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Volumn 11, Issue 4, 2010, Pages 291-297

Conditional knockout of brca1/2 and p53 in mouse ovarian surface epithelium: Do they play a role in ovarian carcinogenesis?

Author keywords

BRCA; Conditional knockout; Ovarian cancer; p53; Tumor suppressor genes

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; BRCA2 PROTEIN, MOUSE; LOX PROTEIN, MOUSE; PROTEIN LYSINE 6 OXIDASE; PROTEIN P53; SCLEROPROTEIN;

EID: 78649504975     PISSN: 1229845X     EISSN: None     Source Type: Journal    
DOI: 10.4142/jvs.2010.11.4.291     Document Type: Article
Times cited : (3)

References (37)
  • 2
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: biology, endocrinology, and pathology
    • Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr Rev 2001, 22, 255-288.
    • (2001) Endocr Rev , vol.22 , pp. 255-288
    • Auersperg, N.1    Wong, A.S.2    Choi, K.C.3    Kang, S.K.4    Leung, P.C.5
  • 3
    • 0034661872 scopus 로고    scopus 로고
    • Absence of premalignant histologic, molecular, or cell biologic alterations in prophylactic oophorectomy specimens from brca1 heterozygotes
    • Barakat RR, Federici MG, Saigo PE, Robson ME, Offit K, Boyd J. Absence of premalignant histologic, molecular, or cell biologic alterations in prophylactic oophorectomy specimens from brca1 heterozygotes. Cancer 2000, 89, 383-390.
    • (2000) Cancer , vol.89 , pp. 383-390
    • Barakat, R.R.1    Federici, M.G.2    Saigo, P.E.3    Robson, M.E.4    Offit, K.5    Boyd, J.6
  • 4
    • 0035479017 scopus 로고    scopus 로고
    • brca1-associated tumorigenesis: what have we learned from knockout mice?
    • Brodie SG, Deng CX. brca1-associated tumorigenesis: what have we learned from knockout mice? Trends Genet 2001, 17, S18-22.
    • (2001) Trends Genet , vol.17
    • Brodie, S.G.1    Deng, C.X.2
  • 5
    • 0035829651 scopus 로고    scopus 로고
    • Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
    • Brodie SG, Xu X, Qiao W, Li WM, Cao L, Deng CX. Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice. Oncogene 2001, 20, 7514-7523.
    • (2001) Oncogene , vol.20 , pp. 7514-7523
    • Brodie, S.G.1    Xu, X.2    Qiao, W.3    Li, W.M.4    Cao, L.5    Deng, C.X.6
  • 6
    • 0037099625 scopus 로고    scopus 로고
    • Epigenetic factors controlling the brca1 and brca2 genes in sporadic ovarian cancer
    • Chan KY, Ozçelik H, Cheung AN, Ngan HY, Khoo US. Epigenetic factors controlling the brca1 and brca2 genes in sporadic ovarian cancer. Cancer Res 2002, 62, 4151-4156.
    • (2002) Cancer Res , vol.62 , pp. 4151-4156
    • Chan, K.Y.1    Ozçelik, H.2    Cheung, A.N.3    Ngan, H.Y.4    Khoo, U.S.5
  • 8
    • 0035009393 scopus 로고    scopus 로고
    • Estradiol up-regulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells
    • Choi KC, Kang SK, Tai CJ, Auersperg N, Leung PCK. Estradiol up-regulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells. Endocrinology 2001, 142, 2351-2360.
    • (2001) Endocrinology , vol.142 , pp. 2351-2360
    • Choi, K.C.1    Kang, S.K.2    Tai, C.J.3    Auersperg, N.4    Leung, P.C.K.5
  • 9
    • 33845644738 scopus 로고    scopus 로고
    • Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes
    • Clark-Knowles KV, Garson K, Jonkers J, Vanderhyden BC. Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes. Exp Cell Res 2007, 313, 133-145.
    • (2007) Exp Cell Res , vol.313 , pp. 133-145
    • Clark-Knowles, K.V.1    Garson, K.2    Jonkers, J.3    Vanderhyden, B.C.4
  • 11
    • 0033865957 scopus 로고    scopus 로고
    • Roles of brca1 and its interacting proteins
    • Deng CX, Brodie SG. Roles of brca1 and its interacting proteins. Bioessays 2000, 22, 728-737.
    • (2000) Bioessays , vol.22 , pp. 728-737
    • Deng, C.X.1    Brodie, S.G.2
  • 12
    • 0038756581 scopus 로고    scopus 로고
    • Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium
    • Flesken-Nikitin A, Choi KC, Eng JP, Shmidt EN, Nikitin AY. Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res 2003, 63, 3459-3463.
    • (2003) Cancer Res , vol.63 , pp. 3459-3463
    • Flesken-Nikitin, A.1    Choi, K.C.2    Eng, J.P.3    Shmidt, E.N.4    Nikitin, A.Y.5
  • 13
    • 0034909194 scopus 로고    scopus 로고
    • Identifying and managing hereditary risk of breast and ovarian cancer
    • Frank TS, Critchfield GC. Identifying and managing hereditary risk of breast and ovarian cancer. Clin Perinatol 2001, 28, 395-406.
    • (2001) Clin Perinatol , vol.28 , pp. 395-406
    • Frank, T.S.1    Critchfield, G.C.2
  • 14
    • 0030051903 scopus 로고    scopus 로고
    • Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    • Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet 1996, 12, 191-194.
    • (1996) Nat Genet , vol.12 , pp. 191-194
    • Gowen, L.C.1    Johnson, B.L.2    Latour, A.M.3    Sulik, K.K.4    Koller, B.H.5
  • 16
    • 0037014776 scopus 로고    scopus 로고
    • Gene expression profiling of hereditary and sporadic ovarian cancers reveals unique brca1 and brca2 signatures
    • Hedenfalk IA. Gene expression profiling of hereditary and sporadic ovarian cancers reveals unique brca1 and brca2 signatures. J Natl Cancer Inst 2002, 94, 960-961.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 960-961
    • Hedenfalk, I.A.1
  • 17
    • 0028290780 scopus 로고
    • The epidemiology of ovarian carcinoma and the current status of tumor markers to detect disease
    • 1099-1097
    • Herbst AL. The epidemiology of ovarian carcinoma and the current status of tumor markers to detect disease. Am J Obstet Gynecol 1994, 170, 1099-1097.
    • (1994) Am J Obstet Gynecol , vol.170
    • Herbst, A.L.1
  • 22
    • 0036080670 scopus 로고    scopus 로고
    • Cell proliferation and apoptosis in BRCA-associated hereditary ovarian cancer
    • Levine DA, Federici MG, Reuter VE, Boyd J. Cell proliferation and apoptosis in BRCA-associated hereditary ovarian cancer. Gynecol Oncol 2002, 85, 431-434.
    • (2002) Gynecol Oncol , vol.85 , pp. 431-434
    • Levine, D.A.1    Federici, M.G.2    Reuter, V.E.3    Boyd, J.4
  • 23
    • 0030924656 scopus 로고    scopus 로고
    • Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
    • Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev 1997, 11, 1226-1241.
    • (1997) Genes Dev , vol.11 , pp. 1226-1241
    • Ludwig, T.1    Chapman, D.L.2    Papaioannou, V.E.3    Efstratiadis, A.4
  • 25
    • 0032506021 scopus 로고    scopus 로고
    • The brca2 gene product functionally interacts with p53 and RAD51
    • Marmorstein LY, Ouchi T, Aaronson SA. The brca2 gene product functionally interacts with p53 and RAD51. Proc Natl Acad Sci USA 1998, 95, 13869-13874.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13869-13874
    • Marmorstein, L.Y.1    Ouchi, T.2    Aaronson, S.A.3
  • 26
    • 0021682037 scopus 로고
    • Surface morphology of ovarian mesothelium (surface epithelium) and of other pelvic and extrapelvic mesothelial sites in the rabbit
    • Nicosia SV, Johnson JH. Surface morphology of ovarian mesothelium (surface epithelium) and of other pelvic and extrapelvic mesothelial sites in the rabbit. Int J Gynecol Pathol 1984, 3, 249-260.
    • (1984) Int J Gynecol Pathol , vol.3 , pp. 249-260
    • Nicosia, S.V.1    Johnson, J.H.2
  • 30
    • 0034707053 scopus 로고    scopus 로고
    • In search of the tumoursuppressor functions of brca1 and brca2
    • Scully R, Livingston DM. In search of the tumoursuppressor functions of brca1 and brca2. Nature 2000, 408, 429-432.
    • (2000) Nature , vol.408 , pp. 429-432
    • Scully, R.1    Livingston, D.M.2
  • 32
    • 0037446145 scopus 로고    scopus 로고
    • Breast cancer gene 1 (brca1): role in cell cycle regulation and DNA repair--perhaps through transcription
    • Somasundaram K. Breast cancer gene 1 (brca1): role in cell cycle regulation and DNA repair--perhaps through transcription. J Cell Biochem 2003, 88, 1084-1091.
    • (2003) J Cell Biochem , vol.88 , pp. 1084-1091
    • Somasundaram, K.1
  • 34
    • 0034753160 scopus 로고    scopus 로고
    • Functions of brca1 and brca2 in the biological response to DNA damage
    • Venkitaraman AR. Functions of brca1 and brca2 in the biological response to DNA damage. J Cell Sci 2001, 114, 3591-3598.
    • (2001) J Cell Sci , vol.114 , pp. 3591-3598
    • Venkitaraman, A.R.1
  • 35
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of brca1 and brca2
    • Venkitaraman AR. Cancer susceptibility and the functions of brca1 and brca2. Cell 2002, 108, 171-182.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 36
    • 0036675318 scopus 로고    scopus 로고
    • Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer
    • Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie SG, Deng CX, Ried T. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene 2002, 21, 5097-5107.
    • (2002) Oncogene , vol.21 , pp. 5097-5107
    • Weaver, Z.1    Montagna, C.2    Xu, X.3    Howard, T.4    Gadina, M.5    Brodie, S.G.6    Deng, C.X.7    Ried, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.