Angiogenic role of orexin-A via the activation of extracellular signal-regulated kinase in endothelial cells

Biochemical and Biophysical Research Communications

Volumn 403, Issue 1, 2010, Pages 59-65

  Kim, Mi Kyoung ^a   Park, Hyun Joo ^a   Kim, Su Ryun ^a   Choi, Yoon Kyung ^b   Shin, Hwa Kyoung ^a   Jeon, Jae Hoon ^a   Jang, Hye Ock ^a   Yun, Il ^a   Bae, Soo Kyung ^a   Bae, Moon Kyoung ^a  

^a Pusan National University   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

Angiogenesis; Extracellular signal regulated kinase 1 2 (ERK1 2); Orexin receptor; Orexin A; Vascular endothelial cells

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OREXIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL MOTILITY; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR RING;

ANIMALS; CELLS, CULTURED; CHEMOTAXIS; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOVASCULARIZATION, PHYSIOLOGIC; NEUROPEPTIDES; RATS;

RATTUS;

EID: 78649707789     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.10.115     Document Type: Article

References (36)

1. Madeddu P. Therapeutic angiogenesis and vasculogenesis for tissue regeneration. Exp. Physiol. 2005, 90:315-326.
2. Carmeliet P. Angiogenesis in health and disease. Nat. Med. 2003, 9:653-660.
3. Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
4. Tonini T., Rossi F., Claudio P.P. Molecular basis of angiogenesis and cancer. Oncogene 2003, 22:6549-6556.
5. Ribatti D., Conconi M.T., Nussdorfer G.G. Nonclassic endogenous novel [corrected] regulators of angiogenesis. Pharmacol. Rev. 2007, 59:185-205.
6. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
7. de Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 1998, 95:322-327.
8. Kilduff T.S., Peyron C. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci. 2000, 23:359-365.
9. Sutcliffe J.G., de Lecea L. The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. J. Neurosci. Res. 2000, 62:161-168.
10. Sakurai T. Orexin: a link between energy homeostasis and adaptive behaviour. Curr Opin. Clin. Nutr. Metab. Care 2003, 6:353-360.
11. Heinonen M.V., Purhonen A.K., Makela K.A., Herzig K.H. Functions of orexins in peripheral tissues. Acta Physiol. (Oxf) 2008, (192):471-485.
12. Arihara Z., Takahashi K., Murakami O., Totsune K., Sone M., Satoh F., Ito S., Mouri T. Immunoreactive orexin-A in human plasma. Peptides 2001, 22:139-142.
13. Sun G., Tian Z., Yao Y., Li H., Higuchi T. Central and/or peripheral immunoreactivity of orexin-A in pregnant rats and women. J. Mol. Endocrinol. 2006, 36:131-138.
14. Jochem J., Zwirska-Korczala K., Zabielski R., Kato I., Kuwahara A. Cardiovascular effects of centrally acting orexin A in haemorrhage-shocked rats. J. Physiol. Pharmacol. 2006, 57(Suppl 11):115-124.
15. Chen C.T., Hwang L.L., Chang J.K., Dun N.J. Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000, 278:R692-R697.
16. Tanida M., Niijima A., Shen J., Yamada S., Sawai H., Fukuda Y., Nagai K. Dose-different effects of orexin-A on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats. Exp. Biol. Med. (Maywood) 2006, (23):1616-1625.
17. Triggle C.R., Hollenberg M., Anderson T.J., Ding H., Jiang Y., Ceroni L., Wiehler W.B., Ng E.S., Ellis A., Andrews K., McGuire J.J., Pannirselvam M. The endothelium in health and disease - a target for therapeutic intervention. J. Smooth Muscle Res. 2003, 39:249-267.
18. Kim S.R., Bae S.K., Choi K.S., Park S.Y., Jun H.O., Lee J.Y., Jang H.O., Yun I., Yoon K.H., Kim Y.J., Yoo M.A., Kim K.W., Bae M.K. Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochem. Biophys. Res. Commun. 2007, 357:150-156.
19. Lee S.J., Namkoong S., Kim Y.M., Kim C.K., Lee H., Ha K.S., Chung H.T., Kwon Y.G., Kim Y.M. Fractalkine stimulates angiogenesis by activating the raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways. Am. J. Physiol. Heart Circ. Physiol. 2006, 291:H2836-H2846.
20. Pages G., Milanini J., Richard D.E., Berra E., Gothie E., Vinals F., Pouyssegur J. Signaling angiogenesis via p42/p44 MAP kinase cascade. Ann. N. Y. Acad. Sci. 2000, 902:187-200.
21. Kukkonen J.P., Holmqvist T., Ammoun S., Akerman K.E. Functions of the orexinergic/hypocretinergic system. Am. J. Physiol. Cell. Physiol. 2002, 283:C1567-C1591.
22. Adam J.A., Menheere P.P., van Dielen F.M., Soeters P.B., Buurman W.A., Greve J.W. Decreased plasma orexin-A levels in obese individuals. Int. J. Obes. Relat. Metab. Disord. 2002, 26:274-276.
23. Kastin A.J., Akerstrom V. Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. J. Pharmacol. Exp. Ther. 1999, 289:219-223.
24. Liu W., Ahmad S.A., Reinmuth N., Shaheen R.M., Jung Y.D., Fan F., Ellis L.M. Endothelial cell survival and apoptosis in the tumor vasculature. Apoptosis 2000, 5:323-328.
25. Ammoun S., Johansson L., Ekholm M.E., Holmqvist T., Danis A.S., Korhonen L., Sergeeva O.A., Haas H.L., Akerman K.E., Kukkonen J.P. OX1 orexin receptors activate extracellular signal-regulated kinase in chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling. Mol. Endocrinol. 2006, 20:80-99.
26. Ramanjaneya M., Conner A.C., Chen J., Kumar P., Brown J.E., Johren O., Lehnert H., Stanfield P.R., Randeva H.S. Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B. J. Endocrinol. 2009, 202:249-261.
27. Tang J., Chen J., Ramanjaneya M., Punn A., Conner A.C., Randeva H.S. The signalling profile of recombinant human orexin-2 receptor. Cell. Signal. 2008, 20:1651-1661.
28. Voisin T., El Firar A., Rouyer-Fessard C., Gratio V., Laburthe M. A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism. FASEB J. 2008, 22:1993-2002.
29. Park S.I., Shah A.N., Zhang J., Gallick G.E. Regulation of angiogenesis and vascular permeability by src family kinases: opportunities for therapeutic treatment of solid tumors. Expert Opin. Ther. Targets 2007, 11:1207-1217.
30. Szabo S., Vincze A. Growth factors in ulcer healing: lessons from recent studies. J. Physiol. Paris 2000, 94:77-81.
31. Fan Y., Yang G.Y. Therapeutic angiogenesis for brain ischemia: a brief review. J. Neuroimmune Pharmacol. 2007, 2:284-289.
32. Beck H., Plate K.H. Angiogenesis after cerebral ischemia. Acta Neuropathol. 2009, 117:481-496.
33. Tarnawski A.S. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig. Dis. Sci. 2005, 50(Suppl 1):S24-S33.
34. Brzozowski T., Konturek P.C., Sliwowski Z., Drozdowicz D., Burnat G., Pajdo R., Pawlik M., Bielanski W., Kato I., Kuwahara A., Konturek S.J., Pawlik W.W. Gastroprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory afferent neuropeptides and nitric oxide. Regul. Pept. 2008, 148:6-20.
35. Kitamura E., Hamada J., Kanazawa N., Yonekura J., Masuda R., Sakai F., Mochizuki H. The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia. Neurosci. Res. 2010, 68:154-157.
36. Sikder D., Kodadek T. The neurohormone orexin stimulates hypoxia-inducible factor-1 activity. Genes Dev. 2007, 21:2995-3005.