Inactivation of 5-HT2C receptors potentiates consequences of serotonin reuptake blockade

Neuropsychopharmacology

Volumn 29, Issue 10, 2004, Pages 1782-1789

  Cremers, Thomas I F H ^a,c,d   Giorgetti, Marco ^b   Bosker, Fokko J ^a   Hogg, Sandra ^c   Arnt, Jørn ^c   Mørk, Arne ^c   Honig, Gerard ^b   Bøgesø, Klaus Peter ^c   Westerink, Ben H C ^a   Den Boer, Hans ^a   Wikstrom, Håkan V ^a   Tecott, Laurence H ^b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c H LUNDBECK A S   (Denmark)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

5 HT2C; Antidepressant; Microdialysis; Mouse; Rat; Receptor; Serotonin

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; 8 [4 (5 AMINO 2,4 DIMETHOXYBENZOYL)BUTYL] 1,3,8 TRIAZASPIRO[4.5]DECANE 2,4 DIONE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; CITALOPRAM; FLUOXETINE; IRINDALONE; KETANSERIN; MEPYRAMINE; PRAZOSIN; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; GENE; GENE INACTIVATION; GENE MUTATION; HIPPOCAMPUS; HTR2C GENE; IN VIVO STUDY; MALE; MICRODIALYSIS; MOUSE; MOUSE MUTANT; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEROTONIN BRAIN LEVEL; SEROTONIN RELEASE;

ANIMALS; BRAIN CHEMISTRY; HINDLIMB SUSPENSION; KETANSERIN; MALE; MICRODIALYSIS; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SYNAPTIC TRANSMISSION;

EID: 4644219875     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300474     Document Type: Article

References (40)

1. Abi-Saab WM, Bubser M, Roth RH, Deutch AY (1999). 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology 20: 92-96.
2. Artigas F (1993). 5-HT and antidepressants: new views from microdialysis studies. Trends Pharmacol Sci 14: 262.
3. Artigas F, Celada P, Laruelle M, Adell A (2001). How does pindolol improve antidepressant action? Trends Pharmacol Sci 22: 224-228.
4. Artigas F, Romero L, de Montigny C, Blier P (1996). Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends Neurosci 378-383.
5. Bagdy G, Graf M, Anheuer ZE, Modos EA, Kantor S (2001). Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635. Int J Neuropsychopharmacol 4: 399-408.
6. Bankson MG, Cunningham KA (2002). Pharmacological studies of the acute effects of (+)-3,4-methylenedioxymethamphetamine on locomotor activity: role of 5-HT(1B/1D) and 5-HT(2) receptors. Neuropsychopharmacology 26: 40-52.
7. Boothman LJ, Allers KA, Rasmussen K, Sharp T (2003). Evidence that central 5-HT(2A) and 5-HT(2B/C) receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat. Br J Pharmacol 139: 998-1004.
8. Brousse G, Schmitt A, Chereau I, Eschalier A, Dubray C, Llorca PM (2003). Interest of the use of pindolol in the treatment of depression: review. Encephale 29: 338-350.
9. Clemett DA, Punhani T, Duxon MS, Blackburn TP, Fone KC (2000). Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS. Neuropharmacology 39: 123-132.
10. Cremers TI, Wiersma LJ, Bosker FJ, den Boer JA, Westerink BH, Wikstrom HV (2001). Is the beneficial antidepressant effect of coadministration of pindolol really due to somatodendritic autoreceptor antagonism? Biol Psychiatry 50: 13-21.
11. Cryan JF, Lucki I (2000). Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine(2C) receptors. J Pharmacol Exp Ther 295: 1120-1126.
12. Davidson RJ, Pizzagalli D, Nitschke JB, Putnam K (2002). Depression: perspectives from affective neuroscience. Annu Rev Psychol 53: 545-574.
13. Fava M (2000). New approaches to the treatment of refractory depression. J Clin Psychiatry 61(Suppl 1): 26-32.
14. Franklin KJ, Paxinos G (1997). The Mouse Brain in Stereotaxic Coordinates. Academic Press Inc.: San Diego, CA.
15. Gervasoni D, Peyron C, Rampon C, Barbagli B, Chouvet G, Urbain N et al (2000). Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons. J Neurosci 20: 4217-4225.
16. Gobert A, Millan MJ (1999). Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats. Neuropharmacology 38: 315-317.
17. Gobert A, Rivet JM, Lejeune F, Newman-Tancredi A, Adhumeau-Auclair A, Nicolas JP et al (2000). Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. Synapse 36: 205-221.
18. Gurevich I, Englander MT, Adlersberg M, Siegal NB, Schmauss C (2002a). Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission. J Neurosci 22: 10529-10532.
19. Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C (2002b). Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 34: 349-356.
20. Halford JC, Blundell JE (2000). Separate systems for serotonin and leptin in appetite control. Ann Med 32: 222-232.
21. Hervas I, Vilaro MT, Romero L, Scorza MC, Mengod G, Artigas F (2001). Desensitization of 5-HT(1A) autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635. Neuropsychopharmacology 24: 11-20.
22. Jenck F, Moreau JL, Mutel V, Martin JR (1994). Brain 5-HT1C receptors and antidepressants. Prog Neuro-Psychopharmacol Biol Psych 18: 563-574.
23. Judd LL (1995). Mood disorders in the general population represent an important and worldwide public health problem. Int Clin Psychopharmacol 10(Suppl 4): 5-10.
24. Kreiss DS, Lucki I (1995). Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. J Pharmacol Exp Ther 274: 866-876.
25. Leysen JE, Janssen PM, Gommeren W, Wynants J, Pauwels PJ, Janssen PA (1992). In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. Mol Pharmacol 41: 494-508.
26. Liu R, Jolas T, Aghajanian G (2000). Serotonin 5-HT(2) receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus. Brain Res 873: 34-45.
27. Martin-Ruiz R, Puig MV, Celada P, Shapiro DA, Roth BL, Mengod G et al (2001). Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. J Neurosci 21: 9856-9866.
28. Murray CJ, Lopez AD (1997). Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Lancet 349: 1498-1504.
29. Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA et al (2001). RNA editing of the human serotonin 5-HT2C receptor, alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology 24: 478-491.
30. 2C receptor. Psychopharmacology 126: 234-240.
31. Porsolt RD (2000). Animal models of depression: utility for transgenic research. Rev Neurosci 11: 53-58.
32. Redrobe JP, Bourin M (1997). Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test. Eur J Pharmacol 325: 129-135.
33. Roth BL, Kroeze WK, Patel S, Lopez E (2000). The multiplicity of serotonin receptors: uselessly diverse molecules or an embarrasment of riches? Neurostientist 6: 252-262.
34. Shen RY, Andrade R (1998). 5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus. J Pharmacol Exp Ther 285: 805-812.
35. Steru L, Chermat R, Thierry B, Simon P (1985). The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85: 367-370.
36. Stockmeier CA (1997). Neurobiology of serotonin in depression and suicide. Ann N Y Acad Sci 836: 220-232.
37. Tao R, Auerbach SB (2003). Influence of inhibitory and excitatory inputs on serotonin efflux differs in the dorsal and median raphe nuclei. Brain Res 961: 109-120.
38. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF et al (1995). Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors. Nature 374: 542-546.
39. Vickers SP, Clifton PG, Dourish CT, Tecott LH (1999). Reduced satiating effect of d-fenfluramine in serotonin 5-HT2C receptor mutant mice. Psychopharmacology 143: 309-314.
40. Wright DE, Seroogy KB, Lundgren KH, Davis BM, Jennes L (1995). Comparative localization of serotonin1A,1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 351: 357-373.