STAT1 is required for redifferentiation during madin-darby canine kidney tubulogenesis

Molecular Biology of the Cell

Volumn 21, Issue 22, 2010, Pages 3926-3933

  Kim, Minji ^a   O'Brien, Lucy Erin ^a,b   Kwon, Sang Ho ^a   Mostov, Keith E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAF PROTEIN; SCATTER FACTOR; STAT1 PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; KIDNEY CYST; KIDNEY TUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; DOGS; ENZYME ACTIVATION; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; GREEN FLUORESCENT PROTEINS; HEPATOCYTE GROWTH FACTOR; IMMUNOBLOTTING; KIDNEY; KIDNEY TUBULES; MUTATION; ORGANOGENESIS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-RAF; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STAT1 TRANSCRIPTION FACTOR; TAMOXIFEN; TYROSINE;

EID: 78649674047     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-02-0112     Document Type: Article

References (42)

1. Affolter, M., Zeller, R., and Caussinus, E. (2009). Tissue remodelling through branching morphogenesis. Nat. Rev. Mol. Cell Biol. 10, 831-842.
2. Bagnat, M., Cheung, I. D., Mostov, K. E., and Stainier, D. Y. (2007). Genetic control of single lumen formation in the zebrafish gut. Nat. Cell Biol. 9, 954-960.
3. Battle, T. E., Lynch, R. A., and Frank, D. A. (2006). Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res. 66, 3649-3657.
4. Bhunia, A. K., Piontek, K., Boletta, A., Liu, L., Qian, F., Xu, P. N., Germino, F. J., and Germino, G. G. (2002). PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109, 157-168.
5. Boccaccio, C., Ando, M., Tamagnone, L., Bardelli, A., Michieli, P., Battistini, C., and Comoglio, P. M. (1998). Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 391, 285-288.
6. Bryant, D. M., and Mostov, K. E. (2008). From cells to organs: building polarized tissue. Nat. Rev. Mol. Cell Biol. 9, 887-901.
7. Caraglia, M., Vitale, G., Marra, M., Budillon, A., Tagliaferri, P., and Abbruzzese, A. (2004). Alpha-interferon and its effects on signalling pathways within cells. Curr. Protein Pept. Sci. 5, 475-485.
8. David, M., Petricoin, E., 3rd, Benjamin, C., Pine, R., Weber, M. J., and Larner, A. C. (1995). Requirement for MAP kinase (ERK2) activity in interferon alpha-and interferon beta-stimulated gene expression through STAT proteins. Science 269, 1721-1723.
9. Delous, M., Hellman, N. E., Gaude, H. M., Silbermann, F., Le Bivic, A., Salomon, R., Antignac, C., and Saunier, S. (2009). Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6. Hum. Mol. Genet. 18, 4711-4723.
10. Felekkis, K. N., Koupepidou, P., Kastanos, E., Witzgall, R., Bai, C. X., Li, L., Tsiokas, L., Gretz, N., and Deltas, C. (2008). Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2. BMC Nephrol. 9, 10.
11. Ferrari, A., Veligodskiy, A., Berge, U., Lucas, M. S., and Kroschewski, R. (2008). ROCK-mediated contractility, tight junctions and channels contribute to the conversion of a preapical patch into apical surface during isochoric lumen initiation. J. Cell Sci. 121, 3649-3663.
12. Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C., and Levy, D. E. (2009). Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 324, 1713-1716.
13. Hansen, S. H., Zegers, M. M., Woodrow, M., Rodriguez-Viciana, P., Chardin, P., Mostov, K. E., and McMahon, M. (2000). Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signalregulated kinase pathway. Mol. Cell Biol. 20, 9364-9375.
14. Hogan, B. L., and Kolodziej, P. A. (2002). Organogenesis: molecular mechanisms of tubulogenesis. Nat. Rev. Genet. 3, 513-523.
15. Hurd, T. W., and Margolis, B. (2009). Cystin, cilia, and cysts: unraveling trafficking determinants. J. Am. Soc. Nephrol. 20, 2485-2486.
16. Kim, M., Datta, A., Brakeman, P., Yu, W., and Mostov, K. E. (2007). Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis. J. Cell Sci. 120, 2309-2317.
17. Kim, S. H., Park, S., Mostov, K., Debnath, J., and Hunt, C. A. (2009). Computational investigation of epithelial cell dynamic phenotype in vitro. Theor. Biol. Med. Model. 6, 8.
18. Krebs, D. L., and Hilton, D. J. (2001). SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19, 378-387.
19. Liu, X., Robinson, G. W., and Hennighausen, L. (1996). Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol. Endocrinol. 10, 1496-1506.
20. Loucks, F. A., Le, S. S., Zimmermann, A. K., Ryan, K. R., Barth, H., Aktories, K., and Linseman, D. A. (2006). Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. J. Neurochem. 97, 957-967.
21. Lubarsky, B., and Krasnow, M. A. (2003). Tube morphogenesis: making and shaping biological tubes. Cell 112, 19-28.
22. Ma, Z., Gong, Y., Patel, V., Karner, C. M., Fischer, E., Hiesberger, T., Carroll, T. J., Pontoglio, M., and Igarashi, P. (2007). Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3. Proc. Natl. Acad. Sci. USA 104, 20386-20391.
23. Martin-Belmonte, F., Yu, W., Rodriguez-Fraticelli, A. E., Ewald, A. J., Werb, Z., Alonso, M. A., and Mostov, K. (2008). Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr. Biol. 18, 507-513.
24. Montesano, R., Matsumoto, K., Nakamura, T., and Orci, L. (1991a). Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 67, 901-908.
25. Montesano, R., Schaller, G., and Orci, L. (1991b). Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors. Cell 66, 697-711. (Pubitemid 121001705)
26. Nelson, K. S., Furuse, M., and Beitel, G. J. (2010) The Drosophila claudin Kune-kune is required for septate junction organization and tracheal tube size control. Genetics 185, 831-839.
27. O'Brien, L. E., Tang, K., Kats, E. S., Schutz-Geschwender, A., Lipschutz, J. H., and Mostov, K. E. (2004). ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev. Cell 7, 21-32.
28. O'Brien, L. E., Zegers, M. M., and Mostov, K. E. (2002). Opinion: building epithelial architecture: insights from three-dimensional culture models. Nat. Rev. Mol. Cell Biol. 3, 531-537.
29. Pollack, A. L., Runyan, R. B., and Mostov, K. E. (1998). Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis. Dev. Biol. 204, 64-79.
30. Reiterer, G., and Yen, A. (2006). Inhibition of the janus kinase family increases extracellular signal-regulated kinase 1/2 phosphorylation and causes endoreduplication. Cancer Res. 66, 9083-9089. (Pubitemid 44521127)
31. Schluter, M. A., Pfarr, C. S., Pieczynski, J., Whiteman, E. L., Hurd, T. W., Fan, S., Liu, C. J., and Margolis, B. (2009). Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation. Mol. Biol. Cell 20, 4652-4663.
32. Shuai, K., Stark, G. R., Kerr, I. M., and Darnell, J. E., Jr. (1993). A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 261, 1744-1746.
33. Sieg, D. J., Hauck, C. R., Ilic, D., Klingbeil, C. K., Schaefer, E., Damsky, C. H., and Schlaepfer, D. D. (2000). FAK integrates growth-factor and integrin signals to promote cell migration. Nat. Cell Biol. 2, 249-256.
34. Sironi, J. J., and Ouchi, T. (2004). STAT1-induced apoptosis is mediated by caspases 2, 3, and 7. J. Biol. Chem. 279, 4066-4074.
35. Stancato, L. F., Yu, C. R., Petricoin, E. F., 3rd, and Larner, A. C. (1998). Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factor. J. Biol. Chem. 273, 18701-18704.
36. Tefft, D., De Langhe, S. P., Del Moral, P. M., Sala, F., Shi, W., Bellusci, S., and Warburton, D. (2005). A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. Dev. Biol. 282, 422-431.
37. Wang, C. Z., Su, H. W., Hsu, Y. C., Shen, M. R., and Tang, M. J. (2006). A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Mol. Biol. Cell 17, 2839-2852.
38. Wang, S., and Koromilas, A. E. (2009). Stat1 is an inhibitor of Ras-MAPK signaling and Rho small GTPase expression with implications in the transcriptional signature of Ras transformed cells. Cell Cycle 8, 2070-2079.
39. Wei, W. C., Kopec, A. K., and Tang, M. J. (2009). Requirement of focal adhesion kinase in branching tubulogenesis. J. Biomed. Sci. 16, 5.
40. Wu, T. R., Hong, Y. K., Wang, X. D., Ling, M. Y., Dragoi, A. M., Chung, A. S., Campbell, A. G., Han, Z. Y., Feng, G. S., and Chin, Y. E. (2002). SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J. Biol. Chem. 277, 47572-47580.
41. Xie, B., Zhao, J., Kitagawa, M., Durbin, J., Madri, J. A., Guan, J. L., and Fu, X. Y. (2001). Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J. Biol. Chem. 276, 19512-19523.
42. Yu, C. L., Jin, Y. J., and Burakoff, S. J. (2000). Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. J. Biol. Chem. 275, 599-604.