메뉴 건너뛰기




Volumn , Issue , 2008, Pages 317-368

Pharmacogenomics in Alzheimer's disease

Author keywords

ACE; Alzheimer's disease; anxiety; APOE; cholinesterase inhibitors; cognition; combination therapy; CYP2D6; genetics; genomics; pharmacogenetics; pharmacogenomics

Indexed keywords

ADRENERGIC RECEPTOR AFFECTING AGENT; AMYLOID; APOLIPOPROTEIN E4; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; BETA SECRETASE INHIBITOR; CASPASE INHIBITOR; CHOLINESTERASE INHIBITOR; CITICOLINE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450 2D6; DONEPEZIL; DOPAMINE UPTAKE INHIBITOR; GALANTAMINE; GAMMA SECRETASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; HISTAMINE H3 RECEPTOR ANTAGONIST; MEMANTINE; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NICERGOLINE; NICOTINIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRACETAM; PSYCHOTROPIC AGENT; RIVASTIGMINE; SEROTONIN AGONIST; TACRINE; UNINDEXED DRUG;

EID: 78649395252     PISSN: 15572153     EISSN: 19406053     Source Type: Book Series    
DOI: 10.1007/978-1-59745-439-1_16     Document Type: Review
Times cited : (8)

References (115)
  • 1
    • 0033850870 scopus 로고    scopus 로고
    • Pharmacological treatment of Alzheimer disease: From psychotropic drugs and cholinesterase inhibitors to pharmacogenomics
    • Cacabelos R, Alvarez XA, Lombardi V et al. Pharmacological treatment of Alzheimer disease: from psychotropic drugs and cholinesterase inhibitors to pharmacogenomics. Drugs Today 2000;36:415-99.
    • (2000) Drugs. Today , vol.36 , pp. 415-499
    • Cacabelos, R.1    Alvarez, X.A.2    Lombardi, V.3
  • 2
    • 36849045117 scopus 로고    scopus 로고
    • Cholinesterases in the human brain: The effect of cholinesterase inhibitors on alzheimers disease and related disorders brain cholinergic system in health and disease
    • Giacobini E, Pepeu G (ed). Oxford
    • Giacobini E. Cholinesterases in the human brain: the effect of cholinesterase inhibitors on Alzheimer's disease and related disorders. In: Giacobini E, Pepeu G (ed). The brain cholinergic system in health and disease. Informa Healthcare, Oxford, 2006 pp 235-64.
    • (2006) Informa. Healthcare , pp. 235-264
    • Giacobini, E.1
  • 3
    • 33644658662 scopus 로고    scopus 로고
    • The clinical and cost-effectiveness of donepezil rivastigmine galantamine, nd memantine for alzheimers disease
    • Loveman E, Green C, Kirby J, et al. The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine, and memantine for Alzheimer's disease. Health Technl Assess 2006;10:1-176.
    • (2006) Health Technl. Assess , vol.10 , pp. 1-176
    • Loveman, E.1    Green, C.2    Kirby, J.3
  • 5
    • 0141851356 scopus 로고    scopus 로고
    • The application of functional genomics to alzheimers disease
    • Cacabelos R. The application of functional genomics to Alzheimer's disease. Pharmacogenomics 2003;4:597-621.
    • (2003) Pharmacogenomics , vol.4 , pp. 597-621
    • Cacabelos, R.1
  • 7
    • 0036484691 scopus 로고    scopus 로고
    • Pharmacogenomics in Alzheimer's disease
    • Cacabelos R. Pharmacogenomics in Alzheimer's disease. Min Rev Med Chem 2002;2:59-84.
    • (2002) Min. Rev. Med. Chem. , vol.2 , pp. 59-84
    • Cacabelos, R.1
  • 8
    • 0036434139 scopus 로고    scopus 로고
    • Pharmacogenomics for the treatment of dementia
    • Cacabelos R. Pharmacogenomics for the treatment of dementia. Ann Med 2002;34:357-79.
    • (2002) Ann. Med. , vol.34 , pp. 357-379
    • Cacabelos, R.1
  • 9
    • 4344684441 scopus 로고    scopus 로고
    • Pharmacogenetics and drug development: The path to safer and more effective drugs
    • Roses AD. Pharmacogenetics and drug development: the path to safer and more effective drugs. Nature Rev Genet 2004;5:645-56.
    • (2004) Nature Rev. Genet. , vol.5 , pp. 645-656
    • Roses, A.D.1
  • 10
    • 27744539497 scopus 로고    scopus 로고
    • Pharmacogenomics and therapeutic prospects in alzheimers disease
    • Cacabelos R. Pharmacogenomics and therapeutic prospects in Alzheimer's disease. Exp Opin Pharmacother 2005;6:1967-87.
    • (2005) Exp. Opin. Pharmacother. , vol.6 , pp. 1967-1987
    • Cacabelos, R.1
  • 11
    • 33751001487 scopus 로고    scopus 로고
    • Pharmacogenomics nutrigenomics and therapeutic optimization in alzheimers disease
    • Cacabelos R. Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer's disease. Aging Health 2005;1:303-48.
    • (2005) Aging Health , vol.1 , pp. 303-348
    • Cacabelos, R.1
  • 12
    • 34547698605 scopus 로고    scopus 로고
    • Pharmacogenomics nutrigenomics and future therapeutics in alzheimers disease
    • Suppl B):
    • Cacabelos R, Takeda M. Pharmacogenomics, nutrigenomics and future therapeutics in Alzheimer's disease. Drugs Future 2006;31(Suppl B):5-146.
    • (2006) Drugs Future , vol.31 , pp. 5-146
    • Cacabelos, R.1    Takeda, M.2
  • 14
    • 1542269164 scopus 로고    scopus 로고
    • The impact of the completed human genome sequence on the development of novel therapeutics for human disease
    • Austin CP. The impact of the completed human genome sequence on the development of novel therapeutics for human disease. Annu Rev Med 2004;55:1-13.
    • (2004) Annu. Rev. Med. , vol.55 , pp. 1-13
    • Austin, C.P.1
  • 16
    • 17444382678 scopus 로고    scopus 로고
    • National estimates of medication use in nursing homes: Findings from 1997 medicare current beneficiary survey and the 1996 medical expenditure survey
    • Doshi JA, Shaffer T, Briesacher BA. National estimates of medication use in nursing homes: findings from 1997 Medicare current beneficiary survey and the 1996 medical expenditure survey. J Am Geriatr Soc 2005;53:438-43.
    • J. Am. Geriatr. Soc. , vol.2005 , Issue.53 , pp. 438-443
    • Doshi, J.A.1    Shaffer, T.2    Briesacher, B.A.3
  • 17
    • 20044362718 scopus 로고    scopus 로고
    • Potentially inappropriate medication use among elderly home care patients in Europe
    • Fialová D, Topinková E, Gambassi G, et al. Potentially inappropriate medication use among elderly home care patients in Europe. JAMA 2005;293:1348-58.
    • (2005) JAMA , vol.293 , pp. 1348-1358
    • Fialová, D.1    Topinková, E.2    Gambassi, G.3
  • 18
    • 15044340359 scopus 로고    scopus 로고
    • Potentially inappropriate medication use by elderly persons in U S health maintenance organizations 2000-2001
    • Simon SR, Chan KA, Soumerai SB, et al. Potentially inappropriate medication use by elderly persons in U.S. health maintenance organizations, 2000-2001. J Am Geriatr Soc 2005;53:227-32.
    • (2005) J. Am. Geriatr. Soc. , vol.53 , pp. 227-232
    • Simon, S.R.1    Chan, K.A.2    Soumerai, S.B.3
  • 19
    • 33750332747 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics: Development science and translation
    • Weinshilboum RM, Wang L. Pharmacogenetics and pharmacogenomics: development, science, and translation. Annu Rev Genomics Hum Genet 2006;7:223-45.
    • (2006) Annu. Rev. Genomics. Hum. Genet. , vol.7 , pp. 223-245
    • Weinshilboum, R.M.1    Wang, L.2
  • 20
    • 78649425019 scopus 로고    scopus 로고
    • http://www.ncbi.nlm.nih.gov/OMIM
  • 21
    • 78649403440 scopus 로고    scopus 로고
    • www.molgen.ua.ac.be/ADMutations/
  • 23
    • 34547774739 scopus 로고    scopus 로고
    • Functional genomics and pharmacogenetics in alzheimers disease
    • Recent progress in Alzheimer's and Parkinson's disease. Hanin I, Cacabelos R, Fisher A. (eds, London
    • Cacabelos R, Kubota Y, Isaza C, et al. Functional genomics and pharmacogenetics in Alzheimer's disease. In: Recent progress in Alzheimer's and Parkinson's disease. Hanin I, Cacabelos R, Fisher A. (eds) Taylor & Francis, London, 2005 pp 89-102.
    • (2005) Taylor & Francis , pp. 89-102
    • Cacabelos, R.1    Kubota, Y.2    Isaza, C.3
  • 24
    • 78649427206 scopus 로고    scopus 로고
    • www.mitomap.org/
  • 25
    • 15944383403 scopus 로고    scopus 로고
    • Gene-environment interactions in human diseases
    • Hunter DJ. Gene-environment interactions in human diseases. Nature Rev Genet 2005;6:287-98.
    • (2005) Nature Rev. Genet. , vol.6 , pp. 287-298
    • Hunter, D.J.1
  • 26
    • 4544233053 scopus 로고    scopus 로고
    • Calibans heritance and the genetics of neuronal aging
    • Teter B, Finch CE. Caliban's heritance and the genetics of neuronal aging. Trends Neurosci 2004;27:627-32.
    • (2004) Trends Neurosci. , vol.27 , pp. 627-632
    • Teter, B.1    Finch, C.E.2
  • 28
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein presenilins and a-synuclein: Molecular pahogenesis and pharmacological applications in alzheimers disease
    • Suh Y-H, Checler F. Amyloid precursor protein, presenilins, and a-synuclein: Molecular pahogenesis and pharmacological applications in Alzheimer's disease. Phamacol Rev 2002;54:469-525.
    • (2002) Phamacol. Rev. , vol.54 , pp. 469-525
    • Suh, Y.-H.1    Checler, F.2
  • 33
    • 0041385937 scopus 로고    scopus 로고
    • Cerebrovascular risk factors in alzheimers disease: Brain hemodynamics and pharmacogenomic implications
    • Cacabelos R, Fernández-Novoa L, Lombardi V, Corzo L, Pichel V, Kubota Y. Cerebrovascular risk factors in Alzheimer's disease: brain hemodynamics and pharmacogenomic implications. Neurol Res 2003;25:567-80.
    • (2003) Neurol. Res. , vol.25 , pp. 567-580
    • Cacabelos, R.1    Fernández-Novoa, L.2    Lombardi, V.3    Corzo, L.4    Pichel, V.5    Kubota, Y.6
  • 34
    • 3042846712 scopus 로고    scopus 로고
    • Phenotypic profiles and functional genomics in dementia with a vascular component
    • Cacabelos R, Fernández-Novoa L, Corzo L, et al. Phenotypic profiles and functional genomics in dementia with a vascular component. Neurol Res 2004;26:459-80.
    • (2004) Neurol. Res. , vol.26 , pp. 459-480
    • Cacabelos, R.1    Fernández-Novoa, L.2    Corzo, L.3
  • 35
    • 3042822718 scopus 로고    scopus 로고
    • A functional genomics approach to the analysis of biological markers in alzheimer disease
    • Takeda M, Tanaka T, Cacabelos R (eds). Karger, Basel
    • Cacabelos R, Lombardi V, Fernández-Novoa L, et al. A functional genomics approach to the analysis of biological markers in Alzheimer disease. In: Molecular neurobiology of Alzheimer disease and related disorders. Takeda M, Tanaka T, Cacabelos R (eds). Karger, Basel, 2004 pp 236-85.
    • (2004) Molecular Neurobiology of Alzheimer Disease and Related Disorders , pp. 236-285
    • Cacabelos, R.1    Lombardi, V.2    Fernández-Novoa, L.3
  • 36
    • 11044230530 scopus 로고    scopus 로고
    • Genomic characterization of Alzheimers disease and genotype-related phenotypic analysis of biological markers in dementia
    • Cacabelos R. Genomic characterization of Alzheimer's disease and genotype-related phenotypic analysis of biological markers in dementia. Pharmacogenomics 2004;5:1049-105.
    • (2004) Pharmacogenomics , vol.5 , pp. 1049-1105
    • Cacabelos, R.1
  • 38
    • 0041864420 scopus 로고    scopus 로고
    • Mapping Progress of Alzheimers and Parkinsons diseases Advances in behavioral biology Mizuno Y, Fisher A, Hanin I (eds). Pergamon Press, New York
    • Cacabelos R. The histamine-cytokine network in Alzheimer disease: Etiopathogenic and pharmacogenomic implications. In: Mapping Progress of Alzheimer's and Parkinson's diseases. Advances in behavioral biology, vol. 51. Mizuno Y, Fisher A, Hanin I (eds). Pergamon Press, New York, 2002 pp 59-64.
    • (2002) The histamine-cytokine network in Alzheimer disease: Etiopathogenic and pharmacogenomic implications , vol.51 , pp. 59-64
    • Cacabelos, R.1
  • 40
    • 4544246618 scopus 로고    scopus 로고
    • Comparison studies of cholinesterase inhibitors for Alzheimers disease
    • Hogan DB, Goldlist B, Naglie G, Patterson C. Comparison studies of cholinesterase inhibitors for Alzheimer''s disease. Lancet Neurol 2004;3:622-8.
    • (2004) Lancet Neurol. , vol.3 , pp. 622-628
    • Hogan, D.B.1    Goldlist, B.2    Naglie, G.3    Patterson, C.4
  • 42
    • 33947712556 scopus 로고    scopus 로고
    • Clinical proteomics: Present and future prospects
    • Verrils NM. Clinical proteomics: present and future prospects. Clin Biochem Rev 2006;27:99-116.
    • (2006) Clin. Biochem. Rev. , vol.27 , pp. 99-116
    • Verrils, N.M.1
  • 43
    • 4344574336 scopus 로고    scopus 로고
    • Pharmacogenetics-five decades of therapeutic lessons from genetic diversity
    • Meyer UA. Pharmacogenetics-five decades of therapeutic lessons from genetic diversity. Nature Rev Genet 2004;5:669-76.
    • (2004) Nature Rev. Genet. , vol.5 , pp. 669-676
    • Meyer, U.A.1
  • 45
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics-drug disposition drug targets and side effects
    • Evans WE, McLeod HL. Pharmacogenomics-drug disposition, drug targets, and side effects. N Engl J Med 2003;348:538-49.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 46
    • 0035749505 scopus 로고    scopus 로고
    • Pharmacogenetics for the individualization of psychiatric treatment
    • Arranz MJ, Collier D, Kerwin RW. Pharmacogenetics for the individualization of psychiatric treatment. Am J Pharmacogenomics 2001;1:3-10.
    • (2001) Am. J. Pharmacogenomics , vol.1 , pp. 3-10
    • Arranz, M.J.1    Collier, D.2    Kerwin, R.W.3
  • 47
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium.
    • International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 2004;431:931-45.
    • (2004) Nature , vol.431 , pp. 931-945
  • 48
    • 12844274439 scopus 로고    scopus 로고
    • Pharmacological treatment of neuropsychiatric symptoms of dementia: A review of the evidence
    • DOI 10.1001/jama.293.5.596
    • Sink KM, Holden KF, Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia. A review of the evidence. JAMA 2005;293:596-608. (Pubitemid 40171242)
    • (2005) Journal of the American Medical Association , vol.293 , Issue.5 , pp. 596-608
    • Sink, K.M.1    Holden, K.F.2    Yaffe, K.3
  • 50
    • 0038647390 scopus 로고    scopus 로고
    • Catalog of 680 variants among eight cytochrome P450 CYP genes nine esterase genes, and two other genes in the Japanese population
    • Saito S, Ishida A, Sekine A, et al. Catalog of 680 variants among eight cytochrome P450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. J Hum Genet 2003;48:249-70.
    • (2003) J. Hum. Genet. , vol.48 , pp. 249-270
    • Saito, S.1    Ishida, A.2    Sekine, A.3
  • 51
    • 33750503415 scopus 로고    scopus 로고
    • Drug discovery in dementia: The role of rodent models
    • Van Dam D, De Deyn PP. Drug discovery in dementia: the role of rodent models. Nature Rev Drug Discov 2006;5:956-70.
    • (2006) Nature Rev. Drug. Discov. , vol.5 , pp. 956-970
    • Van Dam, D.1    De Deyn, P.P.2
  • 52
    • 0036724899 scopus 로고    scopus 로고
    • DNA sequence variations in a 3.7-kb noncoding sequence 5-prime of the CYP1A2 gene: Implications for human population history and natural selection
    • Wooding SP, Watkins WS, Bamshad MJ, et al. DNA sequence variations in a 3.7-kb noncoding sequence 5-prime of the CYP1A2 gene: implications for human population history and natural selection. Am J Hum Genet 2002;71:528-42.
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 528-542
    • Wooding, S.P.1    Watkins, W.S.2    Bamshad, M.J.3
  • 53
    • 0042357440 scopus 로고    scopus 로고
    • PM frequencies of major CYPs in Asians and caucasians
    • Mizutani T. PM frequencies of major CYPs in Asians and Caucasians. Drug Metab Rev 2003;35:99-106.
    • (2003) Drug. Metab. Rev. , vol.35 , pp. 99-106
    • Mizutani, T.1
  • 54
    • 0041410075 scopus 로고    scopus 로고
    • Polymorphisms of drug-metabolizing enzymes CYP2C9 CYP2C19 CYP2D6 CYP1A1 NAT2 and of P-glycoprotein in a Russian population
    • Gaikovitch EA, Cascorbi I, Mrozikiewicz PM, et al. Polymorphisms of drug-metabolizing enzymes CYP2C9;CYP2C19;CYP2D6;CYP1A1;NAT2 and of P-glycoprotein in a Russian population. Eur J Clin Pharmacol 2003;59:303-12.
    • (2003) Eur. J. Clin. Pharmacol. , vol.59 , pp. 303-312
    • Gaikovitch, E.A.1    Cascorbi, I.2    Mrozikiewicz, P.M.3
  • 55
    • 0037131892 scopus 로고    scopus 로고
    • CYP2C9 allelic variants: Ethnic ditribution and functional significance
    • Xie HG, Prasad HG, Kim RB, Stein CM. CYP2C9 allelic variants: ethnic ditribution and functional significance. Adv Drug Deliv Rev 2002;54:1257-70.
    • (2002) Adv. Drug. Deliv. Rev. , vol.54 , pp. 1257-1270
    • Xie, H.G.1    Prasad, H.G.2    Kim, R.B.3    Stein, C.M.4
  • 56
  • 57
    • 0034469337 scopus 로고    scopus 로고
    • Isolation sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population
    • Isaza CA, Henao J, López AM, Cacabelos R. Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population. Meth Find Exp Clin Pharmacol 2000;22:695-705.
    • (2000) Meth. Find. Exp. Clin. Pharmacol. , vol.22 , pp. 695-705
    • Isaza, C.A.1    Henao, J.2    López, A.M.3    Cacabelos, R.4
  • 58
    • 0037379409 scopus 로고    scopus 로고
    • Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    • Madan A, Graham RA, Carroll KM, et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos 2003;31:421-31.
    • (2003) Drug. Metab. Dispos. , vol.31 , pp. 421-431
    • Madan, A.1    Graham, R.A.2    Carroll, K.M.3
  • 59
    • 0037450436 scopus 로고    scopus 로고
    • The expression of CYP2B6 CYP2C9 and CYP2A4 genes: A tangle of networks of nuclear and steroid receptors
    • Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ. The expression of CYP2B6, CYP2C9, and CYP2A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 2003;1619:243-53.
    • (2003) Biochim. Biophys. Acta. , vol.1619 , pp. 243-253
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Drocourt, L.3    Maurel, P.4    Vilarem, M.J.5
  • 60
    • 0034655747 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 CYP genes by nuclear receptors
    • Honkakoski P, Negishi M. Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 2000;347:321-37.
    • (2000) Biochem. J. , vol.347 , pp. 321-337
    • Honkakoski, P.1    Negishi, M.2
  • 62
    • 78649418294 scopus 로고    scopus 로고
    • www.icgeb.org/
  • 63
    • 78649419640 scopus 로고    scopus 로고
    • www.imm.ki.se/CYPalleles/cyp2d6.htm
  • 64
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmoller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997;60:284-95.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 65
    • 0242403526 scopus 로고    scopus 로고
    • Clinically significant drug interactions with cholinesterase inhibitors: A guide for neurologists
    • Bentue-Ferrer D, Tribut O, Polard E, Allain H. Clinically significant drug interactions with cholinesterase inhibitors: a guide for neurologists. CNS Drugs 2003;17:947-63.
    • (2003) CNS Drugs , vol.17 , pp. 947-963
    • Bentue-Ferrer, D.1    Tribut, O.2    Polard, E.3    Allain, H.4
  • 66
    • 0031884233 scopus 로고    scopus 로고
    • Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
    • Griese E-U, Zanger UM, Brudermanns U, et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics 1998;8:15-26.
    • (1998) Pharmacogenetics , vol.8 , pp. 15-26
    • Griese, E.-U.1    Zanger, U.M.2    Brudermanns, U.3
  • 67
    • 0032718495 scopus 로고    scopus 로고
    • Ten percent of north Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine
    • Bernal ML, Sinues B, Johansson I, et al. Ten percent of north Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine. Pharmacogenetics 1999;9:657-60.
    • (1999) Pharmacogenetics , vol.9 , pp. 657-660
    • Bernal, M.L.1    Sinues, B.2    Johansson, I.3
  • 68
    • 34547775843 scopus 로고    scopus 로고
    • Molecular pathology and pharmacogenomics in Alzheimers disease: Polygenicrelated effects of multifactorial treatments on cognition anxiety and depression
    • Suppl. B):
    • Cacabelos R. Molecular pathology and pharmacogenomics in Alzheimer's disease: polygenicrelated effects of multifactorial treatments on cognition, anxiety, and depression. Meth Find Exper Clin Pharmacol 2007;29(Suppl. B):1-91.
    • (2007) Meth. Find. Exper. Clin. Pharmacol. , vol.29 , pp. 1-91
    • Cacabelos, R.1
  • 69
    • 32944461710 scopus 로고    scopus 로고
    • Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S population: Clinical implications
    • Bernard S, Neville KA, Nguyen AT, Flockhart DA. Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications. Oncologist 2006;11:126-35.
    • (2006) Oncologist , vol.11 , pp. 126-135
    • Bernard, S.1    Neville, K.A.2    Nguyen, A.T.3    Flockhart, D.A.4
  • 70
    • 0033790979 scopus 로고    scopus 로고
    • Zanger elucidation of the genetic basis of the common intermediate metabolizer phenotype for drug oxidation by CYP2D6
    • Raimundo S, Fischer J, Eichelbaum M, Griese EU, Schwab M, Zanger. Elucidation of the genetic basis of the common intermediate metabolizer phenotype for drug oxidation by CYP2D6. Pharmacogenetics 2000;10:577-81.
    • (2000) Pharmacogenetics , vol.10 , pp. 577-581
    • Raimundo, S.1    Fischer, J.2    Eichelbaum, M.3    Griese, E.U.4    Schwab, M.5
  • 73
    • 0029122803 scopus 로고
    • The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimers disease
    • Chen X, Xia Y, Alford M, et al. The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer''s disease. Ann Neurol 1995;38 :653-8.
    • (1995) Ann. Neurol. , vol.38 , pp. 653-658
    • Chen, X.1    Xia, Y.2    Alford, M.3
  • 74
    • 0033558071 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms in Alzheimers disease with and without extrapyramidal signs showing no apolipoprotein E epsilon 4 effect modification
    • Cervilla JA, Russ C, Holmes C, et al. CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification. Biol Psychiatry 1999;45:426-9.
    • (1999) Biol. Psychiatry , vol.45 , pp. 426-429
    • Cervilla, J.A.1    Russ, C.2    Holmes, C.3
  • 75
    • 0032918986 scopus 로고    scopus 로고
    • CYP2D6 is associated with parkinsons disease but not with dementia with lewy bodies or Alzheimers disease
    • Atkinson A, Singleton AB, Steward A, et al. CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy bodies or Alzheimer's disease. Pharmacogenetics 1999;9:31-5.
    • (1999) Pharmacogenetics , vol.9 , pp. 31-35
    • Atkinson, A.1    Singleton, A.B.2    Steward, A.3
  • 76
    • 0032740464 scopus 로고    scopus 로고
    • A study of five candidate genes in parkinsons disease and related neurodegenerative disorders
    • European Study Group on Atypical Parkinsonism
    • Nicholl DJ, Bennett P, Hiller L, et al. A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism. Neurology 1999;53:1415-21.
    • (1999) Neurology , vol.53 , pp. 1415-1421
    • Nicholl, D.J.1    Bennett, P.2    Hiller, L.3
  • 77
    • 0035432460 scopus 로고    scopus 로고
    • CYP2D64 polymorphism is not associated with parkinsons disease and has no protective role against Alzheimers disease in the korean population
    • Woo SI, Kim JW, Seo HG, et al. CYP2D64 polymorphism is not associated with Parkinson's disease and has no protective role against Alzheimer's disease in the Korean population. Psychiatry Clin Neurosci 2001;55 :373-7.
    • (2001) Psychiatry. Clin. Neurosci. , vol.55 , pp. 373-377
    • Woo, S.I.1    Kim, J.W.2    Seo, H.G.3
  • 78
    • 0035040634 scopus 로고    scopus 로고
    • No evidence of an association between cyp2d6 polymorphisms among japanese and dementia with lewy bodies
    • Furuno T, Kawanishi C, Iseki E, et al. No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies. Psychiatry Clin Neurosci 2001;55:89-92.
    • (2001) Psychiatry Clin. Neurosci. , vol.55 , pp. 89-92
    • Furuno, T.1    Kawanishi, C.2    Iseki, E.3
  • 79
    • 29344441249 scopus 로고    scopus 로고
    • No association between CYP2D6 polymorphisms and Alzheimers disease in an Italian population
    • Scordo MG, Dahl ML, Spina E, Cordici F, Arena MG. No association between CYP2D6 polymorphisms and Alzheimer's disease in an Italian population. Pharmacol Res 2006;53:162-5.
    • (2006) Pharmacol. Res. , vol.53 , pp. 162-165
    • Scordo, M.G.1    Dahl, M.L.2    Spina, E.3    Cordici, F.4    Arena, M.G.5
  • 80
    • 78649421992 scopus 로고    scopus 로고
    • Pleiotropic effects of APOE in dementia: Influence on functional genomics and Pharmacogenetics advances in Alzheimers and parkinsons disease
    • Fisher A, Memo M, Storchi F, Hanin I (eds Springer, Secaucus, NJ
    • Cacabelos R. Pleiotropic effects of APOE in dementia: influence on functional genomics and pharmacogenetics. In: Advances in Alzheimer's and Parkinson's disease. Insights, progress, and perspectives. Fisher A, Memo M, Storchi F, Hanin I (eds), Springer, Secaucus, NJ, 2007 pp 355-367.
    • (2007) Insights Progress and Perspectives , pp. 355-367
    • Cacabelos, R.1
  • 81
    • 33747888854 scopus 로고    scopus 로고
    • Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimers disease patients
    • Varsaldi F, Miglio G, Scordo MG, et al. Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients. Eur J Clin Pharmacol 2006;62:721-6.
    • (2006) Eur. J. Clin. Pharmacol. , vol.62 , pp. 721-726
    • Varsaldi, F.1    Miglio, G.2    Scordo, M.G.3
  • 82
    • 33750495840 scopus 로고    scopus 로고
    • Prevalence of potentially inappropriate medication use in elderly patients comparison between general medicine and geriatric wards
    • Egger SS, Bachmann A, Hubmann N, Schlienger RG, Krähenbudie;hl S. Prevalence of potentially inappropriate medication use in elderly patients. Comparison between general medicine and geriatric wards. Drugs Aging 2006;23:823-37.
    • (2006) Drugs Aging , vol.23 , pp. 823-837
    • Egger, S.S.1    Bachmann, A.2    Hubmann, N.3    Schlienger, R.G.4    Krähenbudie5    hl, S.6
  • 83
    • 10044288943 scopus 로고    scopus 로고
    • PharGKB update: II CYP3A5 cytochrome P450 family 3 subfamily A polypeptide 5
    • Schuetz EG, Relling MV, Kishi S, et al. PharGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5. Pharmacol Rev 2004;56:159.
    • (2004) Pharmacol. Rev. , vol.56 , pp. 159
    • Schuetz, E.G.1    Relling, M.V.2    Kishi, S.3
  • 84
    • 0007691164 scopus 로고
    • Apolipoprotein E4 allele as a predictor of cholinergic deficits treatment outcome in Alzheimer disease
    • Poirier J, Delisle M-C, Quirion R, et al. Apolipoprotein E4 allele as a predictor of cholinergic deficits treatment outcome in Alzheimer disease. Proc Natl Acad Sci U S A 1995;92:12260.4.
    • (1995) Proc. Natl. Acad. Sci. U S A , vol.92 , pp. 12260-12264
    • Poirier, J.1    Delisle, M.-C.2    Quirion, R.3
  • 85
    • 0032921441 scopus 로고    scopus 로고
    • Apolipoprotein E4; Cholinergic integrity and the pharmacogenetics of Alzheimerfs disease
    • Poirier J. Apolipoprotein E4; cholinergic integrity and the pharmacogenetics of Alzheimerfs disease. J Psychiat Neurosci 1999;24:147.53.
    • (1999) J. Psychiat. Neurosci. , vol.24 , pp. 147-153
    • Poirier, J.1
  • 86
    • 0035189162 scopus 로고    scopus 로고
    • Responder characteristics to a single oral dose of cholinesterase inhibitor: A double-blind placebo-controlled study with tacrine in Alzheimer patients
    • Almkvist O, Jelic V, Amberla K, Hellstrom-Lindahl E, Meurling L, Nordberg A. Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. Dement Geriatr Cogn Disord 2001;12:22.32.
    • (2001) Dement. Geriatr. Cogn. Disord. , vol.12 , pp. 22-32
    • Almkvist, O.1    Jelic, V.2    Amberla, K.3    Hellstrom-Lindahl, E.4    Meurling, L.5    Nordberg, A.6
  • 87
    • 0034901335 scopus 로고    scopus 로고
    • Tacrine and rate of progression in Alzheimerfs disease relation to ApoE allele genotype
    • Sjogren M, Hesse C, Basun H, et al. Tacrine and rate of progression in Alzheimerfs disease. relation to ApoE allele genotype. J Neural Transm 2001;108:451.8.
    • (2001) J. Neural. Transm. , vol.108 , pp. 451-458
    • Sjogren, M.1    Hesse, C.2    Basun, H.3
  • 88
    • 0036253645 scopus 로고    scopus 로고
    • ApoE genotype influences the biological effects of donepezil on APP metabolism in Alzheimer disease: Evidence from a peripheral model
    • Borroni B, Colciaghi F, Pastorino L, et al. ApoE genotype influences the biological effects of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model. Eur Neuropsychopharmacol 2002;12:195.200.
    • (2002) Eur. Neuropsychopharmacol. , vol.12 , pp. 195-200
    • Borroni, B.1    Colciaghi, F.2    Pastorino, L.3
  • 90
    • 0034720816 scopus 로고    scopus 로고
    • Galantamine in AD: A 6-month randomized placebo-controlled trial with a 6-month extension
    • The Galantamine USA-1 Study Group
    • Raskind MA, Peskind ER, Wessel T, Yuan W. Galantamine in AD: a 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group. Neurology 2000;54:2261.2268.
    • (2000) Neurology , vol.54 , pp. 2261-2268
    • Raskind, M.A.1    Peskind, E.R.2    Wessel, T.3    Yuan, W.4
  • 91
    • 33745266146 scopus 로고    scopus 로고
    • Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimerfs disease
    • Risner ME, Saunders AM, Altman JF, et al. Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimerfs disease. Pharmacogenomics 2006;6:246.54.
    • (2006) Pharmacogenomics , vol.6 , pp. 246-254
    • Risner, M.E.1    Saunders, A.M.2    Altman, J.F.3
  • 92
    • 0031657809 scopus 로고    scopus 로고
    • Effect of gender and apolipoprotein E genotype on response to anticholinesterase therapy in Alzheimerfs disease
    • MacGowan SH, Wilcock GK, Scott M. Effect of gender and apolipoprotein E genotype on response to anticholinesterase therapy in Alzheimerfs disease. Int J Geriatr Psychiatry 1998;13:625.30.
    • (1998) Int. J. Geriatr. Psychiatry , vol.13 , pp. 625-630
    • MacGowan, S.H.1    Wilcock, G.K.2    Scott, M.3
  • 93
    • 0034351513 scopus 로고    scopus 로고
    • The apolipoprotein E epsilon 4 allele and the response to tacrine therapy in Alzheimerfs disease
    • Rigaud AS, Traykov L, Caputo L, et al. The apolipoprotein E epsilon 4 allele and the response to tacrine therapy in Alzheimerfs disease. Eur J Neurol 2000;7 :255.8.
    • (2000) Eur. J. Neurol. , vol.7 , pp. 255-258
    • Rigaud, A.S.1    Traykov, L.2    Caputo, L.3
  • 94
    • 0036021007 scopus 로고    scopus 로고
    • Presence of absence of least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimerfs disease
    • Rigaud AS, Traykov L, Latour F, et al. Presence of absence of least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimerfs disease. Pharmacogenetics 2002;12:415.20.
    • (2002) Pharmacogenetics , vol.12 , pp. 415-420
    • Rigaud, A.S.1    Traykov, L.2    Latour, F.3
  • 95
    • 20344381835 scopus 로고    scopus 로고
    • Vitamin E and donepezil for the treatment of mild cognitive impairment
    • Petersen RC, Thomas RG, Grundman M, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005;352:2379.88.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3
  • 96
    • 24744458338 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon-4 allele differentiates the clinical response to donepezil in Alzheimerfs disease
    • Bizzarro A, Marra C, Acciarri A, et al. Apolipoprotein E epsilon-4 allele differentiates the clinical response to donepezil in Alzheimerfs disease. Dement Geriatr Cogn Disord 2005;20:254.61.
    • (2005) Dement. Geriatr. Cogn. Disord. , vol.20 , pp. 254-261
    • Bizzarro, A.1    Marra, C.2    Acciarri, A.3
  • 97
    • 0033403796 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimerfs disease patients effects on cognitive performance brain bioelectrical activity and cerebral perfusion
    • Alvarez XA, Mouzo R, Pichel V, et al. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimerfs disease patients. Effects on cognitive performance, brain bioelectrical activity, and cerebral perfusion. Meth Find Exp Clin Pharmacol 1999;21:633.44.
    • (1999) Meth. Find. Exp. Clin. Pharmacol. , vol.21 , pp. 633-644
    • Alvarez, X.A.1    Mouzo, R.2    Pichel, V.3
  • 98
    • 0034525674 scopus 로고    scopus 로고
    • Double-blind randomized placebo-controlled pilot study with anapsos in senile dementia: Effects on cognition brain bioelectrical activity and cerebral hemodynamics
    • Alvarez XA, Pichel V, Perez PA, et al. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics. Meth Find Exp Clin Pharmacol 2000;22:585.94.
    • (2000) Meth. Find. Exp. Clin. Pharmacol. , vol.22 , pp. 585-594
    • Alvarez, X.A.1    Pichel, V.2    Perez, P.A.3
  • 99
    • 0034718159 scopus 로고    scopus 로고
    • The role of apolipoprotein E in alzheimerfs disease: Pharmacogenomic target selection
    • Saunders A.M. Trowers M.K. Shimkets R.A. et al.
    • Saunders AM, Trowers MK, Shimkets RA, et al. The role of apolipoprotein E in Alzheimerfs disease: pharmacogenomic target selection. Biochem Biophys Acta 2000;1502:85.94.
    • (2000) Biochem. Biophys. Acta. , vol.1502 , pp. 85-94
  • 101
    • 0035930538 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide Aβ; Retards Aβ aggregation deposition fibril formation; And inhibits cytotoxicity
    • Hu J, Igarashi A, Kamata M, Nakagawa H. Angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide (Aβ); retards Aβ aggregation, deposition, fibril formation; and inhibits cytotoxicity. J Biol Chem 2001;276:47863.8.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47863-47868
    • Hu, J.1    Igarashi, A.2    Kamata, M.3    Nakagawa, H.4
  • 102
    • 14944340658 scopus 로고    scopus 로고
    • The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide
    • Oba R, Igarashi A, Kamata M, Nagata K, Takano S, Nakagawa H. The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide. Eur J Neurosci 2005;21:733.40.
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 733-740
    • Oba, R.1    Igarashi, A.2    Kamata, M.3    Nagata, K.4    Takano, S.5    Nakagawa, H.6
  • 103
    • 33750047859 scopus 로고    scopus 로고
    • Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme
    • Eckman EA, Adams SK, Troendle FJ, et al. Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme. J Biol Chem 2006;281:30471-8.
    • (2006) J. Biol. Chem. , vol.281 , pp. 30471-30478
    • Eckman, E.A.1    Adams, S.K.2    Troendle, F.J.3
  • 104
    • 27844534846 scopus 로고    scopus 로고
    • Amyloid β-protein is degraded by cellular angiotensin-converting enzyme ACE and elevated by an ACE inhibitor
    • Hemming ML, Selkoe DJ. Amyloid β-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. J Biol Chem 2005;280:37644-50.
    • (2005) J. Biol. Chem. , vol.280 , pp. 37644-376450
    • Hemming, M.L.1    Selkoe, D.J.2
  • 105
    • 33646131838 scopus 로고    scopus 로고
    • Signaling by the angiotensin-converting enzyme
    • Fleming I. Signaling by the angiotensin-converting enzyme. Circ Res 2006;98:887-96.
    • (2006) Circ. Res. , vol.98 , pp. 887-896
    • Fleming, I.1
  • 106
    • 33750352319 scopus 로고    scopus 로고
    • Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression ACE activity and hypercortisolism
    • Baghai TC, Binder EB, Schule C, et al. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Mol Psychiatry 2006;11:1003-15.
    • (2006) Mol. Psychiatry , vol.11 , pp. 1003-1015
    • Baghai, T.C.1    Binder, E.B.2    Schule, C.3
  • 107
    • 31544460107 scopus 로고    scopus 로고
    • Differences in anxiety-related behaviour between apolipoprotein E-deficient C57BL/6 and wild type C57BL/6 mice
    • McLachlan CS, Yi Xing Soh C. Differences in anxiety-related behaviour between apolipoprotein E-deficient C57BL/6 and wild type C57BL/6 mice. Physiol Res 2005;54 :701-4.
    • (2005) Physiol. Res. , vol.54 , pp. 701-704
    • McLachlan, C.S.1    Yi Xing Soh, C.2
  • 108
    • 0034965373 scopus 로고    scopus 로고
    • Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression
    • Nebes RD, Vora IJ, Meltzer CC, et al. Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression. Am J Psychiatry 2001;158:878-84.
    • (2001) Am. J. Psychiatry. , vol.158 , pp. 878-884
    • Nebes, R.D.1    Vora, I.J.2    Meltzer, C.C.3
  • 109
    • 0036895715 scopus 로고    scopus 로고
    • Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older persons with depression
    • Naismith S, Hickie I, Ward PB, et al. Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older persons with depression. Am J Psychiatry 2002;159:2096-8.
    • (2002) Am. J. Psychiatry , vol.159 , pp. 2096-2098
    • Naismith, S.1    Hickie, I.2    Ward, P.B.3
  • 110
    • 2642512671 scopus 로고    scopus 로고
    • A longitudinal study of hippocampal volume, cortisol levels and cognition in older depressed subjects
    • O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N. A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. Am J Psychiatry 2004;161:2081-90.
    • (2004) Am. J. Psychiatry , vol.161 , pp. 2081-2090
    • O'Brien, J.T.1    Lloyd, A.2    McKeith, I.3    Gholkar, A.4    Ferrier, N.5
  • 111
    • 14844322379 scopus 로고    scopus 로고
    • Reduced hippocampal volumes and memory loss in patients with early-and late-onset depression
    • Hickie I, Naismith S, Ward PB, et al. Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression. Br J Psychiatry 2005;186:197-202.
    • (2005) Br. J. Psychiatry , vol.186 , pp. 197-202
    • Hickie, I.1    Naismith, S.2    Ward, P.B.3
  • 112
    • 4043095455 scopus 로고    scopus 로고
    • Vascular/risk and late-life depression in a Korean community population
    • Kim JM, Stewart R, Shin IS, Yoon JS. Vascular/risk and late-life depression in a Korean community population. Br J Psychiatry 2004;185:102-7.
    • (2004) Br. J. Psychiatry , vol.185 , pp. 102-107
    • Kim, J.M.1    Stewart, R.2    Shin, I.S.3    Yoon, J.S.4
  • 115
    • 22844448777 scopus 로고    scopus 로고
    • Priorities and standards in pharmacogenetic research
    • Need AC, Motulsky AG, Goldstein DB. Priorities and standards in pharmacogenetic research. Nature Genet 2005;37:671-81.
    • (2005) Nature Genet. , vol.37 , pp. 671-681
    • Need, A.C.1    Motulsky, A.G.2    Goldstein, D.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.