Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology

PLoS Computational Biology

Volumn 6, Issue 11, 2010, Pages

  Yuraszeck, Theresa M ^a   Neveu, Pierre ^b,c   Rodriguez Fernandez, Maria ^d   Robinson, Anne ^e   Kosik, Kenneth S ^c   Doyle III, Francis J ^a,c  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d INSTITUTO DE INVESTIGACIONES MARINAS   (Spain)

^e University of Delaware   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEURODEGENERATIVE DISEASES; PHYSIOLOGY;

'CURRENT; ALZHEIMERS DISEASE; HOMOEOSTASIS; IDENTIFIABILITY; IN-SILICO; PATHOPHYSIOLOGY; STATES OF KNOWLEDGE; SYSTEM-LEVEL ANALYSIS; SYSTEMS BIOLOGY; ULTRASENSITIVE;

ORDINARY DIFFERENTIAL EQUATIONS;

TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; HOMEOSTASIS; MATHEMATICAL MODEL; PATHOPHYSIOLOGY; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN INTERACTION; SYSTEMS BIOLOGY; ANIMAL; BIOLOGICAL MODEL; BRAIN LEVEL; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; COMPUTER SIMULATION; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; ANIMALS; BRAIN CHEMISTRY; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; COS CELLS; HUMANS; MODELS, BIOLOGICAL; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TAU PROTEINS;

EID: 78649667895     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000997     Document Type: Article

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