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1
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45549089137
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Simulated drug administration: An emerging tool for teaching clinical pharmacology during anesthesiology training
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Struys MM, De Smet T, Mortier EP. Simulated drug administration: An emerging tool for teaching clinical pharmacology during anesthesiology training. Clin Pharmacol Ther 2008; 84:170-174.
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(2008)
Clin Pharmacol Ther
, vol.84
, pp. 170-174
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Struys, M.M.1
De Smet, T.2
Mortier, E.P.3
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2
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55049120250
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Target-controlled infusion versus manuallycontrolled infusion of propofol for general anaesthesia or sedation in adults
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Leslie K, Clavisi O, Hargrove J. Target-controlled infusion versus manuallycontrolled infusion of propofol for general anaesthesia or sedation in adults. Cochrane Database Syst Rev 2008:CD006059.
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(2008)
Cochrane Database Syst Rev
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Leslie, K.1
Clavisi, O.2
Hargrove, J.3
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3
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74049091284
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A comparison between targetcontrolled and manually controlled propofol infusions in patients undergoing routine surgical procedures
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Chen G, Buell O, Gruenewald M, et al. A comparison between targetcontrolled and manually controlled propofol infusions in patients undergoing routine surgical procedures. Eur J Anaesthesiol 2009; 26:928-935.
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Eur J Anaesthesiol
, vol.26
, pp. 928-935
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Chen, G.1
Buell, O.2
Gruenewald, M.3
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4
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61949453158
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Manual versus targetcontrolled infusion remifentanil administration in spontaneously breathing patients
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This is one of the first publications comparing manually versus target-controlled infusion of remifentanil in spontaneously breathing patients. Remifentanil administered via TCI resulted in a decrease in propofol dosing and in a lower incidence in apnea and respiratory depression, compared to manually controlled administration of remifentanil
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Moerman AT, Herregods LL, De Vos MM, et al. Manual versus targetcontrolled infusion remifentanil administration in spontaneously breathing patients. Anesth Analg 2009; 108:828-834. This is one of the first publications comparing manually versus target-controlled infusion of remifentanil in spontaneously breathing patients. Remifentanil administered via TCI resulted in a decrease in propofol dosing and in a lower incidence in apnea and respiratory depression, compared to manually controlled administration of remifentanil.
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(2009)
Anesth Analg
, vol.108
, pp. 828-834
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Moerman, A.T.1
Herregods, L.L.2
De Vos, M.M.3
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5
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61949245575
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A comparison of propofol and remifentanil target-controlled infusions to facilitate fiberoptic nasotracheal intubation
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This article describes that both propofol and remifentanil TCI is accurate to achieve fast and good intubating conditions and patient comfort during fiberoptic nasotracheal intubation. Remifentanil allows for more patient cooperation, making it safer when spontaneous ventilation is paramount
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Lallo A, Billard V, Bourgain JL. A comparison of propofol and remifentanil target-controlled infusions to facilitate fiberoptic nasotracheal intubation. Anesth Analg 2009; 108:852-857. This article describes that both propofol and remifentanil TCI is accurate to achieve fast and good intubating conditions and patient comfort during fiberoptic nasotracheal intubation. Remifentanil allows for more patient cooperation, making it safer when spontaneous ventilation is paramount.
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(2009)
Anesth Analg
, vol.108
, pp. 852-857
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Lallo, A.1
Billard, V.2
Bourgain, J.L.3
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6
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0033960873
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Comparison of plasma compartment versus two methods for effect compartment-controlled target-controlled infusion for propofol
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Struys MM, De Smet T, Depoorter B, et al. Comparison of plasma compartment versus two methods for effect compartment-controlled target-controlled infusion for propofol. Anesthesiology 2000; 92:399-406.
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(2000)
Anesthesiology
, vol.92
, pp. 399-406
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Struys, M.M.1
De Smet, T.2
Depoorter, B.3
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7
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62749169977
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No evidence of memory processing during propofol-remifentanil target-controlled infusion anesthesia with bispectral index monitoring in cardiac surgery
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Bejjani G, Lequeux PY, Schmartz D, et al. No evidence of memory processing during propofol-remifentanil target-controlled infusion anesthesia with bispectral index monitoring in cardiac surgery. J Cardiothorac Vasc Anesth 2009; 23:175-181.
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(2009)
J Cardiothorac Vasc Anesth
, vol.23
, pp. 175-181
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Bejjani, G.1
Lequeux, P.Y.2
Schmartz, D.3
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8
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61949188696
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Opioid or propofol: What kind of drug for what kind of sedation? Manual dosing or target-controlled infusion?
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Raeder J. Opioid or propofol: What kind of drug for what kind of sedation? Manual dosing or target-controlled infusion? Anesth Analg 2009; 108:704-706.
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(2009)
Anesth Analg
, vol.108
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Raeder, J.1
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9
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67650708119
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Pharmacokinetic models for propofol: Defining and illuminating the devil in the detail
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This is an interesting review article describing how different pharmacokinetic- dynamic models for propofol can lead to different infusion characteristics, certainly in changing populations
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Absalom AR, Mani V, De Smet T, Struys MM. Pharmacokinetic models for propofol: Defining and illuminating the devil in the detail. Br J Anaesth 2009; 103:26-37. This is an interesting review article describing how different pharmacokinetic- dynamic models for propofol can lead to different infusion characteristics, certainly in changing populations.
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(2009)
Br J Anaesth
, vol.103
, pp. 26-37
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Absalom, A.R.1
Mani, V.2
De Smet, T.3
Struys, M.M.4
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10
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76749163049
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The performance of compartmental and physiologically based recirculatory pharmacokinetic models for propofol: A comparison using bolus, continuous, and target-controlled infusion data
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[Epub ahead of print] This article compared the performance of various compartmental and one physiologically based recirculatory pharmaco kinetic model during various infusion regimens. It seems that the Schnider model, although still not perfect, is the recommended model to be used for TCI and advisory displays. Although more detailed, the physiologically based recirculatory pharmacokinetic model did not outperform
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Masui K, Upton RN, Doufas AG, et al. The performance of compartmental and physiologically based recirculatory pharmacokinetic models for propofol: A comparison using bolus, continuous, and target-controlled infusion data. Anesth Analg 2009. [Epub ahead of print] This article compared the performance of various compartmental and one physiologicallybasedrecirculatorypharmacokineticmodel duringvariousinfusion regimens. It seems that the Schnider model, although still not perfect, is the recommended model to be used for TCI and advisory displays. Although more detailed, the physiologically based recirculatory pharmacokinetic model did not outperform.
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(2009)
Anesth Analg
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Masui, K.1
Upton, R.N.2
Doufas, A.G.3
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11
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70349678832
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Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate
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This study found that a combined pharmacokinetic-dynamic model consisting of a two-compartmental model with a LAG time and presystemic compartments and a sigmoidal maximum possible drug effect model accurately described the early phase pharmacology of propofol during infusion rate between 10 and 160mgkg-1 h-1. The infusion rate has an influence on kinetics, but not dynamics. Age was a covariate for LAG time
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Masui K, Kira M, Kazama T, et al. Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate. Anesthesiology 2009; 111:805-817. This study found that a combined pharmacokinetic-dynamic model consisting of a two-compartmental model with a LAG time and presystemic compartments and a sigmoidal maximum possible drug effect model accurately described the early phase pharmacology of propofol during infusion rate between 10 and 160mgkg-1 h-1. The infusion rate has an influence on kinetics, but not dynamics. Age was a covariate for LAG time.
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(2009)
Anesthesiology
, vol.111
, pp. 805-817
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Masui, K.1
Kira, M.2
Kazama, T.3
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12
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66149118296
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Evaluation of the predictive performance of four pharmacokinetic models for propofol
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The authors found that in assessing the predictive performance of pharmacokinetic models, additional information can be obtained by analysis of bias at different phases of an infusion. The evaluation of divergence should involve linear regression analysis of both absolute and signed prediction errors
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Glen JB, Servin F. Evaluation of the predictive performance of four pharmacokinetic models for propofol. Br J Anaesth 2009; 102:626-632. The authors found that in assessing the predictive performance of pharmacokinetic models, additional information can be obtained by analysis of bias at different phases of an infusion. The evaluation of divergence should involve linear regression analysis of both absolute and signed prediction errors.
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(2009)
Br J Anaesth
, vol.102
, pp. 626-632
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Glen, J.B.1
Servin, F.2
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13
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77952001033
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Are there still limitations for the use of targetcontrolled infusion in children?
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Anderson BJ, Hodkinson B. Are there still limitations for the use of targetcontrolled infusion in children? Curr Opin Anesthesiol 2010; 23:356-362.
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(2010)
Curr Opin Anesthesiol
, vol.23
, pp. 356-362
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Anderson, B.J.1
Hodkinson, B.2
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14
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77249157398
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Which model for propofol TCI in children
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This study compared previously published pharmacokinetic models for propofol and found that the Schnider model preformed well over the age of 5 years. However, the authors conclude that whatever is the model, a pharmacodynamic feedback such as the bispectral index may be useful to counteract the interindividual variability in the pediatric population
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Constant I, Rigouzzo A. Which model for propofol TCI in children. Paediatr Anaesth 2010; 20:233-239. This study compared previously published pharmacokinetic models for propofol and found that the Schnider model preformed well over the age of 5 years. However, the authors conclude that whatever is the model, a pharmacodynamic feedback such as the bispectral index may be useful to counteract the interindividual variability in the pediatric population.
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(2010)
Paediatr Anaesth
, vol.20
, pp. 233-239
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Constant, I.1
Rigouzzo, A.2
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15
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68649098077
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High risk infusions: Accuracy compromised by changes in patient venous pressure
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Murphy RS, Wilcox SJ. High risk infusions: Accuracy compromised by changes in patient venous pressure. J Med Eng Technol 2009; 33:470-474.
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(2009)
J Med Eng Technol
, vol.33
, pp. 470-474
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Murphy, R.S.1
Wilcox, S.J.2
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16
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47649104863
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Assessment of propofol concentration in human breath and blood by means of HS-SPME-GC-MS
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Mietisch W, Fuchs P, Kamysek S, et al. Assessment of propofol concentration in human breath and blood by means of HS-SPME-GC-MS. Clin Chim Acta 2008; 395:32-37.
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(2008)
Clin Chim Acta
, vol.395
, pp. 32-37
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Mietisch, W.1
Fuchs, P.2
Kamysek, S.3
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17
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34147142367
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On-line monitoring of end-tidal propofol concentration in anesthetized patients
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Takita A, Masui K, Kazama T. On-line monitoring of end-tidal propofol concentration in anesthetized patients. Anesthesiology 2007; 106:659-664.
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(2007)
Anesthesiology
, vol.106
, pp. 659-664
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Takita, A.1
Masui, K.2
Kazama, T.3
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18
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71749099575
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Determination of serum propofol concentrations by breath analysis using ion mobility spectrometry
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Perl T, Carstens E, Hirn A, et al. Determination of serum propofol concentrations by breath analysis using ion mobility spectrometry. Br J Anaesth 2009; 103:822-827.
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(2009)
Br J Anaesth
, vol.103
, pp. 822-827
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Perl, T.1
Carstens, E.2
Hirn, A.3
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19
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66149101716
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Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery
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Grossherr M, Hengstenberg A, Meier T, et al. Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery. Br J Anaesth 2009; 102:608-613.
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(2009)
Br J Anaesth
, vol.102
, pp. 608-613
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Grossherr, M.1
Hengstenberg, A.2
Meier, T.3
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20
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70350701892
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Blood gas partition coefficient and pulmonary extraction ratio for propofol in goats and pigs
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Grossherr M, Hengstenberg A, Dibbelt L, et al. Blood gas partition coefficient and pulmonary extraction ratio for propofol in goats and pigs. Xenobiotica 2009; 39:782-787.
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(2009)
Xenobiotica
, vol.39
, pp. 782-787
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Grossherr, M.1
Hengstenberg, A.2
Dibbelt, L.3
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21
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2542562742
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Bispectral index monitoring to prevent awareness during anaesthesia: The B-Aware randomised controlled trial
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Myles PS, Leslie K, McNeil J, et al. Bispectral index monitoring to prevent awareness during anaesthesia: The B-Aware randomised controlled trial. Lancet 2004; 363:1757-1763.
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(2004)
Lancet
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, pp. 1757-1763
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Myles, P.S.1
Leslie, K.2
McNeil, J.3
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22
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77949296405
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The effect of bispectral index monitoring on long-term survival in the B-aware trial
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The authors found that monitoring with BIS and absence of BIS values less than 40 for more than 5 min were associated with improved survival and reduced morbidity in patients enrolled in the B-Aware trial
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Leslie K, Myles PS, Forbes A, Chan MT. The effect of bispectral index monitoring on long-term survival in the B-aware trial. Anesth Analg 2010; 110:816-822. The authors found that monitoring with BIS and absence of BIS values less than 40 for more than 5 min were associated with improved survival and reduced morbidity in patients enrolled in the B-Aware trial.
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(2010)
Anesth Analg
, vol.110
, pp. 816-822
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Leslie, K.1
Myles, P.S.2
Forbes, A.3
Chan, M.T.4
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23
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70249088066
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Cerebral state index vs. bispectral index during sevofluranenitrous oxide anaesthesia
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Nishiyama T. Cerebral state index vs. bispectral index during sevofluranenitrous oxide anaesthesia. Eur J Anaesthesiol 2009; 26:638-642.
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(2009)
Eur J Anaesthesiol
, vol.26
, pp. 638-642
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Nishiyama, T.1
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24
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61349124924
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Auditory evoked potentials index versus bispectral index during propofol sedation in spinal anesthesia
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Nishiyama T. Auditory evoked potentials index versus bispectral index during propofol sedation in spinal anesthesia. J Anesth 2009; 23:26-30.
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(2009)
J Anesth
, vol.23
, pp. 26-30
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Nishiyama, T.1
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25
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70449627736
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Comparison of entropy and bispectral index during propofol and fentanyl sedation in monitored anaesthesia care
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Balci C, Karabekir HS, Kahraman F, Sivaci RG. Comparison of entropy and bispectral index during propofol and fentanyl sedation in monitored anaesthesia care. J Int Med Res 2009; 37:1336-1342.
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(2009)
J Int Med Res
, vol.37
, pp. 1336-1342
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Balci, C.1
Karabekir, H.S.2
Kahraman, F.3
Sivaci, R.G.4
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26
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77952260635
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Differences between bispectral index and spectral entropy during xenon anaesthesia: A comparison with propofol anaesthesia
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Hocker J, Raitschew B, Meybohm P, et al. Differences between bispectral index and spectral entropy during xenon anaesthesia: A comparison with propofol anaesthesia. Anaesthesia 2010; 65:595-600.
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(2010)
Anaesthesia
, vol.65
, pp. 595-600
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Hocker, J.1
Raitschew, B.2
Meybohm, P.3
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27
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74549200815
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Correlation and agreement between the bispectral index vs. state entropy during hypothermic cardiopulmonary bypass
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Meybohm P, Gruenewald M, Hocker J, et al. Correlation and agreement between the bispectral index vs. state entropy during hypothermic cardiopulmonary bypass. Acta Anaesthesiol Scand 2010; 54:169-175.
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(2010)
Acta Anaesthesiol Scand
, vol.54
, pp. 169-175
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Meybohm, P.1
Gruenewald, M.2
Hocker, J.3
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28
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70149110898
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Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients
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Haenggi M, Ypparila-Wolters H, Buerki S, et al. Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients. Anesth Analg 2009; 109:807-816.
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Anesth Analg
, vol.109
, pp. 807-816
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Haenggi, M.1
Ypparila-Wolters, H.2
Buerki, S.3
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29
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61849138995
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Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/ remifentanil and dexmedetomidine/ remifentanil in healthy volunteers: An interventional study
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Haenggi M, Ypparila-Wolters H, Hauser K, et al. Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/ remifentanil and dexmedetomidine/remifentanil in healthy volunteers: An interventional study. Crit Care 2009; 13:R20.
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(2009)
Crit Care
, vol.13
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Haenggi, M.1
Ypparila-Wolters, H.2
Hauser, K.3
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30
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65649122661
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EEG entropy values during isoflurane, sevoflurane and halothane anesthesia with and without nitrous oxide
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Prabhakar H, Ali Z, Bithal PK, et al. EEG entropy values during isoflurane, sevoflurane and halothane anesthesia with and without nitrous oxide. J Neurosurg Anesthesiol 2009; 21:108-111.
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(2009)
J Neurosurg Anesthesiol
, vol.21
, pp. 108-111
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Prabhakar, H.1
Ali, Z.2
Bithal, P.K.3
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31
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34147121092
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Behavior of entropy/complexity measures of the electroencephalogram during propofol-induced sedation: Dose-dependent effects of remifentanil
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Ferenets R, Vanluchene A, Lipping T, et al. Behavior of entropy/complexity measures of the electroencephalogram during propofol-induced sedation: Dose-dependent effects of remifentanil. Anesthesiology 2007; 106:696-706.
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(2007)
Anesthesiology
, vol.106
, pp. 696-706
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Ferenets, R.1
Vanluchene, A.2
Lipping, T.3
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32
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69049101206
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Bispectral and spectral entropy indices at propofol-induced loss of consciousness in young and elderly patients
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This article described the influence of age on bispectral index and spectral entropies at loss of consciousness during propofol induction
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Lysakowski C, Elia N, Czarnetzki C, et al. Bispectral and spectral entropy indices at propofol-induced loss of consciousness in young and elderly patients. Br J Anaesth 2009; 103:387-393. This article described the influence of age on bispectral index and spectral entropies at loss of consciousness during propofol induction.
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(2009)
Br J Anaesth
, vol.103
, pp. 387-393
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Lysakowski, C.1
Elia, N.2
Czarnetzki, C.3
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33
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73949154056
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Does patient position influence the reading of the bispectral index monitor?
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Kaki AM, Almarakbi WA. Does patient position influence the reading of the bispectral index monitor? Anesth Analg 2009; 109:1843-1846.
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(2009)
Anesth Analg
, vol.109
, pp. 1843-1846
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Kaki, A.M.1
Almarakbi, W.A.2
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34
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0036064878
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Skin conductance correlates with perioperative stress
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Storm H, Myre K, Rostrup M, et al. Skin conductance correlates with perioperative stress. Acta Anaesthesiol Scand 2002; 46:887-895.
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(2002)
Acta Anaesthesiol Scand
, vol.46
, pp. 887-895
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Storm, H.1
Myre, K.2
Rostrup, M.3
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35
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33645647837
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Heart rate variability-guided prophylactic treatment of severe hypotension after subarachnoid block for elective cesarean delivery
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Hanss R, Bein B, Francksen H, et al. Heart rate variability-guided prophylactic treatment of severe hypotension after subarachnoid block for elective cesarean delivery. Anesthesiology 2006; 104:635-643.
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(2006)
Anesthesiology
, vol.104
, pp. 635-643
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Hanss, R.1
Bein, B.2
Francksen, H.3
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36
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15944389902
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EEG spectral entropy, heart rate, photoplethysmography and motor responses to skin incision during sevoflurane anaesthesia
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Seitsonen ER, Korhonen IK, van Gils MJ, et al. EEG spectral entropy, heart rate, photoplethysmography and motor responses to skin incision during sevoflurane anaesthesia. Acta Anaesthesiol Scand 2005; 49:284-292.
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(2005)
Acta Anaesthesiol Scand
, vol.49
, pp. 284-292
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Seitsonen, E.R.1
Korhonen, I.K.2
Van Gils, M.J.3
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37
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34447105131
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Heart rate variability does not discriminate between different levels of haemodynamic responsiveness during surgical anaesthesia
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Luginbuhl M, Ypparila-Wolters H, Rufenacht M, et al. Heart rate variability does not discriminate between different levels of haemodynamic responsiveness during surgical anaesthesia. Br J Anaesth 2007; 98:728-736.
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Br J Anaesth
, vol.98
, pp. 728-736
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Luginbuhl, M.1
Ypparila-Wolters, H.2
Rufenacht, M.3
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38
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33244498054
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Stimulation induced variability of pulse plethysmography does not discriminate responsiveness to intubation
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Luginbuhl M, Rufenacht M, Korhonen I, et al. Stimulation induced variability of pulse plethysmography does not discriminate responsiveness to intubation. Br J Anaesth 2006; 96:323-329.
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(2006)
Br J Anaesth
, vol.96
, pp. 323-329
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Luginbuhl, M.1
Rufenacht, M.2
Korhonen, I.3
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39
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34548269102
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Changes in a surgical stress index in response to standardized pain stimuli during propofol remifentanil infusion
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Struys MM, Vanpeteghem C, Huiku M, et al. Changes in a surgical stress index in response to standardized pain stimuli during propofol remifentanil infusion. Br J Anaesth 2007; 99:359-367.
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(2007)
Br J Anaesth
, vol.99
, pp. 359-367
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Struys, M.M.1
Vanpeteghem, C.2
Huiku, M.3
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40
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70350482570
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Influence of different remifentanil concentrations on the performance of the surgical stress index to detect a standardized painful stimulus during sevoflurane anaesthesia
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The authors found that the SSI response to tetanic stimulation was dependent on the remifentanil concentration
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Gruenewald M, Meybohm P, Ilies C, et al. Influence of different remifentanil concentrations on the performance of the surgical stress index to detect a standardized painful stimulus during sevoflurane anaesthesia. Br J Anaesth 2009; 103:586-593. The authors found that the SSI response to tetanic stimulation was dependent on the remifentanil concentration.
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(2009)
Br J Anaesth
, vol.103
, pp. 586-593
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Gruenewald, M.1
Meybohm, P.2
Ilies, C.3
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41
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77951681292
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Comparison of surgical stress indexguided analgesia with standard clinical practice during routine general anesthesia: A pilot study
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Chen X, Thee C, Gruenewald M, et al. Comparison of surgical stress indexguided analgesia with standard clinical practice during routine general anesthesia: A pilot study. Anesthesiology 2010; 112:1175-1183.
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Anesthesiology
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, pp. 1175-1183
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Chen, X.1
Thee, C.2
Gruenewald, M.3
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42
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67650094018
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Effects of sevoflurane and propofol on the nociceptive withdrawal reflex and on the H reflex
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The authors found that probably because of the polysynaptic relay, the attenuation of the withdrawal reflex exceeds the attenuation of the H reflex. Sevoflurane produces a larger inhibitory effect on the H reflex than propofol, which confirms that the ventral horn is a more important target for volatile anesthetics, whereas effects of propofol on this site of action are rather limited. Their findings indirectly suggest for propofol a relatively stronger effect within the dorsal horn
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Baars JH, Mager R, Dankert K, et al. Effects of sevoflurane and propofol on the nociceptive withdrawal reflex and on the H reflex. Anesthesiology 2009; 111:72-81. The authors found that probably because of the polysynaptic relay, the attenuation of the withdrawal reflex exceeds the attenuation of the H reflex. Sevoflurane produces a larger inhibitory effect on the H reflex than propofol, which confirms that the ventral horn is a more important target for volatile anesthetics, whereas effects of propofol on this site of action are rather limited. Their findings indirectly suggest for propofol a relatively stronger effect within the dorsal horn.
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(2009)
Anesthesiology
, vol.111
, pp. 72-81
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Baars, J.H.1
Mager, R.2
Dankert, K.3
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43
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76749119090
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Monitoring of the responsiveness to noxious stimuli during anaesthesia with propofol and remifentanil by using RIII reflex threshold and bispectral index
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The authors identified the influence of midazolam on the pharmacokinetics of propofol and found that midazolam reduces the metabolic and rapid and slow distribution clearances of propofol. In addition, a reduction in mean arterial blood pressure was associated with propofol pharmacokinetic alterations that increase the blood propofol concentration
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The authors found that for both electroencephalographic suppression and tolerance to stimulation, the interaction of propofol and sevoflurane was identified as additive. The response surface data can be used for more rational dose finding in case of sequential and co-administration of propofol and sevoflurane
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Schumacher PM, Dossche J, Mortier EP, et al. Response surface modeling of the interaction between propofol and sevoflurane. Anesthesiology 2009; 111:790-804. The authors found that for both electroencephalographic suppression and tolerance to stimulation, the interaction of propofol and sevoflurane was identified as additive. The response surface data can be used for more rational dose finding in case of sequential and co-administration of propofol and sevoflurane.
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