Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells

Toxicology and Applied Pharmacology

Volumn 250, Issue 1, 2011, Pages 29-38

  Ohkuni, Tsuyoshi ^a   Kojima, Takashi ^a   Ogasawara, Noriko ^a   Masaki, Tomoyuki ^a   Fuchimoto, Jun ^a   Kamekura, Ryuta ^a   Koizumi, Jun Ichi ^a   Ichimiya, Shingo ^a   Murata, Masaki ^a   Tanaka, Satoshi ^a   Himi, Tetsuo ^a   Sawada, Norimasa ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Human nasal epithelial cells; JAM A; NF B; Poly(I:C); Proinflammatory cytokines; TLR3

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; JUNCTIONAL ADHESION MOLECULE A; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CYTOKINE RELEASE; EPITHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNE RESPONSE; IN VITRO STUDY; INNATE IMMUNITY; NOSE MUCOSA; PATHOGENESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TIGHT JUNCTION;

CELL ADHESION MOLECULES; CELLS, CULTURED; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; IMMUNOGLOBULINS; INTERFERON INDUCERS; INTERLEUKIN-8; LIGANDS; NASAL MUCOSA; NF-KAPPA B; POLY I-C; RNA, MESSENGER; TELOMERASE; TOLL-LIKE RECEPTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78649630659     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.09.023     Document Type: Article

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