Extrusion-spheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery

International Journal of Pharmaceutics

Volumn 199, Issue 2, 2000, Pages 187-194

  Krogars, Karin ^a   Heinämäki, Jyrki ^a   Vesalahti, Johanna ^a   Marvola, Martti ^b   Antikainen, Osmo ^a   Yliruusi, Jouko ^a  

^a Division of Pharmaceutical Chemistry   (Finland)

^b Div Biopharmaceut Pharmacokin P   (Finland)

Author keywords

Colon targeting Site specific drug delivery lag time; Eudragit(TM) S 100; Hydroxypropyl methylcellulose acetate succinate; Pellets; Shape

Indexed keywords

CITRIC ACID; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; MANNITOL; MICROCRYSTALLINE CELLULOSE;

ARTICLE; COLON; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; DRUG TARGETING; ENTERIC COATED TABLET; PELLET EXTRUSION; PH MEASUREMENT; PRIORITY JOURNAL; SPHERONIZATION; TABLET FRIABILITY; TABLET MANUFACTURE; TABLET MATRIX;

ACRYLIC RESINS; CHEMISTRY, PHARMACEUTICAL; CITRIC ACID; COATED MATERIALS, BIOCOMPATIBLE; COLON; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; IBUPROFEN; MICROSCOPY; MICROSPHERES; POLYMERS; POLYMETHACRYLIC ACIDS; SOLUTIONS;

EID: 0342313576     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00382-3     Document Type: Article

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