BRCA1 and BRCA2 mutations in ovarian cancer: Covariation with specific cytogenetic features

International Journal of Gynecological Cancer

Volumn 10, Issue 4, 2000, Pages 289-295

  Koul, A ^a   Malander, S ^a   Loman, N ^a   Pejovic, T ^b   Heim, S ^c   Willen, R ^a   Johannsson, O ^a   Olsson, H ^a   Ridderheim, M ^a   Borg, A ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Yale Hospital of New Haven   (United States)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

BRCA1; BRCA2; Chromosome 6; Cytogenetics; Karyotype; Ovarian cancer

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER STAGING; CHROMOSOME 6; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENETIC PREDISPOSITION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KARYOTYPE; MUTATION; ONCOGENE; OVARY CARCINOMA; PRIORITY JOURNAL;

EID: 0033813379     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1438.2000.010004289.x     Document Type: Article

References (45)

1. Chromosome aberrations in 35 primary ovarian carcinomas
2. Cytogenetic studies of epithelial ovarian carcinoma
3. Chromosome abnormalities in ovarian adenocarcinoma: II Prognostic impact of nonrandom chromosome abnormalities in 244 cases
4. Allelotype of human ovarian cancer
5. Frequent loss of heterozygosity on chromosome 18 in ovarian adenocarcinoma which does not always include the DCC locus
6. Allele loss on chromosome 11p is associated with poor survival in ovarian cancer
7. Molecular genetics of hereditary ovarian cancer
8. The genetics of breast and ovarian cancer
9. Extracolonic cancer in hereditary non-polyposis colorectal cancer
10. BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population: Relationship to family history and implications for genetic testing
11. Somatic mutations in the BRCA1 gene in sporadic ovarian tumors
12. Mutation analysis of the BRCA1 gene in ovarian cancers
13. Somatic and germline mutations in sporadic ovarian cancer
14. BRCA2 mutations in primary breast and ovarian cancers
15. Founding BRCA1 mutations in hereditary breast and ovarian cancer in Southern Sweden
16. Moderate frequency of BRCA1 and BRCA2 germ-line mutations in Scandinavian familial breast cancer
17. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations
18. Consistent occurrence of a 19p+ marker chromosome and loss of 11p material in ovarian seropapillary cystadenocarcinomas
19. Bilateral ovarian carcinoma: Cytogenetic evidence of unicentric origin
20. A somatic BRCA2 mutation in RER+ endometrial carcinomas that specifically deletes the amino-terminal transactivation domain
21. HER2/neu amplification predict poor prognosis in node-positive breast cancer
22. Estrogen and progesterone receptor analyses in more than 4000 human breast cancer samples
23. A polymorphic stop codon in BRCA2
24. Frequency of germline and somatic BRCA1 mutations in ovarian cancer
25. BRCA1 mutations in familial ovarian cancer
26. Transcriptional activation by BRCA1
27. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
28. Characterization of a carboxy-terminal BRCA1 interacting protein
29. Identification of missense and truncating mutations in the BRCA1 gene in sporadic and familial breast and ovarian cancer
30. Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1
31. Contribution of BRCA1 mutations to ovarian cancer
32. Sequence analysis of BRCA1 and BRCA2: Correlation of mutations with family history and ovarian cancer
33. Survival of BRCA1 breast and ovarian cancer patients: A population-based study from southern Sweden
34. Allelic imbalance of chromosome 6q in ovarian tumours
35. Chromosome analysis of 97 primary carcinomas of the breast: Identification of eight karyotypic subgroups
36. A defined chromosome 6q fragment (at D6S310) harbors a putative tumor suppressor gene for breast cancer
37. Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma
38. Abnormalities of the long arm of chromosome 6 in childhood acute lymphoblastic leukemia
39. Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukemia
40. Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization
41. Pathogenesis of ovarian cancers
42. Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers
43. Mutations of the BRCA2 gene in ovarian carcinomas
44. The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women