloutier HE. Dietary plant materials and development of diabetes in the BB rat. J Nutr 1991;121:908-16.
45. Pozzilli P, Bottazzo GF. Coffee or sugar. Which is to blame in IDDM? Diabetes Care 1991;14:144-5
46. Virtanen SM, Räsänen L, Aro A, et al. Infant feeding in Finnish children < 7 yr of age with newly diagnosed IDDM. Diabetes Care 1991;14:415-7.
47. Blom LG, Persson LÅ, Dahlquist GG. A high linear growth is associated with an increased risk of childhood diabetes. Diabetologia 1992;35:528-33.
48. Price DE, Burden AC. Growth of children before onset of diabetes. Diabetes Care 1992;15:1393-5.
49. 3 against the development of diabetes induced by multiple low-dose streptozotocin injection in CD-1 mice. Metab 1992;41:631-5.
50. Metcalfe MA, Baum JD. Family characteristics and insulin-dependent diabetes. Arch Dis Child 1992;67:731-6.
51. Johansson C, Samuelsson U, Ludvigsson J. A high weight gain early in life is associated with an increased risk of type I (insulin-dependent) diabetes meHitus. Diabetologia 1994;37:91-4.
52. Verge CF, Howard NJ, Irwig L, Simpson JM, Mackerras D, Silink M. Environmental factors in childhood IDDM. Diabetes Care 1994;17: 1381-9.
53. Virtanen SM, Räsänen L, Aro A, et al. Is children's or parent's coffee or tea consumption associated with the risk for type 1 diabetes mellitus in children? Eur J Clin Nutr 1994;48:279-85.
54. Haglund B, Ryckenberg K, Selinus O, Dahlquist G. Evidence of a relationship between childhood-onset type 1 diabetes and groundwater concentration of zinc. Diabetes Care 1996;19:873-5.
55. Tobia MH, Zdanowicz MM, Wingertzahn MA, McHeffey-Atkinson B, Slonim AE, Wapnu RA. The role of dietary zinc in modifying the onset and severity of spontaneous diabetes in the BB Wistar rat. Mol Genet Metab 1998;63:205-13
56. Dahlquist GG, Patterson C, Soltesz G. Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. Diabetes Care 1999;22:1698-702.
57. The EURODIAB Substudy 2 Study Group. Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. Diabetologia 1999;42:51-4.
58. Knekt P, Reunanen A, Marniemi J, Leino A, Aromaa A. Low vitamin E is potential risk factor for IDDM. J Intern Med 1999;245:99-102.
59. Muntoni S, Cocco P, Aru G, Cucca F, Muntoni S. Nutritional factors and worldwide incidence of childhood type 1 diabetes. Am J Clin Nutr 2000;71:1525-9.
60. Stene LC, Ulriksen J, Magnus P, Joner G. Use of cod liver oil during pregnancy associated with lower risk of type I diabetes in the offspring. Diabetologia 2000;43:1093-8.
61. Soltész G, Jeges S, Dahlquist G. Non-genetic risk determinants for type 1 (insulin-dependent) diabetes mellitus in childhood. Hungarian Childhood Diabetes Epidemiology Study Group. Acta Paediatr 1994; 83:730-5.
62. Nigro G, Campea L, De Novellis A, Orsini M. Breastfeeding and insulin-dependent diabetes mellitus. Lancet 1985;1:467.
63. Fort P, Lanes R, Dahlem S, et al. Breast feeding and insulin dependent diabetes mellitus in children. J Am Coll Nutr 1986;5:439-41.
64. Golding J, Haslum M. Breast feeding and diabetes. Med Sci Res 1987;15:1135-7 (letter).
65. Mayer EJ, Hamman RF, Gay EC, Lezotte DC, Savitz DA, Klingensmith GJ. Reduced risk of IDDM among breastfed children. The Colorado IDDM registry. Diabetes 1988;37:1625-32.
66. Blom L, Dahlquist G, Nyström L, Sandström A, Wall S. The Swedish childhood diabetes study - social and perinatal determinants for diabetes m childhood. Diabetologia 1989;32:7-13.
67. Siemiatycki J, Colle E, Campbell S, Dewar RAD, Belmonte MM. Case-control study of IDDM. Diabetes Care 1989;12:209-16.
68. Kostraba JN, Dorman JS, LaPorte RE, et al. Early infant diet and risk of IDDM in blacks and whites. Diabetes Care 1992;15:626-31.
69. Kyvik KO, Green A, Svendsen A, Mortensen K. Breast feeding and the development of type 1 diabetes meilitus. Diabet Med 1992;9: 233-5.
70. Virtanen SM, Räsanen L, Aro A, et al. Feeding in infancy and the risk of type 1 diabetes mellitus in Finnish children. Diabet Med 1992;9: 815-9.
71. Samuelsson U, Johansson C, Ludvigsson J. Breast-feeding seems to play a marginal role in the prevention of insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 1993;19:203-10.
72. Virtanen SM, Räsänen L, Ylönen K, et al. Early introduction of dairy products associated with increased risk of IDDM in Finnish children. Diabetes 1993;42:1786-90.
73. Bodington MJ, McNally PG, Burden AC. Cow's milk and type 1 childhood diabetes: no increase in risk. Diabet Med 1994;11:663-5.
74. Patterson CC, Carson DJ, Hadden DR, Waugh NR, Cole SK. A case-control investigation of perinatal risk factors for childhood IDDM in Northern Ireland and Scotland. Diabetes Care 1994;17: 376-81.
75. Pérez-Bravo F, Carrasco E, Gutierrez-López MD, Martinez MT, López G, Garcia de los Rios M. Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children. J Mol Med 1996;74:105-9.
76. Meloni T, Marinaro AM, Mannazzu MC, et al. IDDM and early infant feeding: Sardinian case-control study. Diabetes Care 1997;20: 340-2.
77. Wadsworth EJK, Shield JPH, Hunt LP, Baum JD. A case-control study of environmental factors associated with diabetes in the under 5s. Diabet Med 1997;14:390-6.
78. Jones ME, Swerdlow AJ, Gill LE, Goldacre MJ. Pre-natal and early life risk factors for childhood onset diabetes mellitus: a record linkage study. Int J Epidemiol 1998;27:444-9.
79. Tai T-Y, Wang C-Y, Lin LL-K, Lee L-T, Tsai S-T, Chen C-J. A case-control study on risk factors for type 1 diabetes in Taipei city. Diabetes Res Clin Pract 1998;42:197-203.
80. Virtanen SM, Hyppönen E, Läärä E, et al. Cow's milk consumption, disease associated autoantibodies and IDDM: a follow-up study in siblings of children with diabetes. Diabet Med 1998;15:730-8.
81. McKinney PA, Parslow R, Gurney KA, Law GR, Bodansky HJ, Williams R. Perinatal and neonatal determinants of childhood type 1 diabetes. Diabetes Care 1999;22:928-32.
82. Rami B, Schneider U, Imhof A, Waldhör T, Schober E. Risk factors for type I diabetes mellitus in children in Austria. Eur J Pediatr 1999;158:362-6.
83. Virtanen SM, Läärä E, Hyppönen E, et al. Cow's milk consumption, HLA-DQB1 genotype and IDDM: a nested case-control study of siblings of children with diabetes. Diabetes 2000;49:912-7.
84. Esfarjani F, Azar MR, Gafarpour M. JDDM and early exposure of infant to cow's milk and solid food. Indian J Pediatr 2001;68:107-10.
85. The EURODIAB Substudy 2 study group. Rapid early growth is associated with increased risk of childhood type 1 diabetes in various European populations. Diabetes Care 2002;25:1755-60.
86. Dahlquist G, Savilahti E, Landin-Olsson M. An increased level of antibodies to betalactoglobulin is a risk determinant for early-onset type 1 (insulin-dependent) diabetes mellitus independent of islet cell antibodies and early introduction of cow's milk. Diabetologia 1992; 35:980-4.
87. Kostraba JN, Cruickshanks KJ, Lawler-Heavner J, et al. Early exposure to cow's milk and solid foods in infancy, genetic predisposition, and risk of IDDM. Diabetes 1993;42:288-95.
88. Virtanen SM, Saukkonen T, Savilahti E, et al. Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children. Diabetologia 1994;37:381-407.
89. Gimeno SGA, de Souza JMP. IDDM and milk consumption: a case-control study in São Paulo, Brazil. Diabetes Care 1997;20: 1256-60.
90. Hyppönen E, Kenward MG, Virtanen SM, et al. Infant feeding, early weight gain and risk of type 1 diabetes. Diabetes Care 1999;22: 1961-5.
91. Thorsdottir I, Birgisdottir BE, Johannsdottir IM, et al. Different β-casein fractions in Icelandic versus Scandinavian cow's milk may influence diabetogenicity of cow's milk in infancy and explain low incidence of insulin-dependent diabetes mellitus in Iceland. Pediatrics 2000;106:719-24.
92. Virtanen SM, Jaakkola L, Râsânen L, et al. Nitrate and nitrite intake and the risk for type 1 diabetes in Finnish children. Diabet Med 1994;11:656-62.
93. Lampeter EF, Klinghammer A, Scherbaum WA, et al. The Deutsche nicotinamide intervention study, an attempt to prevent type 1 diabetes. Diabetes 1998;47:980-4.
94. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth cohort study. Lancet 2001:358:1500-3.
95. McKinney PA, Parslow R, Gurney K, Law G, Bodansky HJ, Williams DRR. Antenatal risk factors for childhood diabetes mellitus; a case-control study of medical record data in Yorkshire, UK. Diabetologia 1997;40:933-9.
96. Bruining GJ, the Netherlands Kolibrie Study Group of Childhood Diabetes. Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Lancet 2000;356:655-6.
97. Hyppönen E, Virtanen SM, Kenward MG, Knip M, Åkerblom HK, The Childhood Diabetes in Finland Study Group. Obesity, increased linear growth, and risk of type 1 diabetes in children. Diabetes Care 2000;23:1-6.
98. Dahlquist G, Sandberg Bennich S, Källén B. Intrauterine growth pattern and risk of childhood onset insulin dependent (type I) diabetes: a population based case-control study. BMJ 1996;313:1174-7.
99. Bock T, Pedersen CR, Völund A, Pallesen CS, Buschard K. Perinatal determinants among children who later develop IDDM. Diabetes Care 1994;17:1154-7.
100. Bache I, Bock T, Volund A, Buschard K. Previous maternal abortion, longer gestation, and younger maternal age decrease the risk of type 1 diabetes among male offspring. Diabetes Care 1999;22:1063-5.
101. Podar T, Onkamo P, Forsen T, et al. Neonatal anthropometric measurements and risk of childhood-onset type 1 diabetes. Diabetes Care 1999;22:2092-4.
102. Stene LC, Magnus P, Lie RT, et al. Birth weight and childhood onset type 1 diabetes: population based cohort study. BMJ 2001;322:889-92.
103. Dahlquist G, Källén B. Maternal-child blood group incompatibility and oiher perinatal events increase the risk for early-onset type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1992;35:671-5.
104. Noms JM, Beaty B, Klingensmith G, et al. Lack of association between early exposure to cow's milk protein and β-cell autoimmunity. JAMA 1996;276:609-14.
105. Hummel M, Fuchtenbush M, Schenker M, Ziegler A-G. No major association of breast-feeding, vaccinations, and childhood viral diseases with early islet autoimmunity in the German BABYDIAB Study. Diabetes Care 2000;23:969-74.
106. Couper JJ, Steele C, Beresford S, et al. Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity. Diabetes 1999;48:2145-9.
107. Kimpimäki T, Erkkola M, Korhonen S, et al. Short exclusive breast feeding predisposes to progressive beta-cell autoimmunity in young children at increased risk for type 1 diabetes. Diabetolosia 2001;44: 63-9.
108. The European Nicotinamide Diabetes Intervention Trial (ENDIT) Group, Gale EAM. Intervening before the onset of type 1 diabetes: baseline data from the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetologia 2003;46:339-46.
109. Åkerblom HK, Virtanen SM, Hämäläinen A, et al. Emergence of diabetes associated autoantibodies in the nutritional prevention of IDDM (TRIGR) project. Diabetes 1999;48(suppl):A45 (abstr).
110. Heinig MJ, Nommsen LA, Peerson JM, Lonnerdal B, Dewey KG. Energy and protein intakes of breast-fed and formula-fed infants during the first year of life and their association with growth velocity: the DARLING study. Am J Clin Nutr 1993;58:152-61.
111. Vignolo M, Naselli A, Di Battista E, Mostest M, Aicardi G. Growth and development in simple obesity. Eur J Pediatr 1988;147:242-4.
112. Nerup J, Mandrup-Poulsen T, Molvig J, Helqvist S, Wogensen L, Egeberg J. Mechanisms of pancreatic beta-cell destruction in type 1 diabetes. Diabetes Care 1988;11(suppl):16-23.
113. Björk E, Kämpe O, Andersson A, Karlsson FA. Expression of the 64 kDa/glutamic acid decarboxylase rat islet cell antigen is influenced by the rate of insulin secretion. Diabetologia 1992;32:490-3.
114. Juto P. Human milk stimulates β cell function. Arch Dis Child 1985;60:610-3.
115. Srivastava MD, Srivastava A, Brouhard B, Saneto R, Groh-Wargo S, Kubit J. Cytokines in human milk. Res Commun Mol Pathol Pharmacol 1996;93:263-87.
116. Shehadeh N, Gelertner L, Blazer S, Perlman R, Solovachik L, Etzioni A. Importance of insulin content in infant diet: suggestion for a new infant formula. Acta Paediatr 2001;90:93-5.
117. Tzigounis V, Katsilambros N, Prevedourakis C, Papaevangelou G. Insulin levels in amniotic fluid and in maternal and fetal blood. J Reprod Med 1977;19:259-61.
118. Axelsson I, Jakobsson I, Lindberg T, Benediktsson B. Bovine beta-lactoglobulin in the human milk. A longitudinal study during the whole lactating period. Acta Paediatr 1984;75:702-7.
119. Høst A. Cow's milk protein allergy and intolerance in infancy. Some clinical, epidemiological and immunological aspects. Pediatr Allergy Immunol 1994;5(suppl):1-36.
120. Vaarala O, Knip M, Paronen J, et al. Cow milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes 1999;48:1389-94.
121. Vaarala O. The gut immune system and type 1 diabetes. Ann N Y Acad Sci 2002;958:39-46.
122. Rakieten N, Rakieten ML, Nadkarni MV. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep 1963; 29:91-8.
123. LeDoux SP, Hall CR, Forbes PM, Patton NJ, Wilson GL. Mechanisms of nicotinamide and thymide protection from alloxan and streptozotocin toxicity. Diabetes 1988;37:1015-9.
124. Sandler S, Welsh N. Mechanisms of pancreatic β-cell degeneration during the course of insulin-dependent diabetes mellitus. Acta Paediatr Scand 1985;320:7-13.
125. Gregori S, Giarratana N, Smiroldo S, Uskokovic M, Adorini L. A 1α,25-dihydroxy vitamin D3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002;51:1367-74.
126. Cantorna MT. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc Soc Exp Biol Med 2000;223:230-3.
127. McDermott MF, Ramachandran A, Ogunkolade BW, et al Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians. Diabetologia 1997;40:971-5.
128. Ames BN. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983;221:1256-64.
129. Mirvish SS. Effects of vitamins C and E on N-nitroso compound formation, carcinogenesis, and cancer. Cancer 1986;58:1842-50.
130. Scott FW, Cloutier HE, Kleemann R, et al. Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats. Diabetes 1997;46:589-98
131. Myers MA, Mackay IR, Rowley MI, Zimmet PZ. Dietary microbial toxins and type 1 diabetes - a new meaning for seed and soil. Diabetologia 2001;44:1199-200 (letter).
132. Scott FW. Cow milk and insulin-dependent diabetes mellitus: is there a relationship? Am J Clin Nutr 1990;51:489-91.
133. Patterson CC, Dahlquist G, Soltesz G, Green A. Childhood-onset type I diabetes a wealth-related disease? An ecological analysis of European incidence rates. Diabetologia 2001;44(suppl):B9-16.
134. Dahlquist G, Mustonen L. Analysis of 20 years of prospective registration of childhood onset diabetes time trends and birth cohort effects. Swedish Childhood Diabetes Study Group. Acta Paediatr 2000;89:1231-7.
135. Kosrraba JN, Gay EC, Rewers M, Hamman RF. Nitrate levels in community drinking waters and risk of IDDM. Diabetes Care 1992; 15:1505-8.
136. Parslow RC, McKinney PA, Law GR, Staines A, Williams R, Bodansky HJ. Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis. Diabetologia 1997;40:550-6.
137. Van Maanen IMS, Albering HJ, Van Breda SGJ, et al. Nitrate in drinking water and risk of childhood diabetes in the Netherlands. Diabetes Care 1999;22:1750 (letter).
138. Casu A, Carlini M, Contu A, Bottazzo GF, Songini M. Type 1 diabetes in Sardinia is not linked to nitrate levels in drinking water. Diabetes Care 2000;23:1043-4 (letter).
139. Joner G. The epidemiology of insulin-dependent diabetes mellitus in Norway: incidence, prevalence, microvascular complications and mortality. PhD thesis. Oslo: Haukeland University Hospital and Aker University Hospital, 1992.
140. Dahlquist G, Mustonen L. Childhood onset diabetes - time trends and climatological factors. Int J Epidemiol 1994;23:1239-41.
141. Hyöty H, Hiltunen M, Knip M, et al. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Diabetes 1995;44:652-7.
142. McGanity WJ, Dawson EB, Fogelman A. Nutrition in pregnancy and lactation In: Shils ME, Olson JA, Shike M, eds. Modern nutrition in health and disease 8th ed. Baltimore: Williams & Wilkins, 1994: 705-27.
143. Hughes DA The influence of the diet on the maturation of the immune system. Allergy 1998;53(suppl):26-8.
144. Tainio V-M, Savilahti E, Arjomaa P, Salmenperä L, Perheentupa J, Siimes MA. Plasma antibodies to cow's milk are increased by early weaning and consumption of unmodified milk, but production of plasma IgA and IgM cow's milk antibodies is stimulated even during exclusive breast-feeding. Acta Paediatr Scand 1988;77:807-11.
145. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6.
146. Nettleton JA. Are n-3 fatty acids essential nutrients for foetal and infant development? J Am Diet Assoc 1993;93:58-64.
147. Calder PC. Fat chance of immunomodulation. Immunol Today 1998; 19:244-7.
148. Wallace FA, Miles EA, Evans C, Stock TE, Yaqoob P, Calder PC. Dietary fatty acids influence the production of Th1- but not Th2-type cytokines. J Leukoc Biol 2001;69:449-57.
149. Norris JM, Barriga K, Rewers M. Does cereal protein in the infant diet play a role in the etiology of beta-cell autoimmunity? The Diabetes Autoimmunity Study in the Young (DAISY). Diabetes 2002;51(suppl):A234 (abstr).
150. 3 prevents insulitis in NOD mice. Diabetes 1992;41:1491-5.
151. 3. Diabetologia 1994;37:552-8.
152. Suarez F, Zeghoud F, Rossignol C, Walrant O, Garabedian M. Association between vitamin D receptor gene polymorphism and sex-dependent growth during the first two years of life. J Clin Endocrinol Metab 1997;82:2966-70.
153. Keen RW, Egger P, Fall C, et al. Polymorphisms of the vitamin D receptor, infant growth, and adult bone mass. Calcif Tissue Int 1997;60:233-5.
154. Savilahti E, Åkerblom HK, Tainio V-M, Koskimies S. Children with newly diagnosed insulin dependent diabetes mellitus have increased levels of cow's milk antibodies. Diabetes Res 1988;7:137-40.
155. Catassi C, Guerrieri A, Bartolotta E, Coppa GV, Giorgi PL. Antigliadin antibodies at the onset of diabetes in children. Lancet 1987; 2:158.
156. Klemetti P, Savilahti E, Ilonen J, Åkerblom HK, Vaarala O. T-cell reactivity to wheat gluten in patients with insulin-dependent diabetes mellitus. Scand J Immunol 1998;47:48-53.
157. Laitinen S, Virtanen SM, Räsänen L, Penttilä P-L. Calculated dietary intakes of nitrate and nitrite by young Finns. Food Addit Contain 1993;10:469-77.
158. Scanlan RA. Formation and occurrence of nitrosamines in food. Cancer Res 1983;43(suppl):2435-40.
159. Toniolo A, Onodera T, Yoon J-W, Notkins AL. Induction of diabetes by cumulative environmental insults from viruses and chemicals. Nature 1980;288:383-5.
160. Leinonen JS, Alho H, Harmoinen A, Lehtimäki T, Knip M. Unaltered antioxidant activity of plasma in subjects at increased risk for IDDM. Free Radie Res 1998;29:159-64.
161. Mandrup-Poulsen T, Reimers JI, Andersen HU, et al. Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus. Diabetes Metab Rev 1993;9:295-309.
162. Manna R, Migliore A, Martini LS, et al. Nicotinamide treatment in subjects at high risk of developine IDDM improves insulin secretion. Br J Clin Pract 1992;46:177-9.
163. Virtanen SM, van't Veer P, Kok F, Kardinaal AFM, Aro A, the EURAMIC Study Group. Predictors of adipose tissue tocopherol and toenail selenium levels in nine countries: the EURAMIC study. Eur J Clin Nutr 1996;50:599-606.
164. Virtanen SM, van't Veer P, Kok F, Kardinaal AFM, Aro A, the EURAMIC Study Group. Predictors of adipose tissue carotenoid and retmol levels in nine countries: the EURAMIC study. Am J Epidemiol 1996;144:968-79.
165. Gibbon G, Smith T, Egger P, Betts P, Phillips D. Early infection and subsequent insulin dependent diabetes. Arch Dis Child 1997;77: 384-5.
166. Wagener DK, LaPorte RE, Orchard TJ, Cavender D, Kuller LH, Drash AL. The Pittsburgh diabetes mellitus study 3: an increased prevalence with older maternal age. Diabetologia 1983;25:82-5.
167. Bingley PJ, Douek IF, Rogers CA, Gale EAM, the BOX Study Group. Influence of maternal age at delivery and birth order on risk of type 1 diabetes in childhood: prospective population based family study. BMJ 2000;321:420-4.
168. The EURODIAB Subsmdy 2 Study Group. Infections and vaccinations as risk factors for childhood type I (insulin-dependent) diabetes mellitus: a multicentre case-control investigation. Diabetologia 2000; 43:47-53.
169. McKinney PA, Okasha M, Parslow RC, et al. Early social mixing and childhood type I diabetes mellitus: a case-control study in Yorkshire, UK. Diabet Med 2000;17:236-42.
170. Brandtzaeg P. Current understanding of gastrointestinal immunorcgulation and its relation to food allergy. Ann N Y Acad Sci 2002;964:13-45.
171. Vaarala O. Gut and the induction of immune tolerance in type 1 diabetes. Diabetes Metab Rev 1999;15:353-61.
172. Wasmuth HE, Kolb H. Cow's milk and immune-mediated diabetes. Proc Nutr Soc 2000;59:573-9.
173. Scott FW, Rowsell P, Wang GS, Burghardt K, Kolb H, Flohe S. Oral exposure to diabetes-promoting food or immunomodulators in neonates alters gut cytokines and diabetes. Diabetes 2002;51:73-8.
174. Lonnrot M, Korpela K, Knip M, et al. Emerovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study. Diabetes 2000;49:1314-8.
175. Honeyman MC, Coulson BS, Stone NL, et al. Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes 2000;49:1319-24.
176. Vaarala O, Klemetti P, Juhela S, Simell O, Hyöty H, Ilonen J. Effect of coincident enterovirus infection and cow's milk exposure on immunisation to insulin in early infancy. Diabetologia 2002;45:531-4.
177. Jenista JA, Powell KR, Menegus MA. Epidemiology of neonatal virus enterovirus infection. J Pediatr 1984;104:685-90.
178. Lithell HO, McKeigue PM, Berglund L, Mohsen R, Lithell UB, Leon DA. Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. BMJ 1996:312:406-10.
179. Pettitt DJ, Forman MR, Hanson RL, Knowler WC, Bennett PH. Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians. Lancet 1997;350:166-8.
180. Wilkin TJ. The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia 2001;44: 914-21.
181. Weets I, Van Autreve J, Van der Auwera BJ, et al. Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index. Diabetologia 2001;44:40-7.
182. Rolandsson O, Hägg E, Hampe C, et al. Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibody index in a regional population is related to glucose intolerance and body mass index. Diabetologia 1999;42:555-9.
183. Dahlquist G, Blom L, Tuvemo T, Nyström L, Sandström A, Wall S. The Swedish childhood diabetes study - results from a nine year case register and a one year case-referent study indicating that Type I (insulin-dependent) diabetes mellitus is associated with both Type II (non-insulin-dependent) diabetes mellitus and autoimmune disorders. Diabetologia 1989;32:2-6
184. Quatraro A, Consoli G, Magno M, Caretta F, Ceriello A, Guigliano D Analysis of diabetic family connection in subjects with insulin-dependent
185. Douek IF, Gillespie KM, Bingley PJ, Gale EAM. Diabetes in the parents of children with Type I diabetes. Diabetologia 2002;45:495-501.
186. Kumar V, Rajadhyaksha M, Wortsman J. Celiac disease-associated autoimmune endocrinopathies. Clin Diagn Lab Immunol 2001;8: 678-85.
187. Toscano V, Conti FG, Anastasi E, et al. Importance of gluten in the induction of endocrine autoantibodies and organ dysfunction in adolescent celiac patients. Am J Gastroenterol 2000;95:1742-8.
188. Burney PGJ, Chinn S, Rona RJ. Has the prevalence of asthma increased in children? Evidence from the national study of health and growth 1973-86 BMJ 1990;300:1306-10.
189. Haahtela T, Lindholm H, Björkstén F, Koskenvuo K, Laitinen LA. Prevalence of asthma in Finnish young men. BMJ 1990;301:266-8.
190. Stene LC, Nafstad P Relation between occurrence of type 1 diabetes and asthma. Lancet 2001;357:607-8.
191. Douek IF, Leech NJ, Gillmor HA, Bingley PJ, Gale EA Children with type-1 diabetes and their unaffected siblings have fewer symptoms of asthma Lancet 1999;353:1850.
192. The EURODIAB Substudy 2 Study Group. Decreased prevalence of atopic diseases in children with diabetes. J Pediatr 2000;137:470-4.
193. Mattila PS, Tarkkanen J, Saxen H, Pitkäniemi J, Karvonen M, Tuomilehto J. Predisposition to atopic symptoms to inhaled antigens may protect from childhood type 1 diabetes. Diabetes Care 2002;25: 865-8.
194. Olesen AB, Juul S, Birkebaek N, Thestrup-Pedersen K. Association between atopic dermatitis and insulin-dependent diabetes mellitus: a case-control study. Lancet 2001;357:1749-52.
195. Strömberg LGE, Ludvigsson GJ, Björkstén B. Atopic allergy and delayed hypersensitivity in children with diabetes. J Allergy Clin Immunol 1995;96:188-92.
196. Kero J, Gissler M, Hemminki E, Isolauri E. Could Th1 and Th2 diseases coexist? Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis: a register study. J Allergy Clin Immunol 2001;108:781-3.
197. Tedeschi A, Airaghi L. Common risk factors in type 1 diabetes and asthma. Lancet 2001;357:1622.
198. Saarinen UM, Kajosaari M. Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old. Lancet 1995;346:1065-9.
199. Willett WC. Overview of nutritional epidemiology. In: Willett WC, ed. Nutritional epidemiology. Monographs in epidemiology and biostatistics 30. 2nd ed. New York: University Press, 1998:3-17.
200. Walstra P, Jenness R. Dairy chemistry and physics. New York: Wiley, 1984.
201. Edgerton DL, Assarsson B, Hummelmose A, Laurila I, Rickertsen K, Vale PH. The consumption of food in the Nordic countries. In: The econometrics of demand systems. Dordrecht. Netherlands: Kluwer Academic Publishers, 1996:7-53.