Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells: Relevance to the de novo synthesis of ceramide

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 6, 2010, Pages

  Altura, Burton M ^a,b,c   Shah, Nilank C ^a   Li, Zhiqiang ^a   Jiang, Xian Cheng ^a,b   Zhang, Aimin ^a   Li, Wenyan ^a   Zheng, Tao ^a   Perez Albela, Jose Luis ^d   Altura, Bella T ^a,b,c  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b Downstate Health Sciences University   (United States)

^c Bio Defense Systems Inc   (United States)

^d Instituto Bien de Salud   (Peru)

Author keywords

Cardiac muscle; Ceramide synthase; De novo ceramide; Vascular muscle; Water borne magnesium

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE; COENZYME A TRANSFERASE; DRINKING WATER; MAGNESIUM; PALMITOYL COENZYME A; PROTEIN P53; SPHINGOMYELIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIET; DRUG SYNTHESIS; ENZYME INDUCTION; FEMALE; HEART MUSCLE CELL; MAGNESIUM DEFICIENCY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

ACYLTRANSFERASES; ANIMALS; AORTA; CELLS, CULTURED; CERAMIDES; CEREBRAL ARTERIES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; MAGNESIUM DEFICIENCY; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; MYOCYTES, SMOOTH MUSCLE; OXIDOREDUCTASES; RATS; RATS, WISTAR; TIME FACTORS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS); TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 78649747014     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00671.2010     Document Type: Article

References (74)

1. Altura BM, Altura BT. Magnesium and contraction of arterial muscle. Microvasc Res 7: 145-155, 1974.
2. Altura BM, Altura BT. Magnesium and cardiovascular biology: an important link between cardiovascular risk factors and atherogenesis. Cell Mol Biol Res 41: 347-359, 1995.
3. Altura BM, Altura BT. Magnesium: forgotten mineral in cardiovascular biology and atherogenesis. In: New Perspectives in Magnesium Research, edited by Nishizawa N, Morii H, Durlach J. New York: Springer, 2007, p. 239-260.
4. Altura BM, Altura BT, Gebrewold A, Ising H, Gunther T. Magnesium deficiency and hypertension: correlation between magnesium deficient diets and microcirculatory changes in situ. Science 223: 1315-1317, 1984.
5. Altura BM, Altura BT, Gebrewold A, Gunther T, Ising H. Noise-induced hypertension and magnesium: relationship to microcirculation and magnesium. J Appl Physiol 72: 194-202, 1992.
6. 31P-NMR study. Biochim Biophys Acta 1182: 329-332, 1993.
7. Altura BM, Gebrewold A, Zhang A, Altura BT. Low extracellular magnesium ions induces lipid peroxidation and activation of nuclear factor κB in canine cerebral vascular smooth muscle: possible relation to traumatic brain injury and strokes. Neurosci Lett 341: 189-192, 2003.
8. Altura BM, Gebrewold A, Zheng T, Altura BT. Sphingomyelinase and ceramide analogs induce vasoconstriction and leukocyte-endothelial interactions in cerebral venules in the intact rat brain: insight into mechanisms and possible relation to brain injury and stroke. Brain Res Bull 58: 271-278, 2002.
9. 2+ in aortic and cerebral vascular smooth muscle cells: possible links to hypertension, atherogenesis and stroke. Am J Hypertens 16: 701-707, 2003.
10. Altura BM, Shah NC, Jiang XC, Li Z, Perez-Albela JL, Sica AC, Altura BT. Short-term magnesium deficiency results in decreased levels of serum sphingomyelin, lipid peroxidation, and apoptosis in cardiovascular tissues. Am J Physiol Heart Circ Physiol 297: H86-H92, 2009.
11. Altura BM, Shah NC, Li Z, Jiang XC, Perez-Albela JL, Altura BT. Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c. Am J Physiol Heart Circ Physiol 299: H932-H938, 2010.
12. Altura BT, Altura BM. Measurement of ionized magnesium in whole blood, plasma and serum with a new ion-selective electrode in healthy and diseased human subjects. Magnes Trace Elem 10: 90-98, 1991.
13. Altura BT, Brust M, Barbour RL, Stempak J, Altura BM. Magnesium dietary intake modulates blood lipid levels and atherogenesis. Proc Natl Acad Sci USA 87: 1840-1844, 1990.
14. Altura BT, Memon ZI, Zhang A, Cracco RQ, Altura BM. Low levels of serum ionized magnesium are found in patients early after stroke which result in rapid elevation in cytosolic free calcium and spasm in cerebral vascular smooth muscle cells. Neurosci Lett 230: 37-40, 1997.
15. Andreassi M. Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage. Mutat Res 543: 67-86, 2003.
16. Andrieu-Abadie N, Gouaze V, Salvayre R, Levade T. Ceramide in apoptosis signaling: relationship with oxidative stress. Free Radic Biol Med 31: 717-728, 2001.
17. Auge N, Andrieu N, Negre-Salvayre R, Thiers JC, Levade T, Salvayre R. Sphingomyelin metabolites in vascular signaling and atherogenesis. Prog Lipid Res 39: 207-239, 2000.
18. Berthelot A, Luthringer C, Myers E, Exinger A. Disturbances of magnesium metabolism in the spontaneously hypertensive rat. J Am Coll Nutr 6: 329-332, 1987.
19. Birbes H, Bawab SE, Hannun YA, Obeid LM. Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J 14: 2669-2679, 2001.
20. Bischoff A, Czyborra P, Fetscher C, Meyer zu Heringdorf D, Jakobs KH, Michel MC. Sphingosine-1-phosphate and sphingosylphorylcholine constrict renal and mesenteric microvessels in vitro. Br J Pharmacol 130: 1871-1877, 2000.
21. Chipperfield B, Chipperfield JR. Relation of myocardial maetal concentrations to water hardness and death from ischemic heart disease. Lancet 2: 709-712, 1979.
22. Dbalbo GS, Pushkareva MY, Rachid RA, Alter N, Smyth MJ, Obeid L, Hannun YA. P53-dependent ceramide response to genotoxic stress. J Clin Invest 102: 329-339, 1998.
23. Ding T, Li Z, Hailemariam TK, Mukherjee S, Maxfield FR, Wu MP, Jiang XC. SMS overexpression and knockdown: impact cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis. J Lipid Res 49: 376-385, 2008.
24. Durlach J, Bara M, Guiet-Bara A. Magnesium level in drinking water and cardiovascular risk factor: a hypothesis. Magnesium 4: 5-15, 1985.
25. Eisenberg MJ. Magnesium deficiency and sudden death. Am Heart J 124: 544-549, 1992.
26. Ford ES, Mokdad AH. Dietary magnesium intake in a national sample of US adults. J Nutr 121: 2879-2882, 2003.
27. Handwerker SM, Altura BT, Royo B, Altura BM. Ionized magnesium and calcium levels in umbilical cord serum of pregnant women with transient hypertension during labor. Am J Hypertens 6: 542-545, 1993. (Pubitemid 23179504)
28. Haimovitz-Friedman A, Kolesnick RN, Fuks Z. Ceramide signaling in apoptosis. Br Med Bull 53: 539-553, 1997.
29. Hannun YA, Obeid LM. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 277: 25847-25850, 2002.
30. Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apopotosis, inflammation, and fibrosis. Hypertension 38: 581-587, 2001.
31. Jaffrezou JP, Maestre de Mas-Mansat VN, Bezombes C, Levade T, Laurent G. Positive feedback control of sphingomyelinase activity by ceramide. FASEB J 12: 999-1006, 1998.
32. Joffres MR, Reed DM, Yano K. Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study. Am J Clin Nutr 45: 469-475, 1987.
33. Kobayashi J. On geographical relationship between the chemical nature of river water and death from apoplexy. Berichte des Ohara Inst fur Landwirtsch Biol 11: 12-21, 1957.
34. Kolesnick R. Signal transduction through the sphingomyelin pathway. Mol Chem Neuropath 21: 287-297, 1994.
35. Kumar V, Abbas AK, Fausto N, Aster JC. (editors). Robbins and Cotran Pathologic Basis of Disease (8th ed.). Philadelphia, PA: Saunders, 2010, p. 487-506.
36. Laurant P, Dalle M, Berthelot A, Rayssiguier Y. Time course of the change in blood pressure level in magnesium-deficient Wistar rats. Br J Nutr 82: 243-251, 1999.
37. Leary WP. Content of magnesium in drinking water and deaths from ischemic heart disease in white South Africans. Magnesium 5: 150-153, 1986.
38. i in rat aortic smooth muscle cells: possible roles of extracellular and intracellular magnesium ions in peroxynitrite-induced cell death. Drug Metab Lett 1: 85-89, 2007.
39. Luberto C, Hannun YA. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. J Biol Chem 273: 14550-14559, 1998.
40. Luthringer C, Rayssiguier Y, Gueux E, Berthelot A. Effect of moderate magnesium deficiency on serum lipids, blood pressure and cardiovascular reactivity in normotensive rats. Br J Nutr 59: 243-250, 1988.
41. Marier JR, Neri LC. Quantifying the role of magnesium in the interrelationship between human mortality/morbidity and water hardness. Magnesium 4: 53-59, 1985.
42. Marx A, Neutra RR. Magnesium in drinking water and deaths from ischemic heart disease. Epidemiol Rev 19: 258-272, 1997.
43. Meek DW. Tumor suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9: 714-723, 2009.
44. Meng A, Luberto C, Meier P, Bai A, Yang X, Hannun YA, Zhou D. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res 292: 385-392, 2004.
45. Menendez D, Inga A, Resnick MA. The expanding universe of p53 targets. Nat Rev Cancer 9: 724-737, 2009.
46. Mercer J, Mahmoudi M, Bennett M. DNA damage, p53, apoptosis and vascular disease. Mutat Res 621: 75-86, 2007.
47. 2+ modulates membrane lipids in vascular smooth muscle: a link to atherogenesis. FEBS Lett 408: 191-197, 1997.
48. 2+ modulates membrane sphingolipids and lipid second messengers in vascular smooth muscle cells. FEBS Lett 440: 167-171, 1998.
49. Mulvany MJ. Small artery remodeling and significance in the development of hypertension. News Physiol Sci 17: 105-109, 2002.
50. 3-induced HL-60 cell differentiation. J Biol Chem 265: 15823-15831, 1990.
51. Pandey S, Murphy RF, Agrawal DK. Recent advances in the immunobiology of ceramide. Exp Mol Pathol 82: 298-309, 2007.
52. Panjarian S, Kozhaya L, Arayssi S, Bielawski YM, Usta J, Hannun YA, Obeid LM, Dbalbo GS. De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prost Other Lipid Med 86: 41-48, 2008.
53. Perry DK, Carton J, Shah AK, Meredith F, Uhlingeri DJ, Hannun YA. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem 275: 9078-9084, 2000.
54. Quillet J, Kilkus J, McShan CI, Gottschalk AR, Dawson G. Ceramide mediates the apoptotic response of WEHI 231 cells to an anti-immunoglobulin, corticosteroids and irradiation. Biochem Biophys Res Commun 202: 710-714, 1994.
55. Rayssiguier Y, Gueux E, Bussiere l Durlach J, Mazur A. Dietary magnesium affects susceptibility of lipoproteins and tissues to peroxidation in rats. J Am Coll Nutr 12: 133-137, 1993.
56. Ravid T, Tsaba A, Gee P, Rasody R, Medina EA, Goldkorn T. Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells. Am J Physiol Lung Cell Mol Physiol 284: L1082-L1092, 2003.
57. Rosanoff A. Magnesium supplements may enhance the effect of antihypertensive medications in stage 1 hypertensive subjects. Magnes Res 23: 27-40, 2010.
58. Rubenowitz E, Molin L, Axellson G, Rylander R. Magnesium in drinking water in relation to morbidity and mortality from acute myocardial indarction. Epidemiology 11: 416-421, 2003.
59. Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam Magnesium A. An update on physiological,clinical and analytical aspects. Clin Chim Acta 294: 1-26, 2000.
60. Sawada M, Nakashima S, Kiyono T, Nakagawa M, Yamada J, Yamakawa H, Banno Y, Shinoda J, Nishimura Y, Nozawa Y, Sakai N. p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells. Oncogene 20: 1368-1378, 2001.
61. Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA, Obeid LM. prICE: a downstream target for ceramide -induced apoptosis and for the laboratory action of Bcl-2. Biochem J 316: 25-28, 1996.
62. Tafesse FG, Huitema K, Hermanson M, van der Poel S, van den Dikkenberg A, Uphoff A, Somerharju P, Holtuis JC. Both sphingomyelin synthases SMS 1 and SMS 2 are required for sphingomyelin homeostasis and growth in human HeLa cells. J Biol Chem 282: 17537-17547, 2007.
63. 2+ deficiency induces cardiac apoptosis in the rat heart. Magnes Res 20: 208-212, 2007.
64. Teiger E, Dam TV, Richard L, Wisnewsky C, Tea BS, Gabory L. Apoptosis in pressure overload-induced heart hypertrophy in the rat. J Clin Invest 97: 2891-2897, 1996.
65. Turlapaty PD, Altura BM. Magnesium deficiency produces spasms of coronary arteries: relationship to etiology of sudden death ischemic heart disease. Science 208: 198-200, 1980.
66. Vandrager AB, Houweling M. Effect of ceramides on phospholipid biosynthesis and its implications for apoptosis. In: Phospholipid Metabolism in Apoptosis, edited by Quinn PJ, Kagan VE. New York: Kluwer Academic, 2002, p. 207-227.
67. Villani M, Subathra M, Im YB, Choi Y, Signorelli P, Del Poeta M, Luberto C. Sphingomyelin synthases regulate production of diacylglycerol at the Golgi. Biochem J 414: 31-41, 2008.
68. Voelker DR, Kennedy EP. Cellular and enzymatic synthesis of sphingomyelin. Biochemistry 21: 2753-2759, 1982.
69. Vousden KH, Ryan KM. p53 and metabolism. Nat Rev Cancer 9: 691-700, 2009.
70. Weglicki WB, Mak IT, Dickens BF, Stafford RE, Komarov AM, Gibson B, Cassidy MM, Phillips TM, Kramer JH. Neuropeptides, free radical stress and antioxidants in models of Mg-deficient cardiomyopathy. In: Magnesium: Current Status and New Developments, edited by Theophanides T, Anastassopolos J. London: Kluwer Academic, 1997, p. 169-178.
71. Wu F, Altura BT, Gao J, Barbour RL, Altura BM. Ferrylmyoglobin formation induced by acute magnesium deficiency in perfused rat heart causes cardiac failure. Biochim Biophys Acta 1225: 158-164, 1994.
72. Wyman M, Schneiter R. Lipid signaling in disease. Nat Rev Mol Cell Biol 9: 162-176, 2008.
73. Zhang A, Cheng TPO, Altura BM. Magnesium regulates intracellular free ionized calcium concentration and cell geometry in vascular smooth muscle cells. Biochim Biophys Acta 1134: 25-29, 1992.
74. i in canine cerebral vascular muscle. Am J Physiol Heart Circ Physiol 278: H1421-H1428, 2000.