Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: Importance of vicinal cysteines 504 and 505

Journal of Biological Chemistry

Volumn 282, Issue 19, 2007, Pages 14403-14412

  Montaudon, Danièle ^a   Palle, Komaraiah ^c   Rivory, Laurent P ^d   Robert, Jacques ^b   Douat Casassus, Céline ^e   Quideau, Stéphane ^e   Bjornsti, Mary Ann ^c   Pourquier, Philippe ^a  

^a INSERM   (France)

^b INSTITUT BERGONIÉ   (France)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d JOHNSON AND JOHNSON   (United States)

^e INSTITUT EUROPÉEN DE CHIMIE ET BIOLOGIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; DNA; ORGANIC COMPOUNDS; PROTEINS; TRANSCRIPTION;

CAMPTOTHECIN; CYSTEINES; TOPOISOMERASE; VICINAL RESIDUES;

ENZYME ACTIVITY;

ALANINE; ARSENOSOBENZENE; CAMPTOTHECIN; DITHIOTHREITOL; DNA TOPOISOMERASE; N ETHYLMALEIMIDE; THIOL DERIVATIVE; CYSTEINE; ENZYME INHIBITOR; ORGANOARSENIC DERIVATIVE;

ARTICLE; DNA CLEAVAGE; ENZYME ACTIVITY; MUTATION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

ARSENICALS; CAMPTOTHECIN; CYSTEINE; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; ENZYME INHIBITORS; ETHYLMALEIMIDE; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SULFHYDRYL COMPOUNDS;

EID: 34347212152     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611673200     Document Type: Article

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