Multi-micronutrient Sprinkles including a low dose of iron provided as microencapsulated ferrous fumarate improves haematologic indices in anaemic children: A randomized clinical trial

Maternal and Child Nutrition

Volumn 2, Issue 3, 2006, Pages 169-180

  Christofides, Anna ^a,b   Asante, Kwaku Poku ^c   Schauer, Claudia ^a,b   Sharieff, Waseem ^a,b,d   Owusu Agyei, Seth ^c   Zlotkin, Stanley ^a,b,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c Health Research Unit Ghana Health Service   (Ghana)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Ferric pyrophosphate; Ferrous fumarate; Ferrous sulphate; Iron deficiency anaemia; Iron dose; Randomized clinical trial; Sprinkles

Indexed keywords

ASCORBIC ACID; COLECALCIFEROL; DESCOTE; FERRIC PYROPHOSPHATE; FERRITIN; FERROUS FUMARATE; FERROUS SULFATE; FOLIC ACID; GLUCONATE ZINC; RETINOL ACETATE; SPRINKLES; SUNACTIVE FE; TRACE ELEMENT; TRANSFERRIN RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; BLOOD ANALYSIS; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; FECES COLOR; FEMALE; FERRITIN BLOOD LEVEL; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN DETERMINATION; HUMAN; IRON DEFICIENCY ANEMIA; IRON THERAPY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; SIDE EFFECT; TOOTH DISCOLORATION; TREATMENT DURATION;

ADMINISTRATION, ORAL; ANEMIA, IRON-DEFICIENCY; CAPSULES; DIETARY SUPPLEMENTS; DIPHOSPHATES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FERROUS COMPOUNDS; FOOD, FORTIFIED; GHANA; HEMOGLOBINS; HUMANS; INFANT; IRON; MALE; MICRONUTRIENTS; PATIENT COMPLIANCE; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 33744792351     PISSN: 17408695     EISSN: 17408709     Source Type: Journal    
DOI: 10.1111/j.1740-8709.2006.00060.x     Document Type: Article

References (30)

1. Behrman J. R., Alderman H. & Hoddinott J. (2004) Copenhagen Consensus: Hunger and Malnutrition. Copenhagen Consesus: Copenhagen, Denmark.
2. Brotanek J. M., Halterman J. S., Auinger P., Flores G. & Weitzman M. (2005) Iron deficiency, prolonged bottle-feeding, and racial/ethnic disparities in young children. Archives of Pediatrics and Adolescent Medicine 159, 1038-1042.
3. Cohen A. R. & Seidl-Friedman J. (1988) HemoCue system of hemoglobin measurement. Evaluation in anemic and nonanemic children. American Journal of Clinical Pathology 90, 302-305.
4. Davidsson L., Kastenmayer P., Szajewska H., Hurrell R. F. & Barclay D. (2000) Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate. American Journal of Clinical Nutrition 71, 1597-1602.
5. Fidler M. C., Walczyk T., Davidsson L., Zeder C., Sakaguchi N., Juneja L. R. et al. (2004) A micronised, dispersible ferric pyrophosphate with high relative bioavailability in man. British Journal of Nutrition 91, 107-112.
6. Hallberg L., Hulten L. & Gramatkovski E. (1997) Iron absorption from the whole diet in men. How effective is the regulation of iron absorption? American Journal of Clinical Nutrition 66, 347-356.
7. Lartey A., Manu A., Brown K. H., Peerson J. M. & Dewey K. G. (1999) A randomized, community-based trial of the effects of improved, centrally processed complementary foods on growth and micronutrient status of Ghanaian infants from 6 to 12 mo of age. American Journal of Clinical Nutrition 70, 391-404.
8. Le Hung Q., de Vries P. J., Giao P. T., Binh T. Q., Nam N. V. & Kager P. A. (2005) Anemia, malaria and hookworm infections in a Vietnamese ethnic minority. Southeast Asian Journal of Tropical Medicine and Public Health 36, 816-821.
9. Lind T., Lonnerdal B., Stenlund H., Ismail D., Seswandhana R., Ekstrom E. C. et al. (2003) A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: Interactions between iron and zinc. American Journal of Clinical Nutrition 77, 883-890.
10. Mamiro P. S., Kolsteren P., Roberfroid D., Tatala S., Opsomer A. S. & Van Camp J. H. (2005) Feeding practices and factors contributing to wasting, stunting, and iron-deficiency anaemia among 3-23-month old children in Kilosa district, rural Tanzania. Journal of Health, Population and Nutrition 23, 222-230.
11. Miles L. E. M., Lipschitz, D. A., Bieber, C. P. & Cook, J. D. (1974) Measurement of serum ferritin by a 2-site immunoradiometric assay. Analytical Biochemistry 61, 209-224.
12. Mora J. O. (2002) Iron supplementation: Overcoming technical and practical barriers. Journal of Nutrition 132 (4 Suppl.), 853S-855S.
13. Nestel P. & Alnwick D. (eds) (1997) Iron/Multi- Micronutrient Supplements for Young Children. Summary and conclusions of a consultation held at UNICEF Copenhagen, Denmark 19-20 August 1996. Washington, DC, International Life Sciences Institute, May 1997.
14. Quarshie K. & Amoaful E. (eds) (1998) Study on Anemia in Ghana. Proceedings of the Workshop on Dissemination of Findings of Vitamin A and Anaemia Prevalence Surveys Accra. Ghana: Ministry of Health, Ghana and UNICEF, 1998.
15. Sandeep A., Manorama G. & Anju A. (2003) Role of the Parasight-F test in the diagnosis of complicated Plasmodium Falciparum malarial infection. The Brazilian Journal of Infectious Diseases 7, 332-338.
16. Sazawal S., Black R. E., Ramsan M., Chwaya H. M., Stoltzfus R. J., Dutta A. et al. (2006) Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Community-based, randomised, placebo-controlled trial. Lancet 367, 133-143.
17. Schultink W., Merzenich M., Gross R., Shrimpton R. & Dillon D. (1997) Effects of iron-zinc supplementation on the iron, zinc, and vitamin A status of anaemic pre-school children in Indonesia. Food and Nutrition Bulletin 18, 311-317.
18. Spinelli M. G., Marchioni D. M., Souza J. M., Souza S. B. & Szarfarc S. C. (2005) Risk factors for anemia among 6- to 12-month-old children in Brazil. Revista Panamericana de Salud Pública 17, 84-91.
19. Stoltzfus R. J., Kvalsvig J. D., Chwaya H. M., Montresor A., Albonico M., Tielsch J. M. et al. (2001) Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: Double blind, placebo controlled study. British Medical Journal 323, 1389-1393.
20. Tielsch J. M., Khatry S., Stoltzfus R. J., Katz J., LeClerq S. C., Adhikari R. et al. (2006) Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: community-based, cluster-randomised, placebo-controlled trial. Lancet 367, 144-152.
21. The Micronutrient Initiative (2004) Vitamin & Mineral Deficiency: A Global Progress Report. The Micronutrient Initiative: Ottawa.
22. Tondeur M. C., Schauer C. S., Christofides A. L., Asante K. P., Newton S., Serfass R. E. et al. (2004) Determination of iron absorption from intrinsically labeled microencapsulated ferrous fumarate (sprinkles) in infants with different iron and hematologic status by using a dual-stable-isotope method. American Journal of Clinical Nutrition 80, 1436-1444.
23. WHO Statement. (2006) Iron Supplementation of Young Children in Regions Where Malaria Transmission Is Intense and Infectious Disease Highly Prevalent. WHO: Heneva. Available at: http://www.who.int/ childadolescent-health/-New_Publications/CHILD_HEALTH/ WHO_FCH_CAH_06.2.pdf
24. WHO/UNICEF (2001) Iron Deficiency Anemia: Assessment, Prevention and Control. A Guide for Programme Managers. WHO/UNICEF: Geneva.
25. Zelee Hill Z., Kirkwood B. & Edmond K. (2004) Family and Community Practices That Promote Child Survival, Growth and Development: A Review of the Evidence. WHO: Geneva.
26. Zlotkin S., Arthur P., Antwi K. & Yeung G. (2001) Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. American Journal of Clinical Nutrition 74, 791-795.
27. Zlotkin S., Antwi K. Y., Schauer C. & Yeung G. (2003a) Use of microencapsulated iron (II) fumarate sprinkles to prevent recurrence of anaemia in infants and young children at high risk. Bulletin of the World Health Organization 81, 108-115.
28. Zlotkin S., Arthur P., Schauer C., Antwi K. Y., Yeung G. & Piekarz A. (2003b) Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children. Journal of Nutrition 133, 1075-1080.
29. Zlotkin S. H., Schauer C., Christofides A., Sharieff W. & Hyder S. M. (2005) Micronutrient Sprinkles to control childhood anemia: A simple powdered sachet may be the key to addressing a global problem. PLoS Medicine 2, DOI: 10.1371/journal.pmed.0020001.
30. Zlotkin S. H., Schauer C., Owusu-Agyei S., Wolfson J., Tondeur M., Asante K. et al. (2006) Demonstrating zinc and iron bioavailability from intrinsically labeled microencapsulated ferrous fumarate and zinc gluconate sprinkles in young children. Journal of Nutrition 136, 920-925.