Mixed-effects Modeling of the Intrinsic Ventilatory Depressant Potency of Propofol in the Non-steady State

Anesthesiology

Volumn 100, Issue 2, 2004, Pages 240-250

  Bouillon, Thomas ^a   Bruhn, Joergen ^b   Radu Radulescu, Lucian ^c   Andresen, Corina ^d   Cohane, Carol ^e   Shafer, Steven L ^f,g,h,i  

^a Inselspital Berne   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c DUKE UNIVERSITY   (United States)

^d ALZA CORPORATION   (United States)

^e ICON CLINICAL RESEARCH   (United States)

^f VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ Anesthesiology Service 112A   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; PROPOFOL;

APNEA; ARTERIAL BLOOD; ARTICLE; BAYES THEOREM; BLOOD SAMPLING; BREATHING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EFFECT; END TIDAL CARBON DIOXIDE TENSION; EXPERIMENTAL MODEL; HUMAN; HUMAN EXPERIMENT; HYPOTENSION; INFUSION PUMP; NORMAL HUMAN; PARAMETER; PRIORITY JOURNAL; REBREATHING; RESPIRATION DEPRESSION; STEADY STATE;

ADULT; BAYES THEOREM; CARBON DIOXIDE; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MODELS, BIOLOGICAL; PROPOFOL; PULMONARY GAS EXCHANGE; RESPIRATORY INSUFFICIENCY;

EID: 1642458343     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200402000-00010     Document Type: Article

References (22)

1. Bouillon T, Schmidt C, Garstka G, Heimbach D, Stafforst D, Schwilden H, Hoeft A: Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of alfentanil. ANESTHESIOLOGY 1999; 91:144-55
2. Glass PS, Iselin-Chaves IA, Goodman D, Delong E, Hermann DJ: Determination of the potency of remifentanil compared with alfentanil using ventilatory depression as the measure of opioid effect. ANESTHESIOLOGY 1999; 90:1556-63
3. Dahan A, Nieuwenhuijs D, Olofsen E, Sarton E, Romberg R, Teppema L: Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and Bispectral Index. ANESTHESIOLOGY 2001; 94:982-91
4. Read DJC: A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med 1967; 16:20-32
5. Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB, Shafer SL, Youngs EJ: The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. ANESTHESIOLOGY 1998; 88:1170-82
6. Bouillon T, Bruhn J, Radu Radulescu L, Bertaccini E, Park S, Shafer SL: Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil. ANESTHESIOLOGY 2002; 97:1350-62
7. Beal SL, Sheiner LB: NONMEM User's Guides. San Francisco, NONMEM Project Group, University of California, 1992
8. Dahan A, Berkenbosch A, DeGoede J, Olievier IC, Bovill JG: On a pseudo-rebreathing technique to assess the ventilatory sensitivity to carbon dioxide in man. J Physiol 1990; 423:615-29
9. Longobardo G, Evangelisti CJ, Cherniack NS: Effects of neural drives on breathing in the awake state in humans. Respir Physiol 2002; 129:317-33
10. Hausmann D, Stoeckel H, Krajewski W, Schuttler J: O2-Aufnahme und CO2-Produktion bei total intravenoser Propofol-Alfentanil-Narkose unter Steady-State-Bedingungen Ist die O2-Aufnahme ein Parameter zur Abschatzung der Narkosetiefe [O2 uptake and CO2 production during total intravenous propofol-alfentanil anesthesia under steady-state conditions. Is O2 uptake a parameter for assessing the depth of anesthesia]? Anasthesiol Intensivmed Notfallmed Schmerzther 1991; 26:12-6
11. Taylor MB, Grounds RM, Mulrooney PD, Morgan M: Ventilatory effects of propofol during induction of anaesthesia: Comparison with thiopentone. Anaesthesia 1986; 41:816-20
12. Allsop P, Taylor MB, Grounds RM, Morgan M: Ventilatory effects of a propofol infusion using a method to rapidly achieve steady-state equilibrium. Eur J Anaesthesiol 1988; 5:293-303
13. Blouin RT, Conard PF, Gross JB: Time course of ventilatory depression following induction doses of propofol and thiopental. ANESTHESIOLOGY 1991; 75:940-4
14. Blouin RT, Seifert HA, Babenco HD, Conard PF, Gross JB: Propofol depresses the hypoxic ventilatory response during conscious sedation and isohypercapnia. ANESTHESIOLOGY 1993; 79:1177-82
15. Bragg P, Zwass MS, Lau M, Fisher DM: Opioid pharmacodynamics in neonatal dogs: Differences between morphine and fentanyl. J Appl Physiol 1995; 79:1519-24
16. Swanson GD, Bellville JW: Step changes in end-tidal CO2: Methods and implications. J Appl Physiol 1975; 39:377-85
17. Nunn JF: Applied Respiratory Physiology, 4th edition. Oxford, Butterworth Heinemann, 1993, p 237
18. Weyland W, Brauer A, Weyland A, Janitzki AS, Braun U: [The effect of sedation on oxygen uptake during spontaneous breathing]. Anaesthesist 1993; 42:391-5
19. Pavlin DJ, Coda B, Shen DD, Tschanz J, Nguyen Q, Schaffer R, Donaldson G, Jacobson RC, Chapman CR: Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers. ANESTHESIOLOGY 1996; 84:23-37
20. Dahan A, Berkenbosch A, DeGoede J, Olievier IC, Bovill JG: On a pseudo-rebreathing technique to assess the ventilatory sensitivity to carbon dioxide in man. J Physiol 1990; 423:615-29
21. Duffin J, Mohan RM, Vasiliou P, Stephenson R, Mahamed S: A model of the chemoreflex control of breathing in humans: Model parameters measurement. Respir Physiol 2000; 120:13-26
22. Duffin J: The chemoreflex control of breathing and its measurement. Can J Anaesth 1990; 37:933-42