Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4617-4625

  Cheng, Yu ^a   An, Lin Kun ^a   Wu, Ning ^a   Wang, Xiao Dong ^a   Bu, Xian Zhang ^a   Huang, Zhi Shu ^a   Gu, Lian Quan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cytotoxic activity; Indolizinoquinoline 5,12 dione derivatives; Structure activity relationship; Topoisomerase I

Indexed keywords

11 ACETYL 10 BROMO INDOLIZINO[3,2 G]QUINOLINE 5,12 DIONE; 11 ACETYL 10 CHLORO INDOLIZINO[3,2 G]QUINOLINE 5,12 DIONE; 11 ACETYL 10 FLUORO INDOLIZINO[3,2 G]QUINOLINE 5,12 DIONE; 11 ACETYLINDOLIZINO[3,2 G]QUINOLINE 5,12 DIONE; 11 METHYLINDOLIZINO[3,2 G]QUINOLINE 5,12 DIONE; 6 ACETYL 7 BROMO INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 6 ACETYL 7 CHLORO INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 6 ACETYL 7 FLUORO INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 6 ACETYLINDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 6 METHYLINDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 6,7 DICHLOROQUINOLINE 5,8 DIONE; DNA TOPOISOMERASE INHIBITOR; ETHYL 10 AMINO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[3,2 G]QUINOLINE 11 CARBOXYLATE; ETHYL 10 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[3,2 G]QUINOLINE 11 CARBOXYLATE; ETHYL 10 CHLORO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[3,2 G]QUINOLINE 11 CARBOXYLATE; ETHYL 10 FLUORO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[3,2 G]QUINOLINE 11 CARBOXYLATE; ETHYL 10 HYDROXY 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[3,2 G]QUINOLINE 11 CARBOXYLATE; ETHYL 10 METHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[3,2 G]QUINOLINE 11 CARBOXYLATE; ETHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; ETHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[3,2 G]QUINOLINE 11 CARBOXYLATE; ETHYL 7 AMINO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; ETHYL 7 BROMO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; ETHYL 7 CHLORO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; ETHYL 7 FLUORO 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; ETHYL 7 HYDROXY 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; ETHYL 7 METHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; INDOLIZINO[3,2 G]QUINOLINE 5,12 DIONE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER CELL CULTURE; CHLORINATION; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG INHIBITION; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HETERONUCLEAR MULTIPLE BOND CORRELATION; HUMAN; HUMAN CELL; HYDROGENATION; IC 50; IN VITRO STUDY; NITRATION; NUCLEAR MAGNETIC RESONANCE; OXIDATION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INDOLES; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42149147572     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.036     Document Type: Article

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