ANIMAL EXPERIMENT;
ANIMAL MODEL;
ARTICLE;
COLON FLORA;
CONTROLLED STUDY;
CYCLIZATION;
DRUG ABSORPTION;
DRUG ACTIVITY;
DRUG DESIGN;
DRUG EFFECT;
DRUG EFFICACY;
DRUG RELEASE;
DRUG STRUCTURE;
DRUG SYNTHESIS;
DRUG TARGETING;
ENTERITIS;
HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM;
MOUSE;
NONHUMAN;
THYMUS ATROPHY;
ADRENAL CORTEX HORMONES;
ANIMALS;
BACTERIA;
COLON;
CYCLIZATION;
DRUG CARRIERS;
DRUG DELIVERY SYSTEMS;
ESTERS;
INFLAMMATORY BOWEL DISEASES;
INTESTINAL ABSORPTION;
MICE;
PRODRUGS;
Scheier, H. In Drug Targeting Technology: A Critical Analysis of Physical, Chemical and Biological Methods; Schreier, H., Ed.; Marcel Dekker Inc.: New York, 2001.
Bauer, K. H. Colon-Specific Drug Delivery. In Drug Targeting Technology: A Critical Analysis of Physical, Chemical and Biological Methods; Schreier, H., Ed.; Marcel Dekker Inc.: New York, 2001.
Targeting of peptide and protein drugs to specific sites in the oral route
Bai, J. P.; Chsang, L. L.; Guo, J. H. Targeting of peptide and protein drugs to specific sites in the oral route. Crit. Rev. Ther. Drug Carrier Syst. 1995, 12, 339-371.
Balsalazide is more effective and better tolerated than mesalamine in the treatment of acute ulcerative colitis
DOI 10.1016/S0016-5085(98)70627-4
Green, J. R. B.; Lobo, A. L.; Holdsworth, C. D. Balsalazide is more effective and better tolerated than mesalazine in the treatment of acute ulcerative colitis. Gastroenterology 1998, 114, 15-22. (Pubitemid 28020949)
Prednisolone 21-sulfate sodium: A colon-specific pro-drug of prednisolone
Jung, Y. J.; Doh, M. J.; Kim, I. H.; Kong, H. S.; Lee, J. S.; Kim, Y. M. Prednisolone 21-sulfate sodium: a colon-specific pro-drug of prednisolone. J. Pharm. Pharmacol. 2003, 55, 1075-1082.
In vitro evaluation of dexamethasone-beta-D-glucuronide for colon-specific drug delivery
Haeberlin, B.; Rubas, W.; Nolen, H. W.; Friend, D. R. In vitro evaluation of dexamethasone-beta-D-glucuronide for colon-specific drug delivery. Pharm. Res. 1993, 11, 1553-1562.
In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery
Leopold, C. S.; Friend, D. R. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J. Pharmacokinet. Biopharm. 1995, 23, 397-406.
Colon-specific delivery of prednisolone-appended α-cyclodextrin conjugate: Alleviation of systemic side effect after oral administration
DOI 10.1016/S0168-3659(01)00532-6, PII S0168365901005326
Yano, H.; Hirayama, F.; Kamada, M.; Arima, H.; Uekama, K. Colon-specific delivery of prednisolone-appended alfa-cyclodextrin conjugate: alleviation of systemic side effect after oral administration. J. Controlled Release 2002, 79, 103-112. (Pubitemid 34164164)
A glucocorticoid prodrug facilitates normal mucosal function in rat colitis without adrenal suppression
McLeod, A. D.; Fedorak, R. N.; Friend, D. R.; Tozer, T. N.; Cui, N. A glucocorticoid prodrug facilitates normal mucosal function in rat colitis without adrenal suppression. Gastroenterology 1994, 106, 405-413. (Pubitemid 24041218)
Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity
Carceller, E.; Salas, J.; Merlos, M.; Giral, M.; Ferrando, R.; Escamilla, I.; Ramis, J.; García-Rafanell, J.; Forn, J. Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity. J. Med. Chem. 2001, 44, 3001-3013.
The relation between swelling properties and enzymatic degradation of azo polymers designed for colon-specific drug delivery
Van den Mooter, G.; Samyn, C.; Kinget, R. The relation between swelling properties and enzymatic degradation of azo polymers designed for colon-specific drug delivery. Pharm. Res. 1994, 11, 1737-1741.
Oral absorption of 21-corticosteroid esters: A function of aqueous stability and intestinal enzyme activity and distribution
Fleisher, D.; Johnson, K. C.; Stewart, B. H.; Amidon, G. L. Oral absorption of 21-corticosteroid esters: a function of aqueous stability and intestinal enzyme activity and distribution. J. Pharm. Sci. 1986, 75, 934-939.
Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety
Fang, L.; Zhang, Y.; Lehmann, J.; Wang, Y.; Ji, H.; Ding, D. Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety. Bioorg. Med. Chem. Lett. 2007, 17, 1062-1066.
Anilide formation from an aliphatic ester. the mechanism of cyclisation of methyl 3-(2-aminophenyl)propionate
Kirby, A. J.; Mujahid, T. G. Anilide formation from an aliphatic ester. The mechanism of cyclisation of methyl 3-(2-aminophenyl)propionate. J. Chem. Soc., Perkin Trans. 2 1979, 1610-1616.
Intramolecular aminolysis of esters. Cyclization of esters of (o-aminophenyl)acetic acid
Fife, T. H.; Duddy, N. W. Intramolecular aminolysis of esters. Cyclization of esters of (o-aminophenyl)acetic acid. J. Am. Chem. Soc. 1983, 105, 74-79.
Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump p-glycoprotein
DOI 10.1097/00054725-200409000-00012
Dilger, K.; Schwab, M.; Fromm, M. Identification of budesodine and prednisone as substrates of the intestinal drug efflux pump Pglycoprotein. Inflammatory Bowel Dis. 2006, 10, 578-583. (Pubitemid 39276465)
A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
Okayasu, I.; Hatakeyama, S.; Yamada, M.; Ohkusa, T.; Inagaki, Y.; Nakaya, R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990, 98, 694-702. (Pubitemid 20069706)
Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism
Smith, P.; Mangan, N. E.; Walsh, C. M.; Fallon, R. E.; McKenzie, A. N.; van Rooijen, N.; Fallon, P. G. Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J. Immunol. 2007, 178, 4557-4566. (Pubitemid 46492408)
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
Cummins, E. P.; Seeballuck, F.; Keely, S. J.; Mangan, N. E.; Callanan, J. J.; Fallon, P. G.; Taylor, C. T. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 2008, 134, 156-165.
Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease
Feighery, L. M.; Smith, P.; O'Mahony, L.; Fallon, P. G.; Brayden, D. J. Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease. Dig. Dis. Sci. 2008, 53, 2495-2506.
Colon-specific delivery of prednisolone-appended α-cyclodextrin conjugate: Alleviation of systemic side effect after oral administration
DOI 10.1016/S0168-3659(01)00532-6, PII S0168365901005326
Yano, H.; Hirayama, F.; Kamada, M.; Arima, H.; Uekama, K. Colon-specific delivery of prednisolone-appended alpha-cyclodextrin conjugate: alleviation of systemic side effect after oral administration. J. Controlled Release 2002, 79, 103-112. (Pubitemid 34164164)
