Improvement of lymphocyte resistance against H2O2-induced DNA damage in Sprague-Dawley rats after eight weeks of a wild blueberry (Vaccinium angustifolium)-enriched diet

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 703, Issue 2, 2010, Pages 158-162

  Del Bo', Cristian ^a   Martini, Daniela ^a   Vendrame, Stefano ^a   Riso, Patrizia ^a   Ciappellano, Salvatore ^a   Klimis Zacas, Dorothy ^b   Porrini, Marisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MAINE   (United States)

Author keywords

Anthocyanins; Comet assay; DNA damage; Rats; TRAP assay; Wild blueberry

Indexed keywords

HYDROGEN PEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BLUEBERRY; BODY WEIGHT; CONTROLLED STUDY; DIETARY INTAKE; DNA DAMAGE; FOOD INTAKE; GROWTH RATE; LYMPHOCYTE; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; VACCINIUM ANGUSTIFOLIUM;

ANIMALS; ANTHOCYANINS; ANTIOXIDANTS; BLUEBERRY PLANT; BODY WEIGHT; DIET; DNA DAMAGE; EATING; GROWTH; HYDROGEN PEROXIDE; LYMPHOCYTES; MALE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

RATTUS; VACCINIUM; VACCINIUM ANGUSTIFOLIUM;

EID: 78549252380     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.08.013     Document Type: Article

References (32)

1. Beecher G.R. Flavonoids in foods. Antioxidant Food Supplements in Human Health 1999, Academic Press, San Diego, CA, pp. 269-281.
2. Graf B.A., Milbury P.E., Blumberg J.B. Flavonols, flavones, flavanones, and human health: epidemiological evidence. J. Med. Food 2005, 8:281-290.
3. Hooper L., Kroon P.A., Rimm E.B., Cohn J.S., Harvey I., Le Cornu K.A., Ryder J.J., Hall W.L., Cassidy A. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2008, 88:38-50.
4. Arts I.C. A review of the epidemiological evidence on tea, flavonoids, and lung cancer. J. Nutr. 2008, 38:1561S-1566S.
5. Qin Y., Xia M., Ma J., Hao Y., Liu J., Mou H., Cao L., Ling W. Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am. J. Clin. Nutr. 2009, 90:485-492.
6. Norton C., Kalea A.Z., Harris P.D., Klimis-Zacas D. Wild blueberry-rich diets affect the contractile machinery of the vascular smooth muscle in the Sprague-Dawley rat. J. Med. Food 2005, 8:8-13.
7. Kalea A.Z., Clark K., Schuschke D.A., Klimis-Zacas D.J. Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. J. Med. Food 2009, 12:21-28.
8. Youdin K.A., Martin A., Joseph J.A. Incorporation of the elderberry anthocyanins by endothelial cells increase protection against oxidative stress. Free Radic. Biol. Med. 2000, 29:51-60.
9. Youdin K.A., Shukitt-Hale B., MacKinnon S., Kalt W., Joseph J.A. Polyphenolics enhance red blood cell resistance to oxidative stress: in vitro and in vivo. Biochim. Biophys. Acta 2000, 1523:117-122.
10. Acquaviva R., Russo A., Galvano F., Galvano G., Barcellona M.L., Li Volti G., Vanella A. Cyanidin and cyanidin 3-O-beta-d-glucoside as DNA cleavage protectors and antioxidants. Cell Biol. Toxicol. 2003, 19:243-252.
11. Russo A., La Fauci L., Acquaviva R., Campis A., Raciti G., Scifo C., Renis M., Galvano G., Vanella A., Galvano F. Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin 3-O-β-d-glucoside. J. Biochem. 2005, 16:31-37.
12. Lazzé M.C., Pizzala R., Savio M., Stivala L.A., Prosperi E., Bianchi L. Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. Mutat. Res. 2003, 535:103-115.
13. Giovannelli L., Testa G., De Filippo C., Cheynier V., Clifford M.N., Dolara P. Effect of complex polyphenols and tannins from red wine on DNA oxidative damage of rat colon mucosa in vivo. Eur. J. Nutr. 2000, 39:207-212.
14. Prior R.L., Cao G., Martin A., Sofic E., McEwen J., O'Brien C., Lischner N., Ehlenfeldt M., Kalt W., Krewer G., Mainland C.M. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. J. Agric. Food Chem. 1998, 46:2686-2693.
15. Kalt W., Ryan D.A., Duy J.C., Prior R.L., Ehlenfeldt M.K., Vander Kloet S.P. Interspecific variation in anthocyanins, phenolics, and antioxidant capacity among genotypes of highbush and lowbush blueberries (Vaccinium section cyanococcus spp.). J. Agric. Food Chem. 2001, 49:4761-4767.
16. Del Bo' C., Ciappellano S., Klimis-Zacas D., Martini D., Gardana C., Riso P., Porrini M. Anthocyanin absorption, metabolism, and distribution from a wild blueberry-enriched diet (Vaccinium angustifolium) is affected by diet duration in the Sprague-Dawley rat. J. Agric. Food Chem. 2010, 58:2491-2497.
17. Dulebohn R.V., Yi W., Srivastava A., Akoh C.C., Krewer G., Fischer J.G. Effects of blueberry (Vaccinium ashei) on DNA damage, lipid peroxidation, and phase II enzyme activities in rats. J. Agric. Food Chem. 2008, 56:11700-11706.
18. Wilms L.C., Boots A.W., de Boer V.C.J., Maas L.M., Pachen D.M.F.A, Gottschalk R.W.H., Ketelslegers H.B., Godschalk R.W.L., Haenen G.R.M.M., van Schooten F.J., Kleinjans J.C.S. Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis 2007, 28:1800-1806.
19. Grace M.H., Ribnicky D.M., Kuhn P., Poulev A., Logendra S., Yousef G.G., Raskin I., Lila M.A. Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine 2009, 16:406-415.
20. Pellegrini N., Serafini M., Colombi B., Del Rio D., Salvatore D., Bianchi M., Brighenti F. Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J. Nutr. 2003, 133:2812-2819.
21. Ghiselli A., Serafini M., Maiani G., Azzini E., Ferro-Luzzi A. A fluorescence-based method for measuring total plasma antioxidant capability. Free Radic. Biol. Med. 1995, 18:29-36.
22. Riso P., Pinder A., Santangelo A., Porrini M. Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?. Am. J. Clin. Nutr. 1999, 69:712-718.
23. Del Bo' C., Kristo A.K., Kalea A.Z., Ciappellano S., Riso P., Porrini M., Klimis-Zacas D.J. The temporal effect of a wild blueberry (Vaccinium angustifolium)-enriched diet on vasomotor tone in the Sprague-Dawley rat. Nutr. Metab. Cardiovasc. Dis. 2010, 10.1016/j.numecd.2010.05.004.
24. Aiyer H.S., Kichambare S., Gupta R.C. Prevention of oxidative DNA damage by bioactive berry components. Nutr. Cancer 2008, 60:36-42.
25. Ramirez-Tortosa C., Andersen O.M., Gardner P.T., Morrice P.C., Wood S.G., Duthie S.J., Collins A.R., Duthie G.C. Anthocyanin rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats. Free Radic. Biol. Med. 2001, 31:1033-1037.
26. Barros D., Amaral O.B., Izquierdo I., Geracitano L., do Carmo Bassols Raseira M., Henriques A.T., Ramirez M.R. Behavioral and genoprotective effects of Vaccinium berries intake in mice. Pharmacol. Biochem. Behav. 2006, 84:229-234.
27. Traustadóttir T., Davies S.S., Stock A.A., Su Y., Heward C.B., Roberts L.J., Harman S.M. Tart cherry juice decreases oxidative stress in healthy older men and women. J. Nutr. 2009, 139:1896-1900.
28. Shih P.H., Yeh C.T., Yen G.C. Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J. Agric. Food Chem. 2007, 55:9427-9435.
29. Boateng J., Verghese M., Shackelford L., Walker L.T., Khatiwada J., Ogutu S., Williams D.S., Jones J., Guyton M., Asiamah D., Henderson F., Grant L., DeBruce M., Johnson A., Washington S., Chawan C.B. Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Food Chem. Toxicol. 2007, 45:725-732.
30. Felgines C., Texier O., Garcin P., Besson C., Lamaison J.L., Scalbert A. Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet. Mol. Nutr. Food Res. 2009, 53:1098-1103.
31. Felgines C., Texier O., Besson C., Fraisse D., Lamaison J.L., Rémésy C. Blackberry anthocyanins are slightly bioavailable in rats. J. Nutr. 2002, 132:1249-1253.
32. Nguyen T., Sherratt P.J., Pickett C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 2003, 43:233-260.