Anthocyanin absorption, metabolism, and distribution from a wild blueberry-enriched diet (vaccinium angustifolium) is affected by diet duration in the sprague-dawley rat

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 4, 2010, Pages 2491-2497

  Del Bò, Christian ^a   Ciappellano, Salvatore ^a   Klimis Zacas, Dorothy ^b   Daniela, Martini ^a   Claudio, Gardana ^a   Riso, Patrizia ^a   Porrini, Marisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MAINE   (United States)

Author keywords

Absorption; Anthocyanins; Excretion; Metabolites; Rat; Vaccinium angustifolium; Wild blueberry

Indexed keywords

RATTUS; VACCINIUM; VACCINIUM ANGUSTIFOLIUM;

EID: 77249175334     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf903472x     Document Type: Article

References (40)

1. Bushway, R. B.; McGann, D. F.; Cook, W. P.; Bushway, A. A. Mineral and vitamin content of lowbush blueberries (Vaccinium angustifolium). J. Food Sci 1983, 48,1878-1880.
2. Bagchi, D.; Sen, C. K.; Bagchi, M.; Atalay, M. Anti-agiogenic, antioxidant, anti-carcinogenic properties of a novel anthocyaninrich berry extract formula. Biochemistry (Moscow) 2004, 69, 75-80.
3. (3) Tsuda, T.; Horio, F.; Osawa, T. Dietary cyanidin 3-O-beta-diglucoside increases ex vivo oxidation resistance of serum, in rats, Lipids 1998, 33, 583-588. (Pubitemid 28283708)
4. Mazza, G.; Kay, C. D.; Cottrell, T.; Holub, B. J. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J. Agric. Food Chem. 2002, 50, 7731-7737.
5. Norton, C.; Kalea, A. Z.; Harris, P. D.; Klimis-Zacas, D. J. Wild blueberry-rich diets affect the contractile machinery of the vascular smooth muscle in the Sprague-Dawley rat. J. Med. Food 2005, 8, 8-13.
6. Kalea, A. Z.; Clark, K.; Schuschke, D. A.; Klimis-Zacas, D. J. Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. J. Med, Food. 2009, 12, 21-28.
7. Youdim, K. A.; McDonald, J.; Kalt, W.; Joseph, J. A. Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults. J. Nutr. Biochem. 2002, 13, 282-288.
8. (8) Wang, J.; Mazza, G. Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-α actived RAW 2647 macrophages. J. Agric. Food Chem. 2002, 50, 850-857. (Pubitemid 34163634)
9. Prior, R. L.; Cao, G. Analysis of botanicals and dietary supplements for antioxidant capacity: a review. J. AOAC Int. 2000, 83, 950-956.
10. Wang, H.; Cao, G.; Prior, R. L. Oxygen radical absorbing capacity of anthocyanins. J. Agric. Food Chem. 1997, 45, 304-309.
11. (11) Passamonti, S.; Vrhovsek, U.; Vanzo, A.; Mattivi, F. The stomach as a site for anthocyanins absorption from food. FEBS Lett. 2003, 5, 210-213. (Pubitemid 36628064)
12. Morazzoni, P.; Livio, S.; Scilingo, A.; Malandrino, S. Vaccinium myrtillus anthocyanosides pharmacokinetics in rats. Drug Res. 1991, 41, 128-131.
13. (13) Miyazawa, T.; Nakagawa, K.; Kudo, M.; Muraishi, K.; Someya, K. Direct intestinal absorption of red fruit anthocyanins, cyanidin-3glucoside and cyanidin-3,5-diglucoside, into rats and humans. J. Agric. Food Chem. 1999, 47,1083-1091. (Pubitemid 29182967)
14. (14) Matsumoto, H.; Inaba, H.; Kishi, M.; Tominaga, S.; Hirayama, M.; Tsuda, T. Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in. the blood as the intact forms. J. Agric. Food Chem. 2001, 49, 1546-1551. (Pubitemid 32884991)
15. (15) McGhie, T. K.; Walton, M. C. The bioavailability and absorption, of anthocyaninis: towards a better understanding. Mol. Nutr. Food Res. 2007, 51, 702-713. (Pubitemid 47083681)
16. (16) Talavera, S.; Felgines, C.; Texier, O.; Besson, C.; Lamaison, J. L.; Rémésy, C. Anthocyanins are efficiently absorbed from the stomach in anaesthetized rats. J. Nutr. 2003, 133, 4178-4182. (Pubitemid 37505495)
17. Felgines, C.; Texier, O.; Besson, C.; Fraisse, D.; Lamaison, J. L.; Rémésy, C Blackberry anthocyanins are slightly bioavailable in rats. J. Nutr. 2002, 132, 1249-1253.
18. (18) Lapidot, T.; Harel, S.; Granit, R.; Kanner, J. Bioavailability of red wine anthocyanins as detected in human urine. J. Agric. Food Chem. 1998, 46,4297-4302. (Pubitemid 128488532)
19. (19) Murkovic, M.; Mulleder, U.; Adam, U.; Pfannhauser, W. Detection of anthocyanins from elderberry juice in human urine. J. Sci. Food. Agric. 2001, 81, 934-937. (Pubitemid 32652997)
20. Nielsen, I. L. F.; Dragsted, L. O.; Ravin-Haren, G.; Freese, R.; Rasmussen, S. E. Absorption and excretion of black currant anthocyanins in humans and Watanabe heritable hyperlipidemic rabbits. J. Agric. Food Chem. 2003, 51, 2813-2820.
21. (21) Cao, G.; Muccitelli, H. U.; Sánchez-Moreno, C.; Prior, R. L. Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study, Am. J. Clin. Nutr. 2001, 73, 920-926. (Pubitemid 32405989)
22. Matuszewski, B. K.; Constanzer, M. L.; Chavez-Eng, C. M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/M.S. Anal. Chem. 2003, 75, 3019-3030.
23. Kalt, W.; Blumberg, J. B.; McDonald, J. E.; Vinqvist-Tymchuk, M. R.; Fillmore, S. A.; Graf, B. A.; O'Leary, J. M.; Milbury, P. E. Identification of anthocyanins in the liver, eye, and brain, of blueberry-fed pigs. J. Agric. Food Chem. 2008, 56, 705-712.
24. Matsumoto, H.; Ichiyanagi, T.; Lida, H.; Ito, K.; Tsuda, T.; Hirayama, M.; Konishi, T. Ingested Delphinidin-3-rutinoside is primarily excreted to urine as the intact form, and to bile as the methylated form in rats. J. Agric. Food Chem. 2006, 54, 578-582.
25. (25) Ohnishi, R.; Ito, H.; Kasajima, N.; Kaneda, M.; Kariyama, R.; Kumon, H.; Hatano, T.; Yoshida, T. Urinary excretion of anthocyanins in humans after cranberry juice ingestion. Biosci. Biotechnol Biochem. 2006, 70,1681-1687. (Pubitemid 44124927)
26. Tian, Q.; Giusti, M. M.; Stoner, G. D.; Schwartz, S. J. Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. J. Agric. Food Chem. 2006, 54,1467-1472.
27. (27) Felgines, C.; Talavéra, S.; Texier, O.; Besson, C.; Fogliano, V.; Lamaison, J. L.; la Fauci, L.; Galvano, G.; Rémésy, C.; Galvano, F. Absorption and metabolism, of red orange juice anthocyanins in rats. Br. J. Nutr. 2006, 95, 898-904. (Pubitemid 43805376)
28. Prior R. L. Absorption and Metabolism of Anthocyanins: Potential Health Effects. In Phytochemicals Mechanisms of Action; Meskin M. S., Bidlack W. R., Davies A. J., Lewis D. S., Randolph R. K., Eds.; CRC Press: Boca Raton, FL, 2004; pp 1-19.
29. Kurilich, A. C.; Clevidence, B. A.; Britz, S. J.; Simon, P. W.; Novotny, J. A. Plasma and urine responses are lower for acylated vs nonacylated anthocyanins from raw and cooked purple carrots. J. Agric. Food Chem. 2005, 53, 6537-6542.
30. Wu, X.; Cao, G.; Prior, R. L. Absortpion and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry. J. Nutr. 2002, 132,1865-1871.
31. McGhie, T. K.; Ainge, G. D.; Barnett, L. E.; Cooney, J. M.; Jensen, D. J. Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolised by both humans and rats J. Agric. Food Chem. 2003, 51, 4539-4548.
32. Wu, X.; Pittman, H. E.; Hager, T.; Hager, A.; Howard, L; Prior, R. L. Phenolic acids in black raspberry and in the gastrointestinal tract of pigs following ingestion of black raspberry. Mol. Nutr. Food Res. 2009, 53, 76-84.
33. (33) Vitaglione, P.; Donnarumma, G.; Napolitano, A.; Galvano, F.; Gallo, A.; Scalfi, L.; Fogliano, V. Protocatechuic acid is the major human metabolite of cyanidin-glucoside J. Nutr. 2007, 137, 2043-2048. (Pubitemid 47367263)
34. Toromanović, J.; Kovac-Besović, E.; Sapcanin, A.; Tahirović, I.; Rimpapa, Z.; Kroyer, G.; Sofić, E Urinary hippuric acid after ingestion of edible fruits, Bosn. J. Basic. Med. Sci. 2008, 8, 38-43.
35. (35) El Mohsen, M. A.; Marks, J.; Kuhnle, G.; Moore, K.; Debnam, E.; Kaila Srai, S.; Rice-Evans, C.; Spencer, J. P. Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats. Br. J. Nutr. 2006, 95, 51-58. (Pubitemid 43250711)
36. Aura, A. M. Microbial metabolism of dietary phenolic compounds in the colon, Phytochem. Rev. 2008, 7, 407-429.
37. (37) Gonthier, M. P.; Verny, M. A.; Besson, C.; Rèmèsy, C.; Scalbert, A. Chlorogenic acid bioavailability largely depends on its metabolism, by gut microflora in rats. J. Nutr. 2003,133,1853-1859. (Pubitemid 36666525)
38. Vissers, M. D.; Zock, P. L.; Roodenburg, A. J. C.; Leene, R.; Katon, B. Olive oil phenols are absorbed in humans. J. Nutr. 2002, 132, 409-417.
39. Nurmi, T.; Mursu, J.; Heinonen, M.; Nurmi, A.; Hiltunen, R.; Voutilainen, S. Metabolism of berry anthocyanins to phenolic acids in humans. J. Agric. Food Chem. 2009, 57, 2274-2281.
40. (40) Talavera, S.; Felgines, C.; Texier, O.; Besson, C.; Gil-Izquierdo, A.; Lamaison, J. L.; Rémésy, C. Anthocyanin metabolism, in rats and their distribution to digestive area, kidney, and brain. J. Agric. Food Chem. 2005, 53, 3902-3908. (Pubitemid 40936741)