Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 24, 2010, Pages 8566-8582

  Pavlović, Dražen ^a,b   Fajdetić, Andrea ^a   Mutak, Stjepan ^a  

^a PLIVA Research Institute Ltd   (Croatia)

^b UNIVERSITÉ BORDEAUX 1   (France)

Author keywords

15 Membered 8a and 9a azahomoerythromycins; Ketolides; Macrolide antibiotics; Macrolide resistance; Quinolones

Indexed keywords

1 CYCLOPROPYL 7 [(3 OXO 8A AZA 8A HOMOERYTHROMYCIN 6 YLOXY) (2'' HYDROXYPROPYL)PIPERAZIN 1 YL] 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 [(3 OXO 8A AZA 8A HOMOERYTHROMYCIN 6 YLOXY) (2'' HYDROXYPROPYLAMINO)ETHYLAMINO] 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 6 [2'' (HYDROXY 3'' ISOBUTYLAMINO PROPOXY] 3 OXO 8A AZA 8A HOMOERYTHROMYCIN A; 6 [2'' HYDROXY 3'' [4 (ISOQUINOLINE 7 SULFONYL) 2 METHYL PIPERAZIN 1 YL]PROPOXY] 3 OXO 8A AZA 8A HOMOERYTHROMYCIN A; 8A AZAHOMOERYTHROMYCIN A KETOLIDE DERIVATIVE; 9A AZAHOMOERYTHROMYCIN A KETOLIDE DERIVATIVE; ANTIBIOTIC AGENT; CETHROMYCIN; ERYTHROMYCIN; KETOLIDE; LINCOSAMIDE; MACROLIDE; MIKAMYCIN B; QUINOLINE DERIVATIVE; QUINOLONE DERIVATIVE; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; MORAXELLA CATARRHALIS; NONHUMAN; PHARMACOPHORE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE; ERYTHROMYCIN; HAEMOPHILUS INFLUENZAE; KETOLIDES; MICROBIAL SENSITIVITY TESTS; MORAXELLA (BRANHAMELLA) CATARRHALIS; QUINOLONES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

HAEMOPHILUS INFLUENZAE; MORAXELLA CATARRHALIS; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 78649449361     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.10.024     Document Type: Article

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