Mixed-effects modeling of the influence of midazolam on propofol pharmacokinetics

Anesthesia and Analgesia

Volumn 108, Issue 5, 2009, Pages 1522-1530

  Vuyk, Jaap ^a   Lichtenbelt, Bart Jan ^b   Olofsen, Erik ^a   Van Kleef, Jack W ^a   Dahan, Albert ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MIDAZOLAM; PROPOFOL; HYPNOTIC SEDATIVE AGENT; INTRAVENOUS ANESTHETIC AGENT;

ADULT; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; COMPARTMENT MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG POTENTIATION; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PRIORITY JOURNAL; BIOLOGICAL MODEL; BIOTRANSFORMATION; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DRUG ADMINISTRATION; DRUG EFFECT; DRUG INTERACTION; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; NONLINEAR SYSTEM; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANESTHETICS, INTRAVENOUS; BIOTRANSFORMATION; BLOOD PRESSURE; COMPUTER SIMULATION; CROSS-OVER STUDIES; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; HUMANS; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; MIDAZOLAM; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PROPOFOL; YOUNG ADULT;

EID: 65349151923     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31819e4058     Document Type: Article

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