Novel lipophilic 7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid derivatives as potential antitumor agents: Improved synthesis and in vitro evaluation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 24, 2010, Pages 8537-8548

  Korolyov, Alexander ^a   Dorbes, Sandra ^a   Azéma, Joëlle ^a   Guidetti, Brigitte ^a   Danel, Mathieu ^a   Lamoral Theys, Delphine ^b   Gras, Thierry ^b   Dubois, Jacques ^b   Kiss, Robert ^b   Martino, Robert ^a   Malet Martino, Myriam ^a  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Fluoroquinolones; In vitro antitumor activity; Lipophilic levofloxacin derivatives; Microwave assisted synthesis

Indexed keywords

6 [(BUTANOYLOXY) METHYL] 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXYLATE; 6 [(DECANOYLOXY) METHYL] 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXYLATE; 6 [(DODECANOYLOXY) METHYL] 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXYLATE; 6 [(HEXADECANOYLOXY) METHYL] 9 FLUORO 3,7 DIHYDRO 3 METHYL 10 (4 METHYLPIPERAZIN 1 YL) 7 OXO [1,4] OXAZINO [2,3,4 IJ] QUINOLINE 6 CARBOXYLATE; 6 [(HEXANOYLOXY) METHYL] 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXYLATE; 6 [(OCTADECANOYLOXY) METHYL] 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXYLATE; 6 [(OCTANOYLOXY) METHYL] 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXYLATE; 6 [(TETRADECANOYLOXY) METHYL] 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXYLATE; ACYLOXYMETHYL ESTER; AMIDE; ANTINEOPLASTIC AGENT; CIPROFLOXACIN; ESTER DERIVATIVE; LEVOFLOXACIN; N BUTYL 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXAMIDE; N DECYL 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXAMIDE; N DODECYL 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXAMIDE; N HEPTYL 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXAMIDE; N HEXYL 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXAMIDE; N OCTYL 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXAMIDE; N PENTADECYL 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXAMIDE; N TETRADECYL 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYL 1 PIPERAZINYL) 7 OXO PYRIDO [1,2,3 DE] 1,4 BENZOXAZINE 6 CARBOXAMIDE; NALIDIXIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN;

AMIDES; ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CARBOXYLIC ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; ESTERS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; OFLOXACIN;

EID: 78649446487     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.10.039     Document Type: Article

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