Prevention of iron deficiency in infancy, childhood and adolescence

Annales Nestle

Volumn 68, Issue 3, 2010, Pages 120-131

  Andersson, Maria ^a   Hurrell, Richard F ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Aadolescents; Children; Complementary food; Infant formula; Infants; Iron deficiency; Iron fortification; Iron supplementation

Indexed keywords

IRON;

BIOAVAILABILITY; CHILD NUTRITION; DIETARY REFERENCE INTAKE; HUMAN; INTERVENTION STUDY; IRON ABSORPTION; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON INTAKE; IRON THERAPY; MATERNAL WELFARE; NUTRITIONAL ASSESSMENT; NUTRITIONAL REQUIREMENT; PREVENTIVE MEDICINE; REVIEW;

EID: 78649242966     PISSN: 05178606     EISSN: 16614011     Source Type: Journal    
DOI: 10.1159/000319967     Document Type: Review

References (127)

1. National Academy of Sciences, Institute of Medicine, Food and Nutrition Board: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, National Academy Press, 2002.
2. Zimmermann MB, Hurrell RF: Nutritional iron def icienc y. Lancet 2007;370:511-520.
3. World Health Organization, Food and Agriculture Organization: Vitamin and Mineral Requirements in Human Nutrition, ed 2. Geneva, World Health Organization, 2004.
4. Cook JD: Diagnosis and management of iron-deficiency anaemia. Best Pract Res Clin Haematol 2005;18:319-332.
5. McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B: Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993-2005. Public Health Nutr 2009;12:444-454.
6. Grantham-McGregor SM, Baker-Henningham H: Iron deficiency in childhood: causes and consequences for child development. Ann Nestlé Engl 2010;68:105-119.
7. Lynch S, Stoltzfus R, Rawat R: Critical review of strategies to prevent and control iron deficiency in children. Food Nutr Bull 2007;28:S610-S620.
8. Lozoff B: Iron deficiency and child development. Food Nutr Bull 2007;28:S560-S571.
9. World Health Organization, United Nations Children's Fund, United Nations University: Iron Deficiency Anaemia. Assessment, Prevention, and Control. A Guide for Programme Managers. WHO/NHD/01.3. Geneva, World Health Organization, 2001.
10. Oski FA: Iron deficiency in infancy and childhood. N Engl J Med 1993;329:190-193.
11. Lönnerdal B, Hernell O: Homeostatic regulation of iron and its role in normal and abnormal iron status in infancy and childhood. A nn Nestlé Engl 2010;68:96-104.
12. World Health Organization, United Nations Children's Fund: Global Strategy for Infant and Young Child Feeding. Geneva, World Health Organization, 2003.
13. Gartner LM, Morton J, Lawrence RA, Naylor AJ, O'Hare D, Schanler RJ, Eidelman AI: Breastfeeding and the use of human milk. Pediatrics 2005;115:496-506.
14. Agostoni C, Decsi T, Fewtrell M, Goulet O, Kolacek S, Koletzko B, Michaelsen KF, Moreno L, Puntis J, Rigo J, Shamir R, Szajewska H, Turck D, van Goudoever J: Complementary feeding: a commentary by the ESP-GHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2008;46:99-110.
15. Committee on Nutrition. American Academy of Pediatrics: Iron fortification of infant formulas. Pediatrics 1999;104:119-123.
16. Koletzko B, Baker S, Cleghorn G, Neto UF, Gopalan S, Hernell O, Hock QS, Jirapinyo P, Lonnerdal B, Pencharz P, Pzyrembel H, Ramirez-Mayans J, Shamir R, Turck D, Yamashiro Y, Zong-Yi D: Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group. J Pediatr Gastroenterol Nutr 2005;41:584-599.
17. World Health Organization: Feeding the Non-Breastfed Child 6-24 Months of Age. Meeting Report, Geneva, Switzerland, 8-10 March 2004. Geneva, World Health Organization, 2004.
18. Dewey KG, Chaparro CM: Session 4: mineral metabolism and body composition iron status of breast-fed infants. Proc Nutr Soc 2007;66:412-422.
19. Dewey KG: Increasing iron intake of children through complementary foods. Food Nutr Bull 2007;28:S595-S609.
20. Gibson RS, Hotz C: The adequacy of micronutrients in complementary foods. Pediatrics 2000;106:1298-1299.
21. Lutter CK, Rivera JA: Nutritional status of infants and young children and characteristics of t heir diets. J Nutr 2003;133:2941S-2949S.
22. World Health Organization: Complementary Feeding: Report of the Global Consultation. Summary of Guiding Principles for Complementary Feeding of the Breastfed Child. Geneva, World Health Organization, 2003.
23. American Academy of Pediatrics Committee on Nutrition: The use of whole cow's milk in infancy. Pediatrics 1992;89:1105-1109.
24. Gidding SS, Dennison BA, Birch LL, Daniels SR, Gillman MW, Lichtenstein AH, Rattay KT, Steinberger J, Stettler N, Van Horn L: Dietary recommendations for children and adolescents: a guide for practitioners: consensus statement from the American Heart Association. Circulation 2005;112:2061-2075.
25. Chantry CJ, Howard CR, Auinger P: Full breastfeeding duration and risk for iron deficiency in US Infants. Breastfeed Med 2007;2:63-73.
26. Fewtrell MS, Morgan JB, Duggan C, Gunnlaugsson G, Hibberd PL, Lucas A, Kleinman RE: Optimal duration of exclusive breastfeeding: what is the evidence to support current recommendations? Am J Clin Nutr 2007;85:635S-638S.
27. Lanigan JA, Bishop JA, Kimber AC, Morgan J: Systematic rev iew concerni ng t he age of introduction of complementary foods to the healthy full-term infant. Eur J Clin Nutr 2001;55:309-320.
28. Yang Z, Lonnerdal B, Adu-Afarwuah S, Brown KH, Chaparro CM, Cohen RJ, Domellof M, Hernell O, Lartey A, Dewey KG: Prevalence and predictors of iron deficiency in fully breastfed infants at 6 months of age: comparison of data from 6 studies. Am J Cli n Nutr 2009;89:1433-1440.
29. European Food Safety Authority (EFSA). EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific opinion on the appropriateage for introduction of complementary feeding of infants. EFSA Journal 2009;7:1423.
30. Kramer MS, Kakuma R: The optimal duration of exclusive breastfeeding: a systematic review. Adv Exp Med Biol 2004;554:63-77.
31. Brown KH: Breastfeeding and complementary feeding of children up to 2 years of age. Nestle Nutr Workshop Ser Pediatr Program 2007;60:1-13.
32. Hurrell R, Egli I: Iron bioavailability and dietary reference values. Am J Clin Nutr 2010;91:1461S-1467S.
33. Andrews NC, Schmidt PJ: Iron homeostasis. Annu Rev Physiol 2007;69:69-85.
34. Hallberg L, Brune M, Rossander L: Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate. Am J Clin Nutr 1989;49:140-144.
35. Hurrell RF, Juillerat MA, Reddy MB, Lynch SR, Dassenko SA, Cook JD: Soy protein, phytate, and iron absorption in humans. Am J Clin Nutr 1992;56:573-578.
36. Hallberg L, Hulthen L: Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron. Am J Clin Nutr 2000;71:1147-1160.
37. Gibson RS, Perlas L, Hotz C: Improving the bioavailability of nutrients in plant foods at the household level. Proc Nutr Soc 2006;65:160-168.
38. Davidsson L: Approaches to improve iron bioavailability from complementary foods. J Nutr 2003;133:1560S-1562S.
39. Egli I, Davidsson L, Juillerat MA, Barclay D, Hurrell RF: The influence of soaking and germination on the phytase activity and phytic acid content of grains and seeds potentially useful for complementary feeding. J Food Sci 2002;67:3484-3488.
40. Hurrell RF, Reddy MB, Juillerat MA, Cook JD: Degradation of phytic acid in cereal porridges improves iron absorption by human subjects. Am J Clin Nutr 2003;77:1213-1219.
41. Troesch B, Egli I, Zeder C, Hurrell RF, de Pee S, Zimmermann MB: Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods. Am J Clin Nutr 2009;89:539-544.
42. Lind T, Lonnerdal B, Persson LA, Stenlund H, Tennefors C, Hernell O: Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and serum zinc: a randomized intervention in infants from 6 to 12 months of age. Am J Clin Nutr 2003;78:168-175.
43. Leung AK, Sauve RS: Whole cow's milk in infancy. Paediatr Child Health 2003;8:419-421.
44. Ziegler EE: Adverse effects of cow's milk in infants. Nestle Nutr Workshop Ser Pediatr Program 2007;60:185-196.
45. Michaelsen KF, Hoppe C, Lauritzen L, Molgaard C: Whole cow's milk: why, what and when? Nestle Nutr Workshop Ser Pediatr Program 2007;60:201-216.
46. Bramhagen AC, Virtanen M, Siimes MA, Axelsson I: Transferrin receptor in children and its correlation with iron status and types of milkcon sumption. Acta Paediatr 2003;92:671-675.
47. Gunnarsson BS, Thorsdottir I, Palsson G: Associations of iron status with dietary and other factors in 6-year-old children. Eur J Clin Nutr 2007;61:398-403.
48. Krebs NF: Meat as an early complementary food for infants: implications for macro- and micronutrient intakes. Nestle Nutr Workshop Ser Pediatr Program 2007;60:221-229.
49. Kleinman RE (ed): American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, ed 6. Elk Grove Village, American Academy of Pediatrics, 2009.
50. Allen LH: To what extent can food-based approaches improve micronutrient status? Asia Pac J Clin Nutr 2008;17(suppl 1):103-105.
51. Kongkachuichai R, Napatthalung P, Charoensiri R: Heme and nonheme iron content of animal products commonly consumed in Thailand. J Food Compost Anal 2002;15:389-398.
52. Thane CW, Walmsley CM, Bates CJ, Prentice A, Cole TJ: Risk factors for poor iron status in British toddlers: further analysis of data from the national diet and nutrition survey of children aged 1. 5-4. 5 years. Public Health Nutr 2000;3:433-440.
53. Thorsdottir I, Gunnarsson BS, Atladottir H, Michaelsen KF, Palsson G: Iron status at 12 months of age - Effects of body size, growth and diet in a population with high birth weight. Eur J Clin Nutr 2003;57:505-513.
54. Engelmann MD, Sandstrom B, Michaelsen KF: Meat intake and iron status in late infancy: an intervention study. J Pediatr Gastroenterol Nutr 1998;26:26-33.
55. Szymlek-Gay EA, Ferguson EL, Heath AL, Gray AR, Gibson RS: Food-based strategies improve iron status in toddlers: a randomized controlled trial. Am J Clin Nutr 2009;90:1541-1551.
56. Fox MK, Pac S, Devaney B, Jankowski L: Feeding infants and toddlers study: what foods are infants and toddlers eating? J Am Diet Assoc 2004;104:s22-s30. (Pubitemid 40013714)
57. Dee DL, Sharma AJ, Cogswell ME, Grummer-Strawn LM, Fein SB, Scanlon KS: Sources of supplemental iron among breastfed infants during the first year of life. Pediatrics 2008;122(suppl 2):S98-S104.
58. Allen LH: Interventions for micronutrient deficiency control in developing countries: past, present and future. J Nutr 2003;133:3875S-3878S.
59. Hallberg L, Hoppe M, Andersson M, Hulthen L: The role of meat to improve the critical iron balance during weaning. Pediatrics 2003;111:864-870.
60. Pachon H, Dominguez MR, Creed-Kanashiro H, Stoltzfus RJ: Acceptability and safety of novel infant porridges containing lyophilized meat powder and iron-fortified wheat flour. Food Nutr Bull 2007;28:35-46.
61. Grillenberger M, Murphy SP, Neumann CG, Bwibo NO, Verhoef H, Hautvast JG: The potential of increased meat intake to improve iron nutrition in rural Kenyan schoolchildren. Int J Vita m Nutr Res 2007;77:193-198.
62. Geerligs PD, Brabin BJ, Omari AA: Food prepared in iron cooking pots as an intervention for reducing iron deficiency anaemia in developing countries: a systematic review. J Hum Nutr Diet 2003;16:275-281.
63. Sharieff W, Dofonsou J, Zlotkin S: Iscooking food in iron pots an appropriate solution for the control of anaemia in developing countries? A randomised clinical trial in Benin. Public Health Nutr 2008;11:971-977.
64. Talley L, Woodruff BA, Seal A, Tripp K, Mselle LS, Abdalla F, Bhatia R, Mirghani Z: Evaluation of the effectiveness of stainless steel cooking pots in reducing iron-deficiency anaemia in food aid-dependent populations. Public Health Nutr 2010;13:107-115.
65. Storcksdieckgenannt Bonsmann S, Hurrell RF: The impact of trace elements from plants on human nutrition: a case for biofortification; in Bañuelos GS, Lin ZQ (eds): Development and Uses of Biofortified Agricultural Products. Boca Raton, CRC Press, 2009, pp 1-15.
66. Lucca P, Hurrell R, Potrykus I: Fighting iron deficiency anemia with iron-rich rice. J Am Coll Nutr 2002;21:184S-190S.
67. Hoppler M, Schonbachler A, Meile L, Hurrell R F, Walczyk T: Ferritin-iron is released during boiling and in vitro gastric digestion. J Nutr 2008;138:878-884.
68. Baltussen R, Knai C, Sharan M: Iron fortification and iron supplementation are cost-effective interventions to reduce iron deficiency in four subregions of the world. J Nutr 2004;134:2678-2684.
69. Horton S: The economics of food fortification. J Nutr 2006;136:1068-1071.
70. World Health Organization (ed): Guidelines on Food Fortification with Micronutrients, ed 2. Geneva, World Health Organization and Food and Agriculture Organization of the United Nations, 2006, pp 1-341.
71. Hurrell RF, Ranum P, de Pee S, Biebinger R, Hulthen L, Johnson Q, Lynch S: Revised recommendations for iron fortification of wheat flour and an evaluation of the expected impact of current national wheat flour fortification programs. Food Nutr Bull 2010;31(1 suppl):S7-S21.
72. Mannar MG: Successful food-based programmes, supplementation and fortification. J Pediatr Gastroenterol Nutr 2006;43(suppl 3):S47-S53.
73. Hurrell R, Egli I: Optimizing the bioavailability of iron compounds for food fortification; in Kraemer K, Zimmermann MB (eds): Nutritional Anemia. Basel, Sight and Life Press, 2007, pp 77-97.
74. World Health Organization: Recommendations on Wheat and Maize Flour Fortification Meeting Report: Interim Consensus Statement. Geneva, World Health Organization, 2009.
75. Hurrell RF, Reddy MB, Dassenko SA, Cook JD: Ferrous fumarate fortification of a chocolate drink powder. Br J Nutr 1991;65:271-283.
76. Moore W, Grant F, Kratky Z, Bothwell T, Rodenstein M, Streekstra H, Turner E, Wreesmann C: A model for calculating the cost of employing iron absorption enhancement strategies in fortification programs. Int J Vitam Nutr Res 2004;74:463-466.
77. Zimmermann MB: The potential of encapsulated iron compounds in food fortification: a review. Int J Vitam Nutr Res 2004;74:453-461.
78. Moretti D, Zimmermann MB, Wegmuller R, Walczyk T, Zeder C, Hurrell RF: Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans. Am J Clin Nutr 2006;83:632-638.
79. Hurrell R: Linking the bioavailability of iron compounds to the efficacy of iron-fortified foods. Int J Vitam Nutr Res 2007;77:166-173.
80. Hurrell RF: Iron fortification: its efficacy and safety in relation to infections. Food Nutr Bull 2007;28(4 Suppl):S585-S594.
81. Wang B, Zhan S, Xia Y, Lee L: Effect of sodium iron ethylenediaminetetra- acetate (NaFeEDTA) on haemoglobin and serum ferritin in iron-deficient populations: a systematic review and meta-analysis of randomised and quasi-randomised controlled trials. Br J Nutr 2008;100:1169-1178.
82. Zlotkin S, Arthur P, Antwi KY, Yeung G: Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. Am J Clin Nutr 2001;74:791-795.
83. Dewey KG, Yang Z, Boy E: Systematic review and meta-analysis of home fortification of complementary foods. Matern Child Nutr 2009;5:283-321.
84. Ip H, Hyder SM, Haseen F, Rahman M, Zlotkin SH: Improved adherence and anaemia cure rates with flex ible administration of micronutrient sprinkles: a new public health approach to anaemia control. Eur J Clin Nutr 2009;63:165-172.
85. World Health Organization Secretariat on behalf of the participants to the Consultation: Conclusions and recommendations of the WHO consultation on prevention and control of iron deficiency in infants and young children in malaria-endemic areas. Food Nutr Bull 2007;28:S621-S627.
86. Christofides A, Asante KP, Schauer C, Sharieff W, Owusu-Agyei S, Zlotkin S: Multi-micronutrient sprinkles including a low dose of iron provided as microencapsulated ferrous fumarate improves haematologic indices in anaemic children: a randomized clinical trial. Matern Child Nutr 2006;2:169-180.
87. Hirve S, Bhave S, Bavdekar A, Naik S, Pandit A, Schauer C, Christofides A, Hyder Z, Zlotkin S: Low dose 'sprinkles' - An innovative approach to treat iron deficiency anemia in infants and young children. Indian Pediatr 2007;44:91-100.
88. Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG: Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana. Am J Clin Nutr 2008;87:929-938.
89. de Pee S, Bloem MW: Current and potential role of specially formulated foods and food supplements for preventing malnutrition among 6- to 23-month-old children and for treating moderate malnutrition among 6- to 59-months-old children. Food Nutr Bull 2009;30:S434-S463.
90. Isanaka S, Nombela N, Djibo A, Poupard M, Van Beckhoven D, Gaboulaud V, Guerin PJ, Grais RF: Effect of preventive supplementation with ready-to-use therapeutic food on the nutritional status, mortality, and morbidity of children aged 6 to 60 months in Niger: a cluster randomized trial. JAMA 2009;301:277-285.
91. Chaparro CM, Dewey KG: Use of lipid-based nutrient supplements (LNS) to improve the nutrient adequacy of general food distribution rations for vulnerable sub-groups in emergency settings. Matern Child Nutr 2010;6(suppl 1):1-69.
92. Stoltzfus R, Dreyfus ML: Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia (Edited by INACG, WHO and UNICEF). Washington, ILSI Press, 1998.
93. Iannotti LL, Tielsch JM, Black MM, Black RE: Iron supplementation in early childhood: health benefits and risks. Am J Clin Nutr 2006;84:1261-1276.
94. Gera T, Sachdev HP, Nestel P, Sachdev SS: Effect of iron supplementation on haemoglobin response in children: systematic review of randomised controlled trials. J Pediatr Gastroenterol Nutr 2007;44:468-486. (Pubitemid 46578073)
95. World Health Organization, United Nations Children's Fund: Iron Supplementation of Young Children in Regions Where Malaria Transmission Is Intense and Infectious Disease Highly Prevalent. Joint Statement. Geneva, World Health Organization, 2006.
96. Cavalli-Sforza T, Berger J, Smitasiri S, Viteri F: Weekly iron-folic acid supplementation of women of reproductive age: impact overview, lessons learned, expansion plans, and contributions toward achievement of the millennium development goals. Nutr Rev 2005;63:S152-S158.
97. World Health Organization: Weekly Iron-Folic Acid Supplementation (WIFS) in Women of Reproductive Age: Its Role in Promoting Optimal Maternal and Child Health. Position Statement. Geneva, World Health Organization, 2009.
98. Beasley NM, Tomkins AM, Hall A, Lorri W, Kihamia CM, Bundy DA: The impact of weekly iron supplementation on the iron status and growth of adolescent girls in Tanzania. Trop Med Int Hea lth 2000;5:794-799.
99. Leenstra T, Kariuki SK, Kurtis JD, Oloo AJ, Kager PA, ter Kuile FO: The effect of weekly iron and vitamin A supplementation on hemog lobin levels and iron status in adolescent schoolgirls in western Kenya. Eur J Clin Nutr 2009;63:173-182.
100. Wijaya-Erhardt M, Erhardt JG, Untoro J, Karyadi E, Wibowo L, Gross R: Effect of daily or weekly multiple-micronutrient and iron foodlike tablets on body iron stores of Indonesian infants aged 6-12 months: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2007;86:1680-1686.
101. Azeredo CM, Cotta RM, Sant'Ana LF, Franceschini Sdo C, Ribeiro Rde C, Lamounier JA, Pedron FA: Greater effectiveness of daily iron supplementation scheme in infants. Rev Saude Publica 2010;44:230-239.
102. Sungthong R, Mo-Suwan L, Chongsuvivatwong V, Geater AF: Once weekly is superior to daily iron supplementation on height gain but not on hematological improvement among schoolchildren in Thailand. J Nutr 2002;132:418-422.
103. Schümann K, Solomons NW: Efficacy and safety of iron administration in juvenile populations. Ann Nestlé Engl 2010;68:132-140.
104. World Health Organization, United Nations Children's Fund: Focusing on Anaemia. Towards an Integrated Approach for Effective Anaemia Control. Joint Statement by the World Health Organization and the United Nations Children's Fund. Geneva, World Health Organization, 2004.
105. Lynch SR: Interaction of iron with other nutrients. Nutr Rev 1997;55:102-110.
106. Zimmermann MB: The influence of iron status on iodine utilization and thyroid function. Annu Rev Nutr 2006;26:367-389.
107. Muthayya S, Eilander A, Transler C, Thomas T, van der Knaap HC, Srinivasan K, van Klinken BJ, Osendarp SJ, Kurpad AV: Effect of fortification with multiple micronutrients and n-3 fatty acids on growth and cognitive performance in Indian schoolchildren: the CHAMPION (Children's Health and Mental Performance Influenced by Optimal Nutrition) study. Am J Clin Nutr 2009;89:1766-1775.
108. Osei AK, Rosenberg IH, Houser RF, Bulusu S, Mathews M, Hamer DH: Communitylevel micronutrient fortification of school lunch meals improved vitamin A, folate, and iron status of schoolchildren in Himalayan villages of India. J Nutr 2010;140:1146-1154.
109. Allen LH, Peerson JM, Olney DK: Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient-deficient children and adults. J Nutr 2009;139:1022-1030.
110. Gera T, Sachdev HP, Nestel P: Effect of combining multiple micronutrients with iron supplementation on Hb response in children: systematic review of randomized controlled trials. Public Health Nutr 2009;12:756-773.
111. Chaparro CM: Setting the stage for child health and development: prevention of iron def icienc y in early infancy. J Nutr 2008;138:2529-2533.
112. Pena-Rosas JP, Viteri FE: Effects and safety of preventive oral iron or iron + folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev 2009;CD004736.
113. Preziosi P, Prual A, Galan P, Daouda H, Bou reima H, Hercberg S: Effectofiron supplementation on the iron status of pregnant women: consequences for newborns. Am J Clin Nutr 1997;66:1178-1182.
114. Viteri FE, Berger J: Importance of pre-pregnancy and pregnancy iron status: can longterm weekly preventive iron and folic acid supplementation achieve desirable and safe status? Nutr Rev 2005;63:S65-S76.
115. Rahimy MC, Fanou L, Somasse YE, Gangbo A, Ahouignan G, Alihonou E: When to start supplementary iron to prevent iron deficiency in early childhood in sub-Saharan Africa setting. Pediatr Blood Cancer 2007;48:544-549.
116. Allen LH, Peerson JM: Impact of multiple micronutrient versus iron-folic acid supplements on maternal anemia and micronutrient status in pregnancy. Food Nutr Bull 2009;30:S527-S532.
117. Cogswell ME, Kettel-Khan L, Ramakrishnan U: Iron supplement use among women in the United States: science, policy and practice. J Nutr 2003;133:1974S-1977S.
118. Siega-Riz AM, Hartzema AG, Turnbull C, Thorp J, McDonald T, Cogswell ME: The effects of prophylactic iron given in prenatal supplements on iron status and birth outcomes: a randomized controlled trial. Am J Obstet Gynecol 2006;194:512-519.
119. Rioux FM, LeBlanc CP: Iron supplementation during pregnancy: what are the risks and benefits of current practices? Appl Physiol Nutr Metab 2007;32:282-288.
120. Eneroth H, El Arifeen S, Persson LA, Lonnerdal B, Hossain MB, Stephensen CB, Ekstrom EC: Maternal multiple micronutrient supplementation has limited impact on micronutrient status of Bangladeshi infants compared with standard iron and folic acid supplementation. J Nutr 2010;140:618-624.
121. Shrimpton R, Huffman SL, Zehner ER, Darnton-Hill I, Dalmiya N: Multiple micronutrient supplementation during pregnancy in developing-country settings: policy and program implications of the results of a meta-analysis. Food Nutr Bull 2009;30:S556-S573.
122. Shah PS, Ohlsson A: Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis. CMAJ 2009;180:E99-E108.
123. Dalmiya N, Darnton-Hill I, Schultink W, Shrimpton R: Multiple micronutrient supplementation during pregnancy: a decade of collaboration in action. Food Nutr Bull 2009;30:S477-S479.
124. Vaidya A, Saville N, Shrestha BP, Costello AM, Manandhar DS, Osrin D: Effects of antenatal multiple micronutrient supplementation on children's weight and size at 2 years of age in Nepal: follow-up of a double-blind randomised controlled trial. Lancet 2008;371:492-499.
125. Hutton EK, Hassan ES: Late versus early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials. JAMA 2007;297:1241-1252.
126. World Health Organization: Infant and Young Child Feeding: Model Chapter for Textbooks for Medical Students and Allied Health Professionals. Geneva, World Health Organization, 2009.
127. World Health Organization, Centers for Disease Control and Prevention: Assessing the Iron Status of Populations, ed 2 (Including Literature Reviews). Geneva, World Health Organization, 2007, pp 1-108.