A novel DNA topoisomerase i inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells

Biochemistry

Volumn 49, Issue 47, 2010, Pages 10131-10136

  Wu, Ning ^a   Wu, Xi Wei ^a   Agama, Keli ^b   Pommier, Yves ^b   Du, Jun ^a   Li, Ding ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a   An, Lin Kun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFTER-TREATMENT; ANTI-CANCER AGENTS; ANTIPROLIFERATIVE ACTIVITIES; BIOLOGICAL ACTIVITIES; CAMPTOTHECINS; CANCER CELL GROWTH; CELL-CYCLE ARREST; CLEAVAGE ACTIVITIES; DIFFERENT MECHANISMS; DNA TOPOISOMERASE I; HUMAN CANCER CELLS; INHIBITORY MECHANISM; K562 CELLS; MICROMOLAR CONCENTRATION; NUCLEAR ENZYME; TERNARY COMPLEX;

CATALYST ACTIVITY; CELL CULTURE; CELLS; DNA; ENZYMES; GROWTH KINETICS;

BODY FLUIDS;

CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; ETHYL 7 FLUORO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER GROWTH; CATALYSIS; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

CAMPTOTHECIN; CELL DIVISION; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; HUMANS; INDOLIZINES; K562 CELLS; QUINOLONES; TOPOISOMERASE I INHIBITORS;

EID: 78649505322     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1009419     Document Type: Article

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