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Volumn 8, Issue 1-2, 2011, Pages 4-20

Nanoparticulate systems for oral drug delivery to the colon

Author keywords

Colon; Drug delivery; Drug targeting; Gastrointestinal tract; Nanogel; Nanoparticle; Nanoparticles in microspheres; Oral; Surface modification

Indexed keywords

CONTROLLED DRUG DELIVERY; DRUG DELIVERY; NANOPARTICLES; NANOSTRUCTURED MATERIALS; SURFACE TREATMENT;

EID: 78649701704     PISSN: 14757435     EISSN: None     Source Type: Journal    
DOI: 10.1504/IJNT.2011.037167     Document Type: Article
Times cited : (8)

References (86)
  • 1
    • 0028033502 scopus 로고
    • Targeting drugs to the colon: Delivery systems for oral administration
    • Ashford, M. and Fell, J.T. (1994) 'Targeting drugs to the colon: delivery systems for oral administration', J. Drug Targeting, Vol. 2, pp.241-258.
    • (1994) J. Drug Targeting , vol.2 , pp. 241-258
    • Ashford, M.1    Fell, J.T.2
  • 4
    • 0032995635 scopus 로고    scopus 로고
    • A pH-dependent colon targeted drug delivery system using methacrylic acid copolymers: I. Manipulation of drug release using Eudragit L100-55 and Eudragit S100 combinations
    • Khan, M.Z.I., Prebeg, Z. and Kurjaković, N. (1999) 'A pH-dependent colon targeted drug delivery system using methacrylic acid copolymers: I. Manipulation of drug release using Eudragit L100-55 and Eudragit S100 combinations', J. Controlled Release, Vol. 58, pp.215-222.
    • (1999) J. Controlled Release , vol.58 , pp. 215-222
    • Khan, M.Z.I.1    Prebeg, Z.2    Kurjaković, N.3
  • 5
    • 78649697804 scopus 로고    scopus 로고
    • Coating composition and technology research of berberine tablets colon delivery system'
    • Wang, J., Xue, H., Liu, X. and Gao, Y. (2008) 'Coating composition and technology research of berberine tablets colon delivery system', Zhongchengyao, Vol. 30, No. 12, pp.1778-1781.
    • (2008) Zhongchengyao , vol.30 , Issue.12 , pp. 1778-1781
    • Wang, J.1    Xue, H.2    Liu, X.3    Gao, Y.4
  • 7
    • 58149510917 scopus 로고    scopus 로고
    • Guar gum as potential film coating material for colon-specific delivery of fluorouracil
    • Ji, C.M., Xu, H.N. and Wu, W. (2009) 'Guar gum as potential film coating material for colon-specific delivery of fluorouracil', J. Biomater. Appl., Vol. 23, No. 4, pp.311-329.
    • (2009) J. Biomater. Appl. , vol.23 , Issue.4 , pp. 311-329
    • Ji, C.M.1    Xu, H.N.2    Wu, W.3
  • 10
    • 0029032599 scopus 로고
    • Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs
    • Niwa, K., Takaya, T., Morimoto, T. and Takada, K. (1995) 'Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs', J. Drug Targeting, Vol. 3, pp.83-89.
    • (1995) J. Drug Targeting , vol.3 , pp. 83-89
    • Niwa, K.1    Takaya, T.2    Morimoto, T.3    Takada, K.4
  • 12
    • 0342313576 scopus 로고    scopus 로고
    • Extrusion-spheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery
    • Krogars, K., Heinämäki, J., Vesalahti, J., Marvola, M., Antkaninen, O. and Yliruusi, J. (2000) 'Extrusion-spheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery', Int. J. Pharm., Vol. 199, pp.187-194.
    • (2000) Int. J. Pharm. , vol.199 , pp. 187-194
    • Krogars, K.1    Heinämäki, J.2    Vesalahti, J.3    Marvola, M.4    Antkaninen, O.5    Yliruusi, J.6
  • 13
    • 0021806456 scopus 로고
    • Clinical pharmacokinetics of sulphasalazine, its metabolites and other prodrugs of 5-aminosalicylic acid
    • Klotz, U. (1985) 'Clinical pharmacokinetics of sulphasalazine, its metabolites and other prodrugs of 5-aminosalicylic acid', Clinical Pharmacokinetics, Vol. 10, pp.285-302.
    • (1985) Clinical Pharmacokinetics , vol.10 , pp. 285-302
    • Klotz, U.1
  • 14
    • 0024891184 scopus 로고
    • Pharmacokinetics of a 5-aminosalicylic acid enteric-coated tablet and suppository dosage form
    • Norlander, B., Gotthard, R. and Stroem, M. (1989) 'Pharmacokinetics of a 5-aminosalicylic acid enteric-coated tablet and suppository dosage form', Alimentary Pharmacology and Therapeutics, Vol. 3, No. 4, pp.333-342.
    • (1989) Alimentary Pharmacology and Therapeutics , vol.3 , Issue.4 , pp. 333-342
    • Norlander, B.1    Gotthard, R.2    Stroem, M.3
  • 15
    • 0042526078 scopus 로고    scopus 로고
    • Prednisolone 21-sulfate sodium: A colon-specific pro-drug of prednisolone
    • Jung, Y.J., Doh, M.J., Kim, I.H., Kong, H.S., Lee, J.S. and Kim, Y.M. (2003) 'Prednisolone 21-sulfate sodium: a colon-specific pro-drug of prednisolone', J. Pharm. Pharmacol., Vol. 55, No. 8, pp.1075-1082.
    • (2003) J. Pharm. Pharmacol. , vol.55 , Issue.8 , pp. 1075-1082
    • Jung, Y.J.1    Doh, M.J.2    Kim, I.H.3    Kong, H.S.4    Lee, J.S.5    Kim, Y.M.6
  • 17
    • 66249102258 scopus 로고    scopus 로고
    • Design, synthesis, and pharmacological effects of a cyclization-activated steroid prodrug for colon targeting in inflammatory bowel disease
    • Ruiz, J.F.M., Radics, G., Windle, H., Serra, H.O., Simplício, A.L., Kedziora, K., Fallon, P.G., Kelleher, D.P. and Gilmer, J.F. (2009) 'Design, synthesis, and pharmacological effects of a cyclization-activated steroid prodrug for colon targeting in inflammatory bowel disease', J. Med. Chem., Vol. 52, No. 10, pp.3205-3211.
    • (2009) J. Med. Chem. , vol.52 , Issue.10 , pp. 3205-3211
    • Ruiz, J.F.M.1    Radics, G.2    Windle, H.3    Serra, H.O.4    Simplício, A.L.5    Kedziora, K.6    Fallon, P.G.7    Kelleher, D.P.8    Gilmer, J.F.9
  • 18
    • 33947507370 scopus 로고    scopus 로고
    • Multiparticulate formulation approach to colon specific drug delivery: Current perspectives
    • Asghar, L.F.A. and Chandran, S. (2006) 'Multiparticulate formulation approach to colon specific drug delivery: current perspectives', Journal of Pharmacy and Pharmaceutical Science, Vol. 9, No. 3, pp.327-338.
    • (2006) Journal of Pharmacy and Pharmaceutical Science , vol.9 , Issue.3 , pp. 327-338
    • Asghar, L.F.A.1    Chandran, S.2
  • 19
    • 30344478532 scopus 로고    scopus 로고
    • Colon drug delivery
    • Mooter, G.V. (2006) 'Colon drug delivery', Expert Opin. Drug Discovery, Vol. 3, No. 1, pp.111-125.
    • (2006) Expert Opin. Drug Discovery , vol.3 , Issue.1 , pp. 111-125
    • Mooter, G.V.1
  • 20
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C.A., Lombardo, F., Dominy, B.W. and Feeney, P.J. (2001) 'Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings', Advanced Drug Delivery Reviews, Vol. 46, pp.2-26.
    • (2001) Advanced Drug Delivery Reviews , vol.46 , pp. 2-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 21
    • 33745721806 scopus 로고    scopus 로고
    • Nanoparticle formulation increases oral bioavailability of poorly soluble drugs: Approaches, experimental evidences and theory
    • Jai, L. (2005) 'Nanoparticle formulation increases oral bioavailability of poorly soluble drugs: approaches, experimental evidences and theory', Current Nanoscience, Vol. 1, No. 3, pp.237-243.
    • (2005) Current Nanoscience , vol.1 , Issue.3 , pp. 237-243
    • Jai, L.1
  • 22
    • 58549089321 scopus 로고    scopus 로고
    • Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles
    • Li, H., Zhao, X., Ma, Y., Zhai, G., Li, L. and Lou, H. (2009a) 'Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles', J. Controlled Release, Vol. 133, pp.238-244
    • (2009) J. Controlled Release , vol.133 , pp. 238-244
    • Li, H.1    Zhao, X.2    Ma, Y.3    Zhai, G.4    Li, L.5    Lou, H.6
  • 23
    • 67349233077 scopus 로고    scopus 로고
    • Targeted delivery of doxorubicin using stealth liposomes modified with transferrin
    • Li, X., Ding, L., Xu, Y., Wang, Y. and Ping, Q. (2009b) 'Targeted delivery of doxorubicin using stealth liposomes modified with transferrin', Int. J. Pharm., Vol. 373, pp.116-123.
    • (2009) Int. J. Pharm. , vol.373 , pp. 116-123
    • Li, X.1    Ding, L.2    Xu, Y.3    Wang, Y.4    Ping, Q.5
  • 24
    • 23244463321 scopus 로고    scopus 로고
    • Liquid filled nanoparticles as a drug delivery tool for protein therapeutics
    • Venkatesan, N., Yoshimitsu, J., Ito, Y., Shibata, N. and Takada, K. (2005) 'Liquid filled nanoparticles as a drug delivery tool for protein therapeutics', Biomaterials, Vol. 26, pp.7154-7163.
    • (2005) Biomaterials , vol.26 , pp. 7154-7163
    • Venkatesan, N.1    Yoshimitsu, J.2    Ito, Y.3    Shibata, N.4    Takada, K.5
  • 25
    • 33751253462 scopus 로고    scopus 로고
    • Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
    • Rieux, A., Fievez, V., Garinot, M., Schneider, Y. and Préat, V. (2006) 'Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach', J. Controlled Release, Vol. 116, pp.1-27.
    • (2006) J. Controlled Release , vol.116 , pp. 1-27
    • Rieux, A.1    Fievez, V.2    Garinot, M.3    Schneider, Y.4    Préat, V.5
  • 27
    • 54049115990 scopus 로고    scopus 로고
    • Gene therapy for type 1 diabetes mellitus in rats by gastrointestinal administration for chitosan nanoparticles containing human insulin gene
    • Niu, L., Xu, Y., Dai, Z. and Tang, H. (2008) 'Gene therapy for type 1 diabetes mellitus in rats by gastrointestinal administration for chitosan nanoparticles containing human insulin gene', World Journal of Gastroenterology, Vol. 14, No. 26, pp.4209-4215.
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.26 , pp. 4209-4215
    • Niu, L.1    Xu, Y.2    Dai, Z.3    Tang, H.4
  • 28
    • 11244298232 scopus 로고
    • Peptidase enzymes of the GI tract: Barriers to peptide delivery, but potential for controlled release
    • Woodley, J.F. (1992) 'Peptidase enzymes of the GI tract: barriers to peptide delivery, but potential for controlled release', Proc. Int. Symp. Controlled Release of Bioactive Material, Vol. 19, pp.2-3.
    • (1992) Proc. Int. Symp. Controlled Release of Bioactive Material , vol.19 , pp. 2-3
    • Woodley, J.F.1
  • 29
    • 50049118724 scopus 로고    scopus 로고
    • Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease
    • Bhavsar, M.D. and Amiji, M.M. (2008) 'Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease', Gene Ther., Vol. 15, pp.1200-1209.
    • (2008) Gene Ther. , vol.15 , pp. 1200-1209
    • Bhavsar, M.D.1    Amiji, M.M.2
  • 30
    • 47049095564 scopus 로고    scopus 로고
    • Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation
    • Woitiski, C.B., Carvalho, R.A., Ribeiro, A.J., Neufeld, R.J. and Veiga, F. (2008) 'Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation', Biodrugs, Vol. 22, No. 4, pp.223-237.
    • (2008) Biodrugs , vol.22 , Issue.4 , pp. 223-237
    • Woitiski, C.B.1    Carvalho, R.A.2    Ribeiro, A.J.3    Neufeld, R.J.4    Veiga, F.5
  • 31
    • 34248642132 scopus 로고    scopus 로고
    • Polymeric nanoparticles for delivery in the gastro-intestinal tract
    • Torchilin, V.P. (Ed.), Imperial College Press, London
    • Bhavsar, M.D., Shenoy, D.B. and Amiji, M.M. (2006) 'Polymeric nanoparticles for delivery in the gastro-intestinal tract', in Torchilin, V.P. (Ed.): Nanoparticulates as Drug Carriers, Imperial College Press, London, pp.609-648.
    • (2006) Nanoparticulates as Drug Carriers , pp. 609-648
    • Bhavsar, M.D.1    Shenoy, D.B.2    Amiji, M.M.3
  • 33
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • Lai, S.K., Wang, Y. and Hanes, J. (2009) 'Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues', Adv. Drug Delivery Rev., Vol. 61, pp.158-171.
    • (2009) Adv. Drug Delivery Rev. , vol.61 , pp. 158-171
    • Lai, S.K.1    Wang, Y.2    Hanes, J.3
  • 34
    • 0030737814 scopus 로고    scopus 로고
    • Histochemistry of the surface mucous gel layer of the human colon
    • Matsuo, K., Ota, H., Akamatsu, T., Sugiyama, A. and Katsuyama, T. (1997) 'Histochemistry of the surface mucous gel layer of the human colon', Gut, Vol. 40, pp.782-789.
    • (1997) Gut , vol.40 , pp. 782-789
    • Matsuo, K.1    Ota, H.2    Akamatsu, T.3    Sugiyama, A.4    Katsuyama, T.5
  • 38
    • 0030948511 scopus 로고    scopus 로고
    • Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon
    • Szentkuti, L. (1997) 'Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon', J. Controlled Release, Vol. 46, pp.233-242.
    • (1997) J. Controlled Release , vol.46 , pp. 233-242
    • Szentkuti, L.1
  • 40
    • 0029927884 scopus 로고    scopus 로고
    • In vivo IgA coating of anaerobic bacteria in human faeces
    • van der Waaij, L.A., Limburg, P.C., Mesander, G. and van der Waaij, D. (1996) 'In vivo IgA coating of anaerobic bacteria in human faeces', Gut, Vol. 38, No. 3, pp.348-354.
    • (1996) Gut , vol.38 , Issue.3 , pp. 348-354
    • Van Der Waaij, L.A.1    Limburg, P.C.2    Mesander, G.3    Van Der Waaij, D.4
  • 41
    • 44049092672 scopus 로고    scopus 로고
    • Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
    • Wang, A. and Li, S. (2008) 'Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect', BMC Biotech., Vol. 8, No. 46, pp.1-7.
    • (2008) BMC Biotech. , vol.8 , Issue.46 , pp. 1-7
    • Wang, A.1    Li, S.2
  • 42
    • 0032912824 scopus 로고    scopus 로고
    • Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats: modification of the body distribution after suspension in surfactant solutions and in oil vehicles
    • Araujo, L., Sheppard, M., Löbenberg, R. and Kreuter, J. (1999) 'Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats: modification of the body distribution after suspension in surfactant solutions and in oil vehicles', Int. J. Pharm., Vol. 176, pp.209-224.
    • (1999) Int. J. Pharm. , vol.176 , pp. 209-224
    • Araujo, L.1    Sheppard, M.2    Löbenberg, R.3    Kreuter, J.4
  • 43
    • 0017363309 scopus 로고
    • Persorption of particles: Physiology and pharmacology
    • Volkheimer, G. (1977) 'Persorption of particles: physiology and pharmacology', Advanced Pharmacology and Chemotherapy, Vol. 14, pp.163-187.
    • (1977) Advanced Pharmacology and Chemotherapy , vol.14 , pp. 163-187
    • Volkheimer, G.1
  • 44
    • 39749178290 scopus 로고    scopus 로고
    • Surface charge of nanoparticles determines their endocytic and transcytotic pathways in polarized MDCK cells
    • Harush-Frenkel, O., Rozentur, E., Benita, S. and Altschuler, Y. (2008) 'Surface charge of nanoparticles determines their endocytic and transcytotic pathways in polarized MDCK cells', Biomacromolecules, Vol. 9, No. 2, pp.435-443.
    • (2008) Biomacromolecules , vol.9 , Issue.2 , pp. 435-443
    • Harush-Frenkel, O.1    Rozentur, E.2    Benita, S.3    Altschuler, Y.4
  • 45
    • 0035940059 scopus 로고    scopus 로고
    • Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
    • Hussain, N., Jaitley, V. and Florence, A. (2001) 'Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics', Adv. Drug Delivery Rev., Vol. 50, pp.107-142.
    • (2001) Adv. Drug Delivery Rev. , vol.50 , pp. 107-142
    • Hussain, N.1    Jaitley, V.2    Florence, A.3
  • 46
    • 0026186291 scopus 로고
    • Peroral administration of nanoparticles
    • Kreuter, J. (1991) 'Peroral administration of nanoparticles', Adv. Drug Delivery Rev., Vol. 7, pp.71-86.
    • (1991) Adv. Drug Delivery Rev. , vol.7 , pp. 71-86
    • Kreuter, J.1
  • 47
    • 0034743412 scopus 로고    scopus 로고
    • Targeting of 3'-Azido 3'-Deoxythymidine (AZT)-loaded poly(isohexylcyanoacrylate) nanospheres to the gastrointestinal mucosa and associated lymphoid tissues
    • Dembri, A., Montisci, M.J., Gantier, J.C., Chacun, H. and Ponchel, G. (2001) 'Targeting of 3'-Azido 3'-Deoxythymidine (AZT)-loaded poly(isohexylcyanoacrylate) nanospheres to the gastrointestinal mucosa and associated lymphoid tissues', Pharm. Res., Vol. 18, No. 4, pp.467-473.
    • (2001) Pharm. Res. , vol.18 , Issue.4 , pp. 467-473
    • Dembri, A.1    Montisci, M.J.2    Gantier, J.C.3    Chacun, H.4    Ponchel, G.5
  • 48
    • 0032402219 scopus 로고    scopus 로고
    • Evaluation of nano and microparticle uptake by the gastrointestinal tract
    • Delie, F. (1998) 'Evaluation of nano and microparticle uptake by the gastrointestinal tract', Advanced Drug Delivery Reviews, Vol. 34, pp.221-233.
    • (1998) Advanced Drug Delivery Reviews , vol.34 , pp. 221-233
    • Delie, F.1
  • 49
    • 0032403490 scopus 로고    scopus 로고
    • Physiological considerations in the design of particulate dosage forms for oral vaccine delivery
    • Yeh, P., Ellens, H. and Smith, P.L. (1998) 'Physiological considerations in the design of particulate dosage forms for oral vaccine delivery', Adv. Drug Delivery Rev., Vol. 34, pp.123-133.
    • (1998) Adv. Drug Delivery Rev. , vol.34 , pp. 123-133
    • Yeh, P.1    Ellens, H.2    Smith, P.L.3
  • 50
    • 0343150936 scopus 로고    scopus 로고
    • The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
    • Borchard, G., Luessen, H.L., de Boer, A.G., Verhoef, J.C., Lehr, C.M. and Junginger, H.E. (1996) 'The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro', J. Controlled Release, Vol. 39, pp.131-138.
    • (1996) J. Controlled Release , vol.39 , pp. 131-138
    • Borchard, G.1    Luessen, H.L.2    De Boer, A.G.3    Verhoef, J.C.4    Lehr, C.M.5    Junginger, H.E.6
  • 51
    • 0035478758 scopus 로고    scopus 로고
    • Chitosan and its derivatives as intestinal absorption enhancers
    • DOI 10.1016/S0169-409X(01)00180-6, PII S0169409X01001806
    • Thanou, M., Verhoef, J.C. and Junginger, H.E. (2001) 'Chitosan and its derivatives as intestinal absorption enhancers', Adv. Drug Delivery Rev., Vol. 50, pp.S91-S101. (Pubitemid 32905357)
    • (2001) Advanced Drug Delivery Reviews , vol.50 , Issue.SUPPL. 1
    • Thanou, M.1    Verhoef, J.C.2    Junginger, H.E.3
  • 52
    • 58149099161 scopus 로고    scopus 로고
    • Oral drug delivery
    • Domb, A.J., Tabata, Y., Ravi Kumar, M.N.V. and Farber, S. (Eds.), American Scientific Publishers
    • Bhardwaj, V. and Ravi Kumar, M.N.V. (2007) 'Oral drug delivery', in Domb, A.J., Tabata, Y., Ravi Kumar, M.N.V. and Farber, S. (Eds.): Nanoparticles for Pharmaceutical Applications, American Scientific Publishers, pp.273-286.
    • (2007) Nanoparticles for Pharmaceutical Applications , pp. 273-286
    • Bhardwaj, V.1    Ravi Kumar, M.N.V.2
  • 53
    • 33947530087 scopus 로고    scopus 로고
    • Novel nanoparticles for oral insulin delivery via the paracellular pathway
    • Lin, Y., Chen, C., Liang, H., Kulkarni, A.R., Lee, P., Chen, C. and Sung, H. (2007) 'Novel nanoparticles for oral insulin delivery via the paracellular pathway', Nanotechnology, Vol. 18, pp.1-11.
    • (2007) Nanotechnology , vol.18 , pp. 1-11
    • Lin, Y.1    Chen, C.2    Liang, H.3    Kulkarni, A.R.4    Lee, P.5    Chen, C.6    Sung, H.7
  • 54
    • 34147176584 scopus 로고    scopus 로고
    • Targeted nanoparticle-based drug delivery and diagnosis
    • Emerich, D.F. and Thanos, C.G. (2007) 'Targeted nanoparticle-based drug delivery and diagnosis', J. Drug Targeting, Vol. 15, No. 3, pp.163-183.
    • (2007) J. Drug Targeting , vol.15 , Issue.3 , pp. 163-183
    • Emerich, D.F.1    Thanos, C.G.2
  • 56
    • 0034872426 scopus 로고    scopus 로고
    • Size-dependent bioadhesion of micro and nanoparticlulate carriers to the inflamed colonic mucosa
    • Lamprecht, A., Schäfer, U. and Lehr, C. (2001a) 'Size-dependent bioadhesion of micro and nanoparticlulate carriers to the inflamed colonic mucosa', Pharm. Res., Vol. 18, No. 6, pp.788-793.
    • (2001) Pharm. Res. , vol.18 , Issue.6 , pp. 788-793
    • Lamprecht, A.1    Schäfer, U.2    Lehr, C.3
  • 58
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel disease
    • Balfour Sartor, R. (2008) 'Microbial influences in inflammatory bowel disease', Gastroenterology, Vol. 134, No. 2, pp.577-594.
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 577-594
    • Balfour Sartor, R.1
  • 60
    • 33646772174 scopus 로고    scopus 로고
    • Nanoparticles in inflammatory bowel disease: Particle targeting versus pH-sensitive delivery
    • Meissner, Y., Pellequer, Y. and Lamprecht, A. (2006) 'Nanoparticles in inflammatory bowel disease: particle targeting versus pH-sensitive delivery', Int. J. Pharm., Vol. 316, pp.138-143.
    • (2006) Int. J. Pharm. , vol.316 , pp. 138-143
    • Meissner, Y.1    Pellequer, Y.2    Lamprecht, A.3
  • 61
    • 36549037212 scopus 로고    scopus 로고
    • The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles
    • Samstein, R.M., Perica, K., Balderrama, F., Look, M. and Fahmy, T.M. (2008) 'The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles', Biomaterials, Vol. 29, pp.703-708.
    • (2008) Biomaterials , vol.29 , pp. 703-708
    • Samstein, R.M.1    Perica, K.2    Balderrama, F.3    Look, M.4    Fahmy, T.M.5
  • 62
    • 19444381516 scopus 로고    scopus 로고
    • A pH-sensitive microsphere system for the colon delivery of tacrolimus containing nanoparticles
    • Lamprecht, A., Yamamoto, H., Takeuchi, H. and Kawashima, Y. (2005) 'A pH-sensitive microsphere system for the colon delivery of tacrolimus containing nanoparticles', J. Controlled Release, Vol. 104, pp.337-346.
    • (2005) J. Controlled Release , vol.104 , pp. 337-346
    • Lamprecht, A.1    Yamamoto, H.2    Takeuchi, H.3    Kawashima, Y.4
  • 64
    • 35748963227 scopus 로고    scopus 로고
    • Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticles
    • Salman, H.H., Gamazo, C., Agüeros, M. and Irache, J.M. (2007) 'Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticles', Vaccine, Vol. 25, pp.8123-8132.
    • (2007) Vaccine , vol.25 , pp. 8123-8132
    • Salman, H.H.1    Gamazo, C.2    Agüeros, M.3    Irache, J.M.4
  • 65
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • Win, K.Y. and Feng, S.S. (2005) 'Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs', Biomaterials, Vol. 26, pp.2713-2722.
    • (2005) Biomaterials , vol.26 , pp. 2713-2722
    • Win, K.Y.1    Feng, S.S.2
  • 66
    • 67349198099 scopus 로고    scopus 로고
    • Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of docetaxel
    • Feng, S., Mei, L., Anitha, P., Gan, C.W. and Zhou, W. (2009) 'Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of docetaxel', Biomaterials, Vol. 30, pp.3297-3306.
    • (2009) Biomaterials , vol.30 , pp. 3297-3306
    • Feng, S.1    Mei, L.2    Anitha, P.3    Gan, C.W.4    Zhou, W.5
  • 67
    • 0037310763 scopus 로고    scopus 로고
    • Regional intestinal absorption of FITC-Dextran 4,400 with nanoparticles based on β-Sitosterol β-D-Glucoside in rats
    • Nakamura, K., Takayama, K., Nagai, T. and Maitani, Y. (2003) 'Regional intestinal absorption of FITC-Dextran 4,400 with nanoparticles based on β-Sitosterol β-D-Glucoside in rats', J. Pharm. Sci., Vol. 92, No. 2, pp.311-318.
    • (2003) J. Pharm. Sci. , vol.92 , Issue.2 , pp. 311-318
    • Nakamura, K.1    Takayama, K.2    Nagai, T.3    Maitani, Y.4
  • 68
    • 0031749555 scopus 로고    scopus 로고
    • Efficacy of pyridoxine to ameliorate the cutaneous toxicity associated with doxorubicin containing pegylated (stealth) liposomes: A randomized, double-blind clinical trial using a canine model
    • Vail, D.M., Chun, R., Thamm, D.H., Garrett, L.D., Cooley, A.J. and Obradovich, J.E. (1998) 'Efficacy of pyridoxine to ameliorate the cutaneous toxicity associated with doxorubicin containing pegylated (stealth) liposomes: a randomized, double-blind clinical trial using a canine model', Clinical Cancer Research, Vol. 4, pp.1567-1571.
    • (1998) Clinical Cancer Research , vol.4 , pp. 1567-1571
    • Vail, D.M.1    Chun, R.2    Thamm, D.H.3    Garrett, L.D.4    Cooley, A.J.5    Obradovich, J.E.6
  • 69
    • 34548482374 scopus 로고    scopus 로고
    • Stealth liposomes: Review of the basic science, rationale, and clinical applications, existing and potential
    • Immordino, M.L., Dosio, F. and Cattel, L. (2006) 'Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential', Int. J. Nanomed., Vol. 1, No. 3, pp.297-315.
    • (2006) Int. J. Nanomed. , vol.1 , Issue.3 , pp. 297-315
    • Immordino, M.L.1    Dosio, F.2    Cattel, L.3
  • 70
  • 71
    • 0029240538 scopus 로고
    • Phagocytosis
    • Brown, E.J. (1994) 'Phagocytosis', BioEssays, Vol. 17, pp.109-117.
    • (1994) BioEssays , vol.17 , pp. 109-117
    • Brown, E.J.1
  • 72
    • 57849099134 scopus 로고    scopus 로고
    • Targeting colon cancer cells using PEGylated liposomes modified with a fibronectin-mimetic peptide
    • Garg, A., Tisdale, A.W., Haidari, E. and Kokkoli, E. (2008) 'Targeting colon cancer cells using PEGylated liposomes modified with a fibronectin-mimetic peptide', Int. J. Pharm., Vol. 366, pp.201-210.
    • (2008) Int. J. Pharm. , vol.366 , pp. 201-210
    • Garg, A.1    Tisdale, A.W.2    Haidari, E.3    Kokkoli, E.4
  • 73
    • 55949096698 scopus 로고    scopus 로고
    • In vitro and cell uptake studies for targeting ligand anchored nanoparticles for colon tumors
    • Jain, A. and Jain, S. (2008) 'In vitro and cell uptake studies for targeting ligand anchored nanoparticles for colon tumors', Eur. J. Pharm. Sci., Vol. 35, pp.404-416.
    • (2008) Eur. J. Pharm. Sci. , vol.35 , pp. 404-416
    • Jain, A.1    Jain, S.2
  • 74
    • 44449141792 scopus 로고    scopus 로고
    • New environmental sensitive system for colon-specific delivery of peptidic drugs
    • Luppi, B., Bigucci, F., Cerchiara, T., Mandrioli, R., Pietra, A.M.D. and Zecchi, V. (2008) 'New environmental sensitive system for colon-specific delivery of peptidic drugs', Int. J. Pharm., Vol. 358, pp.44-49.
    • (2008) Int. J. Pharm. , vol.358 , pp. 44-49
    • Luppi, B.1    Bigucci, F.2    Cerchiara, T.3    Mandrioli, R.4    Pietra, A.M.D.5    Zecchi, V.6
  • 75
    • 52049084593 scopus 로고    scopus 로고
    • The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis
    • Moulari, B., Pertuit, D., Pelleque, Y. and Lamprecht, A. (2008) 'The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis', Biomaterials, Vol. 29, pp.4554-4560.
    • (2008) Biomaterials , vol.29 , pp. 4554-4560
    • Moulari, B.1    Pertuit, D.2    Pelleque, Y.3    Lamprecht, A.4
  • 76
    • 39749178290 scopus 로고    scopus 로고
    • Surface charge of nanoparticles determines their endocytic and transcytotic pathways in polarized MDCK cells
    • Harush-Frenkel, O., Rozentur, E., Benita, S. and Altschuler, Y. (2008) 'Surface charge of nanoparticles determines their endocytic and transcytotic pathways in polarized MDCK cells', Biomacromolecules, Vol. 9, No. 2, pp.435-443.
    • (2008) Biomacromolecules , vol.9 , Issue.2 , pp. 435-443
    • Harush-Frenkel, O.1    Rozentur, E.2    Benita, S.3    Altschuler, Y.4
  • 77
    • 64149087900 scopus 로고    scopus 로고
    • Preparation and characterization of metronidazoleloaded chitosan nanoparticles for drug delivery application
    • Elzatahry, A.A. and Eldin, M.S.M. (2008) 'Preparation and characterization of metronidazoleloaded chitosan nanoparticles for drug delivery application', Polym. Adv. Technol., Vol. 19, pp.1787-1791.
    • (2008) Polym. Adv. Technol. , vol.19 , pp. 1787-1791
    • Elzatahry, A.A.1    Eldin, M.S.M.2
  • 79
    • 0142152952 scopus 로고    scopus 로고
    • Methylation of chitosan with iodomethane: Effect of reaction conditions on chemoselectivity and degree of substitution
    • Curti, E., Britto, D. and Campana-Filho, S.P. (2003) 'Methylation of chitosan with iodomethane: effect of reaction conditions on chemoselectivity and degree of substitution', Macromol. Biosci., Vol. 3, pp.571-576.
    • (2003) Macromol. Biosci. , vol.3 , pp. 571-576
    • Curti, E.1    Britto, D.2    Campana-Filho, S.P.3
  • 80
    • 42649142580 scopus 로고    scopus 로고
    • Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: Ex vivo and in vivo studies
    • Bayat, A., Dorkoosh, F.A., Dehpour, A.R., Moezi, L., Larijani, B., Junginger, H.E. and Rafiee-Tehrani, M. (2008) 'Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies', Int. J. Pharm., Vol. 356, pp.259-266.
    • (2008) Int. J. Pharm. , vol.356 , pp. 259-266
    • Bayat, A.1    Dorkoosh, F.A.2    Dehpour, A.R.3    Moezi, L.4    Larijani, B.5    Junginger, H.E.6    Rafiee-Tehrani, M.7
  • 81
    • 4544343075 scopus 로고    scopus 로고
    • Sparsely cross-linked 'nanogel' matrixes as fluid, mechanically stabilized polymer networks for High-throughput microchannel DNA sequencing
    • Doherty, E.A.S., Kan, C., Paegel, B.M., Yeung, S.H.I., Cao, S., Mathies, R.A. and Barron, A.E. (2004) 'Sparsely cross-linked 'nanogel' matrixes as fluid, mechanically stabilized polymer networks for High-throughput microchannel DNA sequencing', Anal. Chem., Vol. 76, pp.5249-5256.
    • (2004) Anal. Chem. , vol.76 , pp. 5249-5256
    • Doherty, E.A.S.1    Kan, C.2    Paegel, B.M.3    Yeung, S.H.I.4    Cao, S.5    Mathies, R.A.6    Barron, A.E.7
  • 82
    • 33847245460 scopus 로고    scopus 로고
    • Fabrication of single carbonic anhydrase nanogel against denaturation and aggregation at high temperature
    • Yan, M., Liu, Z., Lu, D. and Liu, Z. (2007) 'Fabrication of single carbonic anhydrase nanogel against denaturation and aggregation at high temperature', Biomacromolecules, Vol. 8, pp.560-565.
    • (2007) Biomacromolecules , vol.8 , pp. 560-565
    • Yan, M.1    Liu, Z.2    Lu, D.3    Liu, Z.4
  • 83
    • 35548932074 scopus 로고    scopus 로고
    • Fabrication of a novel pH-sensitive glutaraldehyde cross-linked pectin nanogel for drug delivery
    • Chang, C., Wang, Z., Quan, C., Cheng, H., Cheng, S., Zhang, X. and Zhuo, R. (2007) 'Fabrication of a novel pH-sensitive glutaraldehyde cross-linked pectin nanogel for drug delivery', J. Biomater. Sci., Polym. Ed., Vol. 18, No. 12, pp.1591-1599.
    • (2007) J. Biomater. Sci., Polym. Ed. , vol.18 , Issue.12 , pp. 1591-1599
    • Chang, C.1    Wang, Z.2    Quan, C.3    Cheng, H.4    Cheng, S.5    Zhang, X.6    Zhuo, R.7
  • 84
    • 62749156913 scopus 로고    scopus 로고
    • Synthesis and colon-specific drug delivery of a poly(acrylic acid-co-acrylamide)/MBA nanosized hydrogel
    • Ray, D., Mohapatra, D.K., Mohapatra, R.K., Mohanta, G.P. and Sahoo, R.K. (2008) 'Synthesis and colon-specific drug delivery of a poly(acrylic acid-co-acrylamide)/MBA nanosized hydrogel', J. Biomater. Sci., Polym. Ed., Vol. 19, No. 11, pp.1487-1502.
    • (2008) J. Biomater. Sci., Polym. Ed. , vol.19 , Issue.11 , pp. 1487-1502
    • Ray, D.1    Mohapatra, D.K.2    Mohapatra, R.K.3    Mohanta, G.P.4    Sahoo, R.K.5
  • 85
    • 33845210653 scopus 로고    scopus 로고
    • Functional stimuli-responsive nanogel-particles for oral peptide delivery: Preparation, drug-release behaviors and in vitro cellular interaction
    • Ichikawa, H., Fukumori, Y. and Kamiya, H. (2006) 'Functional stimuli-responsive nanogel-particles for oral peptide delivery: preparation, drug-release behaviors and in vitro cellular interaction', NSTI-Nanotechnology, Vol. 2, pp.392-395.
    • (2006) NSTI-Nanotechnology , vol.2 , pp. 392-395
    • Ichikawa, H.1    Fukumori, Y.2    Kamiya, H.3
  • 86
    • 33947355800 scopus 로고    scopus 로고
    • Double walled polymeric drug delivery systems containing nanoparticle drug intended for colon-specific delivery
    • Siadat, S.O.R., Mahkam, M. and Mohammadi, R. (2007) 'Double walled polymeric drug delivery systems containing nanoparticle drug intended for colon-specific delivery', Asian J. Chem., Vol. 19, No. 3, pp.1875-1882.
    • (2007) Asian J. Chem. , vol.19 , Issue.3 , pp. 1875-1882
    • Siadat, S.O.R.1    Mahkam, M.2    Mohammadi, R.3


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