Mechanism of cell cycle arrest and apoptosis induction by conjugated eicosapentaenoic acid, which is a mammalian DNA polymerase and topoisomerase inhibitor

International Journal of Oncology

Volumn 30, Issue 5, 2007, Pages 1197-1204

  Yonezawa, Yuko ^a   Hada, Takahiko ^b   Uryu, Keisuke ^b   Tsuzuki, Tsuyoshi ^c   Nakagawa, Kiyotaka ^d   Miyazawa, Teruo ^d   Yoshida, Hiromi ^a   Mizushina, Yoshiyuki ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b Bizen Chemical Co Ltd   (Japan)

^c MIYAGI UNIVERSITY   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cell cycle arrest; Cell proliferation; Conjugated eicosapentaenoic acid; DNA polymerase; DNA replication; DNA topoisomerase; Enzyme inhibitor; p53

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; DNA TOPOISOMERASE; ENZYME INHIBITOR; ICOSAPENTAENOIC ACID;

APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN HL 60; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IC 50; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSAPENTAENOIC ACID; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 34447332293     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.30.5.1197     Document Type: Article

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