Hepatic Sinusoidal membrane transport of anionic drugs mediated by anion transporter npt

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 3, 1998, Pages 1391-1396

  Yabuuchi, Hikaru ^a   Tamai, Ikuml ^a   Morita, Kyoko ^b   Kouda, Tomoko ^b   Miyamoto, Ken Ichi ^b   Takeda, Eiji ^b   Tsuji, Akira ^a,c  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; AMPICILLIN; APALCILLIN; BETA LACTAM ANTIBIOTIC; CARRIER PROTEIN; CEFALEXIN; CEFALORIDINE; CEFALOTIN; CEFIXIME; CEFOPERAZONE; CEFRADINE; CEFTIZOXIME; CHLORIDE; CLOXACILLIN; CYCLACILLIN; DICLOXACILLIN; NAFCILLIN; PENICILLIN G; PROBENECID; SODIUM; ANION TRANSPORT PROTEIN; ANTIINFECTIVE AGENT;

ANIMAL CELL; ANION TRANSPORT; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TRANSPORT; EXTRACELLULAR SPACE; IMMUNOCYTOCHEMISTRY; LIVER CELL; LIVER CELL MEMBRANE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TRANSPORT KINETICS; ANIMAL; DOSE RESPONSE; LIVER; METABOLISM; MOUSE; PH; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; XENOPUS LAEVIS;

ANIMALS; ANION TRANSPORT PROTEINS; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHLORIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; LIVER; MICE; PENICILLIN G; XENOPUS LAEVIS;

EID: 0032160713     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Barza N, Brush J, Bergeron NC, Kemmotsu O and Weinstein L (1975) Extraction of antibiotics from the circulation by liver and kidney: Effect of probenecid. J Infect Dis 131:886-897.
2. Biber J, Güster M, Magagnin S, Hayes G, Werner A, Lötscher M, Kaissling B and Magagnin S, Werner A, Markovich D, Sorribas V, Stange G, Biber J and Murer H (1993) Expression cloning of human and rat renal cortex Na/Pi cotransport. Proc Natl Acad Sei USA 90:5979-5983.
3. Biber J, Custer M, Magagnin S, Hayes G, Werner A, Lötscher M, Kaissling B and Murer H (1996) Renal Na/Pi-cotransporters. Kidney Int 49:981-985.
4. Biber J, Custer M, Werner A, Kaissling B and Murer H (1993) Localization of Na/Pi cotransporter, in rabbit kidney proximal tubules. II. Localization by immunohistochemistry. Pflügers Arch 424:210-215.
5. Bossuyt X, Müller M, Hagenbuch B and Meier PJ (1993) Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther 276:891-896.
6. Busch AE, Waldegger S, Herzer T, Biber J, Markovich D, Murer H and Lang F ( 1994) Electrophysiological analysis of Na+/Pi cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes. Proc Natl Acad Sei USA 91:8205-8208.
7. Busch AE, Schuster A, Waldegger S, Wagner CA, Zempel G, Broer S, Biber J, Murer H and Lang F ( 1996) Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions. Proc Natl Acad Sei USA 93:5347-5351.
8. Busch AE, Wagner CA, Schuster A, Waldegger S, Biber J, Murer H and Lang F (1995) Properties of electrogenic Pi transport by a human renal brush border Na+/Pi transporter. J Am Soc Nephrol 6:1547-1551.
9. Chong SS, Kristjansson K, Zoghbi H and Hughes MR (1993) Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. Genomics 18:355-359.
10. Chong SS, Kozak CA, Liu L, Kristjansson K, Dünn ST, Bourdeau JE and Hughes MR (1995) Cloning, genetic mapping, and expression analysis of a mouse renal sodiumdependent phosphate cotransporter. Am J Physiol 268:F1038-F1045.
11. Forti CC, Guerra NC, Barbaro AN, Rossi T and Biagi GL (1975) The influence of lipophilic character on the biliary excretion of penicillins in isolated perfused liver. Boll Soc Ital Biol Sper 51:406-409.
12. Hagenbuch B, Stieger B, Foguet M, Lubbert H and Meier PJ (1991) Functional expression cloning and characterization of the hepatocyte Na/bile acid cotransport system. Proc Natl Acad Sei USA 88:10629-10633.
13. Hagenbuch B, Meier PJ (1994) Molecular cloning, chromosomal localization, and functional characterization of a human liver Na/bile acid cotransporter. J Clin Invest 93:1326-1331.
14. Hayes G, Busch AE, Lang F, Biber J and Murer H (1995) Protein kinase C consensus sites and the regulation of renal Na/Pi-cotransport (NaPi-2) expressed in Xenopus laevis oocytes. Pflügers Arch 430:830-836.
15. Hirom PC, Millburn P, Smith RL and Williams RT (1972) Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions. Biochem J 129:1071-1077.
16. Hisano S, Haga H, Miyamoto K, Takeda E and Fukui Y (1996) The basic amino acid transporter (rBAT)-like immunoreactivity in paraventricular and supraoptic m agnocellular neurons of the rat hypothalamus. Brain Res 710:299-302.
17. +-independent organic anion transporter. Proc Natl Acad Sei USA 91:133-137.
18. Kirn CM, Goldstein JL and Brown MS (1992) cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function. J Biol Chem 297:23113-231121.
19. Kind AC, Tupasi TE, Standiford HC and Kirby WMM (1970) Mechanisms responsible for plasma levels of nafcillin lower than of oxacillin. Arch Intern Med 125:685-690.
20. Kullak-Ublick G-A, Hagenbuch B, Stieger B, Wolkoff A and Meier PJ (1994) Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology 20:411-416.
21. Magagnin S, Werner A, Markovich D, Sorribas V, Stange G, Biber J and Murer H (1993) Expression cloning of human and rat renal cortex Na/Pi cotransport. Proc Natl Acad Sei USA 90:5979-5983.
22. Matsui H, Yano K and Okuda T (1982) Pharmacokinetics of the cephalosporin SM1652 in mice, rats, rabbits, dogs and rhesus monkeys. Antimicrob Agents Chemother 22:213-217.
23. Mizusawa S, Nishimura S and Seela F (1986) Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP. Nucleic Acids Res 14:1319-1324.
24. Nijssen HMJ, Pijning T, Meijer DKF and Groothuis GMM (1991) Mechanistic aspects of uptake and sinusoidal efflux of dibromosulfophtalein in the isolated perfused rat liver. Biochem Pharmacol 42:1997-2002.
25. Oude Elferink RPJ (1989) Biliary secretion of antibiotics. The mechanism of ceftriaxon secretion. In Bile and Bile Duct Abnormalities (Tytgat GNJ and Huibregste K, eds), pp 9-14, Thieme Verlag, New York.
26. Ryrfeldt A (1971) Biliary excretion of penicillins in the rat. J Pharm Pharmacol 23:463-464.
27. Ryrfeldt A, Bodin NO and Hansson E (1973) Biliary excretion of ampicillin, azidocillin and benzylpenicillin in the rat. Ada Pharmacol Toxicol 33:219-228.
28. Saito H, Masuda S and Imii K (1996) Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J Biol Chem 271:20719-20725.
29. Sathirakul K, Suzuki H, Yasuda K, Hanano M, Tagaya O, Horie T and Sugiyama Y ( 1993) Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats. J Pharmacol Exp Ther 265:1301-1312.
30. Sathirakul K, Suzuki H, Yamada T, Hanano M and Sugiyama Y (1994) Multiple transport systems for organic anions across the bile canalicular membrane. J Pharmacol Exp Ther 268:65-73.
31. Sekine T, Watanabe N, Hosoyamada M, Kanai Y and Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
32. Shi XY, Ford AC, Jacquemin E, Burk RD, Bai S, Novikoff PM, Stieger B, Meier I'J and Wolkoff AW (1994) Immunologie distribution of an organic anion transport protein (oatp) in rat liver and kidney. Hepatology 20:205A.
33. Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, Shiraga T, Miyamoto K, Takeca E, Higashida H and Tsuji A (1997) The predominant contribution of oligopepticie transporter PepTl to intestinal absorption of -lactam antibiotics in the rat small intestine. J Pharm Pharmacol 49:796-801.
34. Tamai I, Terasaki T and Tsuji A (1985) Evidence for the existence of a common transport system of -lactam antibiotics in isolated rat hepatocytes. J Antibiot (Tokyo) 38:1774-1780.
35. Tamai I and Tsuji A (1987) Transport mechanism of cephalexin in isolated hepatocytes. J Pharmacobio-Dyn 10:632-638.
36. Terasaki T, Tamai I, Takanosu K, Nakashima E and Tsuji A (1986) Kinetic evidence for a common transport route of benzylpenicillin and probenecid by freshly prepared hepatocytes in rats. Influence of sodium ion, organic anions, amino acids and peptides on benzylpenicillin uptake. J Pharmacobio-Dyn 9:18-28.
37. Tsuji A, Terasaki T, Takanosu K, Tamai I and Nakashima E (1986) Uptake of benzylpenicillin, cefpiramide and cefazolin by freshly prepared rat hepatocytes. Biochem Pharmacol 35:151-158.
38. Tsuji A, Terasaki T, Tamai I and Takeda K (1990) In vivo evidence for carriermediated uptake of/3-lactam antibiotics through organic anion transport system i:i rat kidney and liver. J Pharmacol Exp Ther 253:315-320.
39. Verkade HJ, Wolbers MJ, Havinga R, Uges DR, Vonk RJ and Kuipers F (1990) The uncoupling of biliary lipid from bile acid secretion by organic anions in the ral. Gastroenterology 99:1485-1492.
40. de Vries MH, Groothuis GMM, Mulder GJ, Nguyen H and Meijer DKF (1985) Secretion of the organic anion harmol sulfate from liver into blood. Evidence for ;\ carrier mediated mechanism. Biochem Pharmacol 34:2129-2135.
41. Wolkoff AW, Samuelson AC, Johansen KL, Nakata R, Withers DM and Sosiak A (1987) Influence of Cl~ on organic anion transport in short term cultured rat hepatocytes and isolated perfused rat liver. J Clin Invest 79:1259-1268.
42. Werner A, Moore ML, Mantei N, Biber J, Semenza G and Murer H (1991) Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex. Proc Natl Acad Sei USA 88:9608-9612.
43. Wright WE and Line VD (1980) Biliary excretion of cephalosporins in rats: Influence of molecular weight. Antimicrob Agents Chemother 17:842-846.
44. Yamazaki M, Suzuki H and Sugiyama Y (1996) Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobitics. Pharm Res 13:497-513.